Putative cAMP-specific phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cAMP-specific phosphodiesterase, putative

Species:

Leishmania major

UniProt:

Q95Z92_LEIMA

TriTrypDb:

LmjF.04.0030 , LMJLV39_040005200 , LMJSD75_040005200

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q95Z92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q95Z92

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	12
GO:0009987	cellular process	1	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	12
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	12
GO:0008081	phosphoric diester hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0042578	phosphoric ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.395
CLV_C14_Caspase3-7	436	440	PF00656	0.481
CLV_C14_Caspase3-7	650	654	PF00656	0.434
CLV_NRD_NRD_1	187	189	PF00675	0.478
CLV_NRD_NRD_1	482	484	PF00675	0.558
CLV_NRD_NRD_1	599	601	PF00675	0.507
CLV_PCSK_KEX2_1	525	527	PF00082	0.701
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.600
CLV_PCSK_SKI1_1	114	118	PF00082	0.460
CLV_PCSK_SKI1_1	157	161	PF00082	0.302
CLV_PCSK_SKI1_1	188	192	PF00082	0.392
CLV_PCSK_SKI1_1	306	310	PF00082	0.286
CLV_PCSK_SKI1_1	413	417	PF00082	0.446
CLV_PCSK_SKI1_1	473	477	PF00082	0.484
DEG_APCC_DBOX_1	388	396	PF00400	0.343
DEG_Nend_UBRbox_4	1	3	PF02207	0.355
DEG_SPOP_SBC_1	95	99	PF00917	0.625
DOC_AGCK_PIF_1	167	172	PF00069	0.319
DOC_CKS1_1	290	295	PF01111	0.297
DOC_CYCLIN_RxL_1	182	192	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.496
DOC_MAPK_gen_1	155	162	PF00069	0.366
DOC_MAPK_MEF2A_6	155	162	PF00069	0.400
DOC_MAPK_MEF2A_6	385	392	PF00069	0.297
DOC_MAPK_MEF2A_6	715	723	PF00069	0.770
DOC_MAPK_NFAT4_5	155	163	PF00069	0.443
DOC_PP1_RVXF_1	180	187	PF00149	0.319
DOC_PP1_RVXF_1	428	434	PF00149	0.423
DOC_PP4_FxxP_1	217	220	PF00568	0.415
DOC_PP4_FxxP_1	290	293	PF00568	0.297
DOC_USP7_MATH_1	246	250	PF00917	0.327
DOC_USP7_MATH_1	259	263	PF00917	0.286
DOC_USP7_MATH_1	317	321	PF00917	0.392
DOC_USP7_MATH_1	353	357	PF00917	0.432
DOC_USP7_MATH_1	358	362	PF00917	0.396
DOC_USP7_MATH_1	440	444	PF00917	0.481
DOC_USP7_MATH_1	493	497	PF00917	0.683
DOC_USP7_MATH_1	553	557	PF00917	0.625
DOC_USP7_MATH_1	572	576	PF00917	0.259
DOC_USP7_MATH_1	637	641	PF00917	0.636
DOC_WW_Pin1_4	104	109	PF00397	0.519
DOC_WW_Pin1_4	14	19	PF00397	0.488
DOC_WW_Pin1_4	289	294	PF00397	0.409
DOC_WW_Pin1_4	491	496	PF00397	0.554
DOC_WW_Pin1_4	545	550	PF00397	0.713
DOC_WW_Pin1_4	682	687	PF00397	0.699
DOC_WW_Pin1_4	701	706	PF00397	0.447
LIG_14-3-3_CanoR_1	157	163	PF00244	0.301
LIG_14-3-3_CanoR_1	188	196	PF00244	0.392
LIG_14-3-3_CanoR_1	336	343	PF00244	0.384
LIG_14-3-3_CanoR_1	389	393	PF00244	0.445
LIG_14-3-3_CanoR_1	552	562	PF00244	0.536
LIG_Actin_WH2_2	113	131	PF00022	0.354
LIG_Actin_WH2_2	17	34	PF00022	0.558
LIG_Actin_WH2_2	292	308	PF00022	0.425
LIG_Actin_WH2_2	458	474	PF00022	0.468
LIG_Actin_WH2_2	52	69	PF00022	0.451
LIG_BRCT_BRCA1_1	213	217	PF00533	0.415
LIG_BRCT_BRCA1_1	355	359	PF00533	0.414
LIG_Clathr_ClatBox_1	253	257	PF01394	0.415
LIG_Clathr_ClatBox_1	281	285	PF01394	0.203
