CHCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9NED6_LEIMA

TriTrypDb:

LmjF.04.0660 , LMJLV39_040011800 , LMJSD75_040012200

Length:

149

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q9NED6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NED6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	3
GO:0007005	mitochondrion organization	5	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0071840	cellular component organization or biogenesis	2	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.635
CLV_NRD_NRD_1	28	30	PF00675	0.569
CLV_PCSK_KEX2_1	28	30	PF00082	0.567
DEG_SPOP_SBC_1	30	34	PF00917	0.598
DOC_CKS1_1	107	112	PF01111	0.511
DOC_PP4_MxPP_1	145	148	PF00568	0.778
DOC_USP7_MATH_1	67	71	PF00917	0.590
DOC_WW_Pin1_4	106	111	PF00397	0.573
LIG_14-3-3_CanoR_1	29	39	PF00244	0.596
LIG_FHA_1	107	113	PF00498	0.615
LIG_LIR_Nem_3	20	24	PF02991	0.564
LIG_Pex14_1	131	135	PF04695	0.490
LIG_PTB_Apo_2	75	82	PF02174	0.662
LIG_PTB_Phospho_1	75	81	PF10480	0.724
LIG_SH2_SRC	79	82	PF00017	0.725
LIG_SH2_STAP1	115	119	PF00017	0.436
LIG_SH2_STAT3	135	138	PF00017	0.486
LIG_SH2_STAT5	135	138	PF00017	0.486
LIG_SH2_STAT5	46	49	PF00017	0.612
LIG_SH2_STAT5	79	82	PF00017	0.728
LIG_SH3_1	141	147	PF00018	0.674
LIG_SH3_3	104	110	PF00018	0.495
LIG_SH3_3	141	147	PF00018	0.725
LIG_SH3_3	33	39	PF00018	0.712
LIG_SH3_3	44	50	PF00018	0.673
LIG_SH3_3	85	91	PF00018	0.555
LIG_TRAF2_1	101	104	PF00917	0.706
MOD_CK1_1	125	131	PF00069	0.568
MOD_GlcNHglycan	124	127	PF01048	0.639
MOD_GlcNHglycan	21	24	PF01048	0.672
MOD_GlcNHglycan	56	59	PF01048	0.662
MOD_PIKK_1	134	140	PF00454	0.542
MOD_PIKK_1	86	92	PF00454	0.639
MOD_Plk_4	67	73	PF00069	0.585
MOD_ProDKin_1	106	112	PF00069	0.567
TRG_ER_diArg_1	2	5	PF00400	0.579
TRG_ER_diArg_1	28	30	PF00400	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NKW3	Trypanosomatidae	52%	100%
A0A3S5H5B8	Leishmania donovani	96%	100%
A0A3S5H5B9	Leishmania donovani	97%	98%
A4H401	Leishmania braziliensis	90%	93%
A4HS62	Leishmania infantum	96%	100%
A4HS63	Leishmania infantum	97%	98%
C9ZY60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AK49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AK50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	98%
Q9NED5	Leishmania major	99%	100%
V5BMV1	Trypanosoma cruzi	61%	100%