Conserved WD40 repeat domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/BING4CT (NUC141) domain containing protein, putative

Species:

Leishmania major

UniProt:

Q9NF84_LEIMA

TriTrypDb:

LmjF.23.0620 , LMJLV39_230014300 , LMJSD75_230014600

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0030684	preribosome	3	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q9NF84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NF84

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0030490	maturation of SSU-rRNA	9	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	547	551	PF00656	0.547
CLV_NRD_NRD_1	26	28	PF00675	0.645
CLV_NRD_NRD_1	440	442	PF00675	0.305
CLV_NRD_NRD_1	482	484	PF00675	0.484
CLV_NRD_NRD_1	494	496	PF00675	0.486
CLV_NRD_NRD_1	540	542	PF00675	0.523
CLV_NRD_NRD_1	610	612	PF00675	0.528
CLV_NRD_NRD_1	641	643	PF00675	0.733
CLV_NRD_NRD_1	74	76	PF00675	0.454
CLV_NRD_NRD_1	80	82	PF00675	0.435
CLV_PCSK_KEX2_1	129	131	PF00082	0.501
CLV_PCSK_KEX2_1	39	41	PF00082	0.547
CLV_PCSK_KEX2_1	470	472	PF00082	0.596
CLV_PCSK_KEX2_1	494	496	PF00082	0.519
CLV_PCSK_KEX2_1	640	642	PF00082	0.726
CLV_PCSK_KEX2_1	676	678	PF00082	0.593
CLV_PCSK_KEX2_1	73	75	PF00082	0.484
CLV_PCSK_KEX2_1	80	82	PF00082	0.452
CLV_PCSK_KEX2_1	84	86	PF00082	0.464
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.501
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.585
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.614
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.683
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.524
CLV_PCSK_PC7_1	70	76	PF00082	0.512
CLV_PCSK_PC7_1	80	86	PF00082	0.408
CLV_PCSK_SKI1_1	228	232	PF00082	0.343
CLV_PCSK_SKI1_1	317	321	PF00082	0.348
CLV_PCSK_SKI1_1	371	375	PF00082	0.397
CLV_PCSK_SKI1_1	412	416	PF00082	0.380
CLV_PCSK_SKI1_1	444	448	PF00082	0.358
CLV_PCSK_SKI1_1	529	533	PF00082	0.575
CLV_PCSK_SKI1_1	542	546	PF00082	0.570
CLV_PCSK_SKI1_1	59	63	PF00082	0.481
CLV_PCSK_SKI1_1	601	605	PF00082	0.592
CLV_PCSK_SKI1_1	612	616	PF00082	0.534
CLV_PCSK_SKI1_1	676	680	PF00082	0.691
CLV_PCSK_SKI1_1	85	89	PF00082	0.553
DEG_SPOP_SBC_1	2	6	PF00917	0.742
DEG_SPOP_SBC_1	233	237	PF00917	0.415
DOC_MAPK_gen_1	129	135	PF00069	0.390
DOC_MAPK_gen_1	178	187	PF00069	0.438
DOC_MAPK_gen_1	607	617	PF00069	0.511
DOC_PP1_RVXF_1	140	146	PF00149	0.333
DOC_PP2B_LxvP_1	417	420	PF13499	0.321
DOC_PP2B_LxvP_1	633	636	PF13499	0.647
DOC_PP4_FxxP_1	288	291	PF00568	0.407
DOC_USP7_MATH_1	233	237	PF00917	0.381
DOC_USP7_MATH_1	3	7	PF00917	0.818
DOC_USP7_MATH_1	377	381	PF00917	0.502
DOC_USP7_MATH_1	496	500	PF00917	0.545
DOC_USP7_MATH_1	597	601	PF00917	0.681
DOC_USP7_UBL2_3	523	527	PF12436	0.673
DOC_USP7_UBL2_3	545	549	PF12436	0.593
DOC_USP7_UBL2_3	554	558	PF12436	0.601
DOC_USP7_UBL2_3	604	608	PF12436	0.625
DOC_USP7_UBL2_3	84	88	PF12436	0.560
DOC_WW_Pin1_4	287	292	PF00397	0.341
DOC_WW_Pin1_4	378	383	PF00397	0.470
DOC_WW_Pin1_4	9	14	PF00397	0.637
LIG_14-3-3_CanoR_1	112	118	PF00244	0.423
LIG_14-3-3_CanoR_1	130	134	PF00244	0.393
LIG_14-3-3_CanoR_1	165	170	PF00244	0.511
LIG_14-3-3_CanoR_1	180	188	PF00244	0.500
LIG_14-3-3_CanoR_1	317	323	PF00244	0.458
LIG_14-3-3_CanoR_1	334	340	PF00244	0.400
LIG_14-3-3_CanoR_1	412	418	PF00244	0.340
LIG_14-3-3_CanoR_1	495	501	PF00244	0.655
LIG_14-3-3_CanoR_1	556	562	PF00244	0.573
LIG_14-3-3_CanoR_1	59	67	PF00244	0.485
LIG_APCC_ABBA_1	399	404	PF00400	0.302
LIG_APCC_ABBAyCdc20_2	579	585	PF00400	0.668
LIG_BRCT_BRCA1_1	410	414	PF00533	0.306
LIG_CSL_BTD_1	288	291	PF09270	0.329
LIG_FHA_1	148	154	PF00498	0.360
LIG_FHA_1	2	8	PF00498	0.646
LIG_FHA_1	263	269	PF00498	0.454
LIG_FHA_1	277	283	PF00498	0.294
LIG_FHA_1	348	354	PF00498	0.338
LIG_FHA_1	39	45	PF00498	0.496
LIG_FHA_1	413	419	PF00498	0.380
LIG_FHA_1	445	451	PF00498	0.333
LIG_FHA_1	504	510	PF00498	0.677
LIG_FHA_1	526	532	PF00498	0.584
LIG_FHA_1	591	597	PF00498	0.531
LIG_FHA_1	62	68	PF00498	0.599
LIG_FHA_1	98	104	PF00498	0.592
LIG_FHA_2	247	253	PF00498	0.403
LIG_FHA_2	290	296	PF00498	0.488
LIG_FHA_2	336	342	PF00498	0.510
LIG_GBD_Chelix_1	445	453	PF00786	0.302
LIG_GBD_Chelix_1	617	625	PF00786	0.596
LIG_Integrin_isoDGR_2	315	317	PF01839	0.258
LIG_IRF3_LxIS_1	348	354	PF10401	0.453
LIG_LIR_Apic_2	428	434	PF02991	0.337
LIG_LIR_Gen_1	236	247	PF02991	0.364
LIG_LIR_Gen_1	345	353	PF02991	0.362
LIG_LIR_Gen_1	380	390	PF02991	0.382
LIG_LIR_Gen_1	411	420	PF02991	0.302
LIG_LIR_Nem_3	241	247	PF02991	0.434
LIG_LIR_Nem_3	345	351	PF02991	0.391
LIG_LIR_Nem_3	380	386	PF02991	0.382
LIG_LIR_Nem_3	411	417	PF02991	0.321
LIG_NRP_CendR_1	677	680	PF00754	0.692
LIG_PCNA_yPIPBox_3	670	679	PF02747	0.542
LIG_Pex14_1	370	374	PF04695	0.384
LIG_PTB_Apo_2	423	430	PF02174	0.302
LIG_SH2_CRK	131	135	PF00017	0.517
LIG_SH2_CRK	390	394	PF00017	0.302
LIG_SH2_CRK	431	435	PF00017	0.321
LIG_SH2_GRB2like	431	434	PF00017	0.321
LIG_SH2_SRC	244	247	PF00017	0.431
LIG_SH2_SRC	431	434	PF00017	0.321
LIG_SH2_STAP1	131	135	PF00017	0.411
LIG_SH2_STAP1	342	346	PF00017	0.410
LIG_SH2_STAP1	631	635	PF00017	0.710
LIG_SH2_STAT5	204	207	PF00017	0.369
LIG_SH2_STAT5	225	228	PF00017	0.357
LIG_SH2_STAT5	244	247	PF00017	0.353
LIG_SH3_3	290	296	PF00018	0.379
LIG_SH3_3	376	382	PF00018	0.421
LIG_SUMO_SIM_par_1	349	356	PF11976	0.346
LIG_TRAF2_1	249	252	PF00917	0.434
LIG_TRAF2_1	338	341	PF00917	0.426
LIG_TRAF2_1	533	536	PF00917	0.665
LIG_TYR_ITIM	388	393	PF00017	0.302
LIG_UBA3_1	297	304	PF00899	0.548
MOD_CDK_SPxxK_3	378	385	PF00069	0.464
MOD_CK1_1	237	243	PF00069	0.420
MOD_CK1_1	347	353	PF00069	0.470
MOD_CK1_1	557	563	PF00069	0.567
MOD_CK1_1	6	12	PF00069	0.824
MOD_CK2_1	246	252	PF00069	0.397
MOD_CK2_1	335	341	PF00069	0.576
