Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania major

UniProt:

Q9GRN3_LEIMA

TriTrypDb:

LmjF.33.2140 , LMJLV39_330031700 , LMJSD75_330031200

Length:

956

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005819	spindle	5	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	10
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q9GRN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9GRN3

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.265
CLV_C14_Caspase3-7	535	539	PF00656	0.497
CLV_C14_Caspase3-7	730	734	PF00656	0.645
CLV_C14_Caspase3-7	740	744	PF00656	0.626
CLV_C14_Caspase3-7	841	845	PF00656	0.612
CLV_C14_Caspase3-7	847	851	PF00656	0.556
CLV_NRD_NRD_1	170	172	PF00675	0.306
CLV_NRD_NRD_1	195	197	PF00675	0.295
CLV_NRD_NRD_1	248	250	PF00675	0.315
CLV_NRD_NRD_1	415	417	PF00675	0.442
CLV_NRD_NRD_1	428	430	PF00675	0.368
CLV_NRD_NRD_1	479	481	PF00675	0.475
CLV_NRD_NRD_1	580	582	PF00675	0.543
CLV_NRD_NRD_1	641	643	PF00675	0.534
CLV_NRD_NRD_1	645	647	PF00675	0.506
CLV_NRD_NRD_1	650	652	PF00675	0.464
CLV_NRD_NRD_1	725	727	PF00675	0.585
CLV_NRD_NRD_1	751	753	PF00675	0.636
CLV_NRD_NRD_1	796	798	PF00675	0.741
CLV_NRD_NRD_1	799	801	PF00675	0.725
CLV_NRD_NRD_1	836	838	PF00675	0.593
CLV_NRD_NRD_1	927	929	PF00675	0.585
CLV_PCSK_FUR_1	723	727	PF00082	0.672
CLV_PCSK_KEX2_1	104	106	PF00082	0.405
CLV_PCSK_KEX2_1	195	197	PF00082	0.315
CLV_PCSK_KEX2_1	248	250	PF00082	0.262
CLV_PCSK_KEX2_1	417	419	PF00082	0.441
CLV_PCSK_KEX2_1	479	481	PF00082	0.475
CLV_PCSK_KEX2_1	580	582	PF00082	0.519
CLV_PCSK_KEX2_1	641	643	PF00082	0.534
CLV_PCSK_KEX2_1	645	647	PF00082	0.506
CLV_PCSK_KEX2_1	650	652	PF00082	0.464
CLV_PCSK_KEX2_1	725	727	PF00082	0.575
CLV_PCSK_KEX2_1	751	753	PF00082	0.657
CLV_PCSK_KEX2_1	795	797	PF00082	0.712
CLV_PCSK_KEX2_1	836	838	PF00082	0.575
CLV_PCSK_KEX2_1	927	929	PF00082	0.581
CLV_PCSK_KEX2_1	931	933	PF00082	0.600
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.405
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.446
CLV_PCSK_PC1ET2_1	931	933	PF00082	0.638
CLV_PCSK_PC7_1	641	647	PF00082	0.593
CLV_PCSK_PC7_1	927	933	PF00082	0.640
CLV_PCSK_SKI1_1	125	129	PF00082	0.262
CLV_PCSK_SKI1_1	233	237	PF00082	0.262
CLV_PCSK_SKI1_1	255	259	PF00082	0.317
CLV_PCSK_SKI1_1	298	302	PF00082	0.279
CLV_PCSK_SKI1_1	432	436	PF00082	0.432
CLV_PCSK_SKI1_1	552	556	PF00082	0.582
CLV_PCSK_SKI1_1	65	69	PF00082	0.262
CLV_PCSK_SKI1_1	736	740	PF00082	0.494
CLV_PCSK_SKI1_1	928	932	PF00082	0.789
CLV_PCSK_SKI1_1	95	99	PF00082	0.271
DEG_APCC_DBOX_1	526	534	PF00400	0.552
DEG_APCC_DBOX_1	558	566	PF00400	0.550
DEG_APCC_DBOX_1	645	653	PF00400	0.635
DEG_APCC_KENBOX_2	863	867	PF00400	0.707
DEG_SPOP_SBC_1	762	766	PF00917	0.640
DEG_SPOP_SBC_1	788	792	PF00917	0.733
DOC_CYCLIN_RxL_1	230	237	PF00134	0.262
DOC_CYCLIN_RxL_1	95	102	PF00134	0.279
DOC_MAPK_gen_1	198	206	PF00069	0.239
DOC_MAPK_gen_1	301	310	PF00069	0.382
DOC_MAPK_gen_1	462	471	PF00069	0.432
DOC_MAPK_gen_1	650	658	PF00069	0.626
DOC_MAPK_gen_1	95	103	PF00069	0.279
DOC_MAPK_MEF2A_6	184	191	PF00069	0.262
DOC_MAPK_MEF2A_6	301	310	PF00069	0.389
DOC_MAPK_MEF2A_6	464	473	PF00069	0.433
DOC_MAPK_MEF2A_6	95	103	PF00069	0.290
DOC_PP2B_LxvP_1	310	313	PF13499	0.473
DOC_USP7_MATH_1	363	367	PF00917	0.671
DOC_USP7_MATH_1	42	46	PF00917	0.395
DOC_USP7_MATH_1	600	604	PF00917	0.570
DOC_USP7_MATH_1	763	767	PF00917	0.711
DOC_USP7_MATH_1	870	874	PF00917	0.610
DOC_USP7_MATH_1	876	880	PF00917	0.574
DOC_USP7_MATH_1	945	949	PF00917	0.673
DOC_WW_Pin1_4	104	109	PF00397	0.354
DOC_WW_Pin1_4	592	597	PF00397	0.612
DOC_WW_Pin1_4	666	671	PF00397	0.623
DOC_WW_Pin1_4	756	761	PF00397	0.591
DOC_WW_Pin1_4	916	921	PF00397	0.619
DOC_WW_Pin1_4	951	956	PF00397	0.592
LIG_14-3-3_CanoR_1	198	204	PF00244	0.252
LIG_14-3-3_CanoR_1	217	225	PF00244	0.262
LIG_14-3-3_CanoR_1	233	239	PF00244	0.262
LIG_14-3-3_CanoR_1	294	302	PF00244	0.262
LIG_14-3-3_CanoR_1	441	451	PF00244	0.403
LIG_14-3-3_CanoR_1	589	595	PF00244	0.642
LIG_14-3-3_CanoR_1	723	731	PF00244	0.655
LIG_14-3-3_CanoR_1	752	762	PF00244	0.520
LIG_14-3-3_CanoR_1	783	789	PF00244	0.735
LIG_14-3-3_CanoR_1	837	843	PF00244	0.662
LIG_BIR_II_1	1	5	PF00653	0.351
LIG_Clathr_ClatBox_1	472	476	PF01394	0.474
LIG_deltaCOP1_diTrp_1	486	491	PF00928	0.489
LIG_eIF4E_1	230	236	PF01652	0.375
LIG_FHA_1	188	194	PF00498	0.279
LIG_FHA_1	218	224	PF00498	0.262
LIG_FHA_1	258	264	PF00498	0.262
LIG_FHA_1	271	277	PF00498	0.322
LIG_FHA_1	31	37	PF00498	0.281
LIG_FHA_1	351	357	PF00498	0.379
LIG_FHA_1	715	721	PF00498	0.664
LIG_FHA_1	847	853	PF00498	0.508
LIG_FHA_2	154	160	PF00498	0.309
LIG_FHA_2	565	571	PF00498	0.599
LIG_FHA_2	839	845	PF00498	0.656
LIG_FHA_2	900	906	PF00498	0.672
LIG_HP1_1	306	310	PF01393	0.540
LIG_LIR_Apic_2	806	812	PF02991	0.715
LIG_LIR_Apic_2	865	870	PF02991	0.692
LIG_LIR_Gen_1	155	165	PF02991	0.282
LIG_LIR_LC3C_4	353	358	PF02991	0.377
LIG_LIR_Nem_3	155	160	PF02991	0.301
LIG_LIR_Nem_3	455	459	PF02991	0.452
LIG_LIR_Nem_3	612	617	PF02991	0.566
LIG_NRBOX	258	264	PF00104	0.315
LIG_PCNA_yPIPBox_3	121	132	PF02747	0.279
LIG_PCNA_yPIPBox_3	851	864	PF02747	0.632
LIG_PTB_Apo_2	35	42	PF02174	0.315
LIG_PTB_Phospho_1	35	41	PF10480	0.315
LIG_REV1ctd_RIR_1	144	154	PF16727	0.315
LIG_SH2_CRK	37	41	PF00017	0.262
LIG_SH2_CRK	614	618	PF00017	0.644
LIG_SH2_CRK	886	890	PF00017	0.579
LIG_SH2_GRB2like	230	233	PF00017	0.375
LIG_SH2_NCK_1	116	120	PF00017	0.395
LIG_SH2_NCK_1	26	30	PF00017	0.395
LIG_SH2_NCK_1	37	41	PF00017	0.395
LIG_SH2_NCK_1	886	890	PF00017	0.579
LIG_SH2_SRC	731	734	PF00017	0.642
LIG_SH2_STAP1	116	120	PF00017	0.395
LIG_SH2_STAP1	485	489	PF00017	0.423
LIG_SH2_STAP1	886	890	PF00017	0.784
LIG_SH2_STAT3	361	364	PF00017	0.588
LIG_SH2_STAT3	395	398	PF00017	0.443
LIG_SH2_STAT5	116	119	PF00017	0.265
LIG_SH2_STAT5	230	233	PF00017	0.410
LIG_SH2_STAT5	251	254	PF00017	0.306
LIG_SH2_STAT5	349	352	PF00017	0.500
LIG_SH2_STAT5	35	38	PF00017	0.262
LIG_SH2_STAT5	886	889	PF00017	0.627
LIG_SH3_2	250	255	PF14604	0.339
LIG_SH3_3	247	253	PF00018	0.339
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.315
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.414
LIG_SUMO_SIM_anti_2	352	359	PF11976	0.378
LIG_SUMO_SIM_par_1	150	156	PF11976	0.395
LIG_SUMO_SIM_par_1	532	538	PF11976	0.633
LIG_TRAF2_1	703	706	PF00917	0.737
LIG_TRAF2_1	898	901	PF00917	0.587
LIG_TRAF2_1	902	905	PF00917	0.559
LIG_TYR_ITIM	483	488	PF00017	0.544
LIG_UBA3_1	741	746	PF00899	0.630
LIG_UBA3_1	99	104	PF00899	0.279
LIG_WRC_WIRS_1	154	159	PF05994	0.315
LIG_WRC_WIRS_1	188	193	PF05994	0.262
MOD_CDK_SPxxK_3	104	111	PF00069	0.315
MOD_CK1_1	182	188	PF00069	0.262
MOD_CK1_1	20	26	PF00069	0.371
MOD_CK1_1	234	240	PF00069	0.262
MOD_CK1_1	270	276	PF00069	0.279
MOD_CK1_1	43	49	PF00069	0.263
MOD_CK1_1	446	452	PF00069	0.500
MOD_CK1_1	603	609	PF00069	0.666
MOD_CK1_1	659	665	PF00069	0.649
MOD_CK1_1	666	672	PF00069	0.603
MOD_CK1_1	692	698	PF00069	0.695
MOD_CK1_1	727	733	PF00069	0.607
MOD_CK1_1	756	762	PF00069	0.641
MOD_CK1_1	77	83	PF00069	0.262
MOD_CK1_1	787	793	PF00069	0.770
MOD_CK1_1	950	956	PF00069	0.570
MOD_CK2_1	16	22	PF00069	0.376
MOD_CK2_1	221	227	PF00069	0.279
MOD_CK2_1	42	48	PF00069	0.315
MOD_CK2_1	421	427	PF00069	0.440
MOD_CK2_1	564	570	PF00069	0.536
MOD_CK2_1	617	623	PF00069	0.573
MOD_CK2_1	787	793	PF00069	0.653
MOD_CK2_1	825	831	PF00069	0.808
MOD_CK2_1	850	856	PF00069	0.620
MOD_CK2_1	899	905	PF00069	0.531
MOD_Cter_Amidation	723	726	PF01082	0.659
MOD_Cter_Amidation	798	801	PF01082	0.642
MOD_GlcNHglycan	19	22	PF01048	0.385
MOD_GlcNHglycan	213	216	PF01048	0.262
MOD_GlcNHglycan	269	272	PF01048	0.279
MOD_GlcNHglycan	333	336	PF01048	0.526
MOD_GlcNHglycan	506	509	PF01048	0.619
MOD_GlcNHglycan	517	520	PF01048	0.621
MOD_GlcNHglycan	590	593	PF01048	0.619
MOD_GlcNHglycan	671	674	PF01048	0.620
MOD_GlcNHglycan	727	730	PF01048	0.650
MOD_GlcNHglycan	76	79	PF01048	0.286
MOD_GlcNHglycan	778	781	PF01048	0.767
MOD_GlcNHglycan	827	830	PF01048	0.651
MOD_GlcNHglycan	844	847	PF01048	0.788
MOD_GlcNHglycan	872	875	PF01048	0.602
MOD_GlcNHglycan	89	92	PF01048	0.335
MOD_GSK3_1	103	110	PF00069	0.407
MOD_GSK3_1	16	23	PF00069	0.381
MOD_GSK3_1	209	216	PF00069	0.262
MOD_GSK3_1	217	224	PF00069	0.297
MOD_GSK3_1	289	296	PF00069	0.272
MOD_GSK3_1	314	321	PF00069	0.546
MOD_GSK3_1	42	49	PF00069	0.279
MOD_GSK3_1	421	428	PF00069	0.523
MOD_GSK3_1	439	446	PF00069	0.584
MOD_GSK3_1	584	591	PF00069	0.575
MOD_GSK3_1	652	659	PF00069	0.603
MOD_GSK3_1	737	744	PF00069	0.627
MOD_GSK3_1	752	759	PF00069	0.575
MOD_GSK3_1	784	791	PF00069	0.765
MOD_GSK3_1	838	845	PF00069	0.641
MOD_GSK3_1	846	853	PF00069	0.609
MOD_GSK3_1	910	917	PF00069	0.616
MOD_GSK3_1	945	952	PF00069	0.584
MOD_N-GLC_1	120	125	PF02516	0.273
MOD_N-GLC_1	231	236	PF02516	0.262
MOD_N-GLC_1	43	48	PF02516	0.271
MOD_N-GLC_1	515	520	PF02516	0.455
MOD_N-GLC_1	600	605	PF02516	0.762
MOD_N-GLC_1	65	70	PF02516	0.382
MOD_N-GLC_1	692	697	PF02516	0.634
MOD_N-GLC_1	850	855	PF02516	0.595
MOD_N-GLC_1	865	870	PF02516	0.621
MOD_NEK2_1	103	108	PF00069	0.315
MOD_NEK2_1	25	30	PF00069	0.262
MOD_NEK2_1	262	267	PF00069	0.329
MOD_NEK2_1	286	291	PF00069	0.262
MOD_NEK2_1	293	298	PF00069	0.262
MOD_NEK2_1	343	348	PF00069	0.505
MOD_NEK2_1	356	361	PF00069	0.459
MOD_NEK2_1	656	661	PF00069	0.640
MOD_NEK2_1	682	687	PF00069	0.735
MOD_NEK2_2	120	125	PF00069	0.282
MOD_NEK2_2	542	547	PF00069	0.531
MOD_PIKK_1	293	299	PF00454	0.262
MOD_PIKK_1	692	698	PF00454	0.666
MOD_PIKK_1	768	774	PF00454	0.733
MOD_PIKK_1	899	905	PF00454	0.525
MOD_PKA_1	645	651	PF00069	0.578
MOD_PKA_1	725	731	PF00069	0.662
MOD_PKA_2	293	299	PF00069	0.262
MOD_PKA_2	343	349	PF00069	0.504
