Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9GRM8_LEIMA

TriTrypDb:

LmjF.04.0110 , LMJLV39_040006200 , LMJSD75_040006200

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9GRM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9GRM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.414
CLV_C14_Caspase3-7	12	16	PF00656	0.666
CLV_C14_Caspase3-7	58	62	PF00656	0.608
CLV_NRD_NRD_1	125	127	PF00675	0.630
CLV_NRD_NRD_1	215	217	PF00675	0.677
CLV_NRD_NRD_1	337	339	PF00675	0.587
CLV_PCSK_KEX2_1	125	127	PF00082	0.630
CLV_PCSK_KEX2_1	215	217	PF00082	0.677
CLV_PCSK_KEX2_1	337	339	PF00082	0.581
CLV_PCSK_KEX2_1	87	89	PF00082	0.559
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.634
CLV_PCSK_PC7_1	211	217	PF00082	0.655
CLV_PCSK_SKI1_1	117	121	PF00082	0.581
CLV_PCSK_SKI1_1	125	129	PF00082	0.456
CLV_PCSK_SKI1_1	138	142	PF00082	0.435
CLV_PCSK_SKI1_1	215	219	PF00082	0.673
CLV_PCSK_SKI1_1	273	277	PF00082	0.820
CLV_PCSK_SKI1_1	325	329	PF00082	0.589
CLV_PCSK_SKI1_1	80	84	PF00082	0.548
DEG_APCC_DBOX_1	124	132	PF00400	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DOC_CKS1_1	219	224	PF01111	0.697
DOC_CKS1_1	265	270	PF01111	0.735
DOC_CKS1_1	281	286	PF01111	0.472
DOC_MAPK_gen_1	125	133	PF00069	0.511
DOC_MAPK_RevD_3	202	216	PF00069	0.696
DOC_USP7_MATH_1	186	190	PF00917	0.608
DOC_USP7_MATH_1	301	305	PF00917	0.660
DOC_USP7_MATH_1	47	51	PF00917	0.478
DOC_WW_Pin1_4	195	200	PF00397	0.748
DOC_WW_Pin1_4	202	207	PF00397	0.651
DOC_WW_Pin1_4	218	223	PF00397	0.708
DOC_WW_Pin1_4	264	269	PF00397	0.726
DOC_WW_Pin1_4	280	285	PF00397	0.493
DOC_WW_Pin1_4	297	302	PF00397	0.692
DOC_WW_Pin1_4	316	321	PF00397	0.751
LIG_14-3-3_CanoR_1	11	18	PF00244	0.739
LIG_14-3-3_CanoR_1	273	282	PF00244	0.745
LIG_eIF4E_1	207	213	PF01652	0.692
LIG_FHA_1	195	201	PF00498	0.675
LIG_FHA_1	225	231	PF00498	0.543
LIG_FHA_1	276	282	PF00498	0.718
LIG_FHA_2	10	16	PF00498	0.664
LIG_FHA_2	132	138	PF00498	0.527
LIG_FHA_2	166	172	PF00498	0.588
LIG_FHA_2	18	24	PF00498	0.504
LIG_FHA_2	308	314	PF00498	0.785
LIG_FHA_2	81	87	PF00498	0.510
LIG_Integrin_RGD_1	258	260	PF01839	0.714
LIG_LIR_Gen_1	146	157	PF02991	0.620
LIG_LIR_Gen_1	25	35	PF02991	0.460
LIG_LIR_Nem_3	146	152	PF02991	0.536
LIG_LIR_Nem_3	25	30	PF02991	0.462
LIG_NRBOX	127	133	PF00104	0.550
LIG_SH2_CRK	214	218	PF00017	0.676
LIG_SH2_SRC	207	210	PF00017	0.688
LIG_SH2_SRC	59	62	PF00017	0.606
LIG_SH2_STAP1	59	63	PF00017	0.502
LIG_SH3_1	216	222	PF00018	0.660
LIG_SH3_2	206	211	PF14604	0.692
LIG_SH3_3	203	209	PF00018	0.675
LIG_SH3_3	216	222	PF00018	0.561
LIG_SH3_3	262	268	PF00018	0.699
LIG_SH3_3	278	284	PF00018	0.486
LIG_SH3_3	314	320	PF00018	0.647
LIG_SH3_3	43	49	PF00018	0.520
LIG_Sin3_3	53	60	PF02671	0.613
LIG_SUMO_SIM_anti_2	313	319	PF11976	0.557
LIG_SUMO_SIM_anti_2	61	68	PF11976	0.490
LIG_SUMO_SIM_par_1	200	205	PF11976	0.540
LIG_SUMO_SIM_par_1	42	48	PF11976	0.510
LIG_TRAF2_1	119	122	PF00917	0.500
LIG_TRAF2_1	134	137	PF00917	0.520
LIG_TRAF2_1	168	171	PF00917	0.681
LIG_TRAF2_1	20	23	PF00917	0.669
LIG_TRAF2_1	83	86	PF00917	0.509
LIG_TRAF2_1	99	102	PF00917	0.552
LIG_TYR_ITIM	212	217	PF00017	0.700
LIG_UBA3_1	326	334	PF00899	0.615
MOD_CDK_SPK_2	266	271	PF00069	0.780
MOD_CDK_SPxK_1	297	303	PF00069	0.738
MOD_CDK_SPxxK_3	264	271	PF00069	0.720
MOD_CDK_SPxxK_3	316	323	PF00069	0.733
MOD_CK1_1	112	118	PF00069	0.658
MOD_CK1_1	14	20	PF00069	0.606
MOD_CK1_1	269	275	PF00069	0.739
MOD_CK2_1	131	137	PF00069	0.527
MOD_CK2_1	165	171	PF00069	0.693
MOD_CK2_1	17	23	PF00069	0.612
MOD_CK2_1	241	247	PF00069	0.646
MOD_CK2_1	26	32	PF00069	0.572
MOD_CK2_1	307	313	PF00069	0.790
MOD_CK2_1	80	86	PF00069	0.588
MOD_DYRK1A_RPxSP_1	297	301	PF00069	0.712
MOD_GlcNHglycan	181	184	PF01048	0.665
MOD_GlcNHglycan	188	191	PF01048	0.587
MOD_GlcNHglycan	22	27	PF01048	0.473
MOD_GlcNHglycan	307	310	PF01048	0.829
MOD_GlcNHglycan	48	52	PF01048	0.453
MOD_GSK3_1	105	112	PF00069	0.590
MOD_GSK3_1	2	9	PF00069	0.580
MOD_GSK3_1	22	29	PF00069	0.481
MOD_GSK3_1	269	276	PF00069	0.727
MOD_GSK3_1	289	296	PF00069	0.710
MOD_GSK3_1	297	304	PF00069	0.733
MOD_GSK3_1	339	346	PF00069	0.764
MOD_LATS_1	172	178	PF00433	0.435
MOD_N-GLC_1	289	294	PF02516	0.738
MOD_N-GLC_1	305	310	PF02516	0.830
MOD_NEK2_1	193	198	PF00069	0.717
MOD_NEK2_1	2	7	PF00069	0.617
MOD_NEK2_1	293	298	PF00069	0.655
MOD_PIKK_1	131	137	PF00454	0.612
MOD_PIKK_1	307	313	PF00454	0.740
MOD_PK_1	241	247	PF00069	0.600
MOD_PKA_2	113	119	PF00069	0.611
MOD_PKA_2	302	308	PF00069	0.677
MOD_PKB_1	271	279	PF00069	0.707
MOD_Plk_1	14	20	PF00069	0.608
MOD_Plk_1	143	149	PF00069	0.631
MOD_Plk_1	289	295	PF00069	0.741
MOD_Plk_4	226	232	PF00069	0.602
MOD_Plk_4	277	283	PF00069	0.730
MOD_Plk_4	59	65	PF00069	0.525
MOD_ProDKin_1	195	201	PF00069	0.749
MOD_ProDKin_1	202	208	PF00069	0.650
MOD_ProDKin_1	218	224	PF00069	0.701
MOD_ProDKin_1	264	270	PF00069	0.720
MOD_ProDKin_1	280	286	PF00069	0.490
MOD_ProDKin_1	297	303	PF00069	0.693
MOD_ProDKin_1	316	322	PF00069	0.739
MOD_SUMO_rev_2	331	336	PF00179	0.592
TRG_DiLeu_BaEn_1	123	128	PF01217	0.552
TRG_DiLeu_BaEn_4	136	142	PF01217	0.508
TRG_DiLeu_BaEn_4	331	337	PF01217	0.597
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.691
TRG_DiLeu_LyEn_5	123	128	PF01217	0.552
TRG_ENDOCYTIC_2	214	217	PF00928	0.679
TRG_ER_diArg_1	125	127	PF00400	0.630
TRG_ER_diArg_1	214	216	PF00400	0.686
TRG_ER_diArg_1	255	258	PF00400	0.713
TRG_ER_diArg_1	270	273	PF00400	0.610
TRG_ER_diArg_1	322	325	PF00400	0.619
TRG_ER_diArg_1	336	338	PF00400	0.579
TRG_ER_diArg_1	52	55	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB32	Leptomonas seymouri	48%	96%
A0A3S5H577	Leishmania donovani	92%	100%
A4H3T2	Leishmania braziliensis	73%	100%
A4HS07	Leishmania infantum	92%	100%
E9AJZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%