Putative beta galactofuranosyl transferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta galactofuranosyl transferase

Species:

Leishmania major

UniProt:

Q9NC61_LEIMA

TriTrypDb:

LmjF.25.0010 , LMJLV39_250005100 , LMJSD75_250005000

Length:

434

Annotations

LeishMANIAdb annotations

A large family of glycosyltransferases expanded in parazitic kinetoplastids (and even more in T cruzi). Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 35
NetGPI	no	yes: 0, no: 35

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

Q9NC61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NC61

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	35
GO:0016740	transferase activity	2	35
GO:0016757	glycosyltransferase activity	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.489
CLV_NRD_NRD_1	204	206	PF00675	0.646
CLV_NRD_NRD_1	310	312	PF00675	0.485
CLV_NRD_NRD_1	382	384	PF00675	0.478
CLV_NRD_NRD_1	4	6	PF00675	0.491
CLV_PCSK_FUR_1	202	206	PF00082	0.445
CLV_PCSK_KEX2_1	11	13	PF00082	0.489
CLV_PCSK_KEX2_1	204	206	PF00082	0.646
CLV_PCSK_KEX2_1	381	383	PF00082	0.706
CLV_PCSK_KEX2_1	4	6	PF00082	0.482
CLV_PCSK_PC7_1	378	384	PF00082	0.707
CLV_PCSK_SKI1_1	120	124	PF00082	0.536
CLV_PCSK_SKI1_1	158	162	PF00082	0.438
CLV_PCSK_SKI1_1	215	219	PF00082	0.644
CLV_PCSK_SKI1_1	224	228	PF00082	0.553
CLV_PCSK_SKI1_1	337	341	PF00082	0.659
CLV_PCSK_SKI1_1	365	369	PF00082	0.540
CLV_PCSK_SKI1_1	95	99	PF00082	0.502
DEG_APCC_DBOX_1	119	127	PF00400	0.339
DEG_APCC_DBOX_1	17	25	PF00400	0.454
DEG_COP1_1	213	223	PF00400	0.260
DOC_CYCLIN_RxL_1	117	124	PF00134	0.405
DOC_CYCLIN_RxL_1	378	390	PF00134	0.245
DOC_MAPK_DCC_7	79	89	PF00069	0.330
DOC_MAPK_gen_1	11	19	PF00069	0.570
DOC_MAPK_gen_1	378	387	PF00069	0.254
DOC_MAPK_MEF2A_6	12	21	PF00069	0.505
DOC_MAPK_MEF2A_6	79	87	PF00069	0.327
DOC_PP1_RVXF_1	317	324	PF00149	0.292
DOC_PP1_RVXF_1	423	430	PF00149	0.254
DOC_PP2B_PxIxI_1	168	174	PF00149	0.324
DOC_USP7_MATH_1	118	122	PF00917	0.408
DOC_USP7_MATH_1	226	230	PF00917	0.384
DOC_WW_Pin1_4	46	51	PF00397	0.279
LIG_14-3-3_CanoR_1	11	17	PF00244	0.676
LIG_14-3-3_CanoR_1	117	123	PF00244	0.409
LIG_14-3-3_CanoR_1	243	248	PF00244	0.323
LIG_14-3-3_CanoR_1	311	321	PF00244	0.361
LIG_14-3-3_CanoR_1	55	63	PF00244	0.372
LIG_14-3-3_CanoR_1	69	73	PF00244	0.412
LIG_Actin_WH2_2	203	220	PF00022	0.259
LIG_BIR_II_1	1	5	PF00653	0.726
LIG_BIR_III_4	258	262	PF00653	0.197
LIG_eIF4E_1	133	139	PF01652	0.344
