LeishMANIAdb
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Putative sodium stibogluconate resistance protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative sodium stibogluconate resistance protein
Gene product:
sodium stibogluconate resistance protein, putative
Species:
Leishmania major
UniProt:
Q9BHE5_LEIMA
TriTrypDb:
LmjF.31.0920 , LMJLV39_310015100 , LMJSD75_310014900 , LMJSD75_310015000
Length:
621

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9BHE5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BHE5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 121 125 PF00656 0.775
CLV_C14_Caspase3-7 130 134 PF00656 0.682
CLV_C14_Caspase3-7 246 250 PF00656 0.588
CLV_C14_Caspase3-7 518 522 PF00656 0.588
CLV_NRD_NRD_1 305 307 PF00675 0.601
CLV_NRD_NRD_1 48 50 PF00675 0.419
CLV_NRD_NRD_1 513 515 PF00675 0.657
CLV_NRD_NRD_1 540 542 PF00675 0.679
CLV_NRD_NRD_1 577 579 PF00675 0.543
CLV_NRD_NRD_1 615 617 PF00675 0.516
CLV_PCSK_KEX2_1 48 50 PF00082 0.419
CLV_PCSK_KEX2_1 524 526 PF00082 0.686
CLV_PCSK_KEX2_1 539 541 PF00082 0.489
CLV_PCSK_PC1ET2_1 524 526 PF00082 0.704
CLV_PCSK_PC1ET2_1 539 541 PF00082 0.489
CLV_PCSK_PC7_1 44 50 PF00082 0.405
CLV_PCSK_PC7_1 535 541 PF00082 0.628
CLV_PCSK_SKI1_1 21 25 PF00082 0.514
CLV_PCSK_SKI1_1 231 235 PF00082 0.579
CLV_PCSK_SKI1_1 324 328 PF00082 0.540
CLV_PCSK_SKI1_1 525 529 PF00082 0.649
CLV_PCSK_SKI1_1 535 539 PF00082 0.531
CLV_PCSK_SKI1_1 56 60 PF00082 0.543
DEG_APCC_DBOX_1 353 361 PF00400 0.658
DOC_MAPK_MEF2A_6 146 154 PF00069 0.556
DOC_MAPK_MEF2A_6 553 560 PF00069 0.593
DOC_PP1_RVXF_1 368 375 PF00149 0.638
DOC_PP1_SILK_1 574 579 PF00149 0.342
DOC_PP1_SILK_1 612 617 PF00149 0.452
DOC_PP2B_LxvP_1 478 481 PF13499 0.701
DOC_SPAK_OSR1_1 30 34 PF12202 0.510
DOC_USP7_MATH_1 250 254 PF00917 0.607
DOC_USP7_MATH_1 347 351 PF00917 0.582
DOC_USP7_MATH_1 391 395 PF00917 0.585
DOC_USP7_MATH_1 445 449 PF00917 0.546
DOC_USP7_MATH_1 461 465 PF00917 0.482
DOC_USP7_MATH_1 513 517 PF00917 0.696
DOC_USP7_MATH_1 567 571 PF00917 0.452
DOC_USP7_MATH_1 92 96 PF00917 0.613
DOC_USP7_MATH_2 334 340 PF00917 0.589
DOC_USP7_MATH_2 424 430 PF00917 0.558
DOC_WW_Pin1_4 387 392 PF00397 0.588
DOC_WW_Pin1_4 420 425 PF00397 0.660
LIG_14-3-3_CanoR_1 265 270 PF00244 0.582
LIG_14-3-3_CanoR_1 30 39 PF00244 0.547
LIG_14-3-3_CanoR_1 4 9 PF00244 0.654
LIG_14-3-3_CanoR_1 406 410 PF00244 0.442
LIG_14-3-3_CanoR_1 415 421 PF00244 0.592
LIG_14-3-3_CanoR_1 427 431 PF00244 0.594
LIG_14-3-3_CanoR_1 541 549 PF00244 0.590
LIG_Actin_WH2_2 437 455 PF00022 0.603
LIG_AP2alpha_1 50 54 PF02296 0.550
LIG_BRCT_BRCA1_1 267 271 PF00533 0.548
LIG_BRCT_BRCA1_1 585 589 PF00533 0.454
LIG_CSL_BTD_1 388 391 PF09270 0.573
LIG_EH1_1 608 616 PF00400 0.485
LIG_FHA_1 143 149 PF00498 0.604
LIG_FHA_1 180 186 PF00498 0.553
LIG_FHA_1 201 207 PF00498 0.498