LIG_Clathr_ClatBox_1	657	661	PF01394	0.481
LIG_FHA_1	105	111	PF00498	0.509
LIG_FHA_1	249	255	PF00498	0.275
LIG_FHA_1	277	283	PF00498	0.297
LIG_FHA_1	417	423	PF00498	0.326
LIG_FHA_1	460	466	PF00498	0.528
LIG_FHA_1	626	632	PF00498	0.474
LIG_FHA_2	336	342	PF00498	0.395
LIG_FHA_2	499	505	PF00498	0.507
LIG_LIR_Apic_2	214	220	PF02991	0.415
LIG_LIR_Gen_1	115	125	PF02991	0.346
LIG_LIR_Gen_1	156	167	PF02991	0.330
LIG_LIR_Gen_1	171	180	PF02991	0.274
LIG_LIR_Gen_1	181	191	PF02991	0.407
LIG_LIR_Gen_1	307	318	PF02991	0.361
LIG_LIR_Gen_1	405	415	PF02991	0.308
LIG_LIR_Gen_1	557	566	PF02991	0.376
LIG_LIR_Gen_1	652	663	PF02991	0.481
LIG_LIR_Nem_3	115	120	PF02991	0.412
LIG_LIR_Nem_3	156	162	PF02991	0.349
LIG_LIR_Nem_3	165	170	PF02991	0.286
LIG_LIR_Nem_3	171	176	PF02991	0.293
LIG_LIR_Nem_3	181	186	PF02991	0.275
LIG_LIR_Nem_3	262	267	PF02991	0.350
LIG_LIR_Nem_3	307	313	PF02991	0.335
LIG_LIR_Nem_3	405	410	PF02991	0.314
LIG_LIR_Nem_3	556	562	PF02991	0.396
LIG_LIR_Nem_3	652	658	PF02991	0.480
LIG_MLH1_MIPbox_1	213	217	PF16413	0.415
LIG_MYND_1	14	18	PF01753	0.438
LIG_NRBOX	277	283	PF00104	0.274
LIG_PTB_Apo_2	166	173	PF02174	0.299
LIG_REV1ctd_RIR_1	214	219	PF16727	0.415
LIG_SH2_CRK	310	314	PF00017	0.390
LIG_SH2_GRB2like	200	203	PF00017	0.286
LIG_SH2_GRB2like	407	410	PF00017	0.390
LIG_SH2_PTP2	407	410	PF00017	0.415
LIG_SH2_SRC	407	410	PF00017	0.355
LIG_SH2_STAP1	310	314	PF00017	0.381
LIG_SH2_STAT5	130	133	PF00017	0.342
LIG_SH2_STAT5	407	410	PF00017	0.290
LIG_SH2_STAT5	55	58	PF00017	0.615
LIG_SH2_STAT5	559	562	PF00017	0.353
LIG_SH2_STAT5	594	597	PF00017	0.326
LIG_SH2_STAT5	663	666	PF00017	0.441
LIG_SH3_3	240	246	PF00018	0.415
LIG_SH3_3	387	393	PF00018	0.284
LIG_SH3_3	408	414	PF00018	0.365
LIG_SH3_3	685	691	PF00018	0.767
LIG_Sin3_3	655	662	PF02671	0.316
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.415
LIG_SUMO_SIM_anti_2	419	424	PF11976	0.395
LIG_SUMO_SIM_anti_2	462	469	PF11976	0.465
LIG_SUMO_SIM_anti_2	652	661	PF11976	0.269
LIG_SUMO_SIM_anti_2	674	681	PF11976	0.428
LIG_SUMO_SIM_par_1	237	242	PF11976	0.349
LIG_SUMO_SIM_par_1	249	257	PF11976	0.384
LIG_SUMO_SIM_par_1	274	280	PF11976	0.425
LIG_SUMO_SIM_par_1	652	661	PF11976	0.308
LIG_SUMO_SIM_par_1	674	681	PF11976	0.431
LIG_TRAF2_1	227	230	PF00917	0.365
LIG_WRC_WIRS_1	559	564	PF05994	0.396
MOD_CDC14_SPxK_1	494	497	PF00782	0.668
MOD_CDC14_SPxK_1	704	707	PF00782	0.691
MOD_CDK_SPK_2	109	114	PF00069	0.439
MOD_CDK_SPxK_1	491	497	PF00069	0.599
MOD_CDK_SPxK_1	701	707	PF00069	0.698
MOD_CDK_SPxxK_3	14	21	PF00069	0.485
MOD_CDK_SPxxK_3	545	552	PF00069	0.699
MOD_CK1_1	298	304	PF00069	0.425
MOD_CK1_1	320	326	PF00069	0.398
MOD_CK1_1	463	469	PF00069	0.471
MOD_CK1_1	498	504	PF00069	0.596
MOD_CK1_1	510	516	PF00069	0.659
MOD_CK1_1	537	543	PF00069	0.728
MOD_CK1_1	69	75	PF00069	0.631
MOD_CK1_1	714	720	PF00069	0.730
MOD_CK1_1	98	104	PF00069	0.563
MOD_CK2_1	109	115	PF00069	0.532
MOD_CK2_1	147	153	PF00069	0.409
MOD_CK2_1	224	230	PF00069	0.271
MOD_CK2_1	463	469	PF00069	0.402
MOD_CK2_1	617	623	PF00069	0.430
MOD_CK2_1	624	630	PF00069	0.447
MOD_GlcNHglycan	300	303	PF01048	0.355
