Uncharacterized protein L7845.02

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iron-sulfur assembly protein 2, putative

Species:

Leishmania major

UniProt:

Q9GRP9_LEIMA

TriTrypDb:

LmjF.35.1350 , LMJLV39_350019800 , LMJSD75_350019000

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9GRP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9GRP9

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016226	iron-sulfur cluster assembly	4	2
GO:0019538	protein metabolic process	3	2
GO:0022607	cellular component assembly	4	2
GO:0031163	metallo-sulfur cluster assembly	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0051604	protein maturation	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	2
GO:0106035	protein maturation by [4Fe-4S] cluster transfer	6	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005506	iron ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0051536	iron-sulfur cluster binding	3	2
GO:0051537	2 iron, 2 sulfur cluster binding	4	2
GO:0051539	4 iron, 4 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.529
CLV_NRD_NRD_1	165	167	PF00675	0.513
CLV_NRD_NRD_1	213	215	PF00675	0.616
CLV_NRD_NRD_1	50	52	PF00675	0.503
CLV_NRD_NRD_1	7	9	PF00675	0.534
CLV_PCSK_KEX2_1	213	215	PF00082	0.616
CLV_PCSK_KEX2_1	7	9	PF00082	0.534
CLV_PCSK_PC7_1	209	215	PF00082	0.619
CLV_PCSK_PC7_1	3	9	PF00082	0.576
DEG_Nend_Nbox_1	1	3	PF02207	0.502
DEG_SPOP_SBC_1	173	177	PF00917	0.619
DOC_USP7_MATH_1	12	16	PF00917	0.662
DOC_USP7_MATH_1	174	178	PF00917	0.617
DOC_USP7_MATH_1	199	203	PF00917	0.692
DOC_USP7_MATH_1	68	72	PF00917	0.416
DOC_WW_Pin1_4	101	106	PF00397	0.566
DOC_WW_Pin1_4	113	118	PF00397	0.475
DOC_WW_Pin1_4	22	27	PF00397	0.671
DOC_WW_Pin1_4	39	44	PF00397	0.493
LIG_14-3-3_CanoR_1	166	173	PF00244	0.505
LIG_14-3-3_CanoR_1	3	7	PF00244	0.482
LIG_14-3-3_CanoR_1	51	58	PF00244	0.574
LIG_14-3-3_CterR_2	218	221	PF00244	0.665
LIG_DCNL_PONY_1	1	4	PF03556	0.629
LIG_FHA_2	28	34	PF00498	0.616
LIG_LIR_Gen_1	143	153	PF02991	0.393
LIG_LIR_Gen_1	61	69	PF02991	0.365
LIG_LIR_Nem_3	143	148	PF02991	0.411
LIG_LIR_Nem_3	61	67	PF02991	0.424
LIG_SH2_STAT5	64	67	PF00017	0.407
LIG_SH2_STAT5	77	80	PF00017	0.441
MOD_CDK_SPK_2	113	118	PF00069	0.475
MOD_CDK_SPK_2	39	44	PF00069	0.493
MOD_CK1_1	15	21	PF00069	0.685
MOD_CK1_1	172	178	PF00069	0.620
MOD_CK1_1	212	218	PF00069	0.652
MOD_GlcNHglycan	124	127	PF01048	0.593
MOD_GlcNHglycan	14	17	PF01048	0.605
MOD_GlcNHglycan	142	145	PF01048	0.407
MOD_GlcNHglycan	177	180	PF01048	0.722
MOD_GlcNHglycan	183	186	PF01048	0.709
MOD_GlcNHglycan	192	195	PF01048	0.729
MOD_GlcNHglycan	70	73	PF01048	0.424
MOD_GSK3_1	12	19	PF00069	0.694
MOD_GSK3_1	120	127	PF00069	0.471
MOD_GSK3_1	161	168	PF00069	0.618
MOD_GSK3_1	169	176	PF00069	0.664
MOD_GSK3_1	209	216	PF00069	0.716
MOD_GSK3_1	22	29	PF00069	0.619
MOD_GSK3_1	35	42	PF00069	0.530
MOD_GSK3_1	47	54	PF00069	0.507
MOD_N-GLC_1	130	135	PF02516	0.395
MOD_NEK2_1	124	129	PF00069	0.521
MOD_NEK2_1	140	145	PF00069	0.447
MOD_NEK2_1	161	166	PF00069	0.426
MOD_NEK2_1	2	7	PF00069	0.486
MOD_PK_1	37	43	PF00069	0.510
MOD_PKA_1	166	172	PF00069	0.539
MOD_PKA_1	213	219	PF00069	0.520
MOD_PKA_1	51	57	PF00069	0.496
MOD_PKA_2	165	171	PF00069	0.607
MOD_PKA_2	2	8	PF00069	0.502
MOD_PKA_2	212	218	PF00069	0.664
MOD_Plk_1	130	136	PF00069	0.444
MOD_ProDKin_1	101	107	PF00069	0.567
MOD_ProDKin_1	113	119	PF00069	0.468
MOD_ProDKin_1	22	28	PF00069	0.668
MOD_ProDKin_1	39	45	PF00069	0.488
MOD_SUMO_rev_2	135	143	PF00179	0.439
TRG_ENDOCYTIC_2	64	67	PF00928	0.407
TRG_ER_diArg_1	6	8	PF00400	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD94	Leptomonas seymouri	64%	98%
A0A0S4JDK9	Bodo saltans	43%	100%
A0A1X0NHC3	Trypanosomatidae	55%	100%
A0A3R7LRU0	Trypanosoma rangeli	56%	100%
A0A3S7X981	Leishmania donovani	93%	100%
A4HMF6	Leishmania braziliensis	80%	100%
A4IB28	Leishmania infantum	93%	100%
C9ZNM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B613	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%