MOD_CK2_1	496	502	PF00069	0.654
MOD_CK2_1	530	536	PF00069	0.551
MOD_CK2_1	660	666	PF00069	0.816
MOD_GlcNHglycan	119	122	PF01048	0.544
MOD_GlcNHglycan	355	358	PF01048	0.350
MOD_GlcNHglycan	421	424	PF01048	0.347
MOD_GlcNHglycan	550	553	PF01048	0.571
MOD_GlcNHglycan	662	665	PF01048	0.702
MOD_GSK3_1	1	8	PF00069	0.746
MOD_GSK3_1	143	150	PF00069	0.353
MOD_GSK3_1	202	209	PF00069	0.426
MOD_GSK3_1	233	240	PF00069	0.357
MOD_GSK3_1	347	354	PF00069	0.362
MOD_GSK3_1	408	415	PF00069	0.390
MOD_GSK3_1	557	564	PF00069	0.562
MOD_GSK3_1	643	650	PF00069	0.793
MOD_LATS_1	410	416	PF00433	0.380
MOD_N-GLC_1	147	152	PF02516	0.342
MOD_NEK2_1	232	237	PF00069	0.410
MOD_NEK2_1	245	250	PF00069	0.330
MOD_NEK2_1	318	323	PF00069	0.459
MOD_NEK2_1	351	356	PF00069	0.462
MOD_NEK2_1	561	566	PF00069	0.538
MOD_NEK2_1	643	648	PF00069	0.683
MOD_PIKK_1	111	117	PF00454	0.432
MOD_PIKK_1	123	129	PF00454	0.410
MOD_PIKK_1	172	178	PF00454	0.406
MOD_PKA_1	129	135	PF00069	0.514
MOD_PKA_1	27	33	PF00069	0.627
MOD_PKA_1	494	500	PF00069	0.632
MOD_PKA_1	548	554	PF00069	0.572
MOD_PKA_2	111	117	PF00069	0.432
MOD_PKA_2	129	135	PF00069	0.389
MOD_PKA_2	179	185	PF00069	0.481
MOD_PKA_2	494	500	PF00069	0.632
MOD_PKA_2	561	567	PF00069	0.536
MOD_PKA_2	654	660	PF00069	0.710
MOD_PKA_2	69	75	PF00069	0.549
MOD_Plk_1	143	149	PF00069	0.382
MOD_Plk_1	188	194	PF00069	0.336
MOD_Plk_1	643	649	PF00069	0.783
MOD_Plk_2-3	38	44	PF00069	0.522
MOD_Plk_2-3	456	462	PF00069	0.302
MOD_Plk_4	129	135	PF00069	0.518
MOD_Plk_4	289	295	PF00069	0.407
MOD_Plk_4	413	419	PF00069	0.302
MOD_ProDKin_1	287	293	PF00069	0.348
MOD_ProDKin_1	378	384	PF00069	0.464
MOD_ProDKin_1	9	15	PF00069	0.636
MOD_SUMO_for_1	44	47	PF00179	0.589
MOD_SUMO_rev_2	47	56	PF00179	0.615
MOD_SUMO_rev_2	524	533	PF00179	0.581
MOD_SUMO_rev_2	536	544	PF00179	0.516
TRG_DiLeu_BaEn_1	32	37	PF01217	0.557
TRG_DiLeu_BaEn_4	591	597	PF01217	0.640
TRG_DiLeu_BaLyEn_6	293	298	PF01217	0.517
TRG_ENDOCYTIC_2	131	134	PF00928	0.413
TRG_ENDOCYTIC_2	239	242	PF00928	0.375
TRG_ENDOCYTIC_2	244	247	PF00928	0.347
TRG_ENDOCYTIC_2	383	386	PF00928	0.308
TRG_ENDOCYTIC_2	390	393	PF00928	0.293
TRG_ENDOCYTIC_2	92	95	PF00928	0.607
TRG_ER_diArg_1	493	495	PF00400	0.596
TRG_ER_diArg_1	640	642	PF00400	0.742
TRG_ER_diArg_1	67	70	PF00400	0.522
TRG_ER_diArg_1	73	75	PF00400	0.538
TRG_NLS_Bipartite_1	470	487	PF00514	0.592
TRG_NLS_MonoExtN_4	480	487	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ4	Leptomonas seymouri	81%	100%
A0A0S4IXY1	Bodo saltans	68%	100%
A0A1X0NYJ7	Trypanosomatidae	71%	100%
A0A3Q8IM25	Leishmania donovani	96%	100%
A0A3S5IR25	Trypanosoma rangeli	66%	100%
A4H6H1	Leishmania braziliensis	88%	100%
A4I0B3	Leishmania infantum	96%	100%
C9ZV23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AW77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%