LeishMANIAdb
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DNA topoisomerase I

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA topoisomerase I
Gene product:
DNA topoisomerase IB - large subunit
Species:
Leishmania infantum
UniProt:
Q9GPZ9_LEIIN
TriTrypDb:
LINF_340041300
Length:
635

Annotations

Annotations by Jardim et al.

Topoisomerase, DNA topoisomerase I PE=1 SV=1 - [Q9GPZ9_LEIIN]

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005694 chromosome 5 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0043232 intracellular non-membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0016020 membrane 2 1

Phosphorylation

Promastigote/Amastigote: 623

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

Q9GPZ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9GPZ9

PDB structure(s): 2b9s_A

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006259 DNA metabolic process 4 12
GO:0006265 DNA topological change 5 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0006996 organelle organization 4 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0046483 heterocycle metabolic process 3 12
GO:0051276 chromosome organization 5 12
GO:0071103 DNA conformation change 6 12
GO:0071704 organic substance metabolic process 2 12
GO:0071840 cellular component organization or biogenesis 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0006260 DNA replication 5 1
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0007059 chromosome segregation 2 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003677 DNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0003916 DNA topoisomerase activity 3 12
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity 4 12
GO:0005488 binding 1 12
GO:0016853 isomerase activity 2 12
GO:0097159 organic cyclic compound binding 2 12
GO:0140097 catalytic activity, acting on DNA 3 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 155 159 PF00656 0.325
CLV_C14_Caspase3-7 399 403 PF00656 0.356
CLV_MEL_PAP_1 311 317 PF00089 0.256
CLV_NRD_NRD_1 102 104 PF00675 0.257
CLV_NRD_NRD_1 121 123 PF00675 0.073
CLV_NRD_NRD_1 172 174 PF00675 0.376
CLV_NRD_NRD_1 273 275 PF00675 0.293
CLV_NRD_NRD_1 376 378 PF00675 0.291
CLV_NRD_NRD_1 44 46 PF00675 0.358
CLV_NRD_NRD_1 475 477 PF00675 0.308
CLV_PCSK_KEX2_1 102 104 PF00082 0.266
CLV_PCSK_KEX2_1 11 13 PF00082 0.654
CLV_PCSK_KEX2_1 115 117 PF00082 0.232
CLV_PCSK_KEX2_1 121 123 PF00082 0.073
CLV_PCSK_KEX2_1 172 174 PF00082 0.373
CLV_PCSK_KEX2_1 376 378 PF00082 0.253
CLV_PCSK_KEX2_1 44 46 PF00082 0.255
CLV_PCSK_KEX2_1 531 533 PF00082 0.517
CLV_PCSK_KEX2_1 558 560 PF00082 0.615
CLV_PCSK_KEX2_1 614 616 PF00082 0.604
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.654
CLV_PCSK_PC1ET2_1 115 117 PF00082 0.291
CLV_PCSK_PC1ET2_1 531 533 PF00082 0.517
CLV_PCSK_PC1ET2_1 558 560 PF00082 0.615
CLV_PCSK_PC1ET2_1 614 616 PF00082 0.599
CLV_PCSK_SKI1_1 103 107 PF00082 0.256
CLV_PCSK_SKI1_1 110 114 PF00082 0.256
CLV_PCSK_SKI1_1 151 155 PF00082 0.291
CLV_PCSK_SKI1_1 274 278 PF00082 0.256
CLV_PCSK_SKI1_1 310 314 PF00082 0.256
CLV_PCSK_SKI1_1 420 424 PF00082 0.280
CLV_PCSK_SKI1_1 459 463 PF00082 0.376
CLV_PCSK_SKI1_1 499 503 PF00082 0.461
CLV_PCSK_SKI1_1 559 563 PF00082 0.562
CLV_PCSK_SKI1_1 565 569 PF00082 0.597
CLV_PCSK_SKI1_1 588 592 PF00082 0.649
CLV_PCSK_SKI1_1 72 76 PF00082 0.291
DEG_MDM2_SWIB_1 105 113 PF02201 0.256
DEG_Nend_UBRbox_1 1 4 PF02207 0.661
DEG_SCF_FBW7_2 76 81 PF00400 0.256
DEG_SPOP_SBC_1 256 260 PF00917 0.291
DOC_ANK_TNKS_1 179 186 PF00023 0.272
DOC_CYCLIN_RxL_1 115 129 PF00134 0.257
DOC_MAPK_gen_1 376 384 PF00069 0.301
DOC_MAPK_gen_1 459 468 PF00069 0.403
DOC_PP2B_LxvP_1 55 58 PF13499 0.341
DOC_USP7_MATH_1 257 261 PF00917 0.342
DOC_USP7_MATH_1 579 583 PF00917 0.650
DOC_USP7_MATH_1 599 603 PF00917 0.606
DOC_USP7_UBL2_3 147 151 PF12436 0.264
DOC_USP7_UBL2_3 275 279 PF12436 0.403
DOC_USP7_UBL2_3 455 459 PF12436 0.291
DOC_USP7_UBL2_3 558 562 PF12436 0.612
DOC_USP7_UBL2_3 564 568 PF12436 0.563
DOC_USP7_UBL2_3 572 576 PF12436 0.521
DOC_USP7_UBL2_3 577 581 PF12436 0.596
DOC_USP7_UBL2_3 584 588 PF12436 0.490
DOC_USP7_UBL2_3 7 11 PF12436 0.605
DOC_WW_Pin1_4 376 381 PF00397 0.291
DOC_WW_Pin1_4 74 79 PF00397 0.262
LIG_14-3-3_CanoR_1 284 288 PF00244 0.306
LIG_APCC_ABBA_1 65 70 PF00400 0.304
LIG_BRCT_BRCA1_1 457 461 PF00533 0.376
LIG_CaM_IQ_9 463 479 PF13499 0.403
