Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q95Z90_LEIMA

TriTrypDb:

LmjF.04.0050 , LMJLV39_040005600 , LMJSD75_040005600

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q95Z90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q95Z90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.673
CLV_NRD_NRD_1	195	197	PF00675	0.460
CLV_NRD_NRD_1	219	221	PF00675	0.413
CLV_NRD_NRD_1	249	251	PF00675	0.568
CLV_NRD_NRD_1	298	300	PF00675	0.544
CLV_NRD_NRD_1	312	314	PF00675	0.540
CLV_NRD_NRD_1	449	451	PF00675	0.549
CLV_PCSK_KEX2_1	128	130	PF00082	0.570
CLV_PCSK_KEX2_1	218	220	PF00082	0.424
CLV_PCSK_KEX2_1	249	251	PF00082	0.568
CLV_PCSK_KEX2_1	298	300	PF00082	0.544
CLV_PCSK_KEX2_1	311	313	PF00082	0.552
CLV_PCSK_KEX2_1	437	439	PF00082	0.510
CLV_PCSK_KEX2_1	448	450	PF00082	0.463
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.535
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.484
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.599
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.510
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.420
CLV_PCSK_SKI1_1	300	304	PF00082	0.529
CLV_PCSK_SKI1_1	368	372	PF00082	0.488
DEG_APCC_DBOX_1	412	420	PF00400	0.448
DEG_Nend_UBRbox_1	1	4	PF02207	0.605
DOC_CKS1_1	172	177	PF01111	0.491
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.496
DOC_MAPK_gen_1	149	159	PF00069	0.571
DOC_MAPK_gen_1	413	421	PF00069	0.498
DOC_USP7_MATH_1	202	206	PF00917	0.472
DOC_USP7_MATH_1	43	47	PF00917	0.533
DOC_USP7_MATH_1	477	481	PF00917	0.558
DOC_USP7_MATH_1	503	507	PF00917	0.640
DOC_USP7_MATH_2	29	35	PF00917	0.618
DOC_USP7_UBL2_3	124	128	PF12436	0.634
DOC_USP7_UBL2_3	152	156	PF12436	0.546
DOC_USP7_UBL2_3	228	232	PF12436	0.443
DOC_USP7_UBL2_3	430	434	PF12436	0.479
DOC_USP7_UBL2_3	448	452	PF12436	0.352
DOC_WW_Pin1_4	171	176	PF00397	0.432
DOC_WW_Pin1_4	21	26	PF00397	0.663
DOC_WW_Pin1_4	311	316	PF00397	0.597
DOC_WW_Pin1_4	331	336	PF00397	0.621
LIG_14-3-3_CanoR_1	2	8	PF00244	0.621
LIG_14-3-3_CanoR_1	212	217	PF00244	0.507
LIG_14-3-3_CanoR_1	298	303	PF00244	0.600
LIG_14-3-3_CanoR_1	340	345	PF00244	0.677
LIG_14-3-3_CanoR_1	368	377	PF00244	0.483
LIG_14-3-3_CanoR_1	471	478	PF00244	0.466
LIG_APCC_ABBAyCdc20_2	402	408	PF00400	0.457
LIG_BRCT_BRCA1_1	494	498	PF00533	0.568
LIG_Clathr_ClatBox_1	404	408	PF01394	0.490
LIG_FHA_1	2	8	PF00498	0.595
LIG_FHA_2	369	375	PF00498	0.425
LIG_IBAR_NPY_1	476	478	PF08397	0.581
LIG_LIR_Gen_1	475	486	PF02991	0.559
LIG_LIR_Nem_3	210	216	PF02991	0.524
LIG_LIR_Nem_3	475	481	PF02991	0.501
LIG_SH2_CRK	478	482	PF00017	0.527
LIG_SH2_STAP1	360	364	PF00017	0.458
LIG_SH2_STAP1	478	482	PF00017	0.527
LIG_SH3_2	145	150	PF14604	0.613
LIG_SH3_3	142	148	PF00018	0.618
LIG_SH3_3	163	169	PF00018	0.555
LIG_SH3_3	240	246	PF00018	0.605
LIG_SH3_3	256	262	PF00018	0.551
LIG_SH3_3	347	353	PF00018	0.645
LIG_SH3_4	152	159	PF00018	0.507
LIG_SH3_4	228	235	PF00018	0.446
LIG_SUMO_SIM_par_1	373	380	PF11976	0.446
LIG_TRAF2_1	254	257	PF00917	0.669
LIG_TRAF2_1	50	53	PF00917	0.584
LIG_TRAF2_1	90	93	PF00917	0.660
LIG_TRAF2_2	499	504	PF00917	0.575
LIG_TRFH_1	33	37	PF08558	0.610
LIG_WW_3	314	318	PF00397	0.599
MOD_CDC14_SPxK_1	314	317	PF00782	0.597
MOD_CDC14_SPxK_1	334	337	PF00782	0.625
MOD_CDK_SPK_2	171	176	PF00069	0.432
MOD_CDK_SPxK_1	311	317	PF00069	0.562
MOD_CDK_SPxK_1	331	337	PF00069	0.623
MOD_CK1_1	325	331	PF00069	0.691
MOD_CK1_1	339	345	PF00069	0.622
MOD_CK1_1	46	52	PF00069	0.626
MOD_CK1_1	487	493	PF00069	0.598
MOD_CK1_1	497	503	PF00069	0.545
MOD_CK2_1	10	16	PF00069	0.606
MOD_CK2_1	360	366	PF00069	0.443
MOD_CK2_1	368	374	PF00069	0.404
MOD_CK2_1	46	52	PF00069	0.648
MOD_CK2_1	461	467	PF00069	0.467
MOD_CK2_1	510	516	PF00069	0.631
MOD_CK2_1	87	93	PF00069	0.711
MOD_Cter_Amidation	309	312	PF01082	0.575
MOD_GlcNHglycan	303	306	PF01048	0.612
MOD_GlcNHglycan	330	333	PF01048	0.568
MOD_GlcNHglycan	354	357	PF01048	0.470
MOD_GlcNHglycan	360	363	PF01048	0.392
MOD_GlcNHglycan	486	489	PF01048	0.559
MOD_GlcNHglycan	504	508	PF01048	0.506
MOD_GSK3_1	301	308	PF00069	0.669
MOD_GSK3_1	336	343	PF00069	0.717
MOD_GSK3_1	360	367	PF00069	0.482
MOD_GSK3_1	43	50	PF00069	0.622
MOD_GSK3_1	484	491	PF00069	0.588
MOD_GSK3_1	493	500	PF00069	0.539
MOD_GSK3_1	505	512	PF00069	0.524
MOD_GSK3_1	74	81	PF00069	0.614
MOD_N-GLC_1	21	26	PF02516	0.641
MOD_N-GLC_1	340	345	PF02516	0.715
MOD_NEK2_2	231	236	PF00069	0.432
MOD_NEK2_2	322	327	PF00069	0.599
MOD_NEK2_2	488	493	PF00069	0.485
MOD_PIKK_1	368	374	PF00454	0.442
MOD_PIKK_1	388	394	PF00454	0.369
MOD_PIKK_1	497	503	PF00454	0.621
MOD_PK_1	340	346	PF00069	0.552
MOD_PKA_1	127	133	PF00069	0.645
MOD_PKA_1	298	304	PF00069	0.573
MOD_PKA_2	1	7	PF00069	0.599
MOD_PKA_2	298	304	PF00069	0.733
MOD_PKA_2	336	342	PF00069	0.624
MOD_PKA_2	346	352	PF00069	0.649
MOD_PKA_2	74	80	PF00069	0.564
MOD_Plk_1	340	346	PF00069	0.610
MOD_Plk_2-3	31	37	PF00069	0.642
MOD_Plk_2-3	48	54	PF00069	0.507
MOD_Plk_2-3	510	516	PF00069	0.584
MOD_Plk_4	16	22	PF00069	0.548
MOD_Plk_4	360	366	PF00069	0.451
MOD_Plk_4	477	483	PF00069	0.531
MOD_ProDKin_1	171	177	PF00069	0.425
MOD_ProDKin_1	21	27	PF00069	0.664
MOD_ProDKin_1	311	317	PF00069	0.599
MOD_ProDKin_1	331	337	PF00069	0.623
MOD_SUMO_rev_2	130	139	PF00179	0.601
MOD_SUMO_rev_2	189	199	PF00179	0.427
TRG_DiLeu_BaEn_1	400	405	PF01217	0.497
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.516
TRG_ENDOCYTIC_2	478	481	PF00928	0.570
TRG_ER_diArg_1	311	313	PF00400	0.581
TRG_NES_CRM1_1	410	422	PF08389	0.448
TRG_NLS_Bipartite_1	437	452	PF00514	0.403
TRG_NLS_MonoCore_2	125	130	PF00514	0.541
TRG_NLS_MonoCore_2	148	153	PF00514	0.623
TRG_NLS_MonoCore_2	447	452	PF00514	0.390
TRG_NLS_MonoExtC_3	148	153	PF00514	0.579
TRG_NLS_MonoExtC_3	447	452	PF00514	0.390
TRG_NLS_MonoExtN_4	124	131	PF00514	0.628
TRG_NLS_MonoExtN_4	148	154	PF00514	0.618
TRG_NLS_MonoExtN_4	246	253	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	409	414	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NL96	Trypanosomatidae	25%	100%
A0A3S5H573	Leishmania donovani	88%	98%
A4H3S6	Leishmania braziliensis	57%	94%
A4HS01	Leishmania infantum	88%	98%
E9AJY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%