LIG_eIF4E_1	22	28	PF01652	0.222
LIG_FHA_1	271	277	PF00498	0.339
LIG_FHA_1	388	394	PF00498	0.387
LIG_FHA_1	422	428	PF00498	0.405
LIG_FHA_2	172	178	PF00498	0.213
LIG_FHA_2	43	49	PF00498	0.480
LIG_HCF-1_HBM_1	298	301	PF13415	0.372
LIG_LIR_Gen_1	106	115	PF02991	0.249
LIG_LIR_Gen_1	15	24	PF02991	0.352
LIG_LIR_Gen_1	60	70	PF02991	0.382
LIG_LIR_Gen_1	88	98	PF02991	0.309
LIG_LIR_Nem_3	106	110	PF02991	0.313
LIG_LIR_Nem_3	15	19	PF02991	0.306
LIG_LIR_Nem_3	258	263	PF02991	0.248
LIG_LIR_Nem_3	289	295	PF02991	0.264
LIG_LIR_Nem_3	375	380	PF02991	0.478
LIG_LIR_Nem_3	418	422	PF02991	0.247
LIG_LIR_Nem_3	60	66	PF02991	0.377
LIG_LIR_Nem_3	88	94	PF02991	0.325
LIG_NRBOX	20	26	PF00104	0.354
LIG_Pex14_2	270	274	PF04695	0.352
LIG_Pex14_2	287	291	PF04695	0.203
LIG_PTB_Apo_2	110	117	PF02174	0.335
LIG_PTB_Apo_2	346	353	PF02174	0.319
LIG_PTB_Apo_2	354	361	PF02174	0.225
LIG_SH2_CRK	22	26	PF00017	0.454
LIG_SH2_CRK	377	381	PF00017	0.436
LIG_SH2_PTP2	30	33	PF00017	0.210
LIG_SH2_PTP2	82	85	PF00017	0.219
LIG_SH2_SRC	91	94	PF00017	0.402
LIG_SH2_STAP1	149	153	PF00017	0.230
LIG_SH2_STAP1	22	26	PF00017	0.202
LIG_SH2_STAP1	422	426	PF00017	0.250
LIG_SH2_STAT3	133	136	PF00017	0.194
LIG_SH2_STAT3	345	348	PF00017	0.366
LIG_SH2_STAT3	72	75	PF00017	0.295
LIG_SH2_STAT5	107	110	PF00017	0.343
LIG_SH2_STAT5	133	136	PF00017	0.315
LIG_SH2_STAT5	22	25	PF00017	0.377
LIG_SH2_STAT5	30	33	PF00017	0.332
LIG_SH2_STAT5	313	316	PF00017	0.287
LIG_SH2_STAT5	320	323	PF00017	0.253
LIG_SH2_STAT5	345	348	PF00017	0.392
LIG_SH2_STAT5	82	85	PF00017	0.232
LIG_SH3_3	217	223	PF00018	0.346
LIG_SH3_3	80	86	PF00018	0.375
LIG_TRFH_1	82	86	PF08558	0.437
LIG_TYR_ITIM	80	85	PF00017	0.250
LIG_TYR_ITSM	373	380	PF00017	0.357
LIG_WRC_WIRS_1	13	18	PF05994	0.169
LIG_WRC_WIRS_1	271	276	PF05994	0.356
LIG_WRPW_2	419	422	PF00400	0.268
MOD_CDK_SPK_2	46	51	PF00069	0.326
MOD_CK2_1	38	44	PF00069	0.557
MOD_GlcNHglycan	150	153	PF01048	0.329
MOD_GlcNHglycan	332	335	PF01048	0.341
MOD_GlcNHglycan	40	43	PF01048	0.374
MOD_GSK3_1	270	277	PF00069	0.347
MOD_GSK3_1	38	45	PF00069	0.602
MOD_GSK3_1	99	106	PF00069	0.425
MOD_N-GLC_1	161	166	PF02516	0.194
MOD_N-GLC_1	38	43	PF02516	0.372
MOD_N-GLC_1	387	392	PF02516	0.506
MOD_N-GLC_1	99	104	PF02516	0.311
MOD_NEK2_1	161	166	PF00069	0.242
MOD_NEK2_1	227	232	PF00069	0.382
MOD_NEK2_1	270	275	PF00069	0.343
MOD_NEK2_1	340	345	PF00069	0.544
MOD_NEK2_1	387	392	PF00069	0.464
MOD_PIKK_1	187	193	PF00454	0.392