LIG_EVH1_2 183 187 PF00568 0.272
LIG_FHA_1 207 213 PF00498 0.284
LIG_FHA_1 476 482 PF00498 0.298
LIG_FHA_1 608 614 PF00498 0.696
LIG_FHA_2 144 150 PF00498 0.256
LIG_FHA_2 468 474 PF00498 0.365
LIG_FHA_2 75 81 PF00498 0.256
LIG_HCF-1_HBM_1 92 95 PF13415 0.272
LIG_HP1_1 599 603 PF01393 0.394
LIG_LIR_Gen_1 235 246 PF02991 0.277
LIG_LIR_Gen_1 366 374 PF02991 0.328
LIG_LIR_Gen_1 383 393 PF02991 0.151
LIG_LIR_Gen_1 43 54 PF02991 0.272
LIG_LIR_Gen_1 524 533 PF02991 0.416
LIG_LIR_Gen_1 85 95 PF02991 0.255
LIG_LIR_Nem_3 107 112 PF02991 0.248
LIG_LIR_Nem_3 127 131 PF02991 0.310
LIG_LIR_Nem_3 366 371 PF02991 0.303
LIG_LIR_Nem_3 383 388 PF02991 0.151
LIG_LIR_Nem_3 43 49 PF02991 0.268
LIG_LIR_Nem_3 524 528 PF02991 0.489
LIG_PDZ_Class_2 630 635 PF00595 0.636
LIG_Pex14_1 512 516 PF04695 0.397
LIG_Pex14_2 101 105 PF04695 0.256
LIG_RPA_C_Insects 553 568 PF08784 0.531
LIG_SH2_CRK 368 372 PF00017 0.313
LIG_SH2_GRB2like 357 360 PF00017 0.272
LIG_SH2_GRB2like 439 442 PF00017 0.256
LIG_SH2_PTP2 252 255 PF00017 0.256
LIG_SH2_SRC 60 63 PF00017 0.313
LIG_SH2_STAT5 166 169 PF00017 0.403
LIG_SH2_STAT5 252 255 PF00017 0.256
LIG_SH2_STAT5 306 309 PF00017 0.310
LIG_SH2_STAT5 439 442 PF00017 0.270
LIG_SH2_STAT5 474 477 PF00017 0.272
LIG_SH3_1 423 429 PF00018 0.248
LIG_SH3_3 178 184 PF00018 0.272
LIG_SH3_3 215 221 PF00018 0.260
LIG_SH3_3 423 429 PF00018 0.233
LIG_SH3_3 51 57 PF00018 0.260
LIG_SUMO_SIM_anti_2 360 366 PF11976 0.341
LIG_SUMO_SIM_anti_2 445 451 PF11976 0.291
LIG_SUMO_SIM_anti_2 478 483 PF11976 0.356
LIG_SUMO_SIM_par_1 477 483 PF11976 0.365
LIG_TRAF2_1 146 149 PF00917 0.256
LIG_TRAF2_1 493 496 PF00917 0.484
LIG_TRAF2_1 77 80 PF00917 0.257
LIG_TRAF2_2 390 395 PF00917 0.376
LIG_UBA3_1 195 200 PF00899 0.284
LIG_UBA3_1 465 471 PF00899 0.365
LIG_UBA3_1 86 91 PF00899 0.376
LIG_WRC_WIRS_1 397 402 PF05994 0.254
LIG_WW_1 57 60 PF00397 0.272
MOD_CK1_1 472 478 PF00069 0.279
MOD_CK1_1 515 521 PF00069 0.521
MOD_CK1_1 580 586 PF00069 0.611
MOD_CK2_1 105 111 PF00069 0.272
MOD_CK2_1 143 149 PF00069 0.256
MOD_CK2_1 283 289 PF00069 0.365
MOD_CK2_1 467 473 PF00069 0.415
MOD_CK2_1 490 496 PF00069 0.534
MOD_CK2_1 74 80 PF00069 0.249
MOD_Cter_Amidation 170 173 PF01082 0.256
MOD_Cter_Amidation 555 558 PF01082 0.617
MOD_GlcNHglycan 404 407 PF01048 0.275
MOD_GlcNHglycan 545 548 PF01048 0.627
MOD_GlcNHglycan 552 555 PF01048 0.498
MOD_GlcNHglycan 565 568 PF01048 0.489
MOD_GSK3_1 372 379 PF00069 0.376
MOD_GSK3_1 408 415 PF00069 0.256
MOD_LATS_1 453 459 PF00433 0.291
MOD_N-GLC_1 412 417 PF02516 0.256
MOD_NEK2_1 105 110 PF00069 0.272
MOD_NEK2_1 466 471 PF00069 0.374
MOD_NEK2_2 257 262 PF00069 0.272
MOD_NEK2_2 328 333 PF00069 0.256
MOD_NEK2_2 351 356 PF00069 0.272
MOD_PIKK_1 388 394 PF00454 0.358
MOD_PK_1 490 496 PF00069 0.534
MOD_PKA_1 141 147 PF00069 0.253
MOD_PKA_1 490 496 PF00069 0.482
MOD_PKA_1 541 547 PF00069 0.636
MOD_PKA_1 563 569 PF00069 0.621
MOD_PKA_2 242 248 PF00069 0.261
MOD_PKA_2 283 289 PF00069 0.272
MOD_PKA_2 372 378 PF00069 0.291
MOD_PKA_2 475 481 PF00069 0.345
MOD_Plk_1 206 212 PF00069 0.268
MOD_Plk_1 232 238 PF00069 0.262
MOD_Plk_1 412 418 PF00069 0.256
MOD_Plk_4 234 240 PF00069 0.256
MOD_Plk_4 283 289 PF00069 0.338
MOD_Plk_4 396 402 PF00069 0.284
MOD_Plk_4 82 88 PF00069 0.255
MOD_ProDKin_1 376 382 PF00069 0.291
MOD_ProDKin_1 74 80 PF00069 0.262
MOD_SUMO_for_1 1 4 PF00179 0.591
MOD_SUMO_for_1 10 13 PF00179 0.634
MOD_SUMO_for_1 268 271 PF00179 0.256
MOD_SUMO_for_1 40 43 PF00179 0.499
MOD_SUMO_for_1 590 593 PF00179 0.652
MOD_SUMO_rev_2 144 153 PF00179 0.270
MOD_SUMO_rev_2 286 293 PF00179 0.361
MOD_SUMO_rev_2 424 432 PF00179 0.341
MOD_SUMO_rev_2 539 544 PF00179 0.588
MOD_SUMO_rev_2 70 77 PF00179 0.272
TRG_DiLeu_BaEn_1 335 340 PF01217 0.376
TRG_DiLeu_BaEn_1 366 371 PF01217 0.376
TRG_ENDOCYTIC_2 252 255 PF00928 0.257
TRG_ENDOCYTIC_2 368 371 PF00928 0.272
TRG_ENDOCYTIC_2 95 98 PF00928 0.354
TRG_ER_diArg_1 101 103 PF00400 0.272
TRG_ER_diArg_1 120 122 PF00400 0.073
TRG_ER_diArg_1 187 190 PF00400 0.256
TRG_ER_diArg_1 44 46 PF00400 0.376
TRG_ER_diArg_1 535 538 PF00400 0.601
TRG_NLS_Bipartite_1 476 494 PF00514 0.523
TRG_NLS_Bipartite_1 541 561 PF00514 0.619
TRG_NLS_MonoCore_2 561 566 PF00514 0.663
TRG_NLS_MonoExtC_3 489 495 PF00514 0.512
TRG_NLS_MonoExtN_4 559 566 PF00514 0.580
TRG_Pf-PMV_PEXEL_1 110 114 PF00026 0.241
TRG_Pf-PMV_PEXEL_1 274 278 PF00026 0.341
TRG_Pf-PMV_PEXEL_1 588 592 PF00026 0.510

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0L0P4F8 Candida auris 51% 85%
A0A0N0P5Q3 Leptomonas seymouri 80% 98%
A0A0S4IPT9 Bodo saltans 55% 98%
A0A1X0PA36 Trypanosomatidae 75% 96%
A0A3Q8IHS4 Leishmania donovani 100% 100%
A0A3R7MDP0 Trypanosoma rangeli 65% 95%
A4HB62 Leishmania braziliensis 89% 100%
A9Q1D5 Pan troglodytes 44% 100%
C9ZLY6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 91%
E9B5D3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O17966 Caenorhabditis elegans 50% 79%
P04786 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 44% 83%
P07799 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 53% 78%
P11387 Homo sapiens 52% 83%
P30181 Arabidopsis thaliana 52% 69%
P41512 Xenopus laevis 48% 77%
P93119 Daucus carota 49% 80%
Q00313 Candida albicans 49% 82%
Q04750 Mus musculus 52% 83%
Q07050 Cricetulus griseus 52% 83%
Q4Q2K0 Leishmania major 96% 100%
Q54RC3 Dictyostelium discoideum 49% 71%
Q6IM78 Rattus norvegicus 45% 100%
Q7YR26 Chlorocebus aethiops 51% 83%
Q8R4U6 Mus musculus 46% 100%
Q969P6 Homo sapiens 44% 100%
Q9FJ79 Arabidopsis thaliana 53% 69%
Q9WUL0 Rattus norvegicus 52% 83%
V5BQI4 Trypanosoma cruzi 74% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS