LeishMANIAdb
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Uncharacterized protein L7845.03

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein L7845.03
Gene product:
thioredoxin, putative
Species:
Leishmania major
UniProt:
Q9GRP8_LEIMA
TriTrypDb:
LmjF.35.1330 , LMJLV39_350019700 * , LMJSD75_350018900
Length:
562

Annotations

LeishMANIAdb annotations

Contains a thioredoxin domain. Homologous to ER-associated disulphide isomerases in other Eukaryotes.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 0
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 2
GO:0016020 membrane 2 11
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

Q9GRP8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9GRP8

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 2
GO:0006950 response to stress 2 2
GO:0009987 cellular process 1 2
GO:0033554 cellular response to stress 3 2
GO:0034976 response to endoplasmic reticulum stress 4 2
GO:0050896 response to stimulus 1 2
GO:0051716 cellular response to stimulus 2 2
Molecular functions
Term Name Level Count
GO:0003756 protein disulfide isomerase activity 3 9
GO:0003824 catalytic activity 1 9
GO:0016853 isomerase activity 2 9
GO:0016860 intramolecular oxidoreductase activity 3 9
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4 9
GO:0140096 catalytic activity, acting on a protein 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 315 317 PF00675 0.659
CLV_NRD_NRD_1 391 393 PF00675 0.610
CLV_NRD_NRD_1 552 554 PF00675 0.386
CLV_PCSK_FUR_1 313 317 PF00082 0.579
CLV_PCSK_KEX2_1 315 317 PF00082 0.724
CLV_PCSK_KEX2_1 441 443 PF00082 0.518
CLV_PCSK_KEX2_1 560 562 PF00082 0.484
CLV_PCSK_KEX2_1 76 78 PF00082 0.542
CLV_PCSK_PC1ET2_1 441 443 PF00082 0.583
CLV_PCSK_PC1ET2_1 560 562 PF00082 0.514
CLV_PCSK_PC1ET2_1 76 78 PF00082 0.542
CLV_PCSK_SKI1_1 2 6 PF00082 0.608
CLV_PCSK_SKI1_1 380 384 PF00082 0.531
CLV_PCSK_SKI1_1 444 448 PF00082 0.598
CLV_PCSK_SKI1_1 76 80 PF00082 0.569
CLV_PCSK_SKI1_1 81 85 PF00082 0.466
CLV_PCSK_SKI1_1 96 100 PF00082 0.428
DEG_SCF_FBW7_1 403 409 PF00400 0.296
DEG_SPOP_SBC_1 209 213 PF00917 0.413
DOC_CDC14_PxL_1 373 381 PF14671 0.297
DOC_CKS1_1 403 408 PF01111 0.300
DOC_CKS1_1 460 465 PF01111 0.403
DOC_MAPK_gen_1 422 429 PF00069 0.409
DOC_MAPK_gen_1 7 16 PF00069 0.520
DOC_MAPK_MEF2A_6 10 18 PF00069 0.471
DOC_MAPK_MEF2A_6 356 363 PF00069 0.364
DOC_MAPK_RevD_3 427 442 PF00069 0.306
DOC_PP1_RVXF_1 405 411 PF00149 0.365
DOC_SPAK_OSR1_1 238 242 PF12202 0.268
DOC_USP7_MATH_1 209 213 PF00917 0.397
DOC_USP7_MATH_1 232 236 PF00917 0.316
DOC_USP7_MATH_1 307 311 PF00917 0.507
DOC_USP7_MATH_1 406 410 PF00917 0.371
DOC_USP7_UBL2_3 261 265 PF12436 0.315
DOC_USP7_UBL2_3 554 558 PF12436 0.656
DOC_WW_Pin1_4 402 407 PF00397 0.308
DOC_WW_Pin1_4 459 464 PF00397 0.334
