Axonemal_dynein_light_chain_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

axonemal dynein light chain, putative

Species:

Leishmania major

UniProt:

Q9NED3_LEIMA

TriTrypDb:

LmjF.04.0690 , LMJLV39_040012100 , LMJSD75_040012500

Length:

754

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9NED3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NED3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.618
CLV_C14_Caspase3-7	20	24	PF00656	0.658
CLV_C14_Caspase3-7	239	243	PF00656	0.536
CLV_C14_Caspase3-7	276	280	PF00656	0.700
CLV_C14_Caspase3-7	383	387	PF00656	0.676
CLV_C14_Caspase3-7	668	672	PF00656	0.293
CLV_C14_Caspase3-7	95	99	PF00656	0.534
CLV_NRD_NRD_1	259	261	PF00675	0.480
CLV_NRD_NRD_1	290	292	PF00675	0.676
CLV_NRD_NRD_1	317	319	PF00675	0.558
CLV_NRD_NRD_1	326	328	PF00675	0.464
CLV_NRD_NRD_1	422	424	PF00675	0.549
CLV_NRD_NRD_1	638	640	PF00675	0.335
CLV_NRD_NRD_1	699	701	PF00675	0.313
CLV_NRD_NRD_1	748	750	PF00675	0.672
CLV_PCSK_FUR_1	420	424	PF00082	0.522
CLV_PCSK_KEX2_1	290	292	PF00082	0.676
CLV_PCSK_KEX2_1	317	319	PF00082	0.558
CLV_PCSK_KEX2_1	32	34	PF00082	0.563
CLV_PCSK_KEX2_1	326	328	PF00082	0.464
CLV_PCSK_KEX2_1	422	424	PF00082	0.549
CLV_PCSK_KEX2_1	638	640	PF00082	0.335
CLV_PCSK_KEX2_1	748	750	PF00082	0.672
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.563
CLV_PCSK_PC7_1	286	292	PF00082	0.672
CLV_PCSK_SKI1_1	111	115	PF00082	0.624
CLV_PCSK_SKI1_1	126	130	PF00082	0.496
CLV_PCSK_SKI1_1	2	6	PF00082	0.741
CLV_PCSK_SKI1_1	291	295	PF00082	0.663
CLV_PCSK_SKI1_1	317	321	PF00082	0.517
CLV_PCSK_SKI1_1	347	351	PF00082	0.553
CLV_PCSK_SKI1_1	392	396	PF00082	0.507
CLV_PCSK_SKI1_1	442	446	PF00082	0.565
CLV_PCSK_SKI1_1	624	628	PF00082	0.339
CLV_PCSK_SKI1_1	633	637	PF00082	0.360
CLV_PCSK_SKI1_1	638	642	PF00082	0.391
CLV_PCSK_SKI1_1	651	655	PF00082	0.393
CLV_PCSK_SKI1_1	673	677	PF00082	0.335
CLV_PCSK_SKI1_1	701	705	PF00082	0.380
CLV_Separin_Metazoa	621	625	PF03568	0.313
DEG_APCC_DBOX_1	346	354	PF00400	0.680
DEG_APCC_DBOX_1	381	389	PF00400	0.550
DEG_APCC_DBOX_1	391	399	PF00400	0.509
DEG_APCC_DBOX_1	470	478	PF00400	0.541
DEG_APCC_DBOX_1	690	698	PF00400	0.493
DEG_Nend_UBRbox_1	1	4	PF02207	0.634
DEG_SPOP_SBC_1	376	380	PF00917	0.706
DOC_CKS1_1	565	570	PF01111	0.727
DOC_CYCLIN_RxL_1	315	325	PF00134	0.554
DOC_CYCLIN_RxL_1	491	502	PF00134	0.571
DOC_CYCLIN_RxL_1	633	643	PF00134	0.453
DOC_CYCLIN_yClb5_NLxxxL_5	727	733	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.770
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.647
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.619
DOC_MAPK_gen_1	608	617	PF00069	0.485
DOC_MAPK_MEF2A_6	101	110	PF00069	0.581
DOC_MAPK_MEF2A_6	608	617	PF00069	0.603
DOC_MAPK_RevD_3	626	639	PF00069	0.335
DOC_PP2B_LxvP_1	245	248	PF13499	0.655
DOC_PP2B_LxvP_1	88	91	PF13499	0.616
DOC_PP4_FxxP_1	272	275	PF00568	0.588
DOC_USP7_MATH_1	194	198	PF00917	0.677
DOC_USP7_MATH_1	289	293	PF00917	0.685
DOC_USP7_MATH_1	3	7	PF00917	0.729
DOC_USP7_MATH_1	36	40	PF00917	0.766
DOC_USP7_MATH_1	444	448	PF00917	0.538
DOC_USP7_MATH_1	505	509	PF00917	0.744
DOC_USP7_MATH_1	516	520	PF00917	0.704
DOC_USP7_MATH_1	544	548	PF00917	0.680
DOC_WW_Pin1_4	145	150	PF00397	0.817
DOC_WW_Pin1_4	271	276	PF00397	0.574
DOC_WW_Pin1_4	522	527	PF00397	0.654
DOC_WW_Pin1_4	529	534	PF00397	0.593
DOC_WW_Pin1_4	564	569	PF00397	0.730
LIG_14-3-3_CanoR_1	126	134	PF00244	0.711
LIG_14-3-3_CanoR_1	185	194	PF00244	0.788
LIG_14-3-3_CanoR_1	290	296	PF00244	0.724
LIG_14-3-3_CanoR_1	382	386	PF00244	0.557
LIG_14-3-3_CanoR_1	463	470	PF00244	0.557
LIG_14-3-3_CanoR_1	624	629	PF00244	0.335
LIG_14-3-3_CanoR_1	658	667	PF00244	0.424
LIG_14-3-3_CanoR_1	748	753	PF00244	0.606
LIG_Actin_RPEL_3	617	636	PF02755	0.424
LIG_Actin_WH2_2	367	384	PF00022	0.664
LIG_Actin_WH2_2	428	444	PF00022	0.563
LIG_Actin_WH2_2	608	626	PF00022	0.517
LIG_CaM_IQ_9	118	133	PF13499	0.690
LIG_Clathr_ClatBox_1	458	462	PF01394	0.516
LIG_Clathr_ClatBox_1	474	478	PF01394	0.638
LIG_eIF4E_1	345	351	PF01652	0.667
LIG_EVH1_2	390	394	PF00568	0.627
LIG_FHA_1	376	382	PF00498	0.746
LIG_FHA_1	39	45	PF00498	0.683
LIG_FHA_1	462	468	PF00498	0.573
LIG_FHA_1	572	578	PF00498	0.693
LIG_FHA_1	598	604	PF00498	0.556
LIG_FHA_1	625	631	PF00498	0.335
LIG_FHA_1	735	741	PF00498	0.553
LIG_FHA_2	130	136	PF00498	0.732
LIG_FHA_2	274	280	PF00498	0.700
LIG_FHA_2	425	431	PF00498	0.547
LIG_FHA_2	438	444	PF00498	0.520
LIG_FHA_2	478	484	PF00498	0.630
LIG_FHA_2	50	56	PF00498	0.713
LIG_FHA_2	69	75	PF00498	0.669
LIG_FHA_2	93	99	PF00498	0.606
LIG_LIR_Apic_2	157	162	PF02991	0.697
LIG_LIR_Apic_2	269	275	PF02991	0.569
LIG_LIR_Gen_1	309	320	PF02991	0.677
LIG_LIR_Gen_1	447	457	PF02991	0.509
LIG_LIR_Nem_3	309	315	PF02991	0.535
LIG_LIR_Nem_3	447	452	PF02991	0.508
LIG_MYND_3	251	255	PF01753	0.601
LIG_NRBOX	636	642	PF00104	0.453
LIG_PCNA_PIPBox_1	418	427	PF02747	0.544
LIG_SH2_CRK	159	163	PF00017	0.664
LIG_SH2_NCK_1	159	163	PF00017	0.696
LIG_SH2_NCK_1	449	453	PF00017	0.542
LIG_SH2_PTP2	312	315	PF00017	0.628
LIG_SH2_SRC	164	167	PF00017	0.702
LIG_SH2_SRC	397	400	PF00017	0.481
LIG_SH2_SRC	449	452	PF00017	0.405
LIG_SH2_STAT5	270	273	PF00017	0.537
LIG_SH2_STAT5	312	315	PF00017	0.628
LIG_SH2_STAT5	345	348	PF00017	0.657
LIG_SH2_STAT5	397	400	PF00017	0.497
LIG_SH2_STAT5	473	476	PF00017	0.533
LIG_SH2_STAT5	696	699	PF00017	0.358
LIG_SH3_1	578	584	PF00018	0.639
LIG_SH3_3	146	152	PF00018	0.737
LIG_SH3_3	337	343	PF00018	0.582
LIG_SH3_3	350	356	PF00018	0.585
LIG_SH3_3	385	391	PF00018	0.525
LIG_SH3_3	464	470	PF00018	0.563
LIG_SH3_3	528	534	PF00018	0.564
LIG_SH3_3	578	584	PF00018	0.639
LIG_SH3_3	625	631	PF00018	0.352
LIG_SH3_3	75	81	PF00018	0.722
LIG_SUMO_SIM_anti_2	311	317	PF11976	0.633
LIG_SUMO_SIM_anti_2	430	437	PF11976	0.536
LIG_SUMO_SIM_par_1	318	325	PF11976	0.658
LIG_SUMO_SIM_par_1	457	462	PF11976	0.521
LIG_SUMO_SIM_par_1	60	67	PF11976	0.678
LIG_SUMO_SIM_par_1	626	632	PF11976	0.335
LIG_TRAF2_1	661	664	PF00917	0.324
LIG_TRAF2_1	71	74	PF00917	0.590
LIG_TYR_ITIM	310	315	PF00017	0.524
LIG_WW_3	389	393	PF00397	0.511
MOD_CDK_SPxK_1	564	570	PF00069	0.730
MOD_CK1_1	138	144	PF00069	0.675
MOD_CK1_1	186	192	PF00069	0.762
MOD_CK1_1	274	280	PF00069	0.588
MOD_CK1_1	47	53	PF00069	0.646