LIG_FHA_1 264 270 PF00498 0.579
LIG_FHA_1 402 408 PF00498 0.433
LIG_FHA_1 53 59 PF00498 0.564
LIG_FHA_1 592 598 PF00498 0.430
LIG_FHA_2 30 36 PF00498 0.548
LIG_FHA_2 406 412 PF00498 0.417
LIG_FHA_2 469 475 PF00498 0.721
LIG_GBD_Chelix_1 611 619 PF00786 0.457
LIG_Integrin_RGD_1 122 124 PF01839 0.715
LIG_LIR_Gen_1 174 183 PF02991 0.515
LIG_LIR_Gen_1 226 235 PF02991 0.639
LIG_LIR_Gen_1 298 304 PF02991 0.561
LIG_LIR_Gen_1 605 615 PF02991 0.526
LIG_LIR_Nem_3 149 154 PF02991 0.530
LIG_LIR_Nem_3 163 168 PF02991 0.331
LIG_LIR_Nem_3 17 23 PF02991 0.561
LIG_LIR_Nem_3 174 178 PF02991 0.387
LIG_LIR_Nem_3 226 230 PF02991 0.618
LIG_LIR_Nem_3 298 302 PF02991 0.549
LIG_LIR_Nem_3 464 469 PF02991 0.682
LIG_LIR_Nem_3 605 611 PF02991 0.467
LIG_PCNA_yPIPBox_3 204 217 PF02747 0.362
LIG_Pex14_2 50 54 PF04695 0.550
LIG_SH2_CRK 165 169 PF00017 0.503
LIG_SH2_CRK 20 24 PF00017 0.565
LIG_SH2_CRK 227 231 PF00017 0.604
LIG_SH2_CRK 283 287 PF00017 0.483
LIG_SH2_CRK 291 295 PF00017 0.415
LIG_SH2_CRK 299 303 PF00017 0.399
LIG_SH2_STAP1 143 147 PF00017 0.508
LIG_SH2_STAP1 469 473 PF00017 0.645
LIG_SH2_STAT3 37 40 PF00017 0.550
LIG_SH2_STAT5 175 178 PF00017 0.542
LIG_SH2_STAT5 195 198 PF00017 0.279
LIG_SH2_STAT5 283 286 PF00017 0.519
LIG_SH2_STAT5 291 294 PF00017 0.396
LIG_SH2_STAT5 337 340 PF00017 0.562
LIG_SH2_STAT5 37 40 PF00017 0.550
LIG_SH2_STAT5 432 435 PF00017 0.598
LIG_SH3_3 147 153 PF00018 0.514
LIG_SH3_3 385 391 PF00018 0.621
LIG_SH3_3 439 445 PF00018 0.629
LIG_SH3_3 493 499 PF00018 0.754
LIG_SH3_3 86 92 PF00018 0.701
LIG_SUMO_SIM_anti_2 438 445 PF11976 0.665
LIG_TRAF2_1 25 28 PF00917 0.507
LIG_TRAF2_1 408 411 PF00917 0.455
LIG_TYR_ITIM 18 23 PF00017 0.553
LIG_TYR_ITIM 225 230 PF00017 0.590
LIG_UBA3_1 206 214 PF00899 0.512
LIG_UBA3_1 342 348 PF00899 0.536
LIG_UBA3_1 572 579 PF00899 0.437
LIG_UBA3_1 610 617 PF00899 0.506
LIG_WRC_WIRS_1 371 376 PF05994 0.624
MOD_CDK_SPxxK_3 420 427 PF00069 0.611
MOD_CK1_1 300 306 PF00069 0.582
MOD_CK1_1 414 420 PF00069 0.613
MOD_CK1_1 516 522 PF00069 0.698
MOD_CK1_1 603 609 PF00069 0.405
MOD_CK2_1 249 255 PF00069 0.564
MOD_CK2_1 29 35 PF00069 0.543
MOD_CK2_1 405 411 PF00069 0.458
MOD_CK2_1 420 426 PF00069 0.581
MOD_CK2_1 468 474 PF00069 0.693
MOD_Cter_Amidation 46 49 PF01082 0.411
MOD_GlcNHglycan 127 130 PF01048 0.725
MOD_GlcNHglycan 236 239 PF01048 0.692
MOD_GlcNHglycan 384 387 PF01048 0.712
MOD_GlcNHglycan 393 396 PF01048 0.442
MOD_GlcNHglycan 492 495 PF01048 0.731
MOD_GlcNHglycan 517 521 PF01048 0.740
MOD_GlcNHglycan 580 583 PF01048 0.553
MOD_GlcNHglycan 585 588 PF01048 0.518
MOD_GSK3_1 125 132 PF00069 0.661
MOD_GSK3_1 196 203 PF00069 0.539
MOD_GSK3_1 259 266 PF00069 0.616
MOD_GSK3_1 356 363 PF00069 0.713
MOD_GSK3_1 387 394 PF00069 0.601
MOD_GSK3_1 401 408 PF00069 0.408
MOD_GSK3_1 426 433 PF00069 0.573
MOD_GSK3_1 547 554 PF00069 0.649
MOD_GSK3_1 563 570 PF00069 0.340
MOD_N-GLC_1 411 416 PF02516 0.604
MOD_N-GLC_1 591 596 PF02516 0.469
MOD_N-GLC_2 290 292 PF02516 0.462
MOD_NEK2_1 198 203 PF00069 0.503
MOD_NEK2_1 269 274 PF00069 0.555
MOD_NEK2_1 295 300 PF00069 0.540
MOD_NEK2_1 360 365 PF00069 0.708
MOD_NEK2_1 382 387 PF00069 0.664
MOD_NEK2_1 401 406 PF00069 0.356
MOD_NEK2_1 452 457 PF00069 0.658
MOD_NEK2_1 50 55 PF00069 0.549
MOD_NEK2_1 572 577 PF00069 0.496
MOD_NEK2_2 445 450 PF00069 0.546
MOD_NMyristoyl 1 7 PF02799 0.729
MOD_PIKK_1 200 206 PF00454 0.490
MOD_PIKK_1 365 371 PF00454 0.658
MOD_PIKK_1 389 395 PF00454 0.486
MOD_PIKK_1 414 420 PF00454 0.600
MOD_PK_1 105 111 PF00069 0.619
MOD_PK_1 4 10 PF00069 0.695
MOD_PKA_1 578 584 PF00069 0.560
MOD_PKA_2 29 35 PF00069 0.543
MOD_PKA_2 3 9 PF00069 0.663
MOD_PKA_2 405 411 PF00069 0.449
MOD_PKA_2 414 420 PF00069 0.600
MOD_PKA_2 426 432 PF00069 0.590
MOD_PKA_2 490 496 PF00069 0.756
MOD_PKA_2 513 519 PF00069 0.677
MOD_Plk_1 156 162 PF00069 0.366
MOD_Plk_1 551 557 PF00069 0.641
MOD_Plk_4 171 177 PF00069 0.523
MOD_Plk_4 265 271 PF00069 0.567
MOD_Plk_4 445 451 PF00069 0.580
MOD_Plk_4 567 573 PF00069 0.485
MOD_Plk_4 610 616 PF00069 0.518
MOD_ProDKin_1 387 393 PF00069 0.585
MOD_ProDKin_1 420 426 PF00069 0.662
TRG_DiLeu_BaEn_2 584 590 PF01217 0.478
TRG_DiLeu_BaLyEn_6 163 168 PF01217 0.500
TRG_DiLeu_BaLyEn_6 337 342 PF01217 0.518
TRG_DiLeu_BaLyEn_6 395 400 PF01217 0.575
TRG_DiLeu_BaLyEn_6 532 537 PF01217 0.603
TRG_ENDOCYTIC_2 164 167 PF00928 0.482
TRG_ENDOCYTIC_2 175 178 PF00928 0.404
TRG_ENDOCYTIC_2 195 198 PF00928 0.247
TRG_ENDOCYTIC_2 20 23 PF00928 0.560
TRG_ENDOCYTIC_2 227 230 PF00928 0.604
TRG_ENDOCYTIC_2 282 285 PF00928 0.520
TRG_ENDOCYTIC_2 291 294 PF00928 0.384
TRG_ENDOCYTIC_2 299 302 PF00928 0.379
TRG_ENDOCYTIC_2 469 472 PF00928 0.665
TRG_ER_diArg_1 48 50 PF00400 0.410
TRG_NES_CRM1_1 317 328 PF08389 0.412
TRG_NLS_Bipartite_1 524 543 PF00514 0.667
TRG_NLS_MonoCore_2 537 542 PF00514 0.644
TRG_NLS_MonoExtN_4 535 542 PF00514 0.641
TRG_Pf-PMV_PEXEL_1 166 170 PF00026 0.489

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFG5 Leishmania donovani 90% 100%
A0A3Q8ISI8 Leishmania donovani 88% 100%
A0A3S7X4A3 Leishmania donovani 89% 100%
A4HJ70 Leishmania braziliensis 62% 99%
A4HJ71 Leishmania braziliensis 66% 99%
A4HJ73 Leishmania braziliensis 66% 100%
A4HJW7 Leishmania braziliensis 61% 100%
A4I6I2 Leishmania infantum 90% 94%
A4I6L8 Leishmania infantum 90% 100%
E8NHD1 Leishmania infantum 89% 100%
E8NHD2 Leishmania infantum 86% 100%
E8NHE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E8NHE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9B1P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q6G7 Leishmania major 95% 100%
Q4Q6G8 Leishmania major 98% 100%
Q4Q6H0 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS