RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q9NED8_LEIMA

TriTrypDb:

LmjF.04.0640 , LMJLV39_040011600 , LMJSD75_040012000

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q9NED8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NED8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.640
CLV_C14_Caspase3-7	259	263	PF00656	0.478
CLV_NRD_NRD_1	168	170	PF00675	0.373
CLV_NRD_NRD_1	75	77	PF00675	0.496
CLV_PCSK_KEX2_1	168	170	PF00082	0.373
CLV_PCSK_KEX2_1	75	77	PF00082	0.496
CLV_PCSK_SKI1_1	224	228	PF00082	0.410
CLV_PCSK_SKI1_1	289	293	PF00082	0.266
CLV_PCSK_SKI1_1	325	329	PF00082	0.715
DEG_Nend_UBRbox_2	1	3	PF02207	0.572
DOC_CYCLIN_yCln2_LP_2	181	187	PF00134	0.549
DOC_MAPK_DCC_7	49	57	PF00069	0.317
DOC_MAPK_gen_1	4	11	PF00069	0.486
DOC_MAPK_MEF2A_6	230	238	PF00069	0.552
DOC_MAPK_MEF2A_6	4	11	PF00069	0.424
DOC_MAPK_MEF2A_6	49	57	PF00069	0.335
DOC_SPAK_OSR1_1	66	70	PF12202	0.449
DOC_USP7_MATH_1	105	109	PF00917	0.764
DOC_USP7_MATH_1	283	287	PF00917	0.466
DOC_USP7_MATH_1	35	39	PF00917	0.551
DOC_WW_Pin1_4	114	119	PF00397	0.729
LIG_14-3-3_CanoR_1	224	233	PF00244	0.679
LIG_14-3-3_CanoR_1	289	294	PF00244	0.277
LIG_14-3-3_CanoR_1	78	88	PF00244	0.648
LIG_Actin_WH2_2	209	226	PF00022	0.648
LIG_APCC_ABBA_1	68	73	PF00400	0.527
LIG_BRCT_BRCA1_1	320	324	PF00533	0.399
LIG_FHA_1	208	214	PF00498	0.689
LIG_FHA_1	256	262	PF00498	0.492
LIG_FHA_1	290	296	PF00498	0.449
LIG_FHA_1	313	319	PF00498	0.334
LIG_FHA_2	134	140	PF00498	0.565
LIG_LIR_Gen_1	246	254	PF02991	0.449
LIG_LIR_Gen_1	89	98	PF02991	0.691
LIG_LIR_Nem_3	164	170	PF02991	0.573
LIG_LIR_Nem_3	303	308	PF02991	0.618
LIG_LIR_Nem_3	321	327	PF02991	0.380
LIG_LIR_Nem_3	82	87	PF02991	0.729
LIG_LIR_Nem_3	89	93	PF02991	0.609
LIG_PDZ_Class_2	324	329	PF00595	0.422
LIG_Pex14_1	63	67	PF04695	0.449
LIG_SH2_CRK	167	171	PF00017	0.491
LIG_SH2_CRK	284	288	PF00017	0.399
LIG_SH2_GRB2like	16	19	PF00017	0.442
LIG_SH2_NCK_1	90	94	PF00017	0.670
LIG_SH2_SRC	90	93	PF00017	0.562
LIG_SH2_STAP1	284	288	PF00017	0.449
LIG_SH2_STAP1	301	305	PF00017	0.630
LIG_SH2_STAT5	16	19	PF00017	0.501
LIG_SH2_STAT5	296	299	PF00017	0.597
LIG_SH3_3	135	141	PF00018	0.538
LIG_SH3_3	270	276	PF00018	0.553
LIG_SH3_3	47	53	PF00018	0.291
LIG_SH3_3	99	105	PF00018	0.762
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.563
LIG_SUMO_SIM_par_1	291	297	PF11976	0.387
LIG_SUMO_SIM_par_1	306	311	PF11976	0.312
LIG_TRAF2_1	107	110	PF00917	0.755
LIG_TRFH_1	250	254	PF08558	0.611
LIG_UBA3_1	323	328	PF00899	0.522
MOD_CK1_1	190	196	PF00069	0.587
MOD_CK1_1	36	42	PF00069	0.445
MOD_CK2_1	104	110	PF00069	0.745
MOD_CK2_1	253	259	PF00069	0.499
MOD_CK2_1	86	92	PF00069	0.691
MOD_GlcNHglycan	163	166	PF01048	0.349
MOD_GlcNHglycan	277	280	PF01048	0.592
MOD_GlcNHglycan	320	323	PF01048	0.436
MOD_GlcNHglycan	39	42	PF01048	0.706
MOD_GSK3_1	100	107	PF00069	0.742
MOD_GSK3_1	17	24	PF00069	0.525
MOD_GSK3_1	207	214	PF00069	0.700
MOD_GSK3_1	308	315	PF00069	0.456
MOD_GSK3_1	33	40	PF00069	0.405
MOD_GSK3_1	79	86	PF00069	0.729
MOD_N-GLC_1	17	22	PF02516	0.643
MOD_NEK2_1	207	212	PF00069	0.687
MOD_NEK2_1	243	248	PF00069	0.334
MOD_NEK2_1	318	323	PF00069	0.353
MOD_PIKK_1	105	111	PF00454	0.786
MOD_PKA_1	211	217	PF00069	0.588
MOD_PKA_2	100	106	PF00069	0.719
MOD_PKB_1	222	230	PF00069	0.600
MOD_Plk_1	7	13	PF00069	0.488
MOD_Plk_4	133	139	PF00069	0.483
MOD_Plk_4	211	217	PF00069	0.611
MOD_Plk_4	243	249	PF00069	0.334
MOD_Plk_4	283	289	PF00069	0.399
MOD_Plk_4	308	314	PF00069	0.497
MOD_ProDKin_1	114	120	PF00069	0.728
MOD_SUMO_rev_2	321	329	PF00179	0.584
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.597
TRG_ENDOCYTIC_2	167	170	PF00928	0.491
TRG_ENDOCYTIC_2	250	253	PF00928	0.512
TRG_ENDOCYTIC_2	284	287	PF00928	0.399
TRG_ENDOCYTIC_2	90	93	PF00928	0.671
TRG_ER_diArg_1	167	169	PF00400	0.573
TRG_ER_diArg_1	221	224	PF00400	0.587
TRG_ER_diArg_1	4	7	PF00400	0.569
TRG_ER_diArg_1	75	78	PF00400	0.697
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRM4	Leptomonas seymouri	53%	100%
A0A3S7WNQ6	Leishmania donovani	96%	100%
A4H3Y1	Leishmania braziliensis	77%	99%
A4HS60	Leishmania infantum	95%	100%
E9AK47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%