Putative c2 domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

c2 domain protein, putative

Species:

Leishmania major

UniProt:

Q9BHE7_LEIMA

TriTrypDb:

LmjF.31.0780 , LMJLV39_310013500 , LMJSD75_310013200

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q9BHE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BHE7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.308
CLV_NRD_NRD_1	33	35	PF00675	0.222
CLV_PCSK_SKI1_1	104	108	PF00082	0.323
CLV_PCSK_SKI1_1	138	142	PF00082	0.440
CLV_PCSK_SKI1_1	159	163	PF00082	0.507
DEG_SPOP_SBC_1	45	49	PF00917	0.244
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.459
DOC_PP2B_LxvP_1	224	227	PF13499	0.445
DOC_USP7_MATH_1	130	134	PF00917	0.387
DOC_USP7_MATH_1	173	177	PF00917	0.586
DOC_USP7_UBL2_3	36	40	PF12436	0.269
DOC_WW_Pin1_4	111	116	PF00397	0.329
DOC_WW_Pin1_4	249	254	PF00397	0.505
DOC_WW_Pin1_4	269	274	PF00397	0.490
LIG_14-3-3_CanoR_1	97	107	PF00244	0.370
LIG_Actin_WH2_2	88	106	PF00022	0.217
LIG_FHA_1	147	153	PF00498	0.470
LIG_FHA_1	41	47	PF00498	0.294
LIG_FHA_1	57	63	PF00498	0.282
LIG_FHA_1	94	100	PF00498	0.413
LIG_FHA_2	152	158	PF00498	0.482
LIG_FHA_2	160	166	PF00498	0.512
LIG_GBD_Chelix_1	99	107	PF00786	0.314
LIG_LIR_Apic_2	256	261	PF02991	0.536
LIG_LIR_Gen_1	165	173	PF02991	0.543
LIG_LIR_Gen_1	24	31	PF02991	0.312
LIG_LIR_Nem_3	165	170	PF02991	0.534
LIG_LIR_Nem_3	24	29	PF02991	0.349
LIG_MAD2	44	52	PF02301	0.224
LIG_MYND_1	194	198	PF01753	0.498
LIG_PCNA_yPIPBox_3	77	85	PF02747	0.296
LIG_PDZ_Class_1	269	274	PF00595	0.477
LIG_SH2_CRK	258	262	PF00017	0.591
LIG_SH2_NCK_1	143	147	PF00017	0.344
LIG_SH2_PTP2	26	29	PF00017	0.266
LIG_SH2_STAP1	88	92	PF00017	0.288
LIG_SH2_STAT3	200	203	PF00017	0.538
LIG_SH2_STAT3	213	216	PF00017	0.614
LIG_SH2_STAT3	235	238	PF00017	0.560
LIG_SH2_STAT3	247	250	PF00017	0.545
LIG_SH2_STAT5	223	226	PF00017	0.727
LIG_SH2_STAT5	235	238	PF00017	0.560
LIG_SH2_STAT5	26	29	PF00017	0.272
LIG_SH3_1	223	229	PF00018	0.440
LIG_SH3_1	258	264	PF00018	0.518
LIG_SH3_3	145	151	PF00018	0.467
LIG_SH3_3	167	173	PF00018	0.604
LIG_SH3_3	185	191	PF00018	0.578
LIG_SH3_3	211	217	PF00018	0.523
LIG_SH3_3	223	229	PF00018	0.634
LIG_SH3_3	258	264	PF00018	0.651
LIG_SUMO_SIM_par_1	120	125	PF11976	0.350
LIG_TRFH_1	213	217	PF08558	0.456
LIG_WRC_WIRS_1	57	62	PF05994	0.217
MOD_CK2_1	110	116	PF00069	0.432
MOD_CK2_1	136	142	PF00069	0.372
MOD_CK2_1	151	157	PF00069	0.529
MOD_CK2_1	171	177	PF00069	0.535
MOD_GSK3_1	107	114	PF00069	0.447
MOD_GSK3_1	249	256	PF00069	0.518
MOD_GSK3_1	40	47	PF00069	0.239
MOD_LATS_1	38	44	PF00433	0.217
MOD_NEK2_1	107	112	PF00069	0.467
MOD_PKA_1	159	165	PF00069	0.502
MOD_Plk_4	131	137	PF00069	0.383
MOD_Plk_4	202	208	PF00069	0.500
MOD_Plk_4	253	259	PF00069	0.512
MOD_ProDKin_1	111	117	PF00069	0.317
MOD_ProDKin_1	249	255	PF00069	0.507
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.606
TRG_ENDOCYTIC_2	26	29	PF00928	0.287
TRG_ENDOCYTIC_2	265	268	PF00928	0.488
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D0	Leptomonas seymouri	63%	95%
A0A3Q8IFD2	Leishmania donovani	35%	100%
A0A3S7X4C0	Leishmania donovani	73%	100%
A4HJ46	Leishmania braziliensis	37%	94%
A4HJ57	Leishmania braziliensis	63%	100%
A4HJ58	Leishmania braziliensis	49%	100%
A4I6G2	Leishmania infantum	35%	100%
A4I6H2	Leishmania infantum	74%	100%
E9B1L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	93%
E9B1N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q9BHF8	Leishmania major	38%	100%