Hypothetical transmembrane protein P883.20

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9BHF0_LEIMA

TriTrypDb:

LmjF.31.0600 , LMJLV39_310011700 , LMJSD75_310011400

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q9BHF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BHF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.530
CLV_NRD_NRD_1	174	176	PF00675	0.720
CLV_NRD_NRD_1	230	232	PF00675	0.762
CLV_NRD_NRD_1	381	383	PF00675	0.525
CLV_NRD_NRD_1	68	70	PF00675	0.604
CLV_NRD_NRD_1	78	80	PF00675	0.586
CLV_PCSK_KEX2_1	380	382	PF00082	0.528
CLV_PCSK_KEX2_1	68	70	PF00082	0.604
CLV_PCSK_KEX2_1	78	80	PF00082	0.586
CLV_PCSK_KEX2_1	82	84	PF00082	0.597
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.645
CLV_PCSK_PC7_1	377	383	PF00082	0.449
CLV_PCSK_PC7_1	78	84	PF00082	0.636
CLV_PCSK_SKI1_1	337	341	PF00082	0.650
CLV_PCSK_SKI1_1	348	352	PF00082	0.371
CLV_PCSK_SKI1_1	36	40	PF00082	0.651
CLV_PCSK_SKI1_1	82	86	PF00082	0.579
CLV_Separin_Metazoa	72	76	PF03568	0.419
DEG_APCC_DBOX_1	336	344	PF00400	0.446
DEG_SPOP_SBC_1	168	172	PF00917	0.408
DOC_CKS1_1	440	445	PF01111	0.667
DOC_MAPK_gen_1	175	183	PF00069	0.480
DOC_MAPK_MEF2A_6	175	183	PF00069	0.480
DOC_MIT_MIM_1	117	125	PF04212	0.337
DOC_USP7_MATH_1	169	173	PF00917	0.516
DOC_USP7_MATH_1	235	239	PF00917	0.552
DOC_USP7_MATH_1	49	53	PF00917	0.606
DOC_USP7_UBL2_3	286	290	PF12436	0.489
DOC_WW_Pin1_4	105	110	PF00397	0.484
DOC_WW_Pin1_4	140	145	PF00397	0.438
DOC_WW_Pin1_4	200	205	PF00397	0.562
DOC_WW_Pin1_4	386	391	PF00397	0.758
DOC_WW_Pin1_4	412	417	PF00397	0.748
DOC_WW_Pin1_4	427	432	PF00397	0.794
DOC_WW_Pin1_4	439	444	PF00397	0.773
LIG_14-3-3_CanoR_1	216	226	PF00244	0.556
LIG_14-3-3_CanoR_1	231	239	PF00244	0.563
LIG_14-3-3_CanoR_1	312	316	PF00244	0.469
LIG_14-3-3_CanoR_1	61	70	PF00244	0.509
LIG_14-3-3_CanoR_1	83	89	PF00244	0.471
LIG_Actin_WH2_2	332	350	PF00022	0.444
LIG_APCC_ABBAyCdc20_2	176	182	PF00400	0.506
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_FHA_1	141	147	PF00498	0.429
LIG_FHA_1	358	364	PF00498	0.357
LIG_FHA_1	397	403	PF00498	0.763
LIG_FHA_1	96	102	PF00498	0.507
LIG_FHA_2	2	8	PF00498	0.586
LIG_FHA_2	220	226	PF00498	0.529
LIG_FHA_2	253	259	PF00498	0.480
LIG_FHA_2	416	422	PF00498	0.652
LIG_FHA_2	434	440	PF00498	0.843
LIG_IRF3_LxIS_1	363	368	PF10401	0.501
LIG_NRBOX	69	75	PF00104	0.416
LIG_PCNA_PIPBox_1	133	142	PF02747	0.489
LIG_Pex14_1	324	328	PF04695	0.471
LIG_SH2_PTP2	180	183	PF00017	0.506
LIG_SH2_SRC	180	183	PF00017	0.506
LIG_SH2_STAT3	113	116	PF00017	0.447
LIG_SH2_STAT3	139	142	PF00017	0.491
LIG_SH2_STAT3	376	379	PF00017	0.718
LIG_SH2_STAT5	139	142	PF00017	0.450
LIG_SH2_STAT5	180	183	PF00017	0.509
LIG_SH2_STAT5	315	318	PF00017	0.507
LIG_SH3_1	327	333	PF00018	0.463
LIG_SH3_3	103	109	PF00018	0.497
LIG_SH3_3	144	150	PF00018	0.484
LIG_SH3_3	180	186	PF00018	0.568
LIG_SH3_3	327	333	PF00018	0.432
LIG_SH3_3	336	342	PF00018	0.405
LIG_SH3_3	367	373	PF00018	0.677
LIG_SH3_3	411	417	PF00018	0.789
LIG_SH3_3	437	443	PF00018	0.803
LIG_SUMO_SIM_par_1	355	360	PF11976	0.376
LIG_SUMO_SIM_par_1	362	368	PF11976	0.376
LIG_TRAF2_1	222	225	PF00917	0.581
LIG_TRAF2_1	436	439	PF00917	0.818
LIG_TRAF2_1	445	448	PF00917	0.585
LIG_TRAF2_1	94	97	PF00917	0.429
LIG_UBA3_1	364	372	PF00899	0.360
MOD_CK1_1	415	421	PF00069	0.562
MOD_CK1_1	441	447	PF00069	0.699
MOD_CK1_1	52	58	PF00069	0.702
MOD_CK1_1	6	12	PF00069	0.754
MOD_CK1_1	62	68	PF00069	0.516
MOD_CK2_1	1	7	PF00069	0.755
MOD_CK2_1	219	225	PF00069	0.675
MOD_CK2_1	415	421	PF00069	0.562
MOD_CK2_1	433	439	PF00069	0.776
MOD_CK2_1	441	447	PF00069	0.568
MOD_CK2_1	91	97	PF00069	0.528
MOD_Cter_Amidation	173	176	PF01082	0.503
MOD_GlcNHglycan	233	236	PF01048	0.755
MOD_GlcNHglycan	247	250	PF01048	0.549
MOD_GlcNHglycan	278	281	PF01048	0.573
MOD_GlcNHglycan	290	293	PF01048	0.576
MOD_GlcNHglycan	396	399	PF01048	0.765
MOD_GlcNHglycan	47	50	PF01048	0.649
MOD_GlcNHglycan	62	65	PF01048	0.453
MOD_GlcNHglycan	7	11	PF01048	0.751
MOD_GlcNHglycan	93	96	PF01048	0.647
MOD_GSK3_1	138	145	PF00069	0.569
MOD_GSK3_1	149	156	PF00069	0.577
MOD_GSK3_1	163	170	PF00069	0.709
MOD_GSK3_1	215	222	PF00069	0.676
MOD_GSK3_1	231	238	PF00069	0.689
MOD_GSK3_1	386	393	PF00069	0.745
MOD_GSK3_1	396	403	PF00069	0.761
MOD_GSK3_1	412	419	PF00069	0.572
MOD_GSK3_1	45	52	PF00069	0.662
MOD_GSK3_1	85	92	PF00069	0.620
MOD_NEK2_1	1	6	PF00069	0.711
MOD_NEK2_1	244	249	PF00069	0.680
MOD_NEK2_1	276	281	PF00069	0.574
MOD_NEK2_1	335	340	PF00069	0.473
MOD_NEK2_1	365	370	PF00069	0.401
MOD_NEK2_1	44	49	PF00069	0.675
MOD_NEK2_1	89	94	PF00069	0.742
MOD_PIKK_1	138	144	PF00454	0.567
MOD_PIKK_1	217	223	PF00454	0.621
MOD_PKA_1	231	237	PF00069	0.720
MOD_PKA_1	380	386	PF00069	0.574
MOD_PKA_1	82	88	PF00069	0.411
MOD_PKA_2	120	126	PF00069	0.588
MOD_PKA_2	215	221	PF00069	0.751
MOD_PKA_2	311	317	PF00069	0.587
MOD_PKA_2	380	386	PF00069	0.616
MOD_PKA_2	42	48	PF00069	0.585
MOD_PKA_2	60	66	PF00069	0.588
MOD_PKA_2	82	88	PF00069	0.473
MOD_PKB_1	229	237	PF00069	0.683
MOD_Plk_1	210	216	PF00069	0.723
MOD_Plk_1	85	91	PF00069	0.590
MOD_Plk_4	142	148	PF00069	0.634
MOD_Plk_4	210	216	PF00069	0.725
MOD_Plk_4	311	317	PF00069	0.640
MOD_Plk_4	352	358	PF00069	0.450
MOD_Plk_4	371	377	PF00069	0.725
MOD_ProDKin_1	105	111	PF00069	0.600
MOD_ProDKin_1	140	146	PF00069	0.544
MOD_ProDKin_1	200	206	PF00069	0.719
MOD_ProDKin_1	386	392	PF00069	0.714
MOD_ProDKin_1	412	418	PF00069	0.700
MOD_ProDKin_1	427	433	PF00069	0.762
MOD_ProDKin_1	439	445	PF00069	0.728
MOD_SUMO_rev_2	224	234	PF00179	0.576
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.516
TRG_ENDOCYTIC_2	180	183	PF00928	0.718
TRG_ER_diArg_1	380	382	PF00400	0.665
TRG_ER_diArg_1	67	69	PF00400	0.504
TRG_ER_diArg_1	78	80	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBU0	Leptomonas seymouri	46%	99%
A0A3S7X462	Leishmania donovani	87%	100%
A4HJ39	Leishmania braziliensis	70%	100%
A4I6F4	Leishmania infantum	87%	100%
C9ZN69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B1L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%