Uncharacterized protein P883.19

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9BHF1_LEIMA

TriTrypDb:

LmjF.31.0610 , LMJLV39_310011800 , LMJSD75_310011500

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:1990904	ribonucleoprotein complex	2	2
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q9BHF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BHF1

Function

Biological processes
Term	Name	Level	Count
GO:0001514	selenocysteine incorporation	7	2
GO:0006414	translational elongation	5	2
GO:0006417	regulation of translation	6	2
GO:0006451	translational readthrough	6	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003729	mRNA binding	5	11
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0005488	binding	1	11
GO:0035368	selenocysteine insertion sequence binding	6	11
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0044877	protein-containing complex binding	2	2
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.705
CLV_C14_Caspase3-7	311	315	PF00656	0.530
CLV_NRD_NRD_1	157	159	PF00675	0.683
CLV_NRD_NRD_1	198	200	PF00675	0.543
CLV_NRD_NRD_1	208	210	PF00675	0.483
CLV_NRD_NRD_1	442	444	PF00675	0.686
CLV_NRD_NRD_1	456	458	PF00675	0.601
CLV_PCSK_FUR_1	206	210	PF00082	0.560
CLV_PCSK_KEX2_1	157	159	PF00082	0.674
CLV_PCSK_KEX2_1	168	170	PF00082	0.490
CLV_PCSK_KEX2_1	197	199	PF00082	0.469
CLV_PCSK_KEX2_1	208	210	PF00082	0.369
CLV_PCSK_KEX2_1	442	444	PF00082	0.662
CLV_PCSK_KEX2_1	93	95	PF00082	0.516
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.393
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.493
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.559
CLV_PCSK_SKI1_1	209	213	PF00082	0.510
CLV_PCSK_SKI1_1	22	26	PF00082	0.811
CLV_PCSK_SKI1_1	337	341	PF00082	0.685
CLV_PCSK_SKI1_1	373	377	PF00082	0.412
CLV_PCSK_SKI1_1	398	402	PF00082	0.519
CLV_PCSK_SKI1_1	406	410	PF00082	0.480
CLV_PCSK_SKI1_1	458	462	PF00082	0.617
CLV_PCSK_SKI1_1	532	536	PF00082	0.515
CLV_PCSK_SKI1_1	543	547	PF00082	0.471
DEG_APCC_DBOX_1	403	411	PF00400	0.439
DEG_APCC_DBOX_1	531	539	PF00400	0.543
DEG_SPOP_SBC_1	134	138	PF00917	0.639
DEG_SPOP_SBC_1	28	32	PF00917	0.713
DEG_SPOP_SBC_1	322	326	PF00917	0.691
DOC_MAPK_gen_1	373	383	PF00069	0.441
DOC_MAPK_gen_1	384	393	PF00069	0.409
DOC_MAPK_gen_1	398	407	PF00069	0.474
DOC_MAPK_gen_1	516	525	PF00069	0.521
DOC_MAPK_MEF2A_6	401	409	PF00069	0.505
DOC_PP2B_LxvP_1	424	427	PF13499	0.536
DOC_PP4_FxxP_1	260	263	PF00568	0.700
DOC_USP7_MATH_1	122	126	PF00917	0.637
DOC_USP7_MATH_1	134	138	PF00917	0.768
DOC_USP7_MATH_1	184	188	PF00917	0.587
DOC_USP7_MATH_1	245	249	PF00917	0.730
DOC_USP7_MATH_1	252	256	PF00917	0.753
DOC_USP7_MATH_1	28	32	PF00917	0.767
DOC_USP7_MATH_1	321	325	PF00917	0.666
