LeishMANIAdb
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Hypothetical transmembrane protein L6586.04

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical transmembrane protein L6586.04
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q9NF81_LEIMA
TriTrypDb:
LmjF.23.0590 , LMJLV39_230013900 * , LMJSD75_230014200 *
Length:
411

Annotations

LeishMANIAdb annotations

Unique kinetoplastid membrane protein. Protein duplicated in Leishmanniids as well as in T. rangeli.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

Q9NF81
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NF81

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 272 276 PF00656 0.778
CLV_NRD_NRD_1 117 119 PF00675 0.484
CLV_NRD_NRD_1 131 133 PF00675 0.446
CLV_NRD_NRD_1 183 185 PF00675 0.473
CLV_NRD_NRD_1 307 309 PF00675 0.485
CLV_NRD_NRD_1 385 387 PF00675 0.504
CLV_NRD_NRD_1 79 81 PF00675 0.442
CLV_NRD_NRD_1 89 91 PF00675 0.391
CLV_PCSK_KEX2_1 117 119 PF00082 0.487
CLV_PCSK_KEX2_1 121 123 PF00082 0.464
CLV_PCSK_KEX2_1 131 133 PF00082 0.435
CLV_PCSK_KEX2_1 183 185 PF00082 0.473
CLV_PCSK_KEX2_1 307 309 PF00082 0.485
CLV_PCSK_KEX2_1 385 387 PF00082 0.504
CLV_PCSK_KEX2_1 79 81 PF00082 0.444
CLV_PCSK_KEX2_1 89 91 PF00082 0.389
CLV_PCSK_PC1ET2_1 121 123 PF00082 0.514
CLV_PCSK_PC7_1 117 123 PF00082 0.450
CLV_PCSK_PC7_1 381 387 PF00082 0.545
CLV_PCSK_SKI1_1 183 187 PF00082 0.487
CLV_PCSK_SKI1_1 190 194 PF00082 0.472
CLV_PCSK_SKI1_1 47 51 PF00082 0.527
CLV_PCSK_SKI1_1 97 101 PF00082 0.481
DEG_APCC_DBOX_1 55 63 PF00400 0.324
DOC_CKS1_1 214 219 PF01111 0.619
DOC_CKS1_1 294 299 PF01111 0.770
DOC_MAPK_gen_1 79 85 PF00069 0.650
DOC_PP2B_LxvP_1 10 13 PF13499 0.441
DOC_PP2B_LxvP_1 74 77 PF13499 0.332
DOC_PP4_FxxP_1 263 266 PF00568 0.762
DOC_USP7_MATH_1 215 219 PF00917 0.771
DOC_USP7_MATH_1 329 333 PF00917 0.651
DOC_WW_Pin1_4 213 218 PF00397 0.741
DOC_WW_Pin1_4 264 269 PF00397 0.734
DOC_WW_Pin1_4 293 298 PF00397 0.769
DOC_WW_Pin1_4 372 377 PF00397 0.692
LIG_14-3-3_CanoR_1 172 180 PF00244 0.766
LIG_14-3-3_CanoR_1 292 297 PF00244 0.720
LIG_14-3-3_CanoR_1 300 306 PF00244 0.667
LIG_14-3-3_CanoR_1 359 363 PF00244 0.755
LIG_Actin_WH2_2 14 32 PF00022 0.332
LIG_BIR_II_1 1 5 PF00653 0.575
LIG_BRCT_BRCA1_1 259 263 PF00533 0.779
LIG_EH1_1 22 30 PF00400 0.309
LIG_FHA_1 294 300 PF00498 0.728
LIG_FHA_1 33 39 PF00498 0.350
LIG_FHA_2 270 276 PF00498 0.780
LIG_FHA_2 309 315 PF00498 0.780
LIG_FHA_2 93 99 PF00498 0.684
LIG_GBD_Chelix_1 17 25 PF00786 0.332
LIG_GBD_Chelix_1 66 74 PF00786 0.381
LIG_Integrin_isoDGR_2 129 131 PF01839 0.425
LIG_Integrin_RGD_1 102 104 PF01839 0.394
LIG_Integrin_RGD_1 342 344 PF01839 0.549
LIG_LIR_Apic_2 260 266 PF02991 0.759
LIG_LIR_Apic_2 291 297 PF02991 0.700
LIG_LIR_Gen_1 35 41 PF02991 0.345
LIG_LIR_Nem_3 35 39 PF02991 0.347
LIG_Pex14_1 69 73 PF04695 0.332
LIG_SH2_CRK 294 298 PF00017 0.768
LIG_SH2_NCK_1 294 298 PF00017 0.768
LIG_SH2_STAT5 187 190 PF00017 0.743
LIG_SH2_STAT5 294 297 PF00017 0.765
LIG_SH2_STAT5 61 64 PF00017 0.332
LIG_SH3_3 174 180 PF00018 0.689
LIG_SH3_3 211 217 PF00018 0.619
MOD_CDK_SPxxK_3 293 300 PF00069 0.726
MOD_CK1_1 2 8 PF00069 0.444
