RING finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RING finger protein

Gene product:

Pex2 / Pex12 amino terminal region/Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

Q95ZB8_LEIMA

TriTrypDb:

LmjF.25.2290 , LMJLV39_250030600 , LMJSD75_250030900

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005778	peroxisomal membrane	6	2
GO:0016020	membrane	2	4
GO:0031090	organelle membrane	3	2
GO:0031903	microbody membrane	5	2
GO:0042579	microbody	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	11
GO:0005777	peroxisome	6	8

Expansion

Sequence features

Q95ZB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q95ZB8

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006625	protein targeting to peroxisome	5	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006996	organelle organization	4	2
GO:0007031	peroxisome organization	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0015919	peroxisomal membrane transport	5	2
GO:0016043	cellular component organization	3	2
GO:0016558	protein import into peroxisome matrix	5	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0043574	peroxisomal transport	4	2
GO:0044743	protein transmembrane import into intracellular organelle	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0055085	transmembrane transport	2	2
GO:0065002	intracellular protein transmembrane transport	4	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071806	protein transmembrane transport	3	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072662	protein localization to peroxisome	6	2
GO:0072663	establishment of protein localization to peroxisome	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.276
CLV_C14_Caspase3-7	286	290	PF00656	0.580
CLV_MEL_PAP_1	135	141	PF00089	0.384
CLV_NRD_NRD_1	109	111	PF00675	0.372
CLV_NRD_NRD_1	125	127	PF00675	0.330
CLV_NRD_NRD_1	227	229	PF00675	0.214
CLV_PCSK_KEX2_1	198	200	PF00082	0.375
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.437
CLV_PCSK_SKI1_1	110	114	PF00082	0.201
CLV_PCSK_SKI1_1	127	131	PF00082	0.365
CLV_PCSK_SKI1_1	195	199	PF00082	0.396
CLV_PCSK_SKI1_1	220	224	PF00082	0.241
CLV_PCSK_SKI1_1	26	30	PF00082	0.269
CLV_PCSK_SKI1_1	90	94	PF00082	0.209
CLV_Separin_Metazoa	123	127	PF03568	0.411
CLV_Separin_Metazoa	280	284	PF03568	0.660
DEG_APCC_DBOX_1	89	97	PF00400	0.447
DEG_Nend_UBRbox_3	1	3	PF02207	0.503
DEG_SPOP_SBC_1	205	209	PF00917	0.582
DOC_CYCLIN_RxL_1	107	117	PF00134	0.517
DOC_CYCLIN_RxL_1	144	157	PF00134	0.327
DOC_MAPK_gen_1	145	154	PF00069	0.351
DOC_MAPK_gen_1	217	225	PF00069	0.452
DOC_MAPK_RevD_3	95	111	PF00069	0.394
DOC_PP1_RVXF_1	146	152	PF00149	0.354
DOC_USP7_MATH_1	197	201	PF00917	0.556
LIG_14-3-3_CanoR_1	150	155	PF00244	0.271
LIG_14-3-3_CanoR_1	199	206	PF00244	0.613
LIG_14-3-3_CanoR_1	26	33	PF00244	0.531
LIG_14-3-3_CanoR_1	262	272	PF00244	0.502
LIG_14-3-3_CanoR_1	63	68	PF00244	0.429
LIG_Actin_WH2_2	139	157	PF00022	0.373
LIG_Clathr_ClatBox_1	133	137	PF01394	0.254
LIG_EH1_1	169	177	PF00400	0.276
LIG_eIF4E_1	170	176	PF01652	0.339
LIG_FHA_1	116	122	PF00498	0.536
LIG_FHA_1	265	271	PF00498	0.559
LIG_FHA_2	157	163	PF00498	0.278
LIG_FHA_2	191	197	PF00498	0.545
LIG_FHA_2	205	211	PF00498	0.665
LIG_FHA_2	284	290	PF00498	0.640
LIG_LIR_Gen_1	169	178	PF02991	0.262
LIG_LIR_Gen_1	54	64	PF02991	0.474
LIG_LIR_Gen_1	70	78	PF02991	0.425
LIG_LIR_LC3C_4	180	183	PF02991	0.384
LIG_LIR_Nem_3	137	142	PF02991	0.278
LIG_LIR_Nem_3	169	173	PF02991	0.229
LIG_LIR_Nem_3	54	59	PF02991	0.474
LIG_LIR_Nem_3	70	74	PF02991	0.425
LIG_SH2_STAP1	44	48	PF00017	0.415
LIG_SH2_STAT5	170	173	PF00017	0.241
LIG_SH2_STAT5	18	21	PF00017	0.451
LIG_SH2_STAT5	274	277	PF00017	0.520
LIG_SH2_STAT5	56	59	PF00017	0.405
LIG_SH3_1	79	85	PF00018	0.442
LIG_SH3_2	85	90	PF14604	0.442
LIG_SH3_3	79	85	PF00018	0.442
LIG_SUMO_SIM_par_1	174	180	PF11976	0.240
LIG_UBA3_1	222	229	PF00899	0.414
LIG_UBA3_1	9	15	PF00899	0.484
LIG_WW_3	280	284	PF00397	0.604
MOD_CK1_1	54	60	PF00069	0.508
MOD_CK2_1	190	196	PF00069	0.588
MOD_CK2_1	205	211	PF00069	0.636
MOD_GlcNHglycan	217	220	PF01048	0.394
MOD_GSK3_1	150	157	PF00069	0.272
MOD_GSK3_1	186	193	PF00069	0.554
MOD_GSK3_1	59	66	PF00069	0.501
MOD_NEK2_1	223	228	PF00069	0.478
MOD_NEK2_1	32	37	PF00069	0.552
MOD_NEK2_1	59	64	PF00069	0.474
MOD_PIKK_1	264	270	PF00454	0.559
MOD_PKA_1	198	204	PF00069	0.632
MOD_PKA_2	186	192	PF00069	0.598
MOD_PKA_2	198	204	PF00069	0.660
MOD_PKB_1	148	156	PF00069	0.326
MOD_Plk_4	166	172	PF00069	0.364
MOD_Plk_4	266	272	PF00069	0.530
MOD_Plk_4	51	57	PF00069	0.515
MOD_SUMO_rev_2	191	200	PF00179	0.533
TRG_DiLeu_BaEn_1	70	75	PF01217	0.415
TRG_ENDOCYTIC_2	170	173	PF00928	0.259
TRG_ENDOCYTIC_2	274	277	PF00928	0.526
TRG_ENDOCYTIC_2	56	59	PF00928	0.415
TRG_ER_diArg_1	148	151	PF00400	0.321
TRG_NES_CRM1_1	123	137	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.262
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.218

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N1	Leptomonas seymouri	77%	97%
A0A0S4J0W7	Bodo saltans	40%	100%
A0A1X0NY02	Trypanosomatidae	52%	96%
A0A3R7LE72	Trypanosoma rangeli	47%	100%
A0A3S7WZG1	Leishmania donovani	95%	100%
A4I1S9	Leishmania infantum	96%	100%
B1AUE5	Mus musculus	27%	91%
C0HKD7	Caenorhabditis elegans	22%	94%
C9ZKD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9AXW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O60683	Homo sapiens	25%	91%
Q00940	Pichia angusta	27%	100%
Q05568	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	88%
Q54S31	Dictyostelium discoideum	27%	79%
Q8HXW8	Macaca fascicularis	26%	91%
Q9SYU4	Arabidopsis thaliana	25%	78%
V5D8I1	Trypanosoma cruzi	52%	99%