Putative C-5 sterol desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-5 sterol desaturase, putative

Species:

Leishmania major

UniProt:

Q9BHE9_LEIMA

TriTrypDb:

LmjF.31.0590 , LMJLV39_310011600 , LMJSD75_310011300

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q9BHE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BHE9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005506	iron ion binding	6	12
GO:0016491	oxidoreductase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	111	115	PF00082	0.346
CLV_PCSK_SKI1_1	25	29	PF00082	0.256
CLV_PCSK_SKI1_1	268	272	PF00082	0.505
CLV_PCSK_SKI1_1	77	81	PF00082	0.347
DEG_Nend_UBRbox_2	1	3	PF02207	0.698
DOC_CYCLIN_yCln2_LP_2	104	110	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.519
DOC_MAPK_gen_1	58	67	PF00069	0.402
DOC_MAPK_gen_1	68	75	PF00069	0.279
DOC_MAPK_MEF2A_6	111	120	PF00069	0.479
DOC_MAPK_MEF2A_6	25	33	PF00069	0.250
DOC_MAPK_MEF2A_6	68	75	PF00069	0.286
DOC_MAPK_NFAT4_5	111	119	PF00069	0.519
DOC_PP1_RVXF_1	109	116	PF00149	0.479
DOC_PP1_RVXF_1	237	243	PF00149	0.550
DOC_PP2B_LxvP_1	114	117	PF13499	0.426
DOC_PP2B_LxvP_1	220	223	PF13499	0.519
DOC_USP7_MATH_2	61	67	PF00917	0.278
DOC_USP7_UBL2_3	21	25	PF12436	0.497
DOC_USP7_UBL2_3	268	272	PF12436	0.705
DOC_USP7_UBL2_3	60	64	PF12436	0.413
DOC_WW_Pin1_4	153	158	PF00397	0.254
DOC_WW_Pin1_4	187	192	PF00397	0.280
DOC_WW_Pin1_4	97	102	PF00397	0.588
LIG_14-3-3_CanoR_1	92	99	PF00244	0.607
LIG_BRCT_BRCA1_1	99	103	PF00533	0.582
LIG_CSK_EPIYA_1	2	6	PF00017	0.646
LIG_CSL_BTD_1	114	117	PF09270	0.313
LIG_deltaCOP1_diTrp_1	250	256	PF00928	0.465
LIG_EH1_1	10	18	PF00400	0.520
LIG_FHA_1	160	166	PF00498	0.336
LIG_FHA_1	197	203	PF00498	0.348
LIG_FHA_2	214	220	PF00498	0.454
LIG_LIR_Gen_1	128	138	PF02991	0.313
LIG_LIR_Gen_1	174	185	PF02991	0.260
LIG_LIR_Gen_1	87	96	PF02991	0.426
LIG_LIR_Nem_3	112	118	PF02991	0.330
LIG_LIR_Nem_3	128	134	PF02991	0.232
LIG_LIR_Nem_3	174	180	PF02991	0.260
LIG_LIR_Nem_3	187	192	PF02991	0.259
LIG_LIR_Nem_3	250	256	PF02991	0.455
LIG_LIR_Nem_3	35	39	PF02991	0.292
LIG_LIR_Nem_3	69	75	PF02991	0.261
LIG_LIR_Nem_3	87	91	PF02991	0.394
LIG_Pex14_1	140	144	PF04695	0.261
LIG_Pex14_1	249	253	PF04695	0.454
LIG_Pex14_2	130	134	PF04695	0.297
LIG_Rb_pABgroove_1	121	129	PF01858	0.383
LIG_SH2_CRK	144	148	PF00017	0.292
LIG_SH2_CRK	39	43	PF00017	0.366
LIG_SH2_CRK	88	92	PF00017	0.429
LIG_SH2_STAP1	127	131	PF00017	0.310
LIG_SH2_STAT5	131	134	PF00017	0.297
LIG_SH2_STAT5	172	175	PF00017	0.254
LIG_SH2_STAT5	177	180	PF00017	0.254
LIG_SH2_STAT5	184	187	PF00017	0.254
LIG_SH2_STAT5	224	227	PF00017	0.467
LIG_SH2_STAT5	245	248	PF00017	0.455
LIG_SH2_STAT5	72	75	PF00017	0.340
LIG_SH3_3	115	121	PF00018	0.389
LIG_SH3_3	39	45	PF00018	0.379
LIG_SH3_4	60	67	PF00018	0.408
LIG_TRAF2_1	262	265	PF00917	0.633
LIG_WRC_WIRS_1	253	258	PF05994	0.504
LIG_WRC_WIRS_1	33	38	PF05994	0.320
LIG_WRC_WIRS_1	8	13	PF05994	0.616
LIG_WW_1	141	144	PF00397	0.279
MOD_CDC14_SPxK_1	156	159	PF00782	0.319
MOD_CDK_SPxK_1	153	159	PF00069	0.254
MOD_CK1_1	263	269	PF00069	0.676
MOD_CK1_1	97	103	PF00069	0.559
MOD_GlcNHglycan	264	268	PF01048	0.500
MOD_GSK3_1	209	216	PF00069	0.372
MOD_N-GLC_1	213	218	PF02516	0.254
MOD_NEK2_1	129	134	PF00069	0.333
MOD_NEK2_1	206	211	PF00069	0.340
MOD_NEK2_1	213	218	PF00069	0.450
MOD_PKA_2	91	97	PF00069	0.612
MOD_Plk_1	213	219	PF00069	0.454
MOD_Plk_1	94	100	PF00069	0.568
MOD_Plk_2-3	63	69	PF00069	0.389
MOD_Plk_4	129	135	PF00069	0.322
MOD_Plk_4	142	148	PF00069	0.265
MOD_Plk_4	38	44	PF00069	0.373
MOD_ProDKin_1	153	159	PF00069	0.254
MOD_ProDKin_1	187	193	PF00069	0.280
MOD_ProDKin_1	97	103	PF00069	0.593
TRG_DiLeu_BaEn_1	176	181	PF01217	0.297
TRG_ENDOCYTIC_2	127	130	PF00928	0.297
TRG_ENDOCYTIC_2	131	134	PF00928	0.297
TRG_ENDOCYTIC_2	144	147	PF00928	0.254
TRG_ENDOCYTIC_2	177	180	PF00928	0.254
TRG_ENDOCYTIC_2	245	248	PF00928	0.454
TRG_ENDOCYTIC_2	39	42	PF00928	0.325
TRG_ENDOCYTIC_2	5	8	PF00928	0.744
TRG_ENDOCYTIC_2	72	75	PF00928	0.339
TRG_ENDOCYTIC_2	88	91	PF00928	0.232
TRG_ER_diLys_1	271	274	PF00400	0.725
TRG_NES_CRM1_1	2	14	PF08389	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA25	Leptomonas seymouri	78%	100%
A0A0S4KFW2	Bodo saltans	56%	92%
A0A1X0NKZ9	Trypanosomatidae	53%	100%
A0A3Q8IJV0	Leishmania donovani	94%	100%
A0A3R7P157	Trypanosoma rangeli	62%	100%
A4HJ38	Leishmania braziliensis	85%	96%
A4I6F3	Leishmania infantum	95%	100%
C9ZN68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B1L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DER6	Trypanosoma cruzi	61%	97%