MOD_GlcNHglycan	325	328	PF01048	0.383
MOD_GlcNHglycan	332	336	PF01048	0.335
MOD_GlcNHglycan	517	520	PF01048	0.788
MOD_GlcNHglycan	521	524	PF01048	0.729
MOD_GlcNHglycan	543	546	PF01048	0.662
MOD_GlcNHglycan	574	577	PF01048	0.501
MOD_GlcNHglycan	60	63	PF01048	0.567
MOD_GSK3_1	158	165	PF00069	0.279
MOD_GSK3_1	168	175	PF00069	0.301
MOD_GSK3_1	267	274	PF00069	0.221
MOD_GSK3_1	331	338	PF00069	0.409
MOD_GSK3_1	459	466	PF00069	0.478
MOD_GSK3_1	473	480	PF00069	0.466
MOD_GSK3_1	491	498	PF00069	0.547
MOD_GSK3_1	509	516	PF00069	0.671
MOD_GSK3_1	537	544	PF00069	0.640
MOD_GSK3_1	66	73	PF00069	0.667
MOD_GSK3_1	94	101	PF00069	0.566
MOD_N-GLC_1	168	173	PF02516	0.279
MOD_N-GLC_1	201	206	PF02516	0.365
MOD_N-GLC_1	491	496	PF02516	0.515
MOD_N-GLC_1	513	518	PF02516	0.756
MOD_NEK2_1	103	108	PF00069	0.611
MOD_NEK2_1	139	144	PF00069	0.416
MOD_NEK2_1	158	163	PF00069	0.182
MOD_NEK2_1	172	177	PF00069	0.304
MOD_NEK2_1	196	201	PF00069	0.475
MOD_NEK2_1	276	281	PF00069	0.378
MOD_NEK2_1	288	293	PF00069	0.253
MOD_NEK2_1	461	466	PF00069	0.509
MOD_NEK2_1	617	622	PF00069	0.544
MOD_NEK2_1	66	71	PF00069	0.655
MOD_NEK2_1	96	101	PF00069	0.635
MOD_NEK2_2	124	129	PF00069	0.500
MOD_NEK2_2	168	173	PF00069	0.412
MOD_NEK2_2	259	264	PF00069	0.415
MOD_PIKK_1	358	364	PF00454	0.385
MOD_PIKK_1	495	501	PF00454	0.668
MOD_PKA_1	483	489	PF00069	0.524
MOD_PKA_2	320	326	PF00069	0.331
MOD_PKA_2	335	341	PF00069	0.320
MOD_PKA_2	388	394	PF00069	0.435
MOD_PKA_2	66	72	PF00069	0.706
MOD_Plk_1	168	174	PF00069	0.290
MOD_Plk_1	196	202	PF00069	0.399
MOD_Plk_1	453	459	PF00069	0.654
MOD_Plk_4	147	153	PF00069	0.477
MOD_Plk_4	162	168	PF00069	0.208
MOD_Plk_4	211	217	PF00069	0.329
MOD_Plk_4	248	254	PF00069	0.302
MOD_Plk_4	259	265	PF00069	0.360
MOD_Plk_4	271	277	PF00069	0.348
MOD_Plk_4	320	326	PF00069	0.374
MOD_Plk_4	453	459	PF00069	0.551
MOD_Plk_4	463	469	PF00069	0.502
MOD_Plk_4	651	657	PF00069	0.372
MOD_Plk_4	672	678	PF00069	0.423
MOD_Plk_4	98	104	PF00069	0.602
MOD_ProDKin_1	104	110	PF00069	0.511
MOD_ProDKin_1	14	20	PF00069	0.487
MOD_ProDKin_1	289	295	PF00069	0.409
MOD_ProDKin_1	491	497	PF00069	0.561
MOD_ProDKin_1	545	551	PF00069	0.708
MOD_ProDKin_1	682	688	PF00069	0.700
MOD_ProDKin_1	701	707	PF00069	0.450
MOD_SUMO_rev_2	479	486	PF00179	0.499
TRG_DiLeu_BaEn_1	271	276	PF01217	0.415
TRG_DiLeu_BaEn_1	614	619	PF01217	0.410
TRG_DiLeu_BaEn_1	674	679	PF01217	0.417
TRG_ENDOCYTIC_2	310	313	PF00928	0.390
TRG_ENDOCYTIC_2	407	410	PF00928	0.306
TRG_ENDOCYTIC_2	559	562	PF00928	0.369
TRG_ER_diArg_1	318	321	PF00400	0.286
TRG_ER_diArg_1	719	722	PF00400	0.726
TRG_NES_CRM1_1	229	242	PF08389	0.415
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3J8	Leptomonas seymouri	64%	97%
A0A0S4J2W3	Bodo saltans	26%	100%
A0A1X0NMW5	Trypanosomatidae	38%	100%
A0A3R7NEI4	Trypanosoma rangeli	36%	100%
A0A3S5H571	Leishmania donovani	96%	100%
A4HRZ8	Leishmania infantum	96%	100%
C9ZXZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AI20	Leishmania braziliensis	82%	97%
E9AJY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BDS9	Trypanosoma cruzi	37%	100%