Possible hypothetical 85.8 Kd protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family, putative

Species:

Leishmania major

UniProt:

Q9BHG3_LEIMA

TriTrypDb:

LmjF.31.0740 , LMJLV39_310013200 , LMJSD75_310012900

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9BHG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BHG3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0008104	protein localization	4	9
GO:0009306	protein secretion	4	9
GO:0009987	cellular process	1	9
GO:0015031	protein transport	4	9
GO:0030254	protein secretion by the type III secretion system	4	9
GO:0032940	secretion by cell	3	9
GO:0033036	macromolecule localization	2	9
GO:0035592	establishment of protein localization to extracellular region	4	9
GO:0045184	establishment of protein localization	3	9
GO:0046903	secretion	4	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051641	cellular localization	2	9
GO:0055085	transmembrane transport	2	9
GO:0070727	cellular macromolecule localization	3	9
GO:0071692	protein localization to extracellular region	5	9
GO:0071702	organic substance transport	4	9
GO:0071705	nitrogen compound transport	4	9
GO:0071806	protein transmembrane transport	3	9
GO:0140352	export from cell	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.487
CLV_C14_Caspase3-7	180	184	PF00656	0.499
CLV_NRD_NRD_1	16	18	PF00675	0.411
CLV_NRD_NRD_1	174	176	PF00675	0.594
CLV_NRD_NRD_1	36	38	PF00675	0.393
CLV_PCSK_KEX2_1	174	176	PF00082	0.594
CLV_PCSK_KEX2_1	36	38	PF00082	0.393
CLV_PCSK_SKI1_1	17	21	PF00082	0.340
CLV_PCSK_SKI1_1	207	211	PF00082	0.321
CLV_PCSK_SKI1_1	37	41	PF00082	0.366
CLV_PCSK_SKI1_1	6	10	PF00082	0.393
DEG_APCC_DBOX_1	23	31	PF00400	0.373
DEG_APCC_DBOX_1	248	256	PF00400	0.454
DEG_Nend_UBRbox_3	1	3	PF02207	0.461
DEG_SPOP_SBC_1	281	285	PF00917	0.521
DOC_MAPK_gen_1	17	23	PF00069	0.382
DOC_MAPK_gen_1	249	257	PF00069	0.454
DOC_MAPK_MEF2A_6	198	205	PF00069	0.521
DOC_USP7_MATH_1	158	162	PF00917	0.610
DOC_USP7_MATH_1	188	192	PF00917	0.451
DOC_USP7_MATH_1	89	93	PF00917	0.580
DOC_USP7_UBL2_3	189	193	PF12436	0.398
DOC_WW_Pin1_4	289	294	PF00397	0.457
LIG_14-3-3_CanoR_1	175	185	PF00244	0.643
LIG_14-3-3_CanoR_1	309	314	PF00244	0.512
LIG_14-3-3_CanoR_1	37	43	PF00244	0.397
LIG_APCC_ABBA_1	300	305	PF00400	0.479
LIG_BRCT_BRCA1_1	201	205	PF00533	0.454
LIG_BRCT_BRCA1_2	201	207	PF00533	0.509
LIG_eIF4E_1	233	239	PF01652	0.454
LIG_FHA_1	208	214	PF00498	0.454
LIG_FHA_1	227	233	PF00498	0.454
LIG_FHA_1	281	287	PF00498	0.467
LIG_FHA_2	115	121	PF00498	0.763
LIG_FHA_2	213	219	PF00498	0.521
LIG_GBD_Chelix_1	195	203	PF00786	0.305
LIG_Integrin_RGD_1	24	26	PF01839	0.407
LIG_Integrin_RGD_TGFB_3	24	30	PF01839	0.377
LIG_LIR_Apic_2	41	45	PF02991	0.399
LIG_LIR_Gen_1	216	227	PF02991	0.521
LIG_LIR_Nem_3	216	222	PF02991	0.521
LIG_SH2_CRK	235	239	PF00017	0.454
LIG_SH2_NCK_1	119	123	PF00017	0.555
LIG_SH2_NCK_1	225	229	PF00017	0.521
LIG_SH2_SRC	119	122	PF00017	0.567
LIG_SH2_SRC	225	228	PF00017	0.473
LIG_SH2_SRC	233	236	PF00017	0.434
LIG_SH2_STAP1	235	239	PF00017	0.454
LIG_SH2_STAP1	253	257	PF00017	0.454
LIG_SH2_STAT3	108	111	PF00017	0.657
LIG_SH2_STAT5	233	236	PF00017	0.454
LIG_SH2_STAT5	38	41	PF00017	0.439
LIG_SH3_3	160	166	PF00018	0.548
LIG_SH3_3	240	246	PF00018	0.505
LIG_SUMO_SIM_par_1	278	285	PF11976	0.455
LIG_WW_3	164	168	PF00397	0.617
MOD_CK1_1	177	183	PF00069	0.640
MOD_CK1_1	237	243	PF00069	0.509
MOD_CK2_1	114	120	PF00069	0.761
MOD_Cter_Amidation	15	18	PF01082	0.412
MOD_GlcNHglycan	111	114	PF01048	0.766
MOD_GlcNHglycan	159	163	PF01048	0.619
MOD_GSK3_1	217	224	PF00069	0.454
MOD_GSK3_1	233	240	PF00069	0.454
MOD_GSK3_1	89	96	PF00069	0.598
MOD_LATS_1	75	81	PF00433	0.395
MOD_N-GLC_1	177	182	PF02516	0.576
MOD_N-GLC_1	207	212	PF02516	0.254
MOD_NEK2_1	199	204	PF00069	0.472
MOD_NEK2_1	257	262	PF00069	0.454
MOD_NEK2_1	282	287	PF00069	0.451
MOD_NEK2_1	303	308	PF00069	0.474
MOD_NEK2_2	188	193	PF00069	0.392
MOD_PIKK_1	272	278	PF00454	0.474
MOD_PIKK_1	95	101	PF00454	0.698
MOD_PKA_1	174	180	PF00069	0.574
MOD_PKA_2	114	120	PF00069	0.752
MOD_PKA_2	174	180	PF00069	0.696
MOD_Plk_1	104	110	PF00069	0.578
MOD_Plk_1	207	213	PF00069	0.454
MOD_Plk_1	217	223	PF00069	0.454
MOD_Plk_4	234	240	PF00069	0.506
MOD_Plk_4	257	263	PF00069	0.454
MOD_Plk_4	303	309	PF00069	0.534
MOD_ProDKin_1	289	295	PF00069	0.457
TRG_DiLeu_BaEn_1	46	51	PF01217	0.461
TRG_ENDOCYTIC_2	235	238	PF00928	0.454
TRG_ENDOCYTIC_2	253	256	PF00928	0.454
TRG_ER_diArg_1	174	176	PF00400	0.594
TRG_ER_diArg_1	35	37	PF00400	0.373
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT22	Leptomonas seymouri	57%	96%
A0A1X0P075	Trypanosomatidae	46%	88%
A0A3S7X487	Leishmania donovani	92%	100%
A4HJ54	Leishmania braziliensis	73%	100%
A4I6G8	Leishmania infantum	92%	100%
E9B1M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	96%
V5BJ53	Trypanosoma cruzi	45%	90%