Co-chaperonin CPN10

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Co-chaperonin CPN10

Gene product:

10 kDa heat shock protein, putative

Species:

Leishmania donovani

UniProt:

Q963A7_LEIDO

TriTrypDb:

LdBPK_260610.1 , LdCL_260011600 , LDHU3_26.0790 , LDHU3_26.0810

Length:

100

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, 10 kDa heat shock

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 2
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 15

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q963A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0006458	'de novo' protein folding	3	2
GO:0009987	cellular process	1	2
GO:0051084	'de novo' post-translational protein folding	4	2
GO:0051085	chaperone cofactor-dependent protein refolding	4	2
GO:0061077	chaperone-mediated protein folding	3	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0005488	binding	1	15
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	15
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	22	24	PF00082	0.327
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.427
CLV_PCSK_PC7_1	18	24	PF00082	0.327
DEG_Nend_Nbox_1	1	3	PF02207	0.378
DOC_MAPK_gen_1	28	36	PF00069	0.527
DOC_MAPK_MEF2A_6	57	65	PF00069	0.551
DOC_MAPK_RevD_3	7	23	PF00069	0.402
DOC_PP4_FxxP_1	4	7	PF00568	0.483
DOC_SPAK_OSR1_1	3	7	PF12202	0.347
DOC_USP7_MATH_1	53	57	PF00917	0.570

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JFG4	Bodo saltans	81%	100%
A0A1X0NSW2	Trypanosomatidae	83%	100%
A0A1X0NU48	Trypanosomatidae	84%	100%
A0A3R7NAS6	Trypanosoma rangeli	80%	100%
A0A3R7NCP0	Trypanosoma rangeli	81%	100%
A0A3S7WZQ9	Leishmania donovani	99%	100%
A0AKH6	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	33%	100%
A0PME8	Mycobacterium ulcerans (strain Agy99)	34%	100%
A0Q2T2	Clostridium novyi (strain NT)	37%	100%
A0Q839	Francisella tularensis subsp. novicida (strain U112)	38%	100%

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