Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q95Z88_LEIMA

TriTrypDb:

LmjF.04.0070 , LMJLV39_040005800 , LMJSD75_040005800

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q95Z88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q95Z88

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.443
CLV_PCSK_KEX2_1	18	20	PF00082	0.410
CLV_PCSK_SKI1_1	209	213	PF00082	0.499
DOC_CYCLIN_RxL_1	59	68	PF00134	0.347
DOC_MAPK_gen_1	187	195	PF00069	0.318
DOC_MAPK_MEF2A_6	187	195	PF00069	0.318
DOC_WW_Pin1_4	237	242	PF00397	0.483
LIG_14-3-3_CanoR_1	18	26	PF00244	0.407
LIG_14-3-3_CanoR_1	209	217	PF00244	0.507
LIG_14-3-3_CanoR_1	233	238	PF00244	0.393
LIG_14-3-3_CanoR_1	49	57	PF00244	0.381
LIG_14-3-3_CanoR_1	78	82	PF00244	0.475
LIG_APCC_ABBA_1	140	145	PF00400	0.376
LIG_FHA_1	194	200	PF00498	0.318
LIG_FHA_1	234	240	PF00498	0.450
LIG_FHA_1	58	64	PF00498	0.422
LIG_FHA_2	19	25	PF00498	0.447
LIG_LIR_Apic_2	196	200	PF02991	0.305
LIG_LIR_Gen_1	100	110	PF02991	0.455
LIG_LIR_Gen_1	198	206	PF02991	0.480
LIG_LIR_Gen_1	23	34	PF02991	0.345
LIG_LIR_Nem_3	100	105	PF02991	0.333
LIG_LIR_Nem_3	138	143	PF02991	0.401
LIG_LIR_Nem_3	186	192	PF02991	0.403
LIG_LIR_Nem_3	198	204	PF02991	0.310
LIG_LIR_Nem_3	222	226	PF02991	0.385
LIG_LIR_Nem_3	229	235	PF02991	0.297
LIG_LIR_Nem_3	23	29	PF02991	0.342
LIG_LIR_Nem_3	90	96	PF02991	0.470
LIG_Pex14_1	16	20	PF04695	0.346
LIG_Pex14_1	197	201	PF04695	0.339
LIG_Pex14_2	140	144	PF04695	0.441
LIG_SH2_CRK	102	106	PF00017	0.374
LIG_SH2_CRK	223	227	PF00017	0.385
LIG_SH2_CRK	93	97	PF00017	0.432
LIG_SH2_STAP1	102	106	PF00017	0.424
LIG_SH2_STAP1	235	239	PF00017	0.446
LIG_SH2_STAP1	81	85	PF00017	0.498
LIG_SH2_STAT3	10	13	PF00017	0.394
LIG_SH2_STAT3	48	51	PF00017	0.439
LIG_SH2_STAT5	20	23	PF00017	0.426
LIG_SH2_STAT5	201	204	PF00017	0.380
LIG_SH2_STAT5	206	209	PF00017	0.346
LIG_SH2_STAT5	235	238	PF00017	0.350
LIG_SH3_3	236	242	PF00018	0.487
LIG_TRAF2_1	11	14	PF00917	0.451
LIG_TRAF2_1	21	24	PF00917	0.387
LIG_TYR_ITIM	199	204	PF00017	0.337
LIG_TYR_ITIM	221	226	PF00017	0.357
LIG_TYR_ITSM	98	105	PF00017	0.420
MOD_CK2_1	18	24	PF00069	0.412
MOD_CK2_1	8	14	PF00069	0.433
MOD_GlcNHglycan	101	105	PF01048	0.452
MOD_GSK3_1	205	212	PF00069	0.462
MOD_GSK3_1	233	240	PF00069	0.459
MOD_GSK3_1	65	72	PF00069	0.320
MOD_N-GLC_1	209	214	PF02516	0.476
MOD_N-GLC_1	219	224	PF02516	0.348
MOD_N-GLC_1	57	62	PF02516	0.368
MOD_N-GLC_1	69	74	PF02516	0.244
MOD_NEK2_1	204	209	PF00069	0.371
MOD_NEK2_1	57	62	PF00069	0.499
MOD_PKA_1	18	24	PF00069	0.431
MOD_PKA_2	18	24	PF00069	0.381
MOD_PKA_2	51	57	PF00069	0.516
MOD_PKA_2	77	83	PF00069	0.385
MOD_Plk_1	100	106	PF00069	0.423
MOD_Plk_1	131	137	PF00069	0.414
MOD_Plk_1	219	225	PF00069	0.471
MOD_Plk_1	69	75	PF00069	0.288
MOD_Plk_2-3	149	155	PF00069	0.305
MOD_Plk_4	28	34	PF00069	0.430
MOD_ProDKin_1	237	243	PF00069	0.495
MOD_SUMO_rev_2	76	86	PF00179	0.468
TRG_ENDOCYTIC_2	102	105	PF00928	0.380
TRG_ENDOCYTIC_2	189	192	PF00928	0.300
TRG_ENDOCYTIC_2	201	204	PF00928	0.297
TRG_ENDOCYTIC_2	223	226	PF00928	0.348
TRG_ENDOCYTIC_2	26	29	PF00928	0.355
TRG_ENDOCYTIC_2	93	96	PF00928	0.438
TRG_ER_diArg_1	18	20	PF00400	0.432
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTY0	Leptomonas seymouri	69%	100%
A0A0S4IH71	Bodo saltans	42%	93%
A0A0S4IJP7	Bodo saltans	29%	100%
A0A0S4J8X8	Bodo saltans	41%	100%
A0A1X0NMV1	Trypanosomatidae	47%	