Putative c2 domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

c2 domain protein, putative

Species:

Leishmania major

UniProt:

Q9BHE8_LEIMA

TriTrypDb:

LmjF.31.0790 , LMJLV39_310013600 , LMJSD75_310013300

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q9BHE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BHE8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	275	277	PF00675	0.565
CLV_PCSK_KEX2_1	275	277	PF00082	0.565
DOC_ANK_TNKS_1	127	134	PF00023	0.447
DOC_CDC14_PxL_1	246	254	PF14671	0.493
DOC_CKS1_1	198	203	PF01111	0.576
DOC_MAPK_gen_1	19	29	PF00069	0.333
DOC_MAPK_MEF2A_6	22	31	PF00069	0.333
DOC_PIKK_1	76	84	PF02985	0.377
DOC_PP2B_LxvP_1	176	179	PF13499	0.590
DOC_USP7_UBL2_3	36	40	PF12436	0.391
DOC_WW_Pin1_4	182	187	PF00397	0.573
DOC_WW_Pin1_4	197	202	PF00397	0.577
LIG_14-3-3_CanoR_1	135	141	PF00244	0.498
LIG_EVH1_1	171	175	PF00568	0.528
LIG_FHA_1	101	107	PF00498	0.342
LIG_FHA_1	135	141	PF00498	0.531
LIG_FHA_1	161	167	PF00498	0.492
LIG_FHA_1	94	100	PF00498	0.387
LIG_LIR_Apic_2	152	156	PF02991	0.489
LIG_LIR_Apic_2	236	240	PF02991	0.625
LIG_LIR_Gen_1	102	108	PF02991	0.387
LIG_LIR_Gen_1	24	31	PF02991	0.347
LIG_LIR_Gen_1	64	72	PF02991	0.268
LIG_LIR_Nem_3	102	107	PF02991	0.349
LIG_LIR_Nem_3	24	29	PF02991	0.347
LIG_PCNA_PIPBox_1	68	77	PF02747	0.268
LIG_Pex14_1	54	58	PF04695	0.325
LIG_PTB_Apo_2	52	59	PF02174	0.279
LIG_SH2_CRK	153	157	PF00017	0.481
LIG_SH2_CRK	196	200	PF00017	0.576
LIG_SH2_CRK	226	230	PF00017	0.658
LIG_SH2_CRK	237	241	PF00017	0.725
LIG_SH2_CRK	247	251	PF00017	0.686
LIG_SH2_CRK	268	272	PF00017	0.630
LIG_SH2_CRK	282	286	PF00017	0.604
LIG_SH2_PTP2	159	162	PF00017	0.482
LIG_SH2_PTP2	198	201	PF00017	0.557
LIG_SH2_PTP2	26	29	PF00017	0.370
LIG_SH2_SRC	159	162	PF00017	0.482
LIG_SH2_STAP1	88	92	PF00017	0.443
LIG_SH2_STAT5	159	162	PF00017	0.525
LIG_SH2_STAT5	198	201	PF00017	0.613
LIG_SH2_STAT5	26	29	PF00017	0.317
LIG_SH3_1	198	204	PF00018	0.580
LIG_SH3_1	237	243	PF00018	0.625
LIG_SH3_1	247	253	PF00018	0.620
LIG_SH3_2	201	206	PF14604	0.510
LIG_SH3_2	270	275	PF14604	0.576
LIG_SH3_3	169	175	PF00018	0.569
LIG_SH3_3	17	23	PF00018	0.343
LIG_SH3_3	180	186	PF00018	0.622
LIG_SH3_3	196	202	PF00018	0.638
LIG_SH3_3	209	215	PF00018	0.772
LIG_SH3_3	226	232	PF00018	0.633
LIG_SH3_3	237	243	PF00018	0.602
LIG_SH3_3	247	253	PF00018	0.597
LIG_SH3_3	259	265	PF00018	0.630
LIG_SH3_3	267	273	PF00018	0.507
LIG_SH3_CIN85_PxpxPR_1	186	191	PF14604	0.482
LIG_SUMO_SIM_par_1	120	125	PF11976	0.468
LIG_SUMO_SIM_par_1	136	141	PF11976	0.539
LIG_TYR_ITIM	194	199	PF00017	0.557
MOD_CK1_1	34	40	PF00069	0.222
MOD_CK2_1	110	116	PF00069	0.455
MOD_GlcNHglycan	186	189	PF01048	0.553
MOD_GSK3_1	107	114	PF00069	0.448
MOD_GSK3_1	141	148	PF00069	0.534
MOD_GSK3_1	84	91	PF00069	0.262
MOD_N-GLC_1	233	238	PF02516	0.549
MOD_NEK2_1	107	112	PF00069	0.623
MOD_NEK2_1	31	36	PF00069	0.392
MOD_NEK2_1	84	89	PF00069	0.262
MOD_PIKK_1	160	166	PF00454	0.493
MOD_PIKK_1	218	224	PF00454	0.575
MOD_PIKK_1	34	40	PF00454	0.382
MOD_PKA_2	134	140	PF00069	0.432
MOD_Plk_1	233	239	PF00069	0.546
MOD_Plk_4	100	106	PF00069	0.315
MOD_Plk_4	141	147	PF00069	0.541
MOD_ProDKin_1	182	188	PF00069	0.573
MOD_ProDKin_1	197	203	PF00069	0.576
TRG_ENDOCYTIC_2	196	199	PF00928	0.639
TRG_ENDOCYTIC_2	226	229	PF00928	0.654
TRG_ENDOCYTIC_2	26	29	PF00928	0.311
TRG_ENDOCYTIC_2	65	68	PF00928	0.268
TRG_ER_diArg_1	275	277	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M8	Leptomonas seymouri	59%	100%
A0A3R7ML62	Trypanosoma rangeli	46%	100%
A0A3S7X485	Leishmania donovani	94%	100%
A0A3S7X4C0	Leishmania donovani	48%	100%
A4HJ57	Leishmania braziliensis	52%	100%
A4HJ58	Leishmania braziliensis	70%	100%
A4I6H2	Leishmania infantum	49%	100%
A4I6H3	Leishmania infantum	94%	100%
E9B1N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B1N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q9BHF8	Leishmania major	40%	100%