Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9N858_LEIMA

TriTrypDb:

LmjF.04.0100 , LMJLV39_040006100 , LMJSD75_040006100

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9N858

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9N858

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.426
CLV_C14_Caspase3-7	512	516	PF00656	0.728
CLV_NRD_NRD_1	11	13	PF00675	0.415
CLV_NRD_NRD_1	20	22	PF00675	0.221
CLV_NRD_NRD_1	435	437	PF00675	0.338
CLV_NRD_NRD_1	50	52	PF00675	0.619
CLV_NRD_NRD_1	541	543	PF00675	0.480
CLV_NRD_NRD_1	564	566	PF00675	0.503
CLV_NRD_NRD_1	576	578	PF00675	0.472
CLV_PCSK_FUR_1	562	566	PF00082	0.483
CLV_PCSK_KEX2_1	102	104	PF00082	0.511
CLV_PCSK_KEX2_1	11	13	PF00082	0.416
CLV_PCSK_KEX2_1	19	21	PF00082	0.344
CLV_PCSK_KEX2_1	311	313	PF00082	0.607
CLV_PCSK_KEX2_1	49	51	PF00082	0.620
CLV_PCSK_KEX2_1	543	545	PF00082	0.479
CLV_PCSK_KEX2_1	564	566	PF00082	0.478
CLV_PCSK_KEX2_1	576	578	PF00082	0.483
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.511
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.607
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.467
CLV_PCSK_SKI1_1	124	128	PF00082	0.478
CLV_PCSK_SKI1_1	20	24	PF00082	0.266
CLV_PCSK_SKI1_1	395	399	PF00082	0.594
CLV_PCSK_SKI1_1	546	550	PF00082	0.541
DEG_Nend_UBRbox_2	1	3	PF02207	0.647
DEG_SPOP_SBC_1	509	513	PF00917	0.675
DOC_CYCLIN_RxL_1	392	402	PF00134	0.380
DOC_MAPK_gen_1	19	25	PF00069	0.449
DOC_MAPK_gen_1	436	442	PF00069	0.523
DOC_MAPK_MEF2A_6	122	129	PF00069	0.288
DOC_MAPK_NFAT4_5	122	130	PF00069	0.287
DOC_USP7_MATH_1	140	144	PF00917	0.364
DOC_USP7_MATH_1	244	248	PF00917	0.464
DOC_USP7_MATH_1	262	266	PF00917	0.425
DOC_USP7_MATH_1	298	302	PF00917	0.427
DOC_USP7_MATH_1	403	407	PF00917	0.480
DOC_USP7_MATH_1	483	487	PF00917	0.671
DOC_USP7_MATH_1	514	518	PF00917	0.719
DOC_USP7_MATH_2	530	536	PF00917	0.696
DOC_WW_Pin1_4	421	426	PF00397	0.544
DOC_WW_Pin1_4	498	503	PF00397	0.647
DOC_WW_Pin1_4	536	541	PF00397	0.699
DOC_WW_Pin1_4	67	72	PF00397	0.426
DOC_WW_Pin1_4	95	100	PF00397	0.351
LIG_14-3-3_CanoR_1	212	220	PF00244	0.364
LIG_14-3-3_CanoR_1	370	376	PF00244	0.334
LIG_14-3-3_CanoR_1	430	435	PF00244	0.552
LIG_14-3-3_CanoR_1	546	555	PF00244	0.734
LIG_CSL_BTD_1	492	495	PF09270	0.633
LIG_FHA_1	29	35	PF00498	0.299
LIG_FHA_1	318	324	PF00498	0.402
LIG_FHA_2	400	406	PF00498	0.319
LIG_FHA_2	422	428	PF00498	0.546
LIG_FHA_2	510	516	PF00498	0.688
LIG_FHA_2	547	553	PF00498	0.780
LIG_LIR_Gen_1	170	181	PF02991	0.297
LIG_LIR_Gen_1	401	412	PF02991	0.266
LIG_LIR_Nem_3	170	176	PF02991	0.298
LIG_LIR_Nem_3	401	407	PF02991	0.293
LIG_MYND_1	467	471	PF01753	0.598
LIG_MYND_1	71	75	PF01753	0.464
LIG_NRBOX	332	338	PF00104	0.385
LIG_SH2_STAP1	173	177	PF00017	0.293
LIG_SH2_STAT3	462	465	PF00017	0.654
LIG_SH2_STAT5	189	192	PF00017	0.303
LIG_SH2_STAT5	418	421	PF00017	0.285
LIG_SH2_STAT5	423	426	PF00017	0.538
LIG_SH2_STAT5	462	465	PF00017	0.612
LIG_SH2_STAT5	47	50	PF00017	0.410
LIG_SH3_3	458	464	PF00018	0.629
LIG_SH3_3	496	502	PF00018	0.634
LIG_SH3_3	524	530	PF00018	0.754
LIG_SH3_CIN85_PxpxPR_1	471	476	PF14604	0.609
LIG_SUMO_SIM_anti_2	226	234	PF11976	0.370
LIG_SUMO_SIM_anti_2	374	380	PF11976	0.470
LIG_SUMO_SIM_par_1	356	361	PF11976	0.325
MOD_CDK_SPK_2	498	503	PF00069	0.671
MOD_CDK_SPK_2	67	72	PF00069	0.406
MOD_CDK_SPxK_1	536	542	PF00069	0.700
MOD_CDK_SPxxK_3	536	543	PF00069	0.701
MOD_CDK_SPxxK_3	95	102	PF00069	0.344
MOD_CK1_1	148	154	PF00069	0.415
MOD_CK1_1	277	283	PF00069	0.407
MOD_CK1_1	306	312	PF00069	0.440
MOD_CK1_1	517	523	PF00069	0.684
MOD_CK1_1	535	541	PF00069	0.762
MOD_CK1_1	7	13	PF00069	0.633
MOD_CK2_1	220	226	PF00069	0.335
MOD_CK2_1	399	405	PF00069	0.493
MOD_GlcNHglycan	147	150	PF01048	0.628
MOD_GlcNHglycan	155	159	PF01048	0.510
MOD_GlcNHglycan	170	173	PF01048	0.534
MOD_GlcNHglycan	222	225	PF01048	0.580
MOD_GlcNHglycan	270	273	PF01048	0.608
MOD_GlcNHglycan	479	482	PF01048	0.427
MOD_GlcNHglycan	534	537	PF01048	0.576
MOD_GSK3_1	211	218	PF00069	0.404
MOD_GSK3_1	273	280	PF00069	0.382
MOD_GSK3_1	399	406	PF00069	0.374
MOD_GSK3_1	421	428	PF00069	0.664
MOD_GSK3_1	494	501	PF00069	0.686
MOD_GSK3_1	510	517	PF00069	0.793
MOD_GSK3_1	519	526	PF00069	0.638
MOD_GSK3_1	531	538	PF00069	0.719
MOD_GSK3_1	560	567	PF00069	0.793
MOD_GSK3_1	568	575	PF00069	0.723
MOD_NEK2_1	168	173	PF00069	0.304
MOD_NEK2_1	210	215	PF00069	0.450
MOD_NEK2_1	220	225	PF00069	0.341
MOD_NEK2_1	231	236	PF00069	0.392
MOD_NEK2_1	274	279	PF00069	0.383
MOD_NEK2_1	358	363	PF00069	0.274
MOD_NEK2_1	399	404	PF00069	0.358
MOD_NEK2_1	407	412	PF00069	0.304
MOD_NEK2_1	477	482	PF00069	0.648
MOD_NEK2_2	568	573	PF00069	0.676
MOD_OFUCOSY	355	362	PF10250	0.277
MOD_PIKK_1	148	154	PF00454	0.394
MOD_PIKK_1	231	237	PF00454	0.497
MOD_PIKK_1	303	309	PF00454	0.391
MOD_PKA_1	564	570	PF00069	0.678
MOD_PKA_2	211	217	PF00069	0.363
MOD_PKA_2	563	569	PF00069	0.676
MOD_PKA_2	572	578	PF00069	0.687
MOD_PKA_2	7	13	PF00069	0.608
MOD_PKB_1	544	552	PF00069	0.665
MOD_PKB_1	562	570	PF00069	0.676
MOD_Plk_1	117	123	PF00069	0.327
MOD_Plk_1	483	489	PF00069	0.648
MOD_Plk_4	244	250	PF00069	0.355
MOD_Plk_4	371	377	PF00069	0.461
MOD_Plk_4	494	500	PF00069	0.741
MOD_ProDKin_1	421	427	PF00069	0.545
MOD_ProDKin_1	498	504	PF00069	0.648
MOD_ProDKin_1	536	542	PF00069	0.700
MOD_ProDKin_1	67	73	PF00069	0.426
MOD_ProDKin_1	95	101	PF00069	0.343
TRG_DiLeu_BaEn_1	226	231	PF01217	0.345
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.274
TRG_ENDOCYTIC_2	173	176	PF00928	0.292
TRG_ER_diArg_1	121	124	PF00400	0.290
TRG_ER_diArg_1	18	21	PF00400	0.568
TRG_ER_diArg_1	339	342	PF00400	0.408
TRG_ER_diArg_1	343	346	PF00400	0.344
TRG_ER_diArg_1	429	432	PF00400	0.566
TRG_ER_diArg_1	48	51	PF00400	0.417
TRG_ER_diArg_1	544	547	PF00400	0.668
TRG_ER_diArg_1	562	565	PF00400	0.678
TRG_NLS_MonoExtC_3	541	546	PF00514	0.669
TRG_NLS_MonoExtN_4	540	547	PF00514	0.664
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X8	Leptomonas seymouri	47%	93%
A0A451EJV6	Leishmania donovani	94%	100%
A4H3T1	Leishmania braziliensis	78%	97%
A4HS06	Leishmania infantum	94%	100%
E9AJZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%