Probable hypothetical 6.9 Kd protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q95ZB6_LEIMA

TriTrypDb:

LmjF.25.2310 , LMJLV39_250030800 , LMJSD75_250031100

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q95ZB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q95ZB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.362
CLV_C14_Caspase3-7	368	372	PF00656	0.536
CLV_NRD_NRD_1	148	150	PF00675	0.462
CLV_NRD_NRD_1	45	47	PF00675	0.561
CLV_NRD_NRD_1	505	507	PF00675	0.490
CLV_NRD_NRD_1	98	100	PF00675	0.474
CLV_PCSK_KEX2_1	148	150	PF00082	0.462
CLV_PCSK_KEX2_1	373	375	PF00082	0.545
CLV_PCSK_KEX2_1	45	47	PF00082	0.561
CLV_PCSK_KEX2_1	505	507	PF00082	0.492
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.415
CLV_PCSK_SKI1_1	115	119	PF00082	0.386
CLV_PCSK_SKI1_1	148	152	PF00082	0.407
CLV_PCSK_SKI1_1	29	33	PF00082	0.464
CLV_PCSK_SKI1_1	309	313	PF00082	0.432
CLV_PCSK_SKI1_1	468	472	PF00082	0.452
DEG_APCC_DBOX_1	147	155	PF00400	0.503
DEG_APCC_DBOX_1	467	475	PF00400	0.356
DEG_SCF_TRCP1_1	532	538	PF00400	0.482
DOC_CKS1_1	22	27	PF01111	0.474
DOC_MAPK_gen_1	280	289	PF00069	0.415
DOC_MAPK_MEF2A_6	230	238	PF00069	0.487
DOC_MAPK_MEF2A_6	282	291	PF00069	0.449
DOC_MAPK_MEF2A_6	425	432	PF00069	0.449
DOC_PP1_RVXF_1	113	119	PF00149	0.454
DOC_PP1_SILK_1	260	265	PF00149	0.340
DOC_PP2B_LxvP_1	23	26	PF13499	0.559
DOC_PP4_FxxP_1	526	529	PF00568	0.694
DOC_USP7_MATH_1	12	16	PF00917	0.469
DOC_USP7_MATH_1	127	131	PF00917	0.516
DOC_USP7_MATH_1	158	162	PF00917	0.372
DOC_USP7_MATH_1	384	388	PF00917	0.436
DOC_USP7_MATH_1	44	48	PF00917	0.493
DOC_USP7_MATH_1	535	539	PF00917	0.668
DOC_USP7_UBL2_3	155	159	PF12436	0.501
DOC_USP7_UBL2_3	571	575	PF12436	0.491
DOC_USP7_UBL2_3	59	63	PF12436	0.427
DOC_WW_Pin1_4	21	26	PF00397	0.489
DOC_WW_Pin1_4	270	275	PF00397	0.366
DOC_WW_Pin1_4	291	296	PF00397	0.350
DOC_WW_Pin1_4	317	322	PF00397	0.447
DOC_WW_Pin1_4	423	428	PF00397	0.485
DOC_WW_Pin1_4	525	530	PF00397	0.668
LIG_14-3-3_CanoR_1	29	37	PF00244	0.613
LIG_14-3-3_CanoR_1	347	353	PF00244	0.485
LIG_14-3-3_CanoR_1	45	53	PF00244	0.407
LIG_Actin_WH2_2	140	157	PF00022	0.443
LIG_Actin_WH2_2	453	470	PF00022	0.373
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BRCT_BRCA1_1	194	198	PF00533	0.446
LIG_BRCT_BRCA1_1	448	452	PF00533	0.511
LIG_EH_1	76	80	PF12763	0.449
LIG_eIF4E_1	466	472	PF01652	0.366
LIG_FHA_1	120	126	PF00498	0.474
LIG_FHA_1	183	189	PF00498	0.493
LIG_FHA_1	197	203	PF00498	0.397
LIG_FHA_1	266	272	PF00498	0.308
LIG_FHA_1	343	349	PF00498	0.408
LIG_FHA_1	557	563	PF00498	0.343
LIG_FHA_2	134	140	PF00498	0.583
LIG_FHA_2	205	211	PF00498	0.361
LIG_FHA_2	288	294	PF00498	0.467
LIG_FHA_2	31	37	PF00498	0.437
LIG_FHA_2	334	340	PF00498	0.483
LIG_FHA_2	349	355	PF00498	0.297
LIG_LIR_Apic_2	298	302	PF02991	0.427
LIG_LIR_Apic_2	378	384	PF02991	0.504
LIG_LIR_Gen_1	250	259	PF02991	0.368
LIG_LIR_Gen_1	268	274	PF02991	0.388
LIG_LIR_Gen_1	363	372	PF02991	0.454
LIG_LIR_Gen_1	498	504	PF02991	0.312
LIG_LIR_Gen_1	5	14	PF02991	0.530
LIG_LIR_Nem_3	250	254	PF02991	0.361
LIG_LIR_Nem_3	268	272	PF02991	0.380
LIG_LIR_Nem_3	363	369	PF02991	0.432
LIG_LIR_Nem_3	498	502	PF02991	0.304
LIG_LIR_Nem_3	5	10	PF02991	0.518
LIG_MLH1_MIPbox_1	448	452	PF16413	0.511
LIG_Pex14_1	564	568	PF04695	0.291
LIG_Pex14_2	447	451	PF04695	0.497
LIG_SH2_CRK	299	303	PF00017	0.314
LIG_SH2_CRK	318	322	PF00017	0.452
LIG_SH2_CRK	381	385	PF00017	0.519
LIG_SH2_GRB2like	572	575	PF00017	0.298
LIG_SH2_NCK_1	318	322	PF00017	0.452
LIG_SH2_SRC	381	384	PF00017	0.482
LIG_SH2_SRC	393	396	PF00017	0.342
LIG_SH2_STAP1	251	255	PF00017	0.427
LIG_SH2_STAP1	30	34	PF00017	0.363
LIG_SH2_STAP1	572	576	PF00017	0.428
LIG_SH2_STAT3	85	88	PF00017	0.503
LIG_SH2_STAT5	156	159	PF00017	0.510
LIG_SH2_STAT5	265	268	PF00017	0.323
LIG_SH2_STAT5	318	321	PF00017	0.451
LIG_SH2_STAT5	466	469	PF00017	0.351
LIG_SH3_3	159	165	PF00018	0.451
LIG_SH3_3	19	25	PF00018	0.452
LIG_SH3_3	268	274	PF00018	0.379
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.527
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.269
LIG_SUMO_SIM_par_1	12	18	PF11976	0.474
LIG_SUMO_SIM_par_1	252	258	PF11976	0.336
LIG_SUMO_SIM_par_1	287	294	PF11976	0.397
LIG_SUMO_SIM_par_1	492	498	PF11976	0.430
LIG_TRAF2_1	483	486	PF00917	0.379
LIG_UBA3_1	304	309	PF00899	0.343
LIG_WRC_WIRS_1	266	271	PF05994	0.314
LIG_WRC_WIRS_1	68	73	PF05994	0.416
LIG_WW_1	508	511	PF00397	0.524
MOD_CDK_SPK_2	270	275	PF00069	0.397
MOD_CK1_1	15	21	PF00069	0.477
MOD_CK1_1	48	54	PF00069	0.526
MOD_CK1_1	528	534	PF00069	0.696
MOD_CK1_1	538	544	PF00069	0.571
MOD_CK1_1	546	552	PF00069	0.449
MOD_CK2_1	287	293	PF00069	0.355
MOD_CK2_1	30	36	PF00069	0.447
MOD_CK2_1	333	339	PF00069	0.525
MOD_GlcNHglycan	105	108	PF01048	0.390
MOD_GlcNHglycan	26	29	PF01048	0.573
MOD_GlcNHglycan	298	302	PF01048	0.424
MOD_GlcNHglycan	386	389	PF01048	0.439
MOD_GlcNHglycan	414	417	PF01048	0.519
MOD_GlcNHglycan	42	45	PF01048	0.460
MOD_GlcNHglycan	532	535	PF01048	0.724
MOD_GlcNHglycan	537	540	PF01048	0.667
MOD_GSK3_1	160	167	PF00069	0.516
MOD_GSK3_1	182	189	PF00069	0.389
MOD_GSK3_1	192	199	PF00069	0.377
MOD_GSK3_1	287	294	PF00069	0.388
MOD_GSK3_1	342	349	PF00069	0.528
MOD_GSK3_1	361	368	PF00069	0.231
MOD_GSK3_1	40	47	PF00069	0.463
MOD_GSK3_1	400	407	PF00069	0.594
MOD_GSK3_1	513	520	PF00069	0.699
MOD_GSK3_1	67	74	PF00069	0.507
MOD_N-GLC_1	103	108	PF02516	0.389
MOD_N-GLC_1	192	197	PF02516	0.538
MOD_NEK2_1	160	165	PF00069	0.497
MOD_NEK2_1	184	189	PF00069	0.479
MOD_NEK2_1	255	260	PF00069	0.514
MOD_NEK2_1	328	333	PF00069	0.431
MOD_NEK2_1	342	347	PF00069	0.482
MOD_NEK2_1	348	353	PF00069	0.526
MOD_NEK2_1	358	363	PF00069	0.331
MOD_NEK2_1	400	405	PF00069	0.605
MOD_NEK2_1	447	452	PF00069	0.449
MOD_NEK2_1	495	500	PF00069	0.365
MOD_NEK2_1	71	76	PF00069	0.421
MOD_PIKK_1	202	208	PF00454	0.504
MOD_PIKK_1	48	54	PF00454	0.543
MOD_PIKK_1	71	77	PF00454	0.416
MOD_PK_1	45	51	PF00069	0.597
MOD_PKA_1	45	51	PF00069	0.529
MOD_PKA_2	346	352	PF00069	0.557
MOD_PKA_2	44	50	PF00069	0.474
MOD_Plk_1	447	453	PF00069	0.429
MOD_Plk_4	204	210	PF00069	0.354
MOD_Plk_4	287	293	PF00069	0.362
MOD_Plk_4	348	354	PF00069	0.516
MOD_Plk_4	361	367	PF00069	0.501
MOD_Plk_4	447	453	PF00069	0.406
MOD_ProDKin_1	21	27	PF00069	0.490
MOD_ProDKin_1	270	276	PF00069	0.368
MOD_ProDKin_1	291	297	PF00069	0.354
MOD_ProDKin_1	317	323	PF00069	0.443
MOD_ProDKin_1	423	429	PF00069	0.476
MOD_ProDKin_1	525	531	PF00069	0.669
MOD_SUMO_for_1	221	224	PF00179	0.479
MOD_SUMO_rev_2	210	219	PF00179	0.521
MOD_SUMO_rev_2	368	375	PF00179	0.498
MOD_SUMO_rev_2	56	61	PF00179	0.504
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.295
TRG_ENDOCYTIC_2	251	254	PF00928	0.360
TRG_ENDOCYTIC_2	81	84	PF00928	0.419
TRG_ER_diArg_1	147	149	PF00400	0.447
TRG_ER_diArg_1	504	506	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P620	Leptomonas seymouri	72%	100%
A0A0S4J1E1	Bodo saltans	33%	97%
A0A1X0NY27	Trypanosomatidae	39%	100%
A0A3R7RTJ3	Trypanosoma rangeli	38%	100%
A0A3S7WZE8	Leishmania donovani	95%	100%
A4HED4	Leishmania braziliensis	86%	100%
A4I1T1	Leishmania infantum	95%	100%
E9AXW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B817	Trypanosoma cruzi	40%	100%