Uncharacterized protein L8530.02

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9GRN4_LEIMA

TriTrypDb:

LmjF.33.2130 , LMJLV39_330031600 , LMJSD75_330031100

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9GRN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9GRN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.741
CLV_C14_Caspase3-7	78	82	PF00656	0.576
CLV_NRD_NRD_1	311	313	PF00675	0.590
CLV_NRD_NRD_1	667	669	PF00675	0.372
CLV_NRD_NRD_1	705	707	PF00675	0.623
CLV_NRD_NRD_1	883	885	PF00675	0.774
CLV_PCSK_KEX2_1	132	134	PF00082	0.740
CLV_PCSK_KEX2_1	667	669	PF00082	0.327
CLV_PCSK_KEX2_1	705	707	PF00082	0.623
CLV_PCSK_KEX2_1	882	884	PF00082	0.784
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.718
CLV_PCSK_SKI1_1	273	277	PF00082	0.489
CLV_PCSK_SKI1_1	361	365	PF00082	0.402
CLV_PCSK_SKI1_1	667	671	PF00082	0.404
DEG_Nend_Nbox_1	1	3	PF02207	0.724
DEG_SCF_FBW7_1	723	729	PF00400	0.719
DEG_SPOP_SBC_1	486	490	PF00917	0.586
DOC_CKS1_1	723	728	PF01111	0.798
DOC_CKS1_1	857	862	PF01111	0.801
DOC_CKS1_1	87	92	PF01111	0.809
DOC_CKS1_1	899	904	PF01111	0.683
DOC_CYCLIN_yCln2_LP_2	446	452	PF00134	0.707
DOC_CYCLIN_yCln2_LP_2	896	902	PF00134	0.722
DOC_MAPK_FxFP_2	831	834	PF00069	0.767
DOC_MAPK_MEF2A_6	696	703	PF00069	0.636
DOC_PP1_RVXF_1	546	552	PF00149	0.638
DOC_PP2B_LxvP_1	476	479	PF13499	0.801
DOC_PP2B_LxvP_1	896	899	PF13499	0.725
DOC_PP4_FxxP_1	535	538	PF00568	0.699
DOC_PP4_FxxP_1	783	786	PF00568	0.693
DOC_PP4_FxxP_1	831	834	PF00568	0.767
DOC_PP4_MxPP_1	450	453	PF00568	0.695
DOC_PP4_MxPP_1	827	830	PF00568	0.742
DOC_USP7_MATH_1	220	224	PF00917	0.655
DOC_USP7_MATH_1	264	268	PF00917	0.710
DOC_USP7_MATH_1	419	423	PF00917	0.752
DOC_USP7_MATH_1	453	457	PF00917	0.819
DOC_USP7_MATH_1	467	471	PF00917	0.602
DOC_USP7_MATH_1	502	506	PF00917	0.722
DOC_USP7_MATH_1	568	572	PF00917	0.814
DOC_USP7_MATH_1	627	631	PF00917	0.778
DOC_USP7_MATH_1	786	790	PF00917	0.702
DOC_USP7_MATH_1	812	816	PF00917	0.649
DOC_USP7_MATH_2	593	599	PF00917	0.495
DOC_WW_Pin1_4	238	243	PF00397	0.752
DOC_WW_Pin1_4	250	255	PF00397	0.702
DOC_WW_Pin1_4	266	271	PF00397	0.594
DOC_WW_Pin1_4	301	306	PF00397	0.599
DOC_WW_Pin1_4	354	359	PF00397	0.500
DOC_WW_Pin1_4	465	470	PF00397	0.752
DOC_WW_Pin1_4	479	484	PF00397	0.804
DOC_WW_Pin1_4	519	524	PF00397	0.817
DOC_WW_Pin1_4	533	538	PF00397	0.583
DOC_WW_Pin1_4	561	566	PF00397	0.693
DOC_WW_Pin1_4	719	724	PF00397	0.819
DOC_WW_Pin1_4	750	755	PF00397	0.775
DOC_WW_Pin1_4	856	861	PF00397	0.801
DOC_WW_Pin1_4	86	91	PF00397	0.702
DOC_WW_Pin1_4	898	903	PF00397	0.756
LIG_14-3-3_CanoR_1	135	145	PF00244	0.755
LIG_14-3-3_CanoR_1	288	294	PF00244	0.474
LIG_14-3-3_CanoR_1	391	396	PF00244	0.634
LIG_14-3-3_CanoR_1	504	512	PF00244	0.808
