BHLH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9NEE1_LEIMA

TriTrypDb:

LmjF.04.0610 , LMJLV39_040011200 , LMJSD75_040011600

Length:

168

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9NEE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NEE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.579
CLV_NRD_NRD_1	116	118	PF00675	0.515
CLV_NRD_NRD_1	95	97	PF00675	0.570
CLV_PCSK_FUR_1	114	118	PF00082	0.606
CLV_PCSK_KEX2_1	113	115	PF00082	0.502
CLV_PCSK_KEX2_1	116	118	PF00082	0.502
CLV_PCSK_KEX2_1	95	97	PF00082	0.485
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.502
CLV_PCSK_SKI1_1	117	121	PF00082	0.516
CLV_Separin_Metazoa	130	134	PF03568	0.444
DEG_SCF_TRCP1_1	137	143	PF00400	0.518
DEG_SPOP_SBC_1	148	152	PF00917	0.649
DOC_CDC14_PxL_1	47	55	PF14671	0.541
DOC_CKS1_1	20	25	PF01111	0.551
DOC_USP7_MATH_1	148	152	PF00917	0.695
DOC_USP7_MATH_1	155	159	PF00917	0.676
DOC_USP7_UBL2_3	120	124	PF12436	0.565
DOC_WW_Pin1_4	153	158	PF00397	0.598
DOC_WW_Pin1_4	19	24	PF00397	0.551
LIG_14-3-3_CanoR_1	42	48	PF00244	0.560
LIG_Actin_WH2_2	40	56	PF00022	0.518
LIG_APCC_ABBAyCdc20_2	95	101	PF00400	0.520
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_CaM_IQ_9	106	122	PF13499	0.535
LIG_FHA_2	20	26	PF00498	0.548
LIG_MYND_1	19	23	PF01753	0.556
LIG_PCNA_yPIPBox_3	120	132	PF02747	0.434
LIG_PDZ_Class_3	163	168	PF00595	0.654
LIG_SH2_STAT5	40	43	PF00017	0.480
LIG_SH3_3	13	19	PF00018	0.631
LIG_TRAF2_1	22	25	PF00917	0.545
MOD_CDC14_SPxK_1	156	159	PF00782	0.540
MOD_CDK_SPxK_1	153	159	PF00069	0.541
MOD_CDK_SPxxK_3	19	26	PF00069	0.551
MOD_CK1_1	140	146	PF00069	0.761
MOD_CK1_1	147	153	PF00069	0.635
MOD_CK1_1	158	164	PF00069	0.511
MOD_CK1_1	2	8	PF00069	0.790
MOD_CK2_1	19	25	PF00069	0.573
MOD_GlcNHglycan	137	140	PF01048	0.627
MOD_GlcNHglycan	145	149	PF01048	0.691
MOD_GlcNHglycan	151	154	PF01048	0.642
MOD_GlcNHglycan	6	9	PF01048	0.708
MOD_GSK3_1	131	138	PF00069	0.643
MOD_GSK3_1	140	147	PF00069	0.600
MOD_GSK3_1	149	156	PF00069	0.521
MOD_GSK3_1	61	68	PF00069	0.698
MOD_NEK2_1	1	6	PF00069	0.670
MOD_NEK2_1	131	136	PF00069	0.477
MOD_NEK2_1	149	154	PF00069	0.620
MOD_NEK2_1	53	58	PF00069	0.587
MOD_NEK2_2	43	48	PF00069	0.502
MOD_PK_1	105	111	PF00069	0.529
MOD_PKA_2	158	164	PF00069	0.618
MOD_PKA_2	53	59	PF00069	0.578
MOD_Plk_4	36	42	PF00069	0.570
MOD_ProDKin_1	153	159	PF00069	0.600
MOD_ProDKin_1	19	25	PF00069	0.547
MOD_SUMO_for_1	104	107	PF00179	0.424
TRG_ER_diArg_1	114	117	PF00400	0.578
TRG_ER_diArg_1	51	54	PF00400	0.571
TRG_NLS_Bipartite_1	95	117	PF00514	0.486
TRG_NLS_MonoExtC_3	111	116	PF00514	0.500
TRG_NLS_MonoExtC_3	119	124	PF00514	0.495
TRG_NLS_MonoExtN_4	112	117	PF00514	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNR8	Leishmania donovani	91%	100%
A4H443	Leishmania braziliensis	85%	100%
A4HS56	Leishmania infantum	91%	100%
C9ZY53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AK43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%