MOD_PKA_2	588	594	PF00069	0.681
MOD_PKA_2	645	651	PF00069	0.519
MOD_PKA_2	652	658	PF00069	0.493
MOD_PKA_2	659	665	PF00069	0.536
MOD_PKA_2	724	730	PF00069	0.660
MOD_PKA_2	9	15	PF00069	0.515
MOD_PKB_1	723	731	PF00069	0.665
MOD_Plk_1	120	126	PF00069	0.262
MOD_Plk_1	231	237	PF00069	0.262
MOD_Plk_1	286	292	PF00069	0.275
MOD_Plk_1	46	52	PF00069	0.278
MOD_Plk_1	65	71	PF00069	0.181
MOD_Plk_1	803	809	PF00069	0.733
MOD_Plk_1	850	856	PF00069	0.573
MOD_Plk_2-3	153	159	PF00069	0.395
MOD_Plk_2-3	221	227	PF00069	0.258
MOD_Plk_2-3	421	427	PF00069	0.510
MOD_Plk_2-3	850	856	PF00069	0.573
MOD_Plk_4	199	205	PF00069	0.395
MOD_Plk_4	20	26	PF00069	0.377
MOD_Plk_4	46	52	PF00069	0.278
MOD_Plk_4	529	535	PF00069	0.551
MOD_Plk_4	65	71	PF00069	0.181
MOD_Plk_4	737	743	PF00069	0.628
MOD_Plk_4	79	85	PF00069	0.262
MOD_ProDKin_1	104	110	PF00069	0.354
MOD_ProDKin_1	592	598	PF00069	0.612
MOD_ProDKin_1	666	672	PF00069	0.622
MOD_ProDKin_1	756	762	PF00069	0.593
MOD_ProDKin_1	916	922	PF00069	0.621
MOD_SUMO_for_1	434	437	PF00179	0.511
MOD_SUMO_rev_2	142	152	PF00179	0.258
MOD_SUMO_rev_2	560	568	PF00179	0.536
MOD_SUMO_rev_2	630	636	PF00179	0.500
TRG_DiLeu_BaEn_1	468	473	PF01217	0.488
TRG_DiLeu_BaEn_1	632	637	PF01217	0.498
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.315
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.414
TRG_ENDOCYTIC_2	116	119	PF00928	0.402
TRG_ENDOCYTIC_2	37	40	PF00928	0.262
TRG_ENDOCYTIC_2	485	488	PF00928	0.545
TRG_ENDOCYTIC_2	614	617	PF00928	0.651
TRG_ENDOCYTIC_2	886	889	PF00928	0.680
TRG_ER_diArg_1	195	198	PF00400	0.275
TRG_ER_diArg_1	248	250	PF00400	0.315
TRG_ER_diArg_1	402	405	PF00400	0.492
TRG_ER_diArg_1	479	482	PF00400	0.467
TRG_ER_diArg_1	644	646	PF00400	0.533
TRG_ER_diArg_1	649	651	PF00400	0.486
TRG_ER_diArg_1	7	10	PF00400	0.311
TRG_ER_diArg_1	723	726	PF00400	0.577
TRG_ER_diArg_1	795	797	PF00400	0.732
TRG_NLS_MonoExtC_3	927	932	PF00514	0.602
TRG_NLS_MonoExtN_4	927	932	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYU7	Leptomonas seymouri	68%	97%
A0A1X0P4H8	Trypanosomatidae	51%	100%
A0A3S7X6Y8	Leishmania donovani	94%	100%
A0A422NI32	Trypanosoma rangeli	54%	100%
A4HLS6	Leishmania braziliensis	84%	99%
A4I985	Leishmania infantum	95%	100%
D0A6A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B452	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BTV0	Trypanosoma cruzi	54%	100%