MOD_CK1_1	519	525	PF00069	0.677
MOD_CK2_1	366	372	PF00069	0.685
MOD_CK2_1	430	436	PF00069	0.461
MOD_CK2_1	437	443	PF00069	0.522
MOD_CK2_1	477	483	PF00069	0.508
MOD_CK2_1	49	55	PF00069	0.709
MOD_CK2_1	68	74	PF00069	0.496
MOD_GlcNHglycan	230	233	PF01048	0.701
MOD_GlcNHglycan	276	279	PF01048	0.626
MOD_GlcNHglycan	299	302	PF01048	0.530
MOD_GlcNHglycan	368	371	PF01048	0.725
MOD_GlcNHglycan	516	519	PF01048	0.826
MOD_GlcNHglycan	522	525	PF01048	0.738
MOD_GlcNHglycan	551	554	PF01048	0.757
MOD_GlcNHglycan	589	592	PF01048	0.605
MOD_GlcNHglycan	593	596	PF01048	0.574
MOD_GSK3_1	126	133	PF00069	0.627
MOD_GSK3_1	140	147	PF00069	0.559
MOD_GSK3_1	150	157	PF00069	0.676
MOD_GSK3_1	270	277	PF00069	0.534
MOD_GSK3_1	376	383	PF00069	0.576
MOD_GSK3_1	457	464	PF00069	0.453
MOD_GSK3_1	501	508	PF00069	0.709
MOD_GSK3_1	512	519	PF00069	0.699
MOD_GSK3_1	520	527	PF00069	0.588
MOD_GSK3_1	560	567	PF00069	0.589
MOD_GSK3_1	587	594	PF00069	0.609
MOD_GSK3_1	64	71	PF00069	0.737
MOD_N-GLC_1	542	547	PF02516	0.670
MOD_NEK2_1	228	233	PF00069	0.632
MOD_NEK2_1	322	327	PF00069	0.677
MOD_NEK2_1	499	504	PF00069	0.616
MOD_NEK2_1	64	69	PF00069	0.673
MOD_NEK2_1	92	97	PF00069	0.605
MOD_NEK2_2	11	16	PF00069	0.724
MOD_NEK2_2	544	549	PF00069	0.604
MOD_NEK2_2	573	578	PF00069	0.735
MOD_PIKK_1	534	540	PF00454	0.620
MOD_PIKK_1	659	665	PF00454	0.335
MOD_PKA_1	748	754	PF00069	0.683
MOD_PKA_2	289	295	PF00069	0.679
MOD_PKA_2	381	387	PF00069	0.553
MOD_PKA_2	462	468	PF00069	0.557
MOD_PKA_2	505	511	PF00069	0.685
MOD_PKA_2	747	753	PF00069	0.637
MOD_PKB_1	124	132	PF00069	0.706
MOD_Plk_1	154	160	PF00069	0.718
MOD_Plk_1	430	436	PF00069	0.560
MOD_Plk_1	477	483	PF00069	0.508
MOD_Plk_1	608	614	PF00069	0.607
MOD_Plk_1	64	70	PF00069	0.677
MOD_Plk_2-3	430	436	PF00069	0.537
MOD_Plk_2-3	437	443	PF00069	0.522
MOD_Plk_4	430	436	PF00069	0.537
MOD_Plk_4	560	566	PF00069	0.615
MOD_Plk_4	613	619	PF00069	0.585
MOD_ProDKin_1	145	151	PF00069	0.815
MOD_ProDKin_1	271	277	PF00069	0.578
MOD_ProDKin_1	522	528	PF00069	0.652
MOD_ProDKin_1	529	535	PF00069	0.588
MOD_ProDKin_1	564	570	PF00069	0.730
MOD_SUMO_for_1	475	478	PF00179	0.642
MOD_SUMO_rev_2	709	713	PF00179	0.335
MOD_SUMO_rev_2	73	78	PF00179	0.585
TRG_DiLeu_BaEn_1	311	316	PF01217	0.629
TRG_DiLeu_BaEn_1	632	637	PF01217	0.335
TRG_DiLeu_BaEn_4	436	442	PF01217	0.586
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.638
TRG_DiLeu_BaLyEn_6	636	641	PF01217	0.485
TRG_ENDOCYTIC_2	312	315	PF00928	0.510
TRG_ENDOCYTIC_2	396	399	PF00928	0.523
TRG_ENDOCYTIC_2	449	452	PF00928	0.532
TRG_ER_diArg_1	123	126	PF00400	0.583
TRG_ER_diArg_1	316	318	PF00400	0.540
TRG_ER_diArg_1	420	423	PF00400	0.584
TRG_ER_diArg_1	637	639	PF00400	0.347
TRG_ER_diArg_1	690	693	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	610	614	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	727	731	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTA8	Leptomonas seymouri	43%	100%
A0A3S7WNS6	Leishmania donovani	88%	100%
A4H403	Leishmania braziliensis	68%	100%
A4HS65	Leishmania infantum	88%	100%
E9AK52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%