LIG_14-3-3_CanoR_1	548	552	PF00244	0.633
LIG_14-3-3_CanoR_1	668	678	PF00244	0.517
LIG_14-3-3_CanoR_1	689	695	PF00244	0.508
LIG_14-3-3_CanoR_1	891	897	PF00244	0.678
LIG_14-3-3_CterR_2	918	920	PF00244	0.593
LIG_BIR_III_2	531	535	PF00653	0.587
LIG_BIR_III_4	14	18	PF00653	0.610
LIG_BRCT_BRCA1_1	291	295	PF00533	0.460
LIG_BRCT_BRCA1_1	601	605	PF00533	0.467
LIG_BRCT_BRCA1_1	69	73	PF00533	0.666
LIG_BRCT_BRCA1_2	69	75	PF00533	0.582
LIG_EVH1_2	829	833	PF00568	0.725
LIG_FHA_1	382	388	PF00498	0.545
LIG_FHA_1	523	529	PF00498	0.735
LIG_FHA_1	649	655	PF00498	0.494
LIG_FHA_1	834	840	PF00498	0.665
LIG_FHA_2	103	109	PF00498	0.778
LIG_FHA_2	37	43	PF00498	0.695
LIG_FHA_2	836	842	PF00498	0.640
LIG_Integrin_isoDGR_2	316	318	PF01839	0.655
LIG_LIR_Apic_2	352	358	PF02991	0.509
LIG_LIR_Apic_2	841	847	PF02991	0.645
LIG_LIR_Apic_2	86	90	PF02991	0.726
LIG_LIR_Gen_1	602	613	PF02991	0.489
LIG_LIR_Gen_1	89	98	PF02991	0.706
LIG_LIR_Nem_3	174	180	PF02991	0.610
LIG_LIR_Nem_3	550	554	PF02991	0.644
LIG_LIR_Nem_3	851	857	PF02991	0.744
LIG_LIR_Nem_3	89	95	PF02991	0.706
LIG_LYPXL_yS_3	745	748	PF13949	0.794
LIG_NRBOX	158	164	PF00104	0.606
LIG_Pex14_2	777	781	PF04695	0.714
LIG_PTAP_UEV_1	564	569	PF05743	0.707
LIG_Rb_LxCxE_1	342	365	PF01857	0.496
LIG_SH2_CRK	454	458	PF00017	0.761
LIG_SH2_CRK	462	466	PF00017	0.694
LIG_SH2_CRK	752	756	PF00017	0.666
LIG_SH2_CRK	844	848	PF00017	0.637
LIG_SH2_NCK_1	281	285	PF00017	0.517
LIG_SH2_NCK_1	38	42	PF00017	0.730
LIG_SH2_PTP2	355	358	PF00017	0.502
LIG_SH2_STAT5	158	161	PF00017	0.599
LIG_SH2_STAT5	348	351	PF00017	0.496
LIG_SH2_STAT5	355	358	PF00017	0.502
LIG_SH2_STAT5	38	41	PF00017	0.707
LIG_SH2_STAT5	481	484	PF00017	0.838
LIG_SH2_STAT5	554	557	PF00017	0.680
LIG_SH2_STAT5	600	603	PF00017	0.473
LIG_SH2_STAT5	728	731	PF00017	0.758
LIG_SH2_STAT5	87	90	PF00017	0.704
LIG_SH2_STAT6	91	95	PF00017	0.734
LIG_SH3_3	377	383	PF00018	0.635
LIG_SH3_3	446	452	PF00018	0.723
LIG_SH3_3	454	460	PF00018	0.656
LIG_SH3_3	531	537	PF00018	0.658
LIG_SH3_3	562	568	PF00018	0.706
LIG_SH3_3	626	632	PF00018	0.814
LIG_SH3_3	720	726	PF00018	0.798
LIG_SH3_3	740	746	PF00018	0.712
LIG_SH3_3	748	754	PF00018	0.660
LIG_SH3_3	758	764	PF00018	0.528
LIG_SH3_3	794	800	PF00018	0.731
LIG_SH3_3	816	822	PF00018	0.767
LIG_SH3_3	826	832	PF00018	0.736
LIG_SH3_3	854	860	PF00018	0.798
LIG_SH3_3	896	902	PF00018	0.780
LIG_SH3_3	906	912	PF00018	0.712
LIG_SUMO_SIM_par_1	371	376	PF11976	0.583
LIG_SUMO_SIM_par_1	384	390	PF11976	0.535
LIG_SUMO_SIM_par_1	835	841	PF11976	0.734
LIG_TRAF2_1	196	199	PF00917	0.699
LIG_TRFH_1	92	96	PF08558	0.706
LIG_TYR_ITIM	279	284	PF00017	0.498
LIG_UBA3_1	162	168	PF00899	0.646
LIG_UBA3_1	362	370	PF00899	0.526
LIG_WW_1	451	454	PF00397	0.694