DOC_WW_Pin1_4 76 81 PF00397 0.375
DOC_WW_Pin1_4 86 91 PF00397 0.274
DOC_WW_Pin1_4 9 14 PF00397 0.453
LIG_14-3-3_CanoR_1 407 413 PF00244 0.282
LIG_APCC_ABBA_1 283 288 PF00400 0.305
LIG_BRCT_BRCA1_1 130 134 PF00533 0.278
LIG_BRCT_BRCA1_1 344 348 PF00533 0.324
LIG_BRCT_BRCA1_1 69 73 PF00533 0.290
LIG_CaM_NSCaTE_8 224 231 PF13499 0.390
LIG_eIF4E_1 504 510 PF01652 0.365
LIG_FHA_1 197 203 PF00498 0.469
LIG_FHA_1 21 27 PF00498 0.483
LIG_FHA_1 312 318 PF00498 0.495
LIG_FHA_1 403 409 PF00498 0.374
LIG_FHA_1 51 57 PF00498 0.400
LIG_FHA_2 324 330 PF00498 0.337
LIG_FHA_2 381 387 PF00498 0.336
LIG_FHA_2 438 444 PF00498 0.370
LIG_LIR_Apic_2 287 293 PF02991 0.295
LIG_LIR_Apic_2 52 57 PF02991 0.389
LIG_LIR_Apic_2 69 74 PF02991 0.207
LIG_LIR_Gen_1 117 124 PF02991 0.278
LIG_LIR_Gen_1 12 22 PF02991 0.352
LIG_LIR_Gen_1 188 195 PF02991 0.387
LIG_LIR_Gen_1 329 339 PF02991 0.293
LIG_LIR_Gen_1 345 355 PF02991 0.333
LIG_LIR_Gen_1 409 420 PF02991 0.347
LIG_LIR_Gen_1 532 541 PF02991 0.378
LIG_LIR_LC3C_4 281 285 PF02991 0.376
LIG_LIR_Nem_3 117 122 PF02991 0.377
LIG_LIR_Nem_3 12 18 PF02991 0.360
LIG_LIR_Nem_3 131 136 PF02991 0.197
LIG_LIR_Nem_3 137 142 PF02991 0.145
LIG_LIR_Nem_3 188 193 PF02991 0.383
LIG_LIR_Nem_3 256 262 PF02991 0.306
LIG_LIR_Nem_3 329 334 PF02991 0.292
LIG_LIR_Nem_3 345 351 PF02991 0.380
LIG_LIR_Nem_3 372 378 PF02991 0.387
LIG_LIR_Nem_3 409 415 PF02991 0.342
LIG_LIR_Nem_3 502 507 PF02991 0.314
LIG_LIR_Nem_3 532 536 PF02991 0.315
LIG_MLH1_MIPbox_1 130 134 PF16413 0.278
LIG_OCRL_FandH_1 330 342 PF00620 0.371
LIG_PCNA_yPIPBox_3 126 134 PF02747 0.337
LIG_PCNA_yPIPBox_3 479 490 PF02747 0.417
LIG_Pex14_1 421 425 PF04695 0.289
LIG_PTB_Apo_2 233 240 PF02174 0.313
LIG_PTB_Apo_2 62 69 PF02174 0.335
LIG_REV1ctd_RIR_1 443 452 PF16727 0.312
LIG_SH2_CRK 259 263 PF00017 0.342
LIG_SH2_PTP2 205 208 PF00017 0.316
LIG_SH2_PTP2 412 415 PF00017 0.304
LIG_SH2_SRC 205 208 PF00017 0.287
LIG_SH2_SRC 412 415 PF00017 0.361
LIG_SH2_STAP1 425 429 PF00017 0.384
LIG_SH2_STAP1 516 520 PF00017 0.303
LIG_SH2_STAT3 486 489 PF00017 0.325
LIG_SH2_STAT5 133 136 PF00017 0.293
LIG_SH2_STAT5 144 147 PF00017 0.241
LIG_SH2_STAT5 170 173 PF00017 0.334
LIG_SH2_STAT5 205 208 PF00017 0.280
LIG_SH2_STAT5 296 299 PF00017 0.399
LIG_SH2_STAT5 358 361 PF00017 0.284
LIG_SH2_STAT5 412 415 PF00017 0.361
LIG_SH2_STAT5 500 503 PF00017 0.325
LIG_SH2_STAT5 71 74 PF00017 0.294
LIG_SH3_3 203 209 PF00018 0.274
LIG_SH3_3 537 543 PF00018 0.281
LIG_SH3_3 87 93 PF00018 0.322
LIG_Sin3_3 15 22 PF02671 0.424
LIG_SUMO_SIM_anti_2 40 48 PF11976 0.312
LIG_SUMO_SIM_anti_2 411 417 PF11976 0.318
LIG_SUMO_SIM_anti_2 522 527 PF11976 0.341
LIG_SUMO_SIM_par_1 40 48 PF11976 0.402
LIG_TRAF2_1 399 402 PF00917 0.386
LIG_TYR_ITIM 509 514 PF00017 0.375
LIG_UBA3_1 347 356 PF00899 0.399
LIG_WRC_WIRS_1 530 535 PF05994 0.411
MOD_CDK_SPK_2 402 407 PF00069 0.308
MOD_CDK_SPK_2 76 81 PF00069 0.262
MOD_CDK_SPxK_1 459 465 PF00069 0.398
MOD_CK1_1 218 224 PF00069 0.461
MOD_CK1_1 396 402 PF00069 0.437
MOD_CK1_1 47 53 PF00069 0.408
MOD_CK2_1 176 182 PF00069 0.375
MOD_CK2_1 211 217 PF00069 0.397
MOD_CK2_1 243 249 PF00069 0.407
MOD_CK2_1 323 329 PF00069 0.439
MOD_CK2_1 380 386 PF00069 0.367
MOD_CK2_1 396 402 PF00069 0.488
MOD_GlcNHglycan 213 216 PF01048 0.523
MOD_GlcNHglycan 275 278 PF01048 0.584
MOD_GlcNHglycan 344 347 PF01048 0.617
MOD_GSK3_1 138 145 PF00069 0.242
MOD_GSK3_1 174 181 PF00069 0.391
MOD_GSK3_1 20 27 PF00069 0.582
MOD_GSK3_1 211 218 PF00069 0.392
MOD_GSK3_1 302 309 PF00069 0.486
MOD_GSK3_1 318 325 PF00069 0.366
MOD_GSK3_1 402 409 PF00069 0.402
MOD_GSK3_1 72 79 PF00069 0.301
MOD_N-GLC_1 103 108 PF02516 0.442
MOD_NEK2_1 103 108 PF00069 0.314
MOD_NEK2_1 142 147 PF00069 0.228
MOD_NEK2_1 165 170 PF00069 0.375
MOD_NEK2_1 20 25 PF00069 0.523
MOD_NEK2_1 322 327 PF00069 0.405
MOD_NEK2_1 347 352 PF00069 0.385
MOD_PIKK_1 157 163 PF00454 0.313
MOD_PIKK_1 215 221 PF00454 0.449
MOD_PIKK_1 243 249 PF00454 0.397
MOD_PIKK_1 380 386 PF00454 0.328
MOD_PKA_2 307 313 PF00069 0.501
MOD_PKA_2 406 412 PF00069 0.261
MOD_Plk_1 103 109 PF00069 0.274
MOD_Plk_1 185 191 PF00069 0.322
MOD_Plk_1 302 308 PF00069 0.475
MOD_Plk_1 396 402 PF00069 0.417
MOD_Plk_2-3 176 182 PF00069 0.354
MOD_Plk_4 138 144 PF00069 0.242
MOD_Plk_4 166 172 PF00069 0.332
MOD_Plk_4 56 62 PF00069 0.370
MOD_Plk_4 67 73 PF00069 0.254
MOD_Plk_4 94 100 PF00069 0.266
MOD_ProDKin_1 402 408 PF00069 0.302
MOD_ProDKin_1 459 465 PF00069 0.337
MOD_ProDKin_1 76 82 PF00069 0.375
MOD_ProDKin_1 86 92 PF00069 0.274
MOD_ProDKin_1 9 15 PF00069 0.454
TRG_DiLeu_BaEn_1 41 46 PF01217 0.305
TRG_DiLeu_BaEn_1 469 474 PF01217 0.372
TRG_ENDOCYTIC_2 133 136 PF00928 0.284
TRG_ENDOCYTIC_2 205 208 PF00928 0.339
TRG_ENDOCYTIC_2 259 262 PF00928 0.303
TRG_ENDOCYTIC_2 358 361 PF00928 0.268
TRG_ENDOCYTIC_2 412 415 PF00928 0.304
TRG_ENDOCYTIC_2 504 507 PF00928 0.330
TRG_ENDOCYTIC_2 511 514 PF00928 0.295
TRG_ENDOCYTIC_2 516 519 PF00928 0.284
TRG_ER_diArg_1 313 316 PF00400 0.384
TRG_ER_diArg_1 421 424 PF00400 0.375
TRG_ER_diLys_1 558 562 PF00400 0.634
TRG_Pf-PMV_PEXEL_1 366 370 PF00026 0.615
TRG_Pf-PMV_PEXEL_1 380 384 PF00026 0.431
TRG_Pf-PMV_PEXEL_1 7 11 PF00026 0.524

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYT4 Leptomonas seymouri 66% 100%
A0A0S4KJA1 Bodo saltans 27% 98%
A0A1X0NH48 Trypanosomatidae 38% 100%
A0A3S7X8Z9 Leishmania donovani 95% 100%
A0A422N9H3 Trypanosoma rangeli 40% 100%
A4HMF5 Leishmania braziliensis 82% 100%
A4IB27 Leishmania infantum 95% 100%
C9ZNM3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 95%
E9B612 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5ASA4 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS