Anti-silencing protein asf 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone chaperone ASF1A

Species:

Leishmania major

UniProt:

Q9BJ46_LEIMA

TriTrypDb:

LmjF.20.0050 , LMJLV39_200005400 , LMJSD75_200005400

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005829	cytosol	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q9BJ46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BJ46

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	12
GO:0006335	DNA replication-dependent chromatin assembly	5	2
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030527	structural constituent of chromatin	2	12
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	135	139	PF00082	0.364
CLV_PCSK_SKI1_1	70	74	PF00082	0.385
DOC_USP7_MATH_1	33	37	PF00917	0.387
DOC_USP7_MATH_1	51	55	PF00917	0.383
LIG_BIR_II_1	1	5	PF00653	0.428
LIG_BIR_III_1	1	5	PF00653	0.509
LIG_BIR_III_3	1	5	PF00653	0.509
LIG_BRCT_BRCA1_1	41	45	PF00533	0.240
LIG_Clathr_ClatBox_1	8	12	PF01394	0.240
LIG_Clathr_ClatBox_1	86	90	PF01394	0.268
LIG_FHA_1	32	38	PF00498	0.376
LIG_FHA_1	94	100	PF00498	0.243
LIG_IRF3_LxIS_1	95	101	PF10401	0.240
LIG_LIR_Gen_1	108	115	PF02991	0.288
LIG_LIR_Gen_1	42	51	PF02991	0.261
LIG_LIR_Nem_3	108	112	PF02991	0.288
LIG_LIR_Nem_3	42	48	PF02991	0.240
LIG_SH2_CRK	115	119	PF00017	0.240
LIG_SH2_GRB2like	21	24	PF00017	0.268
LIG_SH2_NCK_1	115	119	PF00017	0.240
LIG_SH2_STAP1	115	119	PF00017	0.269
LIG_SH2_STAP1	21	25	PF00017	0.300
LIG_SH2_STAT3	104	107	PF00017	0.240
LIG_SH2_STAT3	114	117	PF00017	0.240
LIG_SH2_STAT3	21	24	PF00017	0.372
LIG_SH2_STAT5	115	118	PF00017	0.240
LIG_SH2_STAT5	120	123	PF00017	0.240
LIG_SH2_STAT5	21	24	PF00017	0.296
LIG_SH3_1	127	133	PF00018	0.268
LIG_SH3_2	130	135	PF14604	0.334
LIG_SH3_3	127	133	PF00018	0.255
LIG_SH3_3	139	145	PF00018	0.255
LIG_SUMO_SIM_anti_2	10	15	PF11976	0.240
LIG_SUMO_SIM_anti_2	96	101	PF11976	0.240
LIG_SUMO_SIM_par_1	39	44	PF11976	0.400
LIG_SUMO_SIM_par_1	7	12	PF11976	0.240
LIG_SUMO_SIM_par_1	95	101	PF11976	0.240
LIG_WRC_WIRS_1	99	104	PF05994	0.240
LIG_WW_2	130	133	PF00397	0.316
MOD_CK1_1	50	56	PF00069	0.240
MOD_GlcNHglycan	49	52	PF01048	0.261
MOD_GSK3_1	33	40	PF00069	0.427
MOD_GSK3_1	47	54	PF00069	0.313
MOD_NEK2_1	98	103	PF00069	0.260
MOD_PIKK_1	113	119	PF00454	0.240
MOD_PIKK_1	51	57	PF00454	0.383
MOD_Plk_1	73	79	PF00069	0.247
MOD_Plk_4	41	47	PF00069	0.364
MOD_Plk_4	93	99	PF00069	0.240
TRG_ENDOCYTIC_2	115	118	PF00928	0.269
TRG_ER_diArg_1	27	30	PF00400	0.260

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I1	Leptomonas seymouri	37%	87%
A0A0N1I2C8	Leptomonas seymouri	84%	100%
A0A0S4IIL8	Bodo saltans	59%	90%
A0A0S4JR86	Bodo saltans	37%	74%
A0A1X0NWK6	Trypanosomatidae	68%	97%
A0A1X0P1H0	Trypanosomatidae	36%	78%
A0A3Q8IAD9	Leishmania donovani	33%	85%
A0A3Q8IBF3	Leishmania donovani	96%	100%
A0A3R7M8V4	Trypanosoma rangeli	68%	97%
A0A422ND92	Trypanosoma rangeli	34%	77%
A4H8C7	Leishmania braziliensis	32%	85%
A4HBH4	Leishmania braziliensis	90%	96%
A4HWP9	Leishmania infantum	33%	85%
A4HYJ8	Leishmania infantum	96%	100%
C9ZHU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	92%
C9ZW62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	71%
E9AQF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	85%
E9AUE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P0CM26	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	37%	77%
P0CM27	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	37%	76%
Q17QJ0	Bos taurus	39%	78%
Q2KIG1	Bos taurus	41%	77%
Q3C1E9	Gallus gallus	41%	77%
Q4PBU8	Ustilago maydis (strain 521 / FGSC 9021)	35%	91%
Q4QF20	Leishmania major	31%	70%
Q54N45	Dictyostelium discoideum	34%	100%
Q69DB9	Xenopus laevis	41%	79%
Q6DIP1	Xenopus tropicalis	42%	79%
Q6NY34	Danio rerio	40%	80%
Q6NYY4	Danio rerio	40%	80%
Q7T0M6	Xenopus laevis	40%	79%
Q9C9M6	Arabidopsis thaliana	37%	81%
Q9CQE6	Mus musculus	41%	77%
Q9DAP7	Mus musculus	40%	78%
Q9LS09	Arabidopsis thaliana	37%	72%
Q9NVP2	Homo sapiens	39%	78%
Q9V464	Drosophila melanogaster	41%	72%
Q9Y294	Homo sapiens	41%	77%
V5B915	Trypanosoma cruzi	36%	79%
V5C0E3	Trypanosoma cruzi	68%	97%