VPS9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9BJ45_LEIMA

TriTrypDb:

LmjF.20.0040 , LMJLV39_200005300 , LMJSD75_200005300

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9BJ45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BJ45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.588
CLV_NRD_NRD_1	145	147	PF00675	0.512
CLV_NRD_NRD_1	198	200	PF00675	0.451
CLV_NRD_NRD_1	209	211	PF00675	0.462
CLV_NRD_NRD_1	246	248	PF00675	0.540
CLV_NRD_NRD_1	280	282	PF00675	0.581
CLV_NRD_NRD_1	47	49	PF00675	0.585
CLV_PCSK_FUR_1	196	200	PF00082	0.371
CLV_PCSK_KEX2_1	124	126	PF00082	0.630
CLV_PCSK_KEX2_1	144	146	PF00082	0.521
CLV_PCSK_KEX2_1	19	21	PF00082	0.574
CLV_PCSK_KEX2_1	198	200	PF00082	0.474
CLV_PCSK_KEX2_1	209	211	PF00082	0.484
CLV_PCSK_KEX2_1	245	247	PF00082	0.550
CLV_PCSK_KEX2_1	280	282	PF00082	0.583
CLV_PCSK_KEX2_1	321	323	PF00082	0.716
CLV_PCSK_KEX2_1	47	49	PF00082	0.585
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.643
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.696
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.689
CLV_PCSK_PC7_1	317	323	PF00082	0.686
CLV_PCSK_SKI1_1	188	192	PF00082	0.486
CLV_PCSK_SKI1_1	198	202	PF00082	0.460
CLV_PCSK_SKI1_1	281	285	PF00082	0.634
DOC_MAPK_RevD_3	185	199	PF00069	0.414
DOC_MIT_MIM_1	255	265	PF04212	0.528
DOC_USP7_MATH_1	131	135	PF00917	0.670
DOC_USP7_UBL2_3	269	273	PF12436	0.561
LIG_14-3-3_CanoR_1	125	133	PF00244	0.640
LIG_14-3-3_CanoR_1	174	179	PF00244	0.422
LIG_14-3-3_CanoR_1	236	244	PF00244	0.587
LIG_14-3-3_CanoR_1	311	316	PF00244	0.523
LIG_14-3-3_CanoR_1	47	57	PF00244	0.578
LIG_14-3-3_CanoR_1	64	68	PF00244	0.512
LIG_14-3-3_CanoR_1	81	85	PF00244	0.532
LIG_14-3-3_CanoR_1	88	94	PF00244	0.530
LIG_AP2alpha_1	68	72	PF02296	0.680
LIG_APCC_ABBAyCdc20_2	198	204	PF00400	0.455
LIG_APCC_ABBAyCdc20_2	64	70	PF00400	0.510
LIG_BRCT_BRCA1_1	179	183	PF00533	0.565
LIG_BRCT_BRCA1_1	55	59	PF00533	0.563
LIG_Clathr_ClatBox_1	156	160	PF01394	0.595
LIG_deltaCOP1_diTrp_1	40	46	PF00928	0.694
LIG_eIF4E_1	162	168	PF01652	0.430
LIG_FHA_2	189	195	PF00498	0.418
LIG_LIR_Apic_2	98	104	PF02991	0.675
LIG_LIR_Gen_1	173	183	PF02991	0.518
LIG_LIR_Gen_1	217	228	PF02991	0.550
LIG_LIR_Gen_1	257	265	PF02991	0.554
LIG_LIR_Nem_3	217	223	PF02991	0.549
LIG_LIR_Nem_3	230	234	PF02991	0.391
LIG_LIR_Nem_3	257	262	PF02991	0.560
LIG_LIR_Nem_3	40	46	PF02991	0.686
LIG_MLH1_MIPbox_1	179	183	PF16413	0.565
LIG_PCNA_yPIPBox_3	172	183	PF02747	0.491
LIG_Pex14_2	55	59	PF04695	0.675
LIG_Pex14_2	68	72	PF04695	0.702
LIG_RPA_C_Fungi	242	254	PF08784	0.553
LIG_SH2_SRC	101	104	PF00017	0.657
LIG_SH2_STAP1	259	263	PF00017	0.577
LIG_SH2_STAT5	135	138	PF00017	0.677
LIG_Sin3_3	287	294	PF02671	0.620
LIG_SUMO_SIM_par_1	155	160	PF11976	0.596
LIG_TRAF2_1	139	142	PF00917	0.570
LIG_TRAF2_1	152	155	PF00917	0.580
LIG_UBA3_1	109	116	PF00899	0.597
MOD_CK1_1	134	140	PF00069	0.607
MOD_CK1_1	221	227	PF00069	0.549
MOD_CK1_1	310	316	PF00069	0.671
MOD_CK1_1	38	44	PF00069	0.707
MOD_CK1_1	71	77	PF00069	0.691
MOD_CK2_1	188	194	PF00069	0.420
MOD_CK2_1	34	40	PF00069	0.675
MOD_Cter_Amidation	196	199	PF01082	0.546
MOD_Cter_Amidation	319	322	PF01082	0.687
MOD_GlcNHglycan	179	182	PF01048	0.564
MOD_GlcNHglycan	3	6	PF01048	0.647
MOD_GlcNHglycan	73	76	PF01048	0.652
MOD_GSK3_1	170	177	PF00069	0.548
MOD_GSK3_1	218	225	PF00069	0.501
MOD_GSK3_1	307	314	PF00069	0.727
MOD_GSK3_1	34	41	PF00069	0.703
MOD_GSK3_1	53	60	PF00069	0.532
MOD_N-GLC_1	89	94	PF02516	0.732
MOD_N-GLC_2	276	278	PF02516	0.477
MOD_NEK2_1	1	6	PF00069	0.630
MOD_NEK2_1	167	172	PF00069	0.556
MOD_NEK2_1	223	228	PF00069	0.451
MOD_NEK2_1	57	62	PF00069	0.583
MOD_NEK2_1	63	68	PF00069	0.566
MOD_NEK2_2	89	94	PF00069	0.525
MOD_PIKK_1	125	131	PF00454	0.605
MOD_PK_1	311	317	PF00069	0.526
MOD_PKA_1	125	131	PF00069	0.515
MOD_PKA_1	47	53	PF00069	0.679
MOD_PKA_2	131	137	PF00069	0.671
MOD_PKA_2	310	316	PF00069	0.647
MOD_PKA_2	47	53	PF00069	0.663
MOD_PKA_2	63	69	PF00069	0.470
MOD_PKA_2	80	86	PF00069	0.640
MOD_PKB_1	172	180	PF00069	0.508
MOD_PKB_1	86	94	PF00069	0.716
MOD_Plk_1	89	95	PF00069	0.693
MOD_Plk_4	131	137	PF00069	0.636
MOD_Plk_4	174	180	PF00069	0.484
MOD_Plk_4	63	69	PF00069	0.706
MOD_SUMO_rev_2	225	234	PF00179	0.553
TRG_DiLeu_BaEn_1	163	168	PF01217	0.551
TRG_DiLeu_BaEn_1	40	45	PF01217	0.722
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.541
TRG_ENDOCYTIC_2	259	262	PF00928	0.494
TRG_ER_diArg_1	144	146	PF00400	0.575
TRG_ER_diArg_1	172	175	PF00400	0.453
TRG_ER_diArg_1	195	198	PF00400	0.495
TRG_ER_diArg_1	244	247	PF00400	0.567
TRG_ER_diArg_1	279	281	PF00400	0.592
TRG_ER_diArg_1	46	48	PF00400	0.587
TRG_ER_diArg_1	85	88	PF00400	0.645
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL4	Leptomonas seymouri	39%	100%
A0A1X0NX15	Trypanosomatidae	23%	100%
A0A3Q8IBH2	Leishmania donovani	87%	100%
A0A3R7NEK1	Trypanosoma rangeli	27%	100%
A4HYJ7	Leishmania infantum	87%	100%
C9ZHU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AUE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
V5BAF9	Trypanosoma cruzi	26%	93%