DOC_USP7_MATH_1	338	342	PF00917	0.679
DOC_USP7_MATH_1	432	436	PF00917	0.757
DOC_USP7_MATH_1	445	449	PF00917	0.663
DOC_USP7_MATH_1	452	456	PF00917	0.635
DOC_USP7_MATH_1	515	519	PF00917	0.560
DOC_USP7_MATH_1	537	541	PF00917	0.445
DOC_USP7_UBL2_3	21	25	PF12436	0.792
DOC_USP7_UBL2_3	454	458	PF12436	0.693
DOC_WW_Pin1_4	125	130	PF00397	0.774
DOC_WW_Pin1_4	29	34	PF00397	0.668
DOC_WW_Pin1_4	323	328	PF00397	0.714
DOC_WW_Pin1_4	443	448	PF00397	0.776
DOC_WW_Pin1_4	78	83	PF00397	0.683
LIG_14-3-3_CanoR_1	161	167	PF00244	0.501
LIG_14-3-3_CanoR_1	243	253	PF00244	0.685
LIG_14-3-3_CanoR_1	506	512	PF00244	0.545
LIG_14-3-3_CanoR_1	543	553	PF00244	0.486
LIG_14-3-3_CanoR_1	6	10	PF00244	0.717
LIG_BRCT_BRCA1_1	340	344	PF00533	0.616
LIG_CaM_IQ_9	200	216	PF13499	0.500
LIG_CaM_IQ_9	390	406	PF13499	0.508
LIG_EVH1_1	424	428	PF00568	0.533
LIG_FHA_1	125	131	PF00498	0.541
LIG_FHA_1	348	354	PF00498	0.376
LIG_FHA_1	553	559	PF00498	0.573
LIG_FHA_2	154	160	PF00498	0.596
LIG_FHA_2	233	239	PF00498	0.725
LIG_FHA_2	309	315	PF00498	0.603
LIG_FHA_2	410	416	PF00498	0.546
LIG_FHA_2	461	467	PF00498	0.470
LIG_LIR_Apic_2	259	263	PF02991	0.703
LIG_LIR_Gen_1	175	185	PF02991	0.470
LIG_LIR_Gen_1	359	369	PF02991	0.385
LIG_LIR_Gen_1	41	49	PF02991	0.528
LIG_LIR_Nem_3	175	181	PF02991	0.446
LIG_LIR_Nem_3	255	260	PF02991	0.562
LIG_LIR_Nem_3	282	288	PF02991	0.388
LIG_LIR_Nem_3	359	365	PF02991	0.400
LIG_LIR_Nem_3	41	45	PF02991	0.525
LIG_LIR_Nem_3	510	514	PF02991	0.490
LIG_LIR_Nem_3	540	544	PF02991	0.412
LIG_LYPXL_yS_3	285	288	PF13949	0.590
LIG_PROFILIN_1	425	431	PF00235	0.504
LIG_SH2_CRK	42	46	PF00017	0.526
LIG_SH2_NCK_1	162	166	PF00017	0.493
LIG_SH2_STAP1	162	166	PF00017	0.493
LIG_SH2_STAP1	511	515	PF00017	0.401
LIG_SH2_STAP1	541	545	PF00017	0.394
LIG_SH2_STAP1	549	553	PF00017	0.422
LIG_SH2_STAT3	369	372	PF00017	0.403
LIG_SH2_STAT5	348	351	PF00017	0.394
LIG_SH2_STAT5	389	392	PF00017	0.451
LIG_SH2_STAT5	42	45	PF00017	0.528
LIG_SH2_STAT5	544	547	PF00017	0.518
LIG_SH2_STAT5	549	552	PF00017	0.522
LIG_SH3_3	116	122	PF00018	0.682
LIG_SH3_3	414	420	PF00018	0.650
LIG_SH3_3	422	428	PF00018	0.692
LIG_SH3_3	433	439	PF00018	0.639
LIG_SH3_3	474	480	PF00018	0.623
LIG_SUMO_SIM_par_1	406	413	PF11976	0.442
LIG_UBA3_1	364	370	PF00899	0.492
LIG_WRC_WIRS_1	257	262	PF05994	0.677
MOD_CDK_SPxxK_3	443	450	PF00069	0.682
MOD_CK1_1	125	131	PF00069	0.690
MOD_CK1_1	132	138	PF00069	0.769
MOD_CK1_1	219	225	PF00069	0.547
MOD_CK1_1	232	238	PF00069	0.742
MOD_CK1_1	326	332	PF00069	0.678
MOD_CK1_1	453	459	PF00069	0.681
MOD_CK1_1	502	508	PF00069	0.488
MOD_CK2_1	134	140	PF00069	0.763
MOD_CK2_1	153	159	PF00069	0.642
MOD_CK2_1	409	415	PF00069	0.418
MOD_CK2_1	460	466	PF00069	0.483