LIG_WW_1	459	462	PF00397	0.718
LIG_WW_1	478	481	PF00397	0.782
MOD_CDK_SPK_2	238	243	PF00069	0.754
MOD_CDK_SPK_2	356	361	PF00069	0.385
MOD_CDK_SPK_2	898	903	PF00069	0.639
MOD_CDK_SPxxK_3	266	273	PF00069	0.640
MOD_CDK_SPxxK_3	354	361	PF00069	0.379
MOD_CK1_1	214	220	PF00069	0.697
MOD_CK1_1	238	244	PF00069	0.817
MOD_CK1_1	266	272	PF00069	0.594
MOD_CK1_1	304	310	PF00069	0.523
MOD_CK1_1	37	43	PF00069	0.714
MOD_CK1_1	404	410	PF00069	0.711
MOD_CK1_1	434	440	PF00069	0.847
MOD_CK1_1	484	490	PF00069	0.701
MOD_CK1_1	500	506	PF00069	0.794
MOD_CK1_1	518	524	PF00069	0.658
MOD_CK1_1	536	542	PF00069	0.600
MOD_CK1_1	571	577	PF00069	0.753
MOD_CK1_1	606	612	PF00069	0.507
MOD_CK1_1	64	70	PF00069	0.694
MOD_CK1_1	648	654	PF00069	0.529
MOD_CK1_1	691	697	PF00069	0.664
MOD_CK1_1	708	714	PF00069	0.542
MOD_CK1_1	717	723	PF00069	0.759
MOD_CK1_1	885	891	PF00069	0.607
MOD_CK2_1	220	226	PF00069	0.682
MOD_CK2_1	29	35	PF00069	0.680
MOD_CK2_1	36	42	PF00069	0.748
MOD_CK2_1	891	897	PF00069	0.851
MOD_Cter_Amidation	880	883	PF01082	0.781
MOD_DYRK1A_RPxSP_1	250	254	PF00069	0.769
MOD_GlcNHglycan	140	143	PF01048	0.720
MOD_GlcNHglycan	213	216	PF01048	0.705
MOD_GlcNHglycan	222	225	PF01048	0.656
MOD_GlcNHglycan	231	236	PF01048	0.531
MOD_GlcNHglycan	237	240	PF01048	0.594
MOD_GlcNHglycan	285	288	PF01048	0.463
MOD_GlcNHglycan	39	42	PF01048	0.823
MOD_GlcNHglycan	403	407	PF01048	0.754
MOD_GlcNHglycan	421	424	PF01048	0.735
MOD_GlcNHglycan	434	437	PF01048	0.790
MOD_GlcNHglycan	469	472	PF01048	0.687
MOD_GlcNHglycan	513	516	PF01048	0.677
MOD_GlcNHglycan	517	520	PF01048	0.662
MOD_GlcNHglycan	538	541	PF01048	0.690
MOD_GlcNHglycan	570	573	PF01048	0.823
MOD_GlcNHglycan	579	582	PF01048	0.606
MOD_GlcNHglycan	629	632	PF01048	0.780
MOD_GlcNHglycan	637	640	PF01048	0.708
MOD_GlcNHglycan	65	69	PF01048	0.740
MOD_GlcNHglycan	680	683	PF01048	0.504
MOD_GlcNHglycan	707	710	PF01048	0.724
MOD_GlcNHglycan	716	719	PF01048	0.714
MOD_GlcNHglycan	77	80	PF01048	0.576
MOD_GlcNHglycan	788	791	PF01048	0.679
MOD_GlcNHglycan	8	11	PF01048	0.791
MOD_GlcNHglycan	814	817	PF01048	0.700
MOD_GlcNHglycan	886	890	PF01048	0.764
MOD_GSK3_1	190	197	PF00069	0.754
MOD_GSK3_1	214	221	PF00069	0.741
MOD_GSK3_1	231	238	PF00069	0.806
MOD_GSK3_1	250	257	PF00069	0.685
MOD_GSK3_1	30	37	PF00069	0.704
MOD_GSK3_1	321	328	PF00069	0.544
MOD_GSK3_1	402	409	PF00069	0.757
MOD_GSK3_1	427	434	PF00069	0.805
MOD_GSK3_1	437	444	PF00069	0.717
MOD_GSK3_1	477	484	PF00069	0.759
MOD_GSK3_1	500	507	PF00069	0.791
MOD_GSK3_1	511	518	PF00069	0.688
MOD_GSK3_1	568	575	PF00069	0.768
MOD_GSK3_1	591	598	PF00069	0.392
MOD_GSK3_1	599	606	PF00069	0.405
MOD_GSK3_1	608	615	PF00069	0.412
MOD_GSK3_1	67	74	PF00069	0.673
MOD_GSK3_1	722	729	PF00069	0.798
MOD_GSK3_1	913	920	PF00069	0.730
MOD_LATS_1	429	435	PF00433	0.731
MOD_N-GLC_1	136	141	PF02516	0.711
MOD_N-GLC_1	440	445	PF02516	0.776
MOD_N-GLC_1	643	648	PF02516	0.657
MOD_N-GLC_1	823	828	PF02516	0.761
MOD_NEK2_1	190	195	PF00069	0.722
MOD_NEK2_1	56	61	PF00069	0.781
MOD_NEK2_1	573	578	PF00069	0.803
MOD_NEK2_1	608	613	PF00069	0.494
MOD_NEK2_1	645	650	PF00069	0.592
MOD_NEK2_1	670	675	PF00069	0.614
MOD_NEK2_1	913	918	PF00069	0.714
MOD_NEK2_2	325	330	PF00069	0.495
MOD_PIKK_1	172	178	PF00454	0.602
MOD_PIKK_1	441	447	PF00454	0.703
MOD_PIKK_1	522	528	PF00454	0.710
MOD_PKA_1	705	711	PF00069	0.699
MOD_PKA_1	882	888	PF00069	0.642
MOD_PKA_2	311	317	PF00069	0.625
MOD_PKA_2	401	407	PF00069	0.774
MOD_PKA_2	427	433	PF00069	0.715
MOD_PKA_2	503	509	PF00069	0.774
MOD_PKA_2	547	553	PF00069	0.635
MOD_PKA_2	688	694	PF00069	0.551
MOD_PKA_2	705	711	PF00069	0.675
MOD_PKA_2	882	888	PF00069	0.662
MOD_PKA_2	890	896	PF00069	0.647
MOD_PKB_1	133	141	PF00069	0.754
MOD_PKB_1	379	387	PF00069	0.578
MOD_PKB_1	882	890	PF00069	0.602
MOD_Plk_1	34	40	PF00069	0.586
MOD_Plk_1	691	697	PF00069	0.649
MOD_Plk_1	823	829	PF00069	0.759
MOD_Plk_2-3	104	110	PF00069	0.774
MOD_Plk_4	144	150	PF00069	0.675
MOD_Plk_4	158	164	PF00069	0.635
MOD_Plk_4	289	295	PF00069	0.465
MOD_Plk_4	304	310	PF00069	0.514
MOD_Plk_4	325	331	PF00069	0.493
MOD_Plk_4	506	512	PF00069	0.726
MOD_Plk_4	582	588	PF00069	0.632
MOD_Plk_4	599	605	PF00069	0.407
MOD_Plk_4	83	89	PF00069	0.690
MOD_ProDKin_1	238	244	PF00069	0.752
MOD_ProDKin_1	250	256	PF00069	0.700
MOD_ProDKin_1	266	272	PF00069	0.575
MOD_ProDKin_1	301	307	PF00069	0.600
MOD_ProDKin_1	354	360	PF00069	0.502
MOD_ProDKin_1	465	471	PF00069	0.752
MOD_ProDKin_1	479	485	PF00069	0.803
MOD_ProDKin_1	519	525	PF00069	0.818
MOD_ProDKin_1	533	539	PF00069	0.581
MOD_ProDKin_1	561	567	PF00069	0.695
MOD_ProDKin_1	719	725	PF00069	0.819
MOD_ProDKin_1	750	756	PF00069	0.776
MOD_ProDKin_1	856	862	PF00069	0.801
MOD_ProDKin_1	86	92	PF00069	0.705
MOD_ProDKin_1	898	904	PF00069	0.758
MOD_SUMO_rev_2	197	201	PF00179	0.645
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.700
TRG_ENDOCYTIC_2	281	284	PF00928	0.507
TRG_ENDOCYTIC_2	454	457	PF00928	0.832
TRG_ENDOCYTIC_2	462	465	PF00928	0.784
TRG_ENDOCYTIC_2	745	748	PF00928	0.724
TRG_ENDOCYTIC_2	92	95	PF00928	0.678
TRG_ER_diArg_1	667	669	PF00400	0.327
TRG_ER_diArg_1	705	707	PF00400	0.623
TRG_ER_diArg_1	882	884	PF00400	0.784
TRG_ER_FFAT_2	32	43	PF00635	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N1	Leptomonas seymouri	45%	100%
A0A3S7X6V6	Leishmania donovani	90%	100%
A4HLS5	Leishmania braziliensis	72%	99%
A4I984	Leishmania infantum	90%	100%
E9B451	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%