MOD_CK1_1 200 206 PF00069 0.602
MOD_CK1_1 219 225 PF00069 0.529
MOD_CK1_1 237 243 PF00069 0.758
MOD_CK1_1 348 354 PF00069 0.697
MOD_CK1_1 361 367 PF00069 0.672
MOD_CK1_1 372 378 PF00069 0.597
MOD_CK1_1 398 404 PF00069 0.585
MOD_CK2_1 281 287 PF00069 0.659
MOD_CK2_1 308 314 PF00069 0.739
MOD_CK2_1 372 378 PF00069 0.654
MOD_CK2_1 85 91 PF00069 0.481
MOD_CK2_1 92 98 PF00069 0.559
MOD_Cter_Amidation 115 118 PF01082 0.679
MOD_Cter_Amidation 129 132 PF01082 0.532
MOD_Cter_Amidation 383 386 PF01082 0.605
MOD_GlcNHglycan 137 141 PF01048 0.568
MOD_GlcNHglycan 173 176 PF01048 0.684
MOD_GlcNHglycan 206 209 PF01048 0.647
MOD_GlcNHglycan 211 214 PF01048 0.672
MOD_GlcNHglycan 218 221 PF01048 0.583
MOD_GlcNHglycan 241 244 PF01048 0.683
MOD_GlcNHglycan 301 304 PF01048 0.731
MOD_GlcNHglycan 314 318 PF01048 0.485
MOD_GlcNHglycan 320 323 PF01048 0.544
MOD_GlcNHglycan 331 334 PF01048 0.548
MOD_GlcNHglycan 347 350 PF01048 0.699
MOD_GlcNHglycan 371 374 PF01048 0.748
MOD_GlcNHglycan 382 385 PF01048 0.609
MOD_GlcNHglycan 397 400 PF01048 0.601
MOD_GSK3_1 2 9 PF00069 0.490
MOD_GSK3_1 200 207 PF00069 0.692
MOD_GSK3_1 209 216 PF00069 0.647
MOD_GSK3_1 219 226 PF00069 0.515
MOD_GSK3_1 242 249 PF00069 0.661
MOD_GSK3_1 264 271 PF00069 0.746
MOD_GSK3_1 288 295 PF00069 0.624
MOD_GSK3_1 347 354 PF00069 0.797
MOD_GSK3_1 358 365 PF00069 0.635
MOD_GSK3_1 368 375 PF00069 0.610
MOD_N-GLC_1 190 195 PF02516 0.522
MOD_N-GLC_1 32 37 PF02516 0.417
MOD_N-GLC_2 52 54 PF02516 0.510
MOD_NEK2_1 171 176 PF00069 0.622
MOD_NEK2_1 23 28 PF00069 0.274
MOD_NEK2_1 299 304 PF00069 0.611
MOD_NEK2_1 3 8 PF00069 0.433
MOD_NEK2_1 313 318 PF00069 0.560
MOD_NEK2_1 362 367 PF00069 0.634
MOD_NEK2_1 62 67 PF00069 0.441
MOD_NEK2_1 85 90 PF00069 0.525
MOD_PK_1 257 263 PF00069 0.674
MOD_PKA_1 117 123 PF00069 0.594
MOD_PKA_2 117 123 PF00069 0.607
MOD_PKA_2 147 153 PF00069 0.609
MOD_PKA_2 171 177 PF00069 0.684
MOD_PKA_2 204 210 PF00069 0.675
MOD_PKA_2 237 243 PF00069 0.600
MOD_PKA_2 299 305 PF00069 0.621
MOD_PKA_2 329 335 PF00069 0.578
MOD_PKA_2 358 364 PF00069 0.704
MOD_PKA_2 380 386 PF00069 0.781
MOD_Plk_1 104 110 PF00069 0.484
MOD_Plk_1 136 142 PF00069 0.583
MOD_Plk_1 200 206 PF00069 0.654
MOD_Plk_1 32 38 PF00069 0.417
MOD_Plk_2-3 281 287 PF00069 0.607
MOD_Plk_4 225 231 PF00069 0.679
MOD_Plk_4 358 364 PF00069 0.650
MOD_ProDKin_1 213 219 PF00069 0.683
MOD_ProDKin_1 264 270 PF00069 0.675
MOD_ProDKin_1 293 299 PF00069 0.725
MOD_ProDKin_1 372 378 PF00069 0.617
MOD_SUMO_rev_2 46 51 PF00179 0.421
TRG_ER_diArg_1 183 185 PF00400 0.606
TRG_ER_diArg_1 235 238 PF00400 0.630
TRG_ER_diArg_1 306 308 PF00400 0.784
TRG_ER_diArg_1 385 387 PF00400 0.624
TRG_ER_diArg_1 79 81 PF00400 0.546
TRG_ER_diLys_1 407 411 PF00400 0.674
TRG_NES_CRM1_1 278 289 PF08389 0.720
TRG_Pf-PMV_PEXEL_1 184 189 PF00026 0.602
TRG_Pf-PMV_PEXEL_1 190 194 PF00026 0.590
TRG_Pf-PMV_PEXEL_1 79 84 PF00026 0.511

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZ47 Leptomonas seymouri 35% 96%
A0A3Q8IEI6 Leishmania donovani 90% 100%
A4H6H5 Leishmania braziliensis 64% 100%
A4I0B0 Leishmania infantum 90% 100%
E9AW74 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS