C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q95Z91_LEIMA

TriTrypDb:

LmjF.04.0040 , LMJLV39_040005400 , LMJSD75_040005400

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q95Z91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q95Z91

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.636
CLV_PCSK_SKI1_1	324	328	PF00082	0.510
CLV_PCSK_SKI1_1	396	400	PF00082	0.496
CLV_PCSK_SKI1_1	421	425	PF00082	0.641
DEG_Nend_UBRbox_3	1	3	PF02207	0.668
DEG_SCF_FBW7_1	432	438	PF00400	0.544
DEG_SPOP_SBC_1	124	128	PF00917	0.812
DEG_SPOP_SBC_1	176	180	PF00917	0.621
DOC_CKS1_1	432	437	PF01111	0.630
DOC_MAPK_gen_1	130	139	PF00069	0.783
DOC_MAPK_gen_1	182	190	PF00069	0.595
DOC_MAPK_gen_1	312	322	PF00069	0.593
DOC_MAPK_gen_1	366	376	PF00069	0.567
DOC_MAPK_MEF2A_6	267	275	PF00069	0.509
DOC_USP7_MATH_1	124	128	PF00917	0.758
DOC_USP7_MATH_1	183	187	PF00917	0.612
DOC_USP7_MATH_1	199	203	PF00917	0.564
DOC_USP7_MATH_1	244	248	PF00917	0.659
DOC_USP7_MATH_1	348	352	PF00917	0.464
DOC_USP7_MATH_1	401	405	PF00917	0.622
DOC_USP7_MATH_1	72	76	PF00917	0.674
DOC_WW_Pin1_4	113	118	PF00397	0.755
DOC_WW_Pin1_4	423	428	PF00397	0.649
DOC_WW_Pin1_4	431	436	PF00397	0.580
DOC_WW_Pin1_4	61	66	PF00397	0.768
DOC_WW_Pin1_4	88	93	PF00397	0.786
LIG_14-3-3_CanoR_1	182	191	PF00244	0.590
LIG_14-3-3_CanoR_1	218	224	PF00244	0.581
LIG_14-3-3_CanoR_1	304	308	PF00244	0.396
LIG_14-3-3_CanoR_1	347	355	PF00244	0.691
LIG_14-3-3_CanoR_1	366	372	PF00244	0.485
LIG_14-3-3_CanoR_1	421	426	PF00244	0.591
LIG_Actin_WH2_2	351	368	PF00022	0.544
LIG_FHA_1	114	120	PF00498	0.699
LIG_FHA_1	164	170	PF00498	0.592
LIG_FHA_1	279	285	PF00498	0.532
LIG_FHA_1	325	331	PF00498	0.563
LIG_FHA_1	333	339	PF00498	0.549
LIG_FHA_1	418	424	PF00498	0.647
LIG_FHA_2	339	345	PF00498	0.592
LIG_LIR_Nem_3	353	358	PF02991	0.577
LIG_NRBOX	428	434	PF00104	0.595
LIG_PTB_Apo_2	227	234	PF02174	0.569
LIG_PTB_Phospho_1	227	233	PF10480	0.572
LIG_SH2_GRB2like	172	175	PF00017	0.647
LIG_SH2_SRC	18	21	PF00017	0.675
LIG_SH2_STAP1	172	176	PF00017	0.593
LIG_SH2_STAP1	233	237	PF00017	0.561
LIG_SH2_STAP1	251	255	PF00017	0.452
LIG_SH2_STAT3	213	216	PF00017	0.567
LIG_SH2_STAT3	232	235	PF00017	0.553
LIG_SH2_STAT5	18	21	PF00017	0.675
LIG_SH2_STAT5	213	216	PF00017	0.567
LIG_SH2_STAT5	269	272	PF00017	0.495
LIG_SH2_STAT5	294	297	PF00017	0.560
LIG_SH2_STAT5	367	370	PF00017	0.516
LIG_SH2_STAT5	67	70	PF00017	0.733
LIG_SH3_3	21	27	PF00018	0.640
LIG_SH3_3	9	15	PF00018	0.715
LIG_SUMO_SIM_anti_2	334	341	PF11976	0.638
LIG_SUMO_SIM_par_1	428	434	PF11976	0.573
LIG_TRAF2_1	341	344	PF00917	0.674
LIG_UBA3_1	429	436	PF00899	0.714
MOD_CDK_SPK_2	423	428	PF00069	0.649
MOD_CDK_SPK_2	431	436	PF00069	0.580
MOD_CDK_SPK_2	88	93	PF00069	0.786
MOD_CDK_SPxxK_3	88	95	PF00069	0.791
MOD_CK1_1	101	107	PF00069	0.682
MOD_CK1_1	109	115	PF00069	0.690
MOD_CK1_1	118	124	PF00069	0.584
MOD_CK1_1	178	184	PF00069	0.720
MOD_CK1_1	361	367	PF00069	0.492
MOD_CK1_1	417	423	PF00069	0.707
MOD_CK2_1	109	115	PF00069	0.657
MOD_CK2_1	338	344	PF00069	0.580
MOD_CK2_1	347	353	PF00069	0.511
MOD_CK2_1	399	405	PF00069	0.395
MOD_GlcNHglycan	111	114	PF01048	0.697
MOD_GlcNHglycan	122	125	PF01048	0.717
MOD_GlcNHglycan	21	24	PF01048	0.590
MOD_GlcNHglycan	210	213	PF01048	0.421
MOD_GlcNHglycan	246	249	PF01048	0.590
MOD_GlcNHglycan	35	38	PF01048	0.613
MOD_GlcNHglycan	350	353	PF01048	0.670
MOD_GlcNHglycan	414	417	PF01048	0.555
MOD_GlcNHglycan	61	64	PF01048	0.745
MOD_GlcNHglycan	74	77	PF01048	0.656
MOD_GlcNHglycan	98	101	PF01048	0.703
MOD_GSK3_1	109	116	PF00069	0.727
MOD_GSK3_1	120	127	PF00069	0.648
MOD_GSK3_1	163	170	PF00069	0.560
MOD_GSK3_1	334	341	PF00069	0.599
MOD_GSK3_1	343	350	PF00069	0.591
MOD_GSK3_1	412	419	PF00069	0.655
MOD_GSK3_1	431	438	PF00069	0.435
MOD_GSK3_1	84	91	PF00069	0.725
MOD_N-GLC_1	271	276	PF02516	0.510
MOD_NEK2_1	120	125	PF00069	0.815
MOD_NEK2_1	167	172	PF00069	0.567
MOD_NEK2_1	177	182	PF00069	0.544
MOD_NEK2_1	207	212	PF00069	0.630
MOD_NEK2_1	276	281	PF00069	0.515
MOD_NEK2_1	59	64	PF00069	0.762
MOD_NEK2_1	96	101	PF00069	0.712
MOD_NEK2_2	125	130	PF00069	0.772
MOD_NEK2_2	289	294	PF00069	0.382
MOD_PIKK_1	104	110	PF00454	0.697
MOD_PIKK_1	231	237	PF00454	0.561
MOD_PIKK_1	399	405	PF00454	0.523
MOD_PKA_2	217	223	PF00069	0.575
MOD_PKA_2	303	309	PF00069	0.393
MOD_PKB_1	345	353	PF00069	0.478
MOD_Plk_1	271	277	PF00069	0.584
MOD_Plk_1	361	367	PF00069	0.544
MOD_Plk_4	115	121	PF00069	0.799
MOD_Plk_4	14	20	PF00069	0.660
MOD_Plk_4	271	277	PF00069	0.605
MOD_Plk_4	289	295	PF00069	0.311
MOD_Plk_4	334	340	PF00069	0.632
MOD_Plk_4	372	378	PF00069	0.537
MOD_ProDKin_1	113	119	PF00069	0.756
MOD_ProDKin_1	423	429	PF00069	0.642
MOD_ProDKin_1	431	437	PF00069	0.587
MOD_ProDKin_1	61	67	PF00069	0.769
MOD_ProDKin_1	88	94	PF00069	0.787
TRG_DiLeu_BaEn_1	115	120	PF01217	0.719
TRG_DiLeu_BaEn_1	266	271	PF01217	0.630
TRG_ENDOCYTIC_2	31	34	PF00928	0.647
TRG_ENDOCYTIC_2	355	358	PF00928	0.577
TRG_ENDOCYTIC_2	67	70	PF00928	0.697
TRG_ER_diArg_1	345	348	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X9	Leptomonas seymouri	62%	95%
A0A451EJV0	Leishmania donovani	92%	100%
A4H3S4	Leishmania braziliensis	84%	80%
A4HRZ9	Leishmania infantum	93%	100%
E9AJY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%