MOD_PK_1	402	408	PF00069	0.472
MOD_PKA_2	227	233	PF00069	0.408
MOD_PKA_2	68	74	PF00069	0.508
MOD_Plk_1	161	167	PF00069	0.427
MOD_Plk_1	372	378	PF00069	0.592
MOD_Plk_1	99	105	PF00069	0.325
MOD_Plk_2-3	68	74	PF00069	0.314
MOD_Plk_4	103	109	PF00069	0.426
MOD_Plk_4	12	18	PF00069	0.365
MOD_Plk_4	20	26	PF00069	0.474
MOD_Plk_4	372	378	PF00069	0.394
MOD_ProDKin_1	46	52	PF00069	0.339
MOD_SUMO_rev_2	207	217	PF00179	0.364
MOD_SUMO_rev_2	412	421	PF00179	0.438
MOD_SUMO_rev_2	90	97	PF00179	0.407
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.405
TRG_ENDOCYTIC_2	107	110	PF00928	0.464
TRG_ENDOCYTIC_2	22	25	PF00928	0.366
TRG_ENDOCYTIC_2	260	263	PF00928	0.298
TRG_ENDOCYTIC_2	320	323	PF00928	0.259
TRG_ENDOCYTIC_2	377	380	PF00928	0.473
TRG_ENDOCYTIC_2	82	85	PF00928	0.461
TRG_ENDOCYTIC_2	91	94	PF00928	0.412
TRG_ER_diArg_1	11	13	PF00400	0.592
TRG_ER_diArg_1	202	205	PF00400	0.564
TRG_ER_diArg_1	242	245	PF00400	0.387
TRG_ER_diArg_1	3	5	PF00400	0.559
TRG_ER_diArg_1	380	383	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P269	Leptomonas seymouri	52%	100%
A0A0N1PC27	Leptomonas seymouri	32%	96%
A0A0N1PES8	Leptomonas seymouri	55%	98%
A0A1X0NWK3	Trypanosomatidae	34%	100%
A0A1X0NWM3	Trypanosomatidae	35%	100%
A0A3R7N1J7	Trypanosoma rangeli	33%	100%
A0A3S5H7D9	Leishmania donovani	85%	100%
A0A3S7WZK8	Leishmania donovani	29%	81%
A0A3S7X6F1	Leishmania donovani	29%	94%
A4HAG5	Leishmania braziliensis	27%	87%
A4HDU8	Leishmania braziliensis	69%	100%
A4HL36	Leishmania braziliensis	26%	75%
A4I143	Leishmania infantum	85%	100%
A4I1Y7	Leishmania infantum	29%	81%
A4I8P7	Leishmania infantum	29%	94%
E9AHM5	Leishmania infantum	27%	73%
E9AXX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AY34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	81%
E9B3H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	74%
E9B3L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	98%
Q05889	Leishmania donovani	85%	100%
Q4Q9D9	Leishmania major	29%	100%
Q6XFB5	Leishmania major	30%	100%
V5AJW5	Trypanosoma cruzi	31%	100%
V5AM55	Trypanosoma cruzi	31%	100%
V5AR28	Trypanosoma cruzi	31%	100%
V5ASN8	Trypanosoma cruzi	32%	100%
V5AUJ2	Trypanosoma cruzi	30%	100%
V5B2H2	Trypanosoma cruzi	33%	100%
V5B4V1	Trypanosoma cruzi	31%	100%
V5B8H6	Trypanosoma cruzi	31%	100%
V5BB47	Trypanosoma cruzi	30%	100%
V5BRK8	Trypanosoma cruzi	32%	100%
V5BXG8	Trypanosoma cruzi	32%	100%
V5DD11	Trypanosoma cruzi	31%	100%