LeishMANIAdb
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TNFR-Cys domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TNFR-Cys domain-containing protein
Gene product:
hypothetical protein, conserved in leishmania
Species:
Leishmania major
UniProt:
Q9N853_LEIMA
TriTrypDb:
LmjF.04.0160 , LMJLV39_040006600 , LMJSD75_040006600
Length:
531

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 8
NetGPI no yes: 0, no: 19
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 4
GO:0110165 cellular anatomical entity 1 4
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Expansion

Sequence features

Q9N853
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9N853

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 4
GO:0008233 peptidase activity 3 4
GO:0016787 hydrolase activity 2 4
GO:0140096 catalytic activity, acting on a protein 2 4
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 359 363 PF00656 0.438
CLV_PCSK_SKI1_1 34 38 PF00082 0.619
CLV_PCSK_SKI1_1 456 460 PF00082 0.663
DOC_MAPK_FxFP_2 282 285 PF00069 0.401
DOC_PP4_FxxP_1 282 285 PF00568 0.401
DOC_USP7_MATH_1 110 114 PF00917 0.481
DOC_USP7_MATH_1 126 130 PF00917 0.325
DOC_USP7_MATH_1 137 141 PF00917 0.365
DOC_USP7_MATH_1 154 158 PF00917 0.502
DOC_USP7_MATH_1 224 228 PF00917 0.423
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P251 Leptomonas seymouri 23% 100%
A0A381M9M8 Leishmania infantum 92% 100%
A0A3S5H581 Leishmania donovani 91% 100%
A0A3S5H583 Leishmania donovani 91% 100%
A0A451EJW1 Leishmania donovani 91% 100%
A0A451EJW4 Leishmania donovani 91% 100%
A0A451EJW6 Leishmania donovani 23% 75%
A4H3T7 Leishmania braziliensis 77% 100%
A4H3T8 Leishmania braziliensis 68% 93%
A4H3T9 Leishmania braziliensis 69% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS