Possible LRR calcium-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania major

UniProt:

Q95ZB7_LEIMA

TriTrypDb:

LmjF.25.2300 , LMJLV39_250030700 , LMJSD75_250031000

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0016020	membrane	2	1

Expansion

Sequence features

Q95ZB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q95ZB7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.593
CLV_C14_Caspase3-7	171	175	PF00656	0.566
CLV_C14_Caspase3-7	27	31	PF00656	0.300
CLV_C14_Caspase3-7	275	279	PF00656	0.457
CLV_C14_Caspase3-7	336	340	PF00656	0.615
CLV_NRD_NRD_1	213	215	PF00675	0.469
CLV_NRD_NRD_1	306	308	PF00675	0.754
CLV_NRD_NRD_1	357	359	PF00675	0.787
CLV_NRD_NRD_1	369	371	PF00675	0.661
CLV_NRD_NRD_1	440	442	PF00675	0.514
CLV_NRD_NRD_1	479	481	PF00675	0.382
CLV_NRD_NRD_1	592	594	PF00675	0.508
CLV_PCSK_KEX2_1	213	215	PF00082	0.435
CLV_PCSK_KEX2_1	273	275	PF00082	0.557
CLV_PCSK_KEX2_1	306	308	PF00082	0.754
CLV_PCSK_KEX2_1	357	359	PF00082	0.745
CLV_PCSK_KEX2_1	369	371	PF00082	0.605
CLV_PCSK_KEX2_1	440	442	PF00082	0.514
CLV_PCSK_KEX2_1	486	488	PF00082	0.434
CLV_PCSK_KEX2_1	592	594	PF00082	0.508
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.518
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.434
CLV_PCSK_SKI1_1	213	217	PF00082	0.370
CLV_PCSK_SKI1_1	226	230	PF00082	0.377
CLV_PCSK_SKI1_1	259	263	PF00082	0.477
CLV_PCSK_SKI1_1	380	384	PF00082	0.377
CLV_PCSK_SKI1_1	476	480	PF00082	0.461
CLV_PCSK_SKI1_1	570	574	PF00082	0.332
CLV_Separin_Metazoa	477	481	PF03568	0.349
DOC_CDC14_PxL_1	110	118	PF14671	0.523
DOC_CDC14_PxL_1	85	93	PF14671	0.455
DOC_CYCLIN_RxL_1	210	218	PF00134	0.432
DOC_CYCLIN_RxL_1	566	574	PF00134	0.347
DOC_MAPK_gen_1	38	47	PF00069	0.337
DOC_MAPK_HePTP_8	563	575	PF00069	0.426
DOC_MAPK_MEF2A_6	566	575	PF00069	0.456
DOC_MAPK_MEF2A_6	582	590	PF00069	0.489
DOC_MAPK_MEF2A_6	90	98	PF00069	0.511
DOC_PP2B_LxvP_1	98	101	PF13499	0.623
DOC_PP4_FxxP_1	583	586	PF00568	0.392
DOC_USP7_MATH_1	157	161	PF00917	0.557
DOC_USP7_MATH_1	168	172	PF00917	0.466
DOC_USP7_MATH_1	368	372	PF00917	0.597
DOC_USP7_MATH_1	522	526	PF00917	0.372
DOC_USP7_MATH_1	558	562	PF00917	0.484
DOC_USP7_MATH_1	616	620	PF00917	0.534
DOC_USP7_MATH_1	632	636	PF00917	0.529
DOC_USP7_UBL2_3	395	399	PF12436	0.407
DOC_WW_Pin1_4	324	329	PF00397	0.670
DOC_WW_Pin1_4	343	348	PF00397	0.517
DOC_WW_Pin1_4	552	557	PF00397	0.746
LIG_14-3-3_CanoR_1	238	244	PF00244	0.413
LIG_14-3-3_CanoR_1	25	30	PF00244	0.448
LIG_14-3-3_CanoR_1	321	325	PF00244	0.682
LIG_14-3-3_CanoR_1	369	374	PF00244	0.663
LIG_14-3-3_CanoR_1	472	476	PF00244	0.512
LIG_14-3-3_CanoR_1	90	95	PF00244	0.490
LIG_Actin_WH2_2	411	427	PF00022	0.404
LIG_Actin_WH2_2	488	506	PF00022	0.308
LIG_Actin_WH2_2	637	655	PF00022	0.384
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BRCT_BRCA1_1	642	646	PF00533	0.381
LIG_CtBP_PxDLS_1	56	60	PF00389	0.325
LIG_DLG_GKlike_1	25	32	PF00625	0.309
LIG_EH1_1	3	11	PF00400	0.332
LIG_FHA_1	120	126	PF00498	0.491
LIG_FHA_1	372	378	PF00498	0.504
LIG_FHA_1	389	395	PF00498	0.252
LIG_FHA_1	431	437	PF00498	0.367
LIG_FHA_1	527	533	PF00498	0.483
LIG_FHA_2	175	181	PF00498	0.556
LIG_FHA_2	194	200	PF00498	0.437
LIG_FHA_2	25	31	PF00498	0.391
LIG_FHA_2	334	340	PF00498	0.658
LIG_FHA_2	472	478	PF00498	0.334
LIG_FHA_2	504	510	PF00498	0.391
LIG_FHA_2	61	67	PF00498	0.287
LIG_FHA_2	637	643	PF00498	0.414
LIG_LIR_Apic_2	151	157	PF02991	0.633
LIG_LIR_Gen_1	164	175	PF02991	0.474
LIG_LIR_Gen_1	180	189	PF02991	0.308
LIG_LIR_Gen_1	371	379	PF02991	0.502
LIG_LIR_Gen_1	567	575	PF02991	0.367
LIG_LIR_Gen_1	585	591	PF02991	0.289
LIG_LIR_Gen_1	606	614	PF02991	0.371
LIG_LIR_Nem_3	164	170	PF02991	0.458
LIG_LIR_Nem_3	178	184	PF02991	0.317
LIG_LIR_Nem_3	218	224	PF02991	0.459
LIG_LIR_Nem_3	255	261	PF02991	0.521
LIG_LIR_Nem_3	371	376	PF02991	0.627
LIG_LIR_Nem_3	461	467	PF02991	0.350
LIG_LIR_Nem_3	509	515	PF02991	0.339
LIG_LIR_Nem_3	567	571	PF02991	0.362
LIG_LIR_Nem_3	585	590	PF02991	0.256
LIG_LIR_Nem_3	606	610	PF02991	0.338
LIG_NRBOX	239	245	PF00104	0.524
LIG_PTB_Apo_2	514	521	PF02174	0.404
LIG_PTB_Phospho_1	514	520	PF10480	0.400
LIG_SH2_CRK	415	419	PF00017	0.343
LIG_SH2_GRB2like	184	187	PF00017	0.425
LIG_SH2_PTP2	587	590	PF00017	0.475
LIG_SH2_STAP1	217	221	PF00017	0.418
LIG_SH2_STAP1	246	250	PF00017	0.442
LIG_SH2_STAP1	254	258	PF00017	0.399
LIG_SH2_STAP1	390	394	PF00017	0.407
LIG_SH2_STAT5	390	393	PF00017	0.481
LIG_SH2_STAT5	415	418	PF00017	0.391
LIG_SH2_STAT5	535	538	PF00017	0.465
LIG_SH2_STAT5	587	590	PF00017	0.439
LIG_SH3_3	346	352	PF00018	0.727
LIG_SH3_3	93	99	PF00018	0.409
LIG_SUMO_SIM_par_1	490	496	PF11976	0.399
LIG_TRAF2_1	127	130	PF00917	0.560
LIG_TRAF2_1	177	180	PF00917	0.493
LIG_UBA3_1	385	393	PF00899	0.481
LIG_WRC_WIRS_1	1	6	PF05994	0.556
LIG_WRC_WIRS_1	637	642	PF05994	0.418
MOD_CDK_SPxxK_3	324	331	PF00069	0.580
MOD_CK1_1	162	168	PF00069	0.512
MOD_CK1_1	371	377	PF00069	0.537
MOD_CK1_1	60	66	PF00069	0.427
MOD_CK2_1	174	180	PF00069	0.462
MOD_CK2_1	193	199	PF00069	0.405
MOD_CK2_1	282	288	PF00069	0.560
MOD_CK2_1	302	308	PF00069	0.621
MOD_CK2_1	45	51	PF00069	0.393
MOD_CK2_1	471	477	PF00069	0.331
MOD_CK2_1	503	509	PF00069	0.409
MOD_CK2_1	60	66	PF00069	0.300
MOD_CK2_1	614	620	PF00069	0.481
MOD_CK2_1	636	642	PF00069	0.331
MOD_GlcNHglycan	132	136	PF01048	0.645
MOD_GlcNHglycan	159	162	PF01048	0.525
MOD_GlcNHglycan	21	24	PF01048	0.410
MOD_GlcNHglycan	247	250	PF01048	0.528
MOD_GlcNHglycan	292	295	PF01048	0.594
MOD_GlcNHglycan	317	320	PF01048	0.711
MOD_GlcNHglycan	489	492	PF01048	0.512
MOD_GlcNHglycan	524	527	PF01048	0.362
MOD_GSK3_1	155	162	PF00069	0.467
MOD_GSK3_1	320	327	PF00069	0.640
MOD_GSK3_1	329	336	PF00069	0.674
MOD_GSK3_1	356	363	PF00069	0.683
MOD_GSK3_1	371	378	PF00069	0.406
MOD_GSK3_1	522	529	PF00069	0.546
MOD_GSK3_1	554	561	PF00069	0.681
MOD_GSK3_1	632	639	PF00069	0.387
MOD_GSK3_1	90	97	PF00069	0.524
MOD_N-GLC_1	119	124	PF02516	0.463
MOD_N-GLC_1	45	50	PF02516	0.331
MOD_N-GLC_1	658	663	PF02516	0.475
MOD_NEK2_1	119	124	PF00069	0.403
MOD_NEK2_1	19	24	PF00069	0.378
MOD_NEK2_1	290	295	PF00069	0.429
MOD_NEK2_1	329	334	PF00069	0.703
MOD_NEK2_1	338	343	PF00069	0.739
MOD_NEK2_1	45	50	PF00069	0.360
MOD_NEK2_1	503	508	PF00069	0.498
MOD_NEK2_1	57	62	PF00069	0.260
MOD_NEK2_1	640	645	PF00069	0.440
MOD_NEK2_1	652	657	PF00069	0.528
MOD_NEK2_1	68	73	PF00069	0.246
MOD_NEK2_1	94	99	PF00069	0.489
MOD_PIKK_1	175	181	PF00454	0.529
MOD_PIKK_1	356	362	PF00454	0.748
MOD_PIKK_1	558	564	PF00454	0.557
MOD_PIKK_1	632	638	PF00454	0.438
MOD_PKA_1	369	375	PF00069	0.656
MOD_PKA_2	24	30	PF00069	0.448
MOD_PKA_2	264	270	PF00069	0.548
MOD_PKA_2	320	326	PF00069	0.719
MOD_PKA_2	356	362	PF00069	0.753
MOD_PKA_2	368	374	PF00069	0.636
MOD_PKA_2	406	412	PF00069	0.381
MOD_PKA_2	471	477	PF00069	0.349
MOD_PKA_2	503	509	PF00069	0.532
MOD_PKA_2	89	95	PF00069	0.433
MOD_Plk_1	17	23	PF00069	0.428
MOD_Plk_1	338	344	PF00069	0.638
MOD_Plk_1	57	63	PF00069	0.300
MOD_Plk_2-3	159	165	PF00069	0.307
MOD_Plk_2-3	282	288	PF00069	0.554
MOD_Plk_4	162	168	PF00069	0.543
MOD_Plk_4	239	245	PF00069	0.444
MOD_Plk_4	606	612	PF00069	0.393
MOD_ProDKin_1	324	330	PF00069	0.670
MOD_ProDKin_1	343	349	PF00069	0.516
MOD_ProDKin_1	552	558	PF00069	0.741
MOD_SUMO_for_1	4	7	PF00179	0.444
MOD_SUMO_rev_2	359	368	PF00179	0.741
TRG_DiLeu_BaEn_2	461	467	PF01217	0.345
TRG_DiLeu_BaEn_2	641	647	PF01217	0.325
TRG_DiLeu_BaEn_3	620	626	PF01217	0.344
TRG_DiLeu_BaEn_4	549	555	PF01217	0.678
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.486
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.446
TRG_ENDOCYTIC_2	415	418	PF00928	0.347
TRG_ENDOCYTIC_2	587	590	PF00928	0.475
TRG_ER_diArg_1	213	215	PF00400	0.485
TRG_ER_diArg_1	40	43	PF00400	0.397
TRG_ER_diArg_1	439	441	PF00400	0.507
TRG_ER_diArg_1	591	593	PF00400	0.497
TRG_NES_CRM1_1	562	574	PF08389	0.371
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P4	Leptomonas seymouri	62%	99%
A0A0S4IQL8	Bodo saltans	27%	100%
A0A0S4J4H6	Bodo saltans	38%	97%
A0A1X0NY28	Trypanosomatidae	40%	97%
A0A3R7KSG2	Trypanosoma rangeli	40%	97%
A0A3S7WZE2	Leishmania donovani	95%	100%
A4I1T0	Leishmania infantum	95%	100%
E9AIR7	Leishmania braziliensis	79%	100%
E9AXW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5ASI1	Trypanosoma cruzi	40%	90%