C2 domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

C2 domain protein

Gene product:

C2 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q9BHF8_LEIMA

TriTrypDb:

LmjF.31.0680 , LMJLV39_310012500 , LMJSD75_310012200

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9BHF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BHF8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005509	calcium ion binding	5	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.397
CLV_PCSK_KEX2_1	142	144	PF00082	0.541
CLV_PCSK_KEX2_1	34	36	PF00082	0.334
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.541
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.325
CLV_PCSK_PC7_1	138	144	PF00082	0.531
DOC_CKS1_1	194	199	PF01111	0.579
DOC_MAPK_gen_1	104	113	PF00069	0.427
DOC_MAPK_MEF2A_6	106	115	PF00069	0.396
DOC_PP4_FxxP_1	55	58	PF00568	0.331
DOC_SPAK_OSR1_1	54	58	PF12202	0.333
DOC_USP7_MATH_1	221	225	PF00917	0.594
DOC_USP7_MATH_1	233	237	PF00917	0.558
DOC_USP7_UBL2_3	92	96	PF12436	0.353
DOC_WW_Pin1_4	193	198	PF00397	0.638
LIG_AP2alpha_2	24	26	PF02296	0.353
LIG_Clathr_ClatBox_1	115	119	PF01394	0.416
LIG_FHA_1	131	137	PF00498	0.499
LIG_FHA_1	36	42	PF00498	0.355
LIG_FHA_1	89	95	PF00498	0.397
LIG_FHA_2	105	111	PF00498	0.397
LIG_FHA_2	72	78	PF00498	0.353
LIG_LIR_Apic_2	224	228	PF02991	0.606
LIG_LIR_Apic_2	236	242	PF02991	0.578
LIG_LIR_Apic_2	52	58	PF02991	0.331
LIG_LIR_Gen_1	24	31	PF02991	0.410
LIG_LIR_Nem_3	119	123	PF02991	0.452
LIG_LIR_Nem_3	24	29	PF02991	0.410
LIG_LIR_Nem_3	97	102	PF02991	0.400
LIG_Pex14_1	49	53	PF04695	0.381
LIG_SH2_CRK	239	243	PF00017	0.623
LIG_SH2_CRK	251	255	PF00017	0.700
LIG_SH2_NCK_1	251	255	PF00017	0.566
LIG_SH2_SRC	187	190	PF00017	0.675
LIG_SH2_STAP1	75	79	PF00017	0.428
LIG_SH2_STAP1	83	87	PF00017	0.476
LIG_SH2_STAT3	195	198	PF00017	0.617
LIG_SH2_STAT3	204	207	PF00017	0.679
LIG_SH2_STAT3	238	241	PF00017	0.696
LIG_SH2_STAT3	250	253	PF00017	0.556
LIG_SH2_STAT3	259	262	PF00017	0.569
LIG_SH2_STAT3	36	39	PF00017	0.353
LIG_SH2_STAT5	100	103	PF00017	0.400
LIG_SH2_STAT5	187	190	PF00017	0.612
LIG_SH2_STAT5	195	198	PF00017	0.576
LIG_SH2_STAT5	204	207	PF00017	0.603
LIG_SH2_STAT5	251	254	PF00017	0.592
LIG_SH3_1	213	219	PF00018	0.726
LIG_SH3_1	225	231	PF00018	0.646
LIG_SH3_1	239	245	PF00018	0.638
LIG_SH3_3	167	173	PF00018	0.700
LIG_SH3_3	175	181	PF00018	0.610
LIG_SH3_3	185	191	PF00018	0.582
LIG_SH3_3	203	209	PF00018	0.587
LIG_SH3_3	213	219	PF00018	0.716
LIG_SH3_3	224	230	PF00018	0.667
LIG_SH3_3	239	245	PF00018	0.681
LIG_SUMO_SIM_par_1	114	119	PF11976	0.556
LIG_TRAF2_1	124	127	PF00917	0.487
LIG_WW_2	218	221	PF00397	0.574
MOD_CK2_1	104	110	PF00069	0.489
MOD_GlcNHglycan	235	238	PF01048	0.594
MOD_GSK3_1	249	256	PF00069	0.549
MOD_N-GLC_2	71	73	PF02516	0.331
MOD_NEK2_1	102	107	PF00069	0.497
MOD_NEK2_2	49	54	PF00069	0.351
MOD_PIKK_1	104	110	PF00454	0.431
MOD_PIKK_1	249	255	PF00454	0.605
MOD_PIKK_1	35	41	PF00454	0.445
MOD_PIKK_1	60	66	PF00454	0.364
MOD_Plk_1	4	10	PF00069	0.353
MOD_Plk_1	49	55	PF00069	0.355
MOD_Plk_4	221	227	PF00069	0.615
MOD_ProDKin_1	193	199	PF00069	0.638
MOD_SUMO_for_1	124	127	PF00179	0.464
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.395
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.577
TRG_ENDOCYTIC_2	82	85	PF00928	0.353
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NKX3	Trypanosomatidae	45%	88%
A0A3Q8IFD2	Leishmania donovani	87%	95%
A0A3S7X485	Leishmania donovani	36%	93%
A0A3S7X4C0	Leishmania donovani	39%	100%
A4HJ46	Leishmania braziliensis	68%	100%
A4HJ57	Leishmania braziliensis	41%	100%
A4HJ58	Leishmania braziliensis	40%	98%
A4I6G2	Leishmania infantum	87%	95%
A4I6H2	Leishmania infantum	38%	100%
A4I6H3	Leishmania infantum	36%	93%
E9B1L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	95%
E9B1N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	95%
E9B1N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	96%
Q9BHE7	Leishmania major	38%	100%
Q9BHE8	Leishmania major	40%	100%