MOD_GlcNHglycan	114	117	PF01048	0.674
MOD_GlcNHglycan	149	153	PF01048	0.633
MOD_GlcNHglycan	247	250	PF01048	0.737
MOD_GlcNHglycan	274	277	PF01048	0.559
MOD_GlcNHglycan	421	424	PF01048	0.692
MOD_GlcNHglycan	447	450	PF01048	0.713
MOD_GSK3_1	125	132	PF00069	0.678
MOD_GSK3_1	221	228	PF00069	0.648
MOD_GSK3_1	241	248	PF00069	0.784
MOD_GSK3_1	252	259	PF00069	0.576
MOD_GSK3_1	28	35	PF00069	0.778
MOD_GSK3_1	322	329	PF00069	0.702
MOD_GSK3_1	347	354	PF00069	0.416
MOD_GSK3_1	441	448	PF00069	0.694
MOD_GSK3_1	5	12	PF00069	0.734
MOD_GSK3_1	543	550	PF00069	0.456
MOD_NEK2_1	216	221	PF00069	0.574
MOD_NEK2_1	231	236	PF00069	0.671
MOD_NEK2_1	256	261	PF00069	0.589
MOD_NEK2_1	332	337	PF00069	0.646
MOD_NEK2_1	339	344	PF00069	0.520
MOD_NEK2_1	360	365	PF00069	0.403
MOD_NEK2_1	499	504	PF00069	0.522
MOD_NEK2_1	553	558	PF00069	0.544
MOD_NEK2_1	9	14	PF00069	0.756
MOD_NEK2_2	460	465	PF00069	0.573
MOD_PIKK_1	160	166	PF00454	0.590
MOD_PIKK_1	332	338	PF00454	0.710
MOD_PIKK_1	49	55	PF00454	0.772
MOD_PKA_2	160	166	PF00069	0.467
MOD_PKA_2	225	231	PF00069	0.692
MOD_PKA_2	441	447	PF00069	0.715
MOD_PKA_2	482	488	PF00069	0.712
MOD_PKA_2	5	11	PF00069	0.708
MOD_PKA_2	507	513	PF00069	0.544
MOD_PKA_2	54	60	PF00069	0.762
MOD_PKA_2	87	93	PF00069	0.598
MOD_Plk_1	553	559	PF00069	0.566
MOD_Plk_2-3	140	146	PF00069	0.749
MOD_Plk_2-3	308	314	PF00069	0.606
MOD_Plk_2-3	5	11	PF00069	0.612
MOD_Plk_4	252	258	PF00069	0.660
MOD_Plk_4	262	268	PF00069	0.588
MOD_Plk_4	339	345	PF00069	0.577
MOD_Plk_4	41	47	PF00069	0.764
MOD_Plk_4	553	559	PF00069	0.488
MOD_ProDKin_1	125	131	PF00069	0.774
MOD_ProDKin_1	29	35	PF00069	0.666
MOD_ProDKin_1	323	329	PF00069	0.720
MOD_ProDKin_1	443	449	PF00069	0.775
MOD_ProDKin_1	78	84	PF00069	0.676
TRG_DiLeu_BaEn_1	466	471	PF01217	0.544
TRG_ENDOCYTIC_2	178	181	PF00928	0.444
TRG_ENDOCYTIC_2	257	260	PF00928	0.572
TRG_ENDOCYTIC_2	285	288	PF00928	0.590
TRG_ENDOCYTIC_2	42	45	PF00928	0.528
TRG_ER_diArg_1	198	200	PF00400	0.500
TRG_ER_diArg_1	205	208	PF00400	0.495
TRG_ER_diArg_1	386	389	PF00400	0.445
TRG_ER_diArg_1	404	407	PF00400	0.533
TRG_ER_diArg_1	441	443	PF00400	0.708
TRG_ER_diArg_1	506	509	PF00400	0.457
TRG_ER_diArg_1	86	89	PF00400	0.623
TRG_NLS_Bipartite_1	442	461	PF00514	0.677
TRG_NLS_MonoExtN_4	195	201	PF00514	0.527
TRG_NLS_MonoExtN_4	454	461	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN8	Leptomonas seymouri	50%	100%
A0A1X0NJ63	Trypanosomatidae	27%	88%
A0A3R7LBH7	Trypanosoma rangeli	31%	99%
A0A3S7X464	Leishmania donovani	91%	100%
A4HJ40	Leishmania braziliensis	70%	99%
A4I6F5	Leishmania infantum	92%	100%
C9ZN70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B1L2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BDV6	Trypanosoma cruzi	28%	94%