LeishMANIAdb
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Hypothetical transmembrane protein L1994.14

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical transmembrane protein L1994.14
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q95ZC0_LEIMA
TriTrypDb:
LmjF.25.2270 , LMJLV39_250030400 , LMJSD75_250030700 *
Length:
453

Annotations

LeishMANIAdb annotations

Unique Kinetoplastid protein of unclear topology and structure. Might not be a TM protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q95ZC0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q95ZC0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 117 119 PF00675 0.351
CLV_NRD_NRD_1 198 200 PF00675 0.597
CLV_NRD_NRD_1 202 204 PF00675 0.574
CLV_NRD_NRD_1 34 36 PF00675 0.392
CLV_NRD_NRD_1 401 403 PF00675 0.608
CLV_NRD_NRD_1 99 101 PF00675 0.459
CLV_PCSK_KEX2_1 116 118 PF00082 0.431
CLV_PCSK_KEX2_1 14 16 PF00082 0.462
CLV_PCSK_KEX2_1 198 200 PF00082 0.622
CLV_PCSK_KEX2_1 202 204 PF00082 0.605
CLV_PCSK_KEX2_1 34 36 PF00082 0.221
CLV_PCSK_KEX2_1 401 403 PF00082 0.652
CLV_PCSK_PC1ET2_1 14 16 PF00082 0.490
CLV_PCSK_PC7_1 198 204 PF00082 0.637
CLV_PCSK_SKI1_1 108 112 PF00082 0.421
CLV_PCSK_SKI1_1 150 154 PF00082 0.362
CLV_PCSK_SKI1_1 210 214 PF00082 0.541
CLV_PCSK_SKI1_1 272 276 PF00082 0.581
CLV_PCSK_SKI1_1 383 387 PF00082 0.589
CLV_PCSK_SKI1_1 401 405 PF00082 0.591
CLV_PCSK_SKI1_1 69 73 PF00082 0.375
CLV_PCSK_SKI1_1 81 85 PF00082 0.384
CLV_Separin_Metazoa 151 155 PF03568 0.653
DEG_APCC_DBOX_1 382 390 PF00400 0.419
DOC_CDC14_PxL_1 57 65 PF14671 0.636
DOC_CYCLIN_RxL_1 9 22 PF00134 0.599
DOC_CYCLIN_yClb1_LxF_4 13 18 PF00134 0.611
DOC_CYCLIN_yCln2_LP_2 228 231 PF00134 0.365
DOC_CYCLIN_yCln2_LP_2 301 307 PF00134 0.510
DOC_CYCLIN_yCln2_LP_2 404 410 PF00134 0.422
DOC_MAPK_DCC_7 297 307 PF00069 0.353
DOC_MAPK_gen_1 164 174 PF00069 0.502
DOC_MAPK_gen_1 297 307 PF00069 0.439
DOC_MAPK_gen_1 81 90 PF00069 0.514
DOC_MAPK_MEF2A_6 167 176 PF00069 0.453
DOC_MAPK_MEF2A_6 300 307 PF00069 0.416
DOC_MAPK_MEF2A_6 310 319 PF00069 0.395
DOC_MAPK_MEF2A_6 69 76 PF00069 0.607
DOC_PP1_RVXF_1 12 19 PF00149 0.604
DOC_PP1_RVXF_1 165 171 PF00149 0.556
DOC_PP1_RVXF_1 374 380 PF00149 0.425
DOC_PP1_RVXF_1 430 436 PF00149 0.427
DOC_PP1_RVXF_1 99 106 PF00149 0.613
DOC_PP2B_LxvP_1 228 231 PF13499 0.336
DOC_PP2B_LxvP_1 404 407 PF13499 0.423
DOC_PP2B_LxvP_1 63 66 PF13499 0.595
DOC_USP7_MATH_1 122 126 PF00917 0.739
DOC_USP7_MATH_1 224 228 PF00917 0.390
DOC_USP7_MATH_1 395 399 PF00917 0.432
DOC_USP7_UBL2_3 422 426 PF12436 0.431
LIG_14-3-3_CanoR_1 116 121 PF00244 0.709
LIG_14-3-3_CanoR_1 210 215 PF00244 0.323
LIG_14-3-3_CanoR_1 328 333 PF00244 0.489
LIG_14-3-3_CanoR_1 9 13 PF00244 0.597
LIG_Actin_WH2_2 347 362 PF00022 0.421
LIG_Actin_WH2_2 70 86 PF00022 0.617
LIG_AP2alpha_1 445 449 PF02296 0.448
LIG_BIR_II_1 1 5 PF00653 0.684
LIG_BIR_III_4 238 242 PF00653 0.452
LIG_FHA_1 184 190 PF00498 0.425
LIG_FHA_2 215 221 PF00498 0.384
LIG_FHA_2 369 375 PF00498 0.452
LIG_LIR_Gen_1 160 170 PF02991 0.593
LIG_LIR_Gen_1 273 282 PF02991 0.337
LIG_LIR_Gen_1 294 303 PF02991 0.437
LIG_LIR_Nem_3 207 212 PF02991 0.383
LIG_LIR_Nem_3 273 278 PF02991 0.339
LIG_LIR_Nem_3 294 298 PF02991 0.437
LIG_LIR_Nem_3 313 317 PF02991 0.392
LIG_LIR_Nem_3 443 448 PF02991 0.368
LIG_MYND_1 335 339 PF01753 0.424
LIG_PCNA_PIPBox_1 64 73 PF02747 0.521
LIG_PCNA_yPIPBox_3 37 51 PF02747 0.604
LIG_Pex14_2 445 449 PF04695 0.407
LIG_PTB_Apo_2 35 42 PF02174 0.606
LIG_PTB_Phospho_1 35 41 PF10480 0.612
LIG_SH2_CRK 181 185 PF00017 0.439
LIG_SH2_CRK 225 229 PF00017 0.361
LIG_SH2_NCK_1 236 240 PF00017 0.450
LIG_SH2_STAP1 225 229 PF00017 0.427
LIG_SH2_STAP1 245 249 PF00017 0.165
LIG_SH2_STAP1 26 30 PF00017 0.593
LIG_SH2_STAT3 41 44 PF00017 0.611
LIG_SH2_STAT5 191 194 PF00017 0.332
LIG_SH2_STAT5 208 211 PF00017 0.321
LIG_SH2_STAT5 41 44 PF00017 0.564
LIG_SH2_STAT5 448 451 PF00017 0.396
LIG_SH3_3 302 308 PF00018 0.478
LIG_SH3_3 329 335 PF00018 0.364
LIG_SH3_3 359 365 PF00018 0.386
LIG_SH3_3 55 61 PF00018 0.582
LIG_TYR_ITIM 179 184 PF00017 0.402
LIG_TYR_ITIM 189 194 PF00017 0.332
LIG_UBA3_1 76 84 PF00899 0.675
LIG_WW_1 222 225 PF00397 0.370
MOD_CK1_1 183 189 PF00069 0.542
MOD_CK2_1 214 220 PF00069 0.406
MOD_CK2_1 277 283 PF00069 0.416
MOD_CK2_1 327 333 PF00069 0.467
MOD_CK2_1 368 374 PF00069 0.377
MOD_CK2_1 447 453 PF00069 0.402
MOD_GlcNHglycan 126 129 PF01048 0.530
MOD_GlcNHglycan 131 134 PF01048 0.487
MOD_GlcNHglycan 367 371 PF01048 0.584
MOD_GlcNHglycan 397 400 PF01048 0.606
MOD_GSK3_1 210 217 PF00069 0.369
MOD_N-GLC_1 257 262 PF02516 0.561
MOD_N-GLC_1 328 333 PF02516 0.740
MOD_NEK2_1 214 219 PF00069 0.451
MOD_NEK2_1 327 332 PF00069 0.515
MOD_NEK2_1 368 373 PF00069 0.410
MOD_NEK2_1 76 81 PF00069 0.626
MOD_NEK2_2 270 275 PF00069 0.349
MOD_PIKK_1 19 25 PF00454 0.599
MOD_PK_1 116 122 PF00069 0.563
MOD_PK_1 328 334 PF00069 0.365
MOD_PKA_1 116 122 PF00069 0.607
MOD_PKA_2 116 122 PF00069 0.705
MOD_PKA_2 327 333 PF00069 0.488
MOD_PKA_2 8 14 PF00069 0.603
MOD_Plk_1 139 145 PF00069 0.671
MOD_Plk_1 257 263 PF00069 0.374
MOD_Plk_1 270 276 PF00069 0.357
MOD_Plk_1 328 334 PF00069 0.482
MOD_Plk_1 416 422 PF00069 0.301
MOD_Plk_2-3 291 297 PF00069 0.437
MOD_Plk_2-3 447 453 PF00069 0.461
MOD_Plk_4 157 163 PF00069 0.630
MOD_Plk_4 224 230 PF00069 0.421
MOD_Plk_4 257 263 PF00069 0.389
MOD_Plk_4 270 276 PF00069 0.368
MOD_Plk_4 416 422 PF00069 0.310
MOD_SUMO_rev_2 104 113 PF00179 0.649
MOD_SUMO_rev_2 387 395 PF00179 0.451
TRG_DiLeu_BaEn_3 97 103 PF01217 0.616
TRG_DiLeu_BaLyEn_6 72 77 PF01217 0.670
TRG_ENDOCYTIC_2 162 165 PF00928 0.579
TRG_ENDOCYTIC_2 181 184 PF00928 0.455
TRG_ENDOCYTIC_2 191 194 PF00928 0.308
TRG_ENDOCYTIC_2 225 228 PF00928 0.370
TRG_ENDOCYTIC_2 448 451 PF00928 0.344
TRG_ENDOCYTIC_2 54 57 PF00928 0.579
TRG_ER_diArg_1 116 118 PF00400 0.561
TRG_ER_diArg_1 15 18 PF00400 0.646
TRG_ER_diArg_1 197 199 PF00400 0.438
TRG_ER_diArg_1 34 36 PF00400 0.501
TRG_ER_diArg_1 401 403 PF00400 0.313
TRG_NES_CRM1_1 439 453 PF08389 0.425
TRG_NLS_MonoExtC_3 13 19 PF00514 0.620
TRG_NLS_MonoExtN_4 13 18 PF00514 0.628
TRG_Pf-PMV_PEXEL_1 100 104 PF00026 0.457
TRG_Pf-PMV_PEXEL_1 203 207 PF00026 0.582

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYH4 Leptomonas seymouri 67% 97%
A0A0S4J1E4 Bodo saltans 40% 100%
A0A1X0NYG5 Trypanosomatidae 50% 100%
A0A3Q8ICN7 Leishmania donovani 95% 100%
A4HED2 Leishmania braziliensis 85% 100%
C9ZKD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AXW1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5BH15 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS