LeishMANIAdb
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Hypothetical transmembrane protein L6586.03

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical transmembrane protein L6586.03
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q9NF82_LEIMA
TriTrypDb:
LmjF.23.0600 , LMJLV39_230014000 , LMJSD75_230014300 *
Length:
261

Annotations

LeishMANIAdb annotations

Unique kinetoplastid membrane protein. Protein duplicated in Leishmanniids as well as in T. rangeli.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

Q9NF82
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NF82

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.450
CLV_NRD_NRD_1 175 177 PF00675 0.750
CLV_NRD_NRD_1 95 97 PF00675 0.745
CLV_PCSK_FUR_1 93 97 PF00082 0.732
CLV_PCSK_KEX2_1 175 177 PF00082 0.750
CLV_PCSK_KEX2_1 95 97 PF00082 0.742
CLV_Separin_Metazoa 102 106 PF03568 0.487
DEG_SPOP_SBC_1 85 89 PF00917 0.377
DOC_MAPK_gen_1 52 62 PF00069 0.593
DOC_MAPK_MEF2A_6 55 64 PF00069 0.490
DOC_MAPK_RevD_3 68 83 PF00069 0.375
DOC_PP4_FxxP_1 149 152 PF00568 0.533
DOC_USP7_MATH_1 141 145 PF00917 0.600
DOC_USP7_MATH_1 150 154 PF00917 0.518
DOC_USP7_MATH_1 171 175 PF00917 0.567
DOC_USP7_MATH_1 219 223 PF00917 0.556
DOC_USP7_MATH_1 245 249 PF00917 0.560
DOC_USP7_MATH_1 41 45 PF00917 0.616
DOC_WW_Pin1_4 125 130 PF00397 0.549
DOC_WW_Pin1_4 137 142 PF00397 0.451
DOC_WW_Pin1_4 155 160 PF00397 0.391
LIG_14-3-3_CanoR_1 107 117 PF00244 0.433
LIG_Actin_WH2_2 14 32 PF00022 0.470
LIG_Clathr_ClatBox_1 71 75 PF01394 0.470
LIG_DLG_GKlike_1 96 103 PF00625 0.520
LIG_FHA_1 111 117 PF00498 0.536
LIG_FHA_1 118 124 PF00498 0.510
LIG_FHA_1 125 131 PF00498 0.436
LIG_FHA_1 13 19 PF00498 0.335
LIG_FHA_1 163 169 PF00498 0.472
LIG_FHA_1 189 195 PF00498 0.507
LIG_FHA_1 3 9 PF00498 0.393
LIG_FHA_1 33 39 PF00498 0.510
LIG_FHA_2 107 113 PF00498 0.453
LIG_GBD_Chelix_1 17 25 PF00786 0.533
LIG_IRF3_LxIS_1 59 65 PF10401 0.327
LIG_LIR_Apic_2 147 152 PF02991 0.532
LIG_LIR_Apic_2 255 261 PF02991 0.458
LIG_LIR_Gen_1 35 41 PF02991 0.696
LIG_LIR_Nem_3 35 39 PF02991 0.699
LIG_Pex14_2 59 63 PF04695 0.343
LIG_RPA_C_Fungi 227 239 PF08784 0.546
LIG_SH2_NCK_1 9 13 PF00017 0.470
LIG_SH2_STAP1 227 231 PF00017 0.651
LIG_SH2_STAT5 258 261 PF00017 0.677
LIG_SH2_STAT5 61 64 PF00017 0.533
LIG_SH3_3 201 207 PF00018 0.609
LIG_SUMO_SIM_par_1 14 19 PF11976 0.470
LIG_SUMO_SIM_par_1 239 244 PF11976 0.549
LIG_SUMO_SIM_par_1 69 76 PF11976 0.467
LIG_TRAF2_1 252 255 PF00917 0.655
LIG_UBA3_1 78 83 PF00899 0.491
LIG_WRC_WIRS_1 74 79 PF05994 0.470
MOD_CK1_1 144 150 PF00069 0.692
MOD_CK1_1 158 164 PF00069 0.513
MOD_CK1_1 180 186 PF00069 0.739
MOD_CK1_1 196 202 PF00069 0.621
MOD_CK1_1 244 250 PF00069 0.713
MOD_CK2_1 106 112 PF00069 0.545
MOD_CK2_1 249 255 PF00069 0.741
MOD_CK2_1 96 102 PF00069 0.723
MOD_GlcNHglycan 143 146 PF01048 0.736
MOD_GlcNHglycan 179 182 PF01048 0.819
MOD_GlcNHglycan 200 203 PF01048 0.604
MOD_GlcNHglycan 215 218 PF01048 0.669
MOD_GlcNHglycan 221 224 PF01048 0.655
MOD_GlcNHglycan 243 246 PF01048 0.694
MOD_GlcNHglycan 247 250 PF01048 0.670
MOD_GlcNHglycan 25 28 PF01048 0.279
MOD_GlcNHglycan 251 254 PF01048 0.621
MOD_GSK3_1 106 113 PF00069 0.535
MOD_GSK3_1 12 19 PF00069 0.502
MOD_GSK3_1 137 144 PF00069 0.653
MOD_GSK3_1 151 158 PF00069 0.529
MOD_GSK3_1 171 178 PF00069 0.619
MOD_GSK3_1 193 200 PF00069 0.667
MOD_GSK3_1 241 248 PF00069 0.785
MOD_N-GLC_1 212 217 PF02516 0.667
MOD_N-GLC_1 32 37 PF02516 0.626
MOD_NEK2_1 103 108 PF00069 0.483
MOD_NEK2_1 124 129 PF00069 0.503
MOD_NEK2_1 16 21 PF00069 0.462
MOD_NEK2_1 193 198 PF00069 0.627
MOD_NEK2_1 23 28 PF00069 0.439
MOD_NEK2_1 241 246 PF00069 0.552
MOD_NEK2_1 62 67 PF00069 0.533
MOD_NMyristoyl 1 7 PF02799 0.579
MOD_PKA_1 175 181 PF00069 0.695
MOD_PKA_2 106 112 PF00069 0.530
MOD_PKA_2 175 181 PF00069 0.695
MOD_Plk_1 32 38 PF00069 0.626
MOD_Plk_4 158 164 PF00069 0.669
MOD_Plk_4 16 22 PF00069 0.470
MOD_Plk_4 73 79 PF00069 0.446
MOD_ProDKin_1 125 131 PF00069 0.691
MOD_ProDKin_1 137 143 PF00069 0.548
MOD_ProDKin_1 155 161 PF00069 0.469
MOD_SUMO_rev_2 44 51 PF00179 0.544
TRG_DiLeu_BaEn_1 255 260 PF01217 0.654
TRG_DiLeu_BaLyEn_6 237 242 PF01217 0.545
TRG_ENDOCYTIC_2 227 230 PF00928 0.702
TRG_ENDOCYTIC_2 61 64 PF00928 0.375
TRG_ER_diArg_1 104 107 PF00400 0.496
TRG_ER_diArg_1 92 95 PF00400 0.690

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IBQ7 Leishmania donovani 85% 100%
A4H6G9 Leishmania braziliensis 64% 100%
A4I0B1 Leishmania infantum 85% 100%
E9AW75 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS