Possible lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Possible lipase

Gene product:

lipase precursor-like protein

Species:

Leishmania major

UniProt:

Q9BHD5_LEIMA

TriTrypDb:

LmjF.31.0840 , LMJLV39_310014200 , LMJSD75_310013900

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 9
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q9BHD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BHD5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	17
GO:0008152	metabolic process	1	17
GO:0044238	primary metabolic process	2	17
GO:0071704	organic substance metabolic process	2	17

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004806	triglyceride lipase activity	5	11
GO:0016298	lipase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0052689	carboxylic ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	172	176	PF00082	0.294
DEG_Nend_UBRbox_4	1	3	PF02207	0.363
DOC_CKS1_1	204	209	PF01111	0.572
DOC_MIT_MIM_1	130	138	PF04212	0.244
DOC_PP4_FxxP_1	152	155	PF00568	0.317
DOC_USP7_MATH_1	12	16	PF00917	0.607
DOC_USP7_MATH_1	23	27	PF00917	0.442
DOC_WW_Pin1_4	137	142	PF00397	0.232
DOC_WW_Pin1_4	203	208	PF00397	0.560
LIG_14-3-3_CanoR_1	177	185	PF00244	0.320
LIG_14-3-3_CanoR_1	198	205	PF00244	0.538
LIG_14-3-3_CanoR_1	3	8	PF00244	0.392
LIG_Actin_WH2_2	131	147	PF00022	0.244
LIG_BRCT_BRCA1_1	199	203	PF00533	0.496
LIG_FHA_1	107	113	PF00498	0.404
LIG_FHA_1	223	229	PF00498	0.526
LIG_FHA_1	40	46	PF00498	0.337
LIG_FHA_1	50	56	PF00498	0.202
LIG_HCF-1_HBM_1	237	240	PF13415	0.272
LIG_LIR_Apic_2	151	155	PF02991	0.336
LIG_LIR_Apic_2	201	207	PF02991	0.533
LIG_LIR_Gen_1	109	114	PF02991	0.516
LIG_LIR_Nem_3	109	113	PF02991	0.357
LIG_LIR_Nem_3	83	89	PF02991	0.379
LIG_PDZ_Class_1	274	279	PF00595	0.360
LIG_PTB_Apo_2	104	111	PF02174	0.207
LIG_PTB_Apo_2	156	163	PF02174	0.326
LIG_PTB_Phospho_1	104	110	PF10480	0.207
LIG_REV1ctd_RIR_1	229	237	PF16727	0.291
LIG_SH2_CRK	204	208	PF00017	0.331
LIG_SH2_CRK	89	93	PF00017	0.426
LIG_SH2_SRC	110	113	PF00017	0.207
LIG_SH2_STAP1	110	114	PF00017	0.351
LIG_SH2_STAP1	195	199	PF00017	0.239
LIG_SH2_STAP1	86	90	PF00017	0.282
LIG_SH2_STAT5	150	153	PF00017	0.327
LIG_SH3_3	183	189	PF00018	0.323
LIG_Sin3_3	122	129	PF02671	0.284
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.244
LIG_SUMO_SIM_anti_2	98	105	PF11976	0.287
LIG_SUMO_SIM_par_1	145	151	PF11976	0.443
LIG_TRAF2_1	219	222	PF00917	0.285
LIG_TYR_ITIM	274	279	PF00017	0.360
LIG_WRC_WIRS_1	149	154	PF05994	0.336
LIG_WRC_WIRS_1	16	21	PF05994	0.321
MOD_CK1_1	148	154	PF00069	0.474
MOD_CK1_1	15	21	PF00069	0.448
MOD_CK1_1	208	214	PF00069	0.597
MOD_CK1_1	224	230	PF00069	0.370
MOD_CK1_1	253	259	PF00069	0.590
MOD_CK1_1	74	80	PF00069	0.415
MOD_CK1_1	88	94	PF00069	0.314
MOD_CK2_1	216	222	PF00069	0.429
MOD_CK2_1	74	80	PF00069	0.415
MOD_CK2_1	96	102	PF00069	0.432
MOD_GlcNHglycan	10	13	PF01048	0.365
MOD_GlcNHglycan	210	213	PF01048	0.553
MOD_GlcNHglycan	217	221	PF01048	0.427
MOD_GlcNHglycan	255	258	PF01048	0.499
MOD_GlcNHglycan	82	85	PF01048	0.268
MOD_GSK3_1	23	30	PF00069	0.416
MOD_GSK3_1	70	77	PF00069	0.259
MOD_GSK3_1	8	15	PF00069	0.556
MOD_N-GLC_1	208	213	PF02516	0.466
MOD_NEK2_1	242	247	PF00069	0.464
MOD_NEK2_1	49	54	PF00069	0.386
MOD_NEK2_1	85	90	PF00069	0.360
MOD_OFUCOSY	2	9	PF10250	0.324
MOD_PIKK_1	39	45	PF00454	0.459
MOD_PIKK_1	74	80	PF00454	0.231
MOD_PK_1	145	151	PF00069	0.207
MOD_PKA_2	176	182	PF00069	0.306
MOD_PKA_2	197	203	PF00069	0.255
MOD_PKA_2	49	55	PF00069	0.329
MOD_PKA_2	96	102	PF00069	0.257
MOD_Plk_1	208	214	PF00069	0.409
MOD_Plk_4	145	151	PF00069	0.439
MOD_Plk_4	165	171	PF00069	0.379
MOD_Plk_4	85	91	PF00069	0.329
MOD_Plk_4	96	102	PF00069	0.374
MOD_ProDKin_1	137	143	PF00069	0.232
MOD_ProDKin_1	203	209	PF00069	0.573
MOD_SUMO_rev_2	139	147	PF00179	0.244
MOD_SUMO_rev_2	15	24	PF00179	0.288
TRG_ENDOCYTIC_2	110	113	PF00928	0.446
TRG_ENDOCYTIC_2	276	279	PF00928	0.685
TRG_ENDOCYTIC_2	89	92	PF00928	0.379
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D0	Leptomonas seymouri	38%	78%
A0A0S4IJE8	Bodo saltans	32%	85%
A0A0S4J5D7	Bodo saltans	37%	89%
A0A0S4JTA1	Bodo saltans	35%	90%
A0A1X0NH29	Trypanosomatidae	36%	100%
A0A1X0P001	Trypanosomatidae	36%	82%
A0A3Q8IFI3	Leishmania donovani	39%	76%
A0A3Q8IG97	Leishmania donovani	36%	91%
A0A3S7X4C1	Leishmania donovani	81%	100%
A2QSY5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	31%	99%
A4HJN0	Leishmania braziliensis	39%	75%
A4HLK7	Leishmania braziliensis	46%	83%
A4I6H7	Leishmania infantum	36%	91%
A4I6H8	Leishmania infantum	82%	100%
A4I752	Leishmania infantum	39%	76%
B8NIB8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	31%	99%
C9ZME7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	76%
E9B246	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	77%
O42807	Aspergillus niger	31%	99%
O42815	Aspergillus tubingensis	31%	100%
O59952	Thermomyces lanuginosus	33%	96%
P0CT91	Sodiomyces alcalophilus	29%	67%
P19515	Rhizomucor miehei	33%	77%
P47145	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	85%
P61869	Penicillium cyclopium	35%	91%
P61870	Penicillium camembertii	35%	91%
P61871	Rhizopus niveus	30%	71%
P61872	Rhizopus oryzae	30%	71%
Q0CBM7	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	32%	99%
Q2UNW5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	99%
Q4Q615	Leishmania major	38%	100%
Q4Q6I0	Leishmania major	35%	100%
Q6F358	Oryza sativa subsp. japonica	28%	68%
Q9P979	Aspergillus awamori	31%	99%
Q9XTR8	Caenorhabditis elegans	28%	79%
V5B761	Trypanosoma cruzi	37%	100%