Uncharacterized protein L5213T.03

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Oligomerisation domain containing protein, putative

Species:

Leishmania major

UniProt:

Q9NE59_LEIMA

TriTrypDb:

LmjF.30.2120 , LMJLV39_300028100 , LMJSD75_300027900

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q9NE59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NE59

PDB structure(s): 7am2_CB

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006396	RNA processing	6	4
GO:0006417	regulation of translation	6	2
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009889	regulation of biosynthetic process	4	2
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009987	cellular process	1	4
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010629	negative regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	4
GO:0017148	negative regulation of translation	7	2
GO:0019222	regulation of metabolic process	3	2
GO:0031123	RNA 3'-end processing	7	4
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034249	negative regulation of amide metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051248	negative regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071076	RNA 3' uridylation	8	4
GO:0071704	organic substance metabolic process	2	4
GO:0080090	regulation of primary metabolic process	4	2
GO:0090069	regulation of ribosome biogenesis	5	2
GO:0090071	negative regulation of ribosome biogenesis	5	2
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	2
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0016779	nucleotidyltransferase activity	4	4
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0043023	ribosomal large subunit binding	4	2
GO:0044877	protein-containing complex binding	2	2
GO:0050265	RNA uridylyltransferase activity	4	4
GO:0070569	uridylyltransferase activity	5	4
GO:0140098	catalytic activity, acting on RNA	3	4
GO:0140640	catalytic activity, acting on a nucleic acid	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.418
CLV_NRD_NRD_1	146	148	PF00675	0.293
CLV_PCSK_KEX2_1	114	116	PF00082	0.293
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.289
CLV_PCSK_SKI1_1	169	173	PF00082	0.491
CLV_PCSK_SKI1_1	195	199	PF00082	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DOC_MAPK_gen_1	64	73	PF00069	0.293
DOC_MAPK_MEF2A_6	129	136	PF00069	0.293
DOC_MAPK_MEF2A_6	24	32	PF00069	0.355
DOC_USP7_MATH_1	13	17	PF00917	0.528
LIG_14-3-3_CanoR_1	115	124	PF00244	0.291
LIG_CaM_IQ_9	98	114	PF13499	0.293
LIG_Clathr_ClatBox_1	29	33	PF01394	0.395
LIG_eIF4E_1	193	199	PF01652	0.394
LIG_FHA_1	116	122	PF00498	0.293
LIG_FHA_1	176	182	PF00498	0.413
LIG_FHA_2	39	45	PF00498	0.523
LIG_LIR_Gen_1	119	130	PF02991	0.293
LIG_LIR_Gen_1	22	32	PF02991	0.358
LIG_LIR_Gen_1	77	85	PF02991	0.323
LIG_LIR_Nem_3	119	125	PF02991	0.293
LIG_LIR_Nem_3	81	85	PF02991	0.284
LIG_SH2_STAT5	193	196	PF00017	0.401
LIG_TRAF2_1	6	9	PF00917	0.535
LIG_UBA3_1	59	64	PF00899	0.293
LIG_WRC_WIRS_1	136	141	PF05994	0.476
MOD_CK1_1	74	80	PF00069	0.403
MOD_CK2_1	135	141	PF00069	0.293
MOD_GSK3_1	71	78	PF00069	0.353
MOD_NEK2_1	135	140	PF00069	0.313
MOD_PKA_2	108	114	PF00069	0.293
MOD_Plk_1	141	147	PF00069	0.293
MOD_Plk_1	38	44	PF00069	0.398
MOD_Plk_2-3	141	147	PF00069	0.293
MOD_SUMO_rev_2	141	150	PF00179	0.293
MOD_SUMO_rev_2	39	48	PF00179	0.435
MOD_SUMO_rev_2	51	56	PF00179	0.349
TRG_ENDOCYTIC_2	82	85	PF00928	0.363
TRG_NES_CRM1_1	55	67	PF08389	0.248
TRG_NLS_MonoExtC_3	45	51	PF00514	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X3L3	Leishmania donovani	95%	100%
A4HIE4	Leishmania braziliensis	91%	100%
Q96EH3	Homo sapiens	28%	86%