CHCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9NED5_LEIMA

TriTrypDb:

LmjF.04.0670 , LMJLV39_040011900 , LMJSD75_040012300

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q9NED5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NED5

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	3
GO:0007005	mitochondrion organization	5	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0071840	cellular component organization or biogenesis	2	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.571
DOC_CKS1_1	110	115	PF01111	0.444
DOC_CKS1_1	32	37	PF01111	0.618
DOC_PP4_MxPP_1	148	151	PF00568	0.675
DOC_USP7_MATH_1	70	74	PF00917	0.561
DOC_USP7_MATH_1	8	12	PF00917	0.663
DOC_WW_Pin1_4	109	114	PF00397	0.491
DOC_WW_Pin1_4	31	36	PF00397	0.659
LIG_BIR_II_1	1	5	PF00653	0.575
LIG_FHA_1	110	116	PF00498	0.518
LIG_Pex14_1	134	138	PF04695	0.453
LIG_PTB_Apo_2	78	85	PF02174	0.623
LIG_PTB_Phospho_1	78	84	PF10480	0.618
LIG_SH2_SRC	82	85	PF00017	0.618
LIG_SH2_STAP1	118	122	PF00017	0.403
LIG_SH2_STAT3	138	141	PF00017	0.449
LIG_SH2_STAT5	138	141	PF00017	0.459
LIG_SH2_STAT5	49	52	PF00017	0.588
LIG_SH2_STAT5	82	85	PF00017	0.619
LIG_SH3_1	144	150	PF00018	0.587
LIG_SH3_2	21	26	PF14604	0.559
LIG_SH3_3	107	113	PF00018	0.625
LIG_SH3_3	144	150	PF00018	0.624
LIG_SH3_3	18	24	PF00018	0.613
LIG_SH3_3	36	42	PF00018	0.701
LIG_SH3_3	47	53	PF00018	0.633
LIG_SH3_3	88	94	PF00018	0.531
LIG_TRAF2_1	104	107	PF00917	0.605
MOD_CK1_1	11	17	PF00069	0.641
MOD_CK1_1	128	134	PF00069	0.483
MOD_GlcNHglycan	10	13	PF01048	0.729
MOD_GlcNHglycan	127	130	PF01048	0.537
MOD_GlcNHglycan	59	62	PF01048	0.662
MOD_GSK3_1	8	15	PF00069	0.684
MOD_NEK2_1	1	6	PF00069	0.648
MOD_NEK2_1	30	35	PF00069	0.619
MOD_PIKK_1	137	143	PF00454	0.511
MOD_PIKK_1	89	95	PF00454	0.600
MOD_PKA_2	8	14	PF00069	0.703
MOD_Plk_4	70	76	PF00069	0.588
MOD_ProDKin_1	109	115	PF00069	0.485
MOD_ProDKin_1	31	37	PF00069	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NKW3	Trypanosomatidae	47%	100%
A0A3S5H5B8	Leishmania donovani	97%	100%
A0A3S5H5B9	Leishmania donovani	98%	100%
A4H401	Leishmania braziliensis	84%	95%
A4HS62	Leishmania infantum	96%	100%
A4HS63	Leishmania infantum	98%	100%
C9ZY60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AK49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AK50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q9NED6	Leishmania major	99%	100%
V5BMV1	Trypanosoma cruzi	52%	100%