LeishMANIAdb
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TNFR-Cys domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TNFR-Cys domain-containing protein
Gene product:
hypothetical protein, conserved in leishmania
Species:
Leishmania major
UniProt:
Q9N852_LEIMA
TriTrypDb:
LmjF.04.0170 , LMJLV39_040006600 * , LMJSD75_040006600 *
Length:
531

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 8
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

Q9N852
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9N852

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0008233 peptidase activity 3 4
GO:0016787 hydrolase activity 2 4
GO:0140096 catalytic activity, acting on a protein 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 359 363 PF00656 0.400
CLV_PCSK_SKI1_1 34 38 PF00082 0.591
CLV_PCSK_SKI1_1 456 460 PF00082 0.640
DOC_MAPK_FxFP_2 282 285 PF00069 0.377
DOC_PP4_FxxP_1 282 285 PF00568 0.377
DOC_USP7_MATH_1 110 114 PF00917 0.446
DOC_USP7_MATH_1 126 130 PF00917 0.318
DOC_USP7_MATH_1 137 141 PF00917 0.357
DOC_USP7_MATH_1 154 158 PF00917 0.497
DOC_USP7_MATH_1 224 228 PF00917 0.394
DOC_USP7_MATH_1 275 279 PF00917 0.411
DOC_USP7_MATH_1 319 323 PF00917 0.438
DOC_USP7_MATH_1 385 389 PF00917 0.414
DOC_USP7_MATH_1 476 480 PF00917 0.399
DOC_USP7_MATH_1 482 486 PF00917 0.383
DOC_USP7_MATH_1 79 83 PF00917 0.485
DOC_WW_Pin1_4 401 406 PF00397 0.393
DOC_WW_Pin1_4 491 496 PF00397 0.385
DOC_WW_Pin1_4 80 85 PF00397 0.549
LIG_14-3-3_CanoR_1 116 126 PF00244 0.433
LIG_14-3-3_CanoR_1 220 228 PF00244 0.343
LIG_14-3-3_CanoR_1 439 447 PF00244 0.459
LIG_14-3-3_CanoR_1 493 499 PF00244 0.434
LIG_14-3-3_CanoR_1 88 94 PF00244 0.458
LIG_BRCT_BRCA1_1 236 240 PF00533 0.413
LIG_BRCT_BRCA1_1 39 43 PF00533 0.354
LIG_FHA_1 119 125 PF00498 0.366
LIG_FHA_1 141 147 PF00498 0.445
LIG_FHA_1 158 164 PF00498 0.305
LIG_FHA_1 176 182 PF00498 0.362
LIG_FHA_1 31 37 PF00498 0.452
LIG_FHA_1 406 412 PF00498 0.400
LIG_FHA_1 45 51 PF00498 0.498
LIG_FHA_1 513 519 PF00498 0.445
LIG_FHA_1 59 65 PF00498 0.325
LIG_FHA_2 260 266 PF00498 0.360
LIG_FHA_2 357 363 PF00498 0.431
LIG_FHA_2 39 45 PF00498 0.453
LIG_FHA_2 422 428 PF00498 0.360
LIG_FHA_2 439 445 PF00498 0.349
LIG_LIR_Gen_1 44 52 PF02991 0.377
LIG_LIR_Nem_3 132 136 PF02991 0.426
LIG_LIR_Nem_3 267 272 PF02991 0.343
LIG_LIR_Nem_3 304 310 PF02991 0.460
LIG_LIR_Nem_3 40 46 PF02991 0.416
LIG_PDZ_Class_2 526 531 PF00595 0.644
LIG_SH2_CRK 46 50 PF00017 0.424
LIG_SH2_STAP1 272 276 PF00017 0.305
LIG_SH2_STAP1 46 50 PF00017 0.416
LIG_SH2_STAT5 269 272 PF00017 0.406
LIG_SH2_STAT5 46 49 PF00017 0.478
LIG_SH2_STAT5 496 499 PF00017 0.355
LIG_SH3_3 148 154 PF00018 0.457
LIG_SH3_3 407 413 PF00018 0.398
LIG_SUMO_SIM_anti_2 16 21 PF11976 0.488
LIG_SUMO_SIM_anti_2 162 167 PF11976 0.414
LIG_SUMO_SIM_par_1 142 147 PF11976 0.431
LIG_SUMO_SIM_par_1 162 167 PF11976 0.253
LIG_SUMO_SIM_par_1 230 235 PF11976 0.398
LIG_SUMO_SIM_par_1 47 56 PF11976 0.432
LIG_TRAF2_2 413 418 PF00917 0.397
MOD_CK1_1 101 107 PF00069 0.353
MOD_CK1_1 140 146 PF00069 0.386
MOD_CK1_1 157 163 PF00069 0.476
MOD_CK1_1 167 173 PF00069 0.401
MOD_CK1_1 257 263 PF00069 0.367
MOD_CK1_1 264 270 PF00069 0.359
MOD_CK1_1 300 306 PF00069 0.356
MOD_CK1_1 356 362 PF00069 0.414
MOD_CK1_1 367 373 PF00069 0.413
MOD_CK1_1 39 45 PF00069 0.467
MOD_CK1_1 448 454 PF00069 0.366
MOD_CK1_1 487 493 PF00069 0.473
MOD_CK1_1 494 500 PF00069 0.428
MOD_CK1_1 53 59 PF00069 0.435
MOD_CK1_1 67 73 PF00069 0.387
MOD_CK1_1 82 88 PF00069 0.399
MOD_CK2_1 271 277 PF00069 0.401
MOD_CK2_1 337 343 PF00069 0.333
MOD_CK2_1 385 391 PF00069 0.418
MOD_GlcNHglycan 100 103 PF01048 0.483
MOD_GlcNHglycan 105 108 PF01048 0.659
MOD_GlcNHglycan 132 136 PF01048 0.615
MOD_GlcNHglycan 166 169 PF01048 0.648
MOD_GlcNHglycan 222 225 PF01048 0.556
MOD_GlcNHglycan 256 259 PF01048 0.591
MOD_GlcNHglycan 265 269 PF01048 0.678
MOD_GlcNHglycan 273 276 PF01048 0.565
MOD_GlcNHglycan 277 280 PF01048 0.604
MOD_GlcNHglycan 299 302 PF01048 0.622
MOD_GlcNHglycan 367 370 PF01048 0.666
MOD_GlcNHglycan 387 390 PF01048 0.585
MOD_GlcNHglycan 484 487 PF01048 0.670
MOD_GlcNHglycan 55 58 PF01048 0.649
MOD_GlcNHglycan 69 72 PF01048 0.590
MOD_GlcNHglycan 85 88 PF01048 0.559
MOD_GSK3_1 199 206 PF00069 0.424
MOD_GSK3_1 220 227 PF00069 0.345
MOD_GSK3_1 253 260 PF00069 0.388
MOD_GSK3_1 26 33 PF00069 0.559
MOD_GSK3_1 271 278 PF00069 0.456
MOD_GSK3_1 297 304 PF00069 0.380
MOD_GSK3_1 319 326 PF00069 0.434
MOD_GSK3_1 34 41 PF00069 0.398
MOD_GSK3_1 345 352 PF00069 0.393
MOD_GSK3_1 356 363 PF00069 0.343
MOD_GSK3_1 383 390 PF00069 0.484
MOD_GSK3_1 391 398 PF00069 0.396
MOD_GSK3_1 401 408 PF00069 0.352
MOD_GSK3_1 434 441 PF00069 0.446
MOD_GSK3_1 456 463 PF00069 0.452
MOD_GSK3_1 465 472 PF00069 0.463
MOD_GSK3_1 484 491 PF00069 0.419
MOD_GSK3_1 79 86 PF00069 0.470
MOD_GSK3_1 89 96 PF00069 0.376
MOD_N-GLC_1 140 145 PF02516 0.631
MOD_N-GLC_1 184 189 PF02516 0.539
MOD_N-GLC_2 438 440 PF02516 0.649
MOD_NEK2_1 13 18 PF00069 0.472
MOD_NEK2_1 131 136 PF00069 0.409
MOD_NEK2_1 184 189 PF00069 0.455
MOD_NEK2_1 254 259 PF00069 0.415
MOD_NEK2_1 297 302 PF00069 0.440
MOD_NEK2_1 310 315 PF00069 0.367
MOD_NEK2_1 327 332 PF00069 0.314
MOD_NEK2_1 38 43 PF00069 0.408
MOD_NEK2_1 406 411 PF00069 0.412
MOD_NEK2_1 50 55 PF00069 0.380
MOD_NEK2_1 64 69 PF00069 0.327
MOD_NEK2_1 89 94 PF00069 0.408
MOD_NEK2_2 126 131 PF00069 0.357
MOD_PIKK_1 196 202 PF00454 0.400
MOD_PIKK_1 360 366 PF00454 0.392
MOD_PIKK_1 64 70 PF00454 0.435
MOD_PKA_2 219 225 PF00069 0.351
MOD_PKA_2 438 444 PF00069 0.453
MOD_PKA_2 79 85 PF00069 0.507
MOD_PKA_2 87 93 PF00069 0.428
MOD_Plk_1 140 146 PF00069 0.449
MOD_Plk_1 184 190 PF00069 0.344
MOD_Plk_1 234 240 PF00069 0.376
MOD_Plk_1 264 270 PF00069 0.406
MOD_Plk_1 34 40 PF00069 0.463
MOD_Plk_1 44 50 PF00069 0.304
MOD_Plk_4 126 132 PF00069 0.454
MOD_Plk_4 13 19 PF00069 0.472
MOD_Plk_4 140 146 PF00069 0.356
MOD_Plk_4 159 165 PF00069 0.372
MOD_Plk_4 190 196 PF00069 0.481
MOD_Plk_4 235 241 PF00069 0.349
MOD_Plk_4 303 309 PF00069 0.378
MOD_Plk_4 356 362 PF00069 0.451
MOD_Plk_4 406 412 PF00069 0.404
MOD_Plk_4 44 50 PF00069 0.364
MOD_ProDKin_1 401 407 PF00069 0.390
MOD_ProDKin_1 491 497 PF00069 0.385
MOD_ProDKin_1 80 86 PF00069 0.547
TRG_ENDOCYTIC_2 46 49 PF00928 0.351
TRG_NES_CRM1_1 128 139 PF08389 0.422

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P251 Leptomonas seymouri 23% 100%
A0A381M9M8 Leishmania infantum 92% 100%
A0A3S5H581 Leishmania donovani 91% 100%
A0A3S5H583 Leishmania donovani 92% 100%
A0A451EJW1 Leishmania donovani 91% 100%
A0A451EJW4 Leishmania donovani 91% 100%
A0A451EJW6 Leishmania donovani 23% 75%
A4H3T7 Leishmania braziliensis 77% 100%
A4H3T8 Leishmania braziliensis 69% 93%
A4H3T9 Leishmania braziliensis 69% 100%
A4H3U0 Leishmania braziliensis 67% 100%
A4H3U1 Leishmania braziliensis 67% 100%
A4HS14 Leishmania infantum 23% 75%
E9AJZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 87%
E9AK01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 75%
Q9N853 Leishmania major 100% 100%
Q9N856 Leishmania major 100% 100%
Q9XZX9 Leishmania major 23% 75%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS