FtsJ-like methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FtsJ-like methyltransferase, putative

Species:

Leishmania major

UniProt:

Q9BHC8_LEIMA

TriTrypDb:

LmjF.31.0650 , LMJLV39_310012200 , LMJSD75_310011900

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	2
GO:0016020	membrane	2	1

Expansion

Sequence features

Q9BHC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9BHC8

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0000460	maturation of 5.8S rRNA	9	2
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000470	maturation of LSU-rRNA	9	2
GO:0001510	RNA methylation	4	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	13
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0031167	rRNA methylation	5	2
GO:0032259	methylation	2	13
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:0051301	cell division	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0008171	O-methyltransferase activity	5	2
GO:0008173	RNA methyltransferase activity	4	2
GO:0008649	rRNA methyltransferase activity	5	2
GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	6	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016435	rRNA (guanine) methyltransferase activity	6	2
GO:0016436	rRNA (uridine) methyltransferase activity	6	2
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13
GO:0062105	RNA 2'-O-methyltransferase activity	5	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140102	catalytic activity, acting on a rRNA	4	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.497
CLV_NRD_NRD_1	272	274	PF00675	0.547
CLV_PCSK_KEX2_1	272	274	PF00082	0.547
CLV_PCSK_KEX2_1	331	333	PF00082	0.666
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.508
CLV_PCSK_SKI1_1	228	232	PF00082	0.340
DEG_Nend_Nbox_1	1	3	PF02207	0.370
DEG_SPOP_SBC_1	101	105	PF00917	0.548
DEG_SPOP_SBC_1	192	196	PF00917	0.496
DOC_MAPK_DCC_7	193	203	PF00069	0.555
DOC_MAPK_gen_1	22	31	PF00069	0.531
DOC_PP1_RVXF_1	296	303	PF00149	0.362
DOC_PP2B_LxvP_1	257	260	PF13499	0.479
DOC_PP4_FxxP_1	285	288	PF00568	0.506
DOC_USP7_MATH_1	175	179	PF00917	0.532
DOC_USP7_MATH_1	192	196	PF00917	0.393
DOC_USP7_MATH_1	232	236	PF00917	0.522
DOC_USP7_MATH_1	280	284	PF00917	0.609
DOC_WW_Pin1_4	102	107	PF00397	0.555
LIG_14-3-3_CanoR_1	100	106	PF00244	0.471
LIG_14-3-3_CanoR_1	108	117	PF00244	0.568
LIG_14-3-3_CanoR_1	137	142	PF00244	0.560
LIG_14-3-3_CanoR_1	184	192	PF00244	0.568
LIG_14-3-3_CanoR_1	193	201	PF00244	0.545
LIG_14-3-3_CanoR_1	24	29	PF00244	0.496
LIG_14-3-3_CanoR_1	256	260	PF00244	0.576
LIG_14-3-3_CanoR_1	277	283	PF00244	0.598
LIG_14-3-3_CanoR_1	3	11	PF00244	0.470
LIG_BIR_III_2	172	176	PF00653	0.496
LIG_BRCT_BRCA1_1	156	160	PF00533	0.489
LIG_FHA_1	117	123	PF00498	0.494
LIG_FHA_1	150	156	PF00498	0.467
LIG_FHA_1	218	224	PF00498	0.533
LIG_FHA_1	277	283	PF00498	0.531
LIG_FHA_2	25	31	PF00498	0.483
LIG_LIR_Apic_2	283	288	PF02991	0.540
LIG_LIR_Gen_1	211	219	PF02991	0.407
LIG_LIR_Nem_3	15	20	PF02991	0.453
LIG_LIR_Nem_3	211	216	PF02991	0.405
LIG_NRBOX	149	155	PF00104	0.541
LIG_PCNA_yPIPBox_3	147	158	PF02747	0.530
LIG_SH2_STAT3	2	5	PF00017	0.541
LIG_SH2_STAT5	243	246	PF00017	0.532
LIG_SH3_3	164	170	PF00018	0.530
LIG_SH3_3	226	232	PF00018	0.396
LIG_SH3_3	257	263	PF00018	0.646
LIG_SH3_3	285	291	PF00018	0.391
LIG_SH3_3	319	325	PF00018	0.587
LIG_SH3_3	65	71	PF00018	0.477
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.459
LIG_SUMO_SIM_par_1	151	157	PF11976	0.467
LIG_SUMO_SIM_par_1	60	65	PF11976	0.541
LIG_SUMO_SIM_par_1	9	15	PF11976	0.470
LIG_WW_3	105	109	PF00397	0.496
MOD_CDC14_SPxK_1	105	108	PF00782	0.555
MOD_CDK_SPxK_1	102	108	PF00069	0.555
MOD_CK1_1	112	118	PF00069	0.499
MOD_CK1_1	186	192	PF00069	0.529
MOD_CK1_1	278	284	PF00069	0.623
MOD_CK2_1	232	238	PF00069	0.541
MOD_Cter_Amidation	329	332	PF01082	0.490
MOD_GlcNHglycan	111	114	PF01048	0.296
MOD_GlcNHglycan	195	198	PF01048	0.336
MOD_GlcNHglycan	332	335	PF01048	0.746
MOD_GlcNHglycan	5	8	PF01048	0.267
MOD_GlcNHglycan	54	57	PF01048	0.330
MOD_GSK3_1	108	115	PF00069	0.552
MOD_GSK3_1	183	190	PF00069	0.525
MOD_GSK3_1	232	239	PF00069	0.541
MOD_GSK3_1	276	283	PF00069	0.621
MOD_GSK3_1	96	103	PF00069	0.525
MOD_NEK2_1	139	144	PF00069	0.450
MOD_NEK2_1	148	153	PF00069	0.450
MOD_NEK2_1	154	159	PF00069	0.450
MOD_NEK2_1	217	222	PF00069	0.537
MOD_NEK2_1	96	101	PF00069	0.446
MOD_NEK2_2	280	285	PF00069	0.594
MOD_PIKK_1	217	223	PF00454	0.520
MOD_PK_1	137	143	PF00069	0.555
MOD_PK_1	187	193	PF00069	0.394
MOD_PKA_2	183	189	PF00069	0.548
MOD_PKA_2	192	198	PF00069	0.486
MOD_PKA_2	23	29	PF00069	0.496
MOD_PKA_2	255	261	PF00069	0.607
MOD_PKA_2	276	282	PF00069	0.671
MOD_PKB_1	22	30	PF00069	0.496
MOD_Plk_4	128	134	PF00069	0.467
MOD_Plk_4	149	155	PF00069	0.502
MOD_Plk_4	24	30	PF00069	0.518
MOD_Plk_4	280	286	PF00069	0.584
MOD_ProDKin_1	102	108	PF00069	0.555
TRG_ENDOCYTIC_2	17	20	PF00928	0.497
TRG_ER_diArg_1	271	273	PF00400	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S5	Leptomonas seymouri	54%	94%
A0A0S4IVN5	Bodo saltans	31%	100%
A0A0S4IYL1	Bodo saltans	32%	99%
A0A1X0NJE7	Trypanosomatidae	34%	100%
A0A3R7L564	Trypanosoma rangeli	39%	100%
A0A3S7X469	Leishmania donovani	91%	100%
A0A422NPF8	Trypanosoma rangeli	24%	89%
A0A451EJH4	Leishmania donovani	24%	73%
A1URN3	Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)	26%	100%
A4HRN5	Leishmania infantum	24%	73%
A4I6F9	Leishmania infantum	91%	100%
A8GV60	Rickettsia bellii (strain OSU 85-389)	25%	100%
A9IMA1	Bartonella tribocorum (strain CIP 105476 / IBS 506)	26%	100%
C9ZN77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ACB3	Leishmania major	24%	73%
E9AIU3	Leishmania braziliensis	76%	100%
E9AJK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	74%
E9B1L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O36015	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P38238	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q1RHG3	Rickettsia bellii (strain RML369-C)	25%	100%
Q22031	Caenorhabditis elegans	21%	99%
Q54VA8	Dictyostelium discoideum	23%	100%
Q6G0S9	Bartonella quintana (strain Toulouse)	24%	100%
Q6G4Z3	Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)	25%	100%
V5ANC5	Trypanosoma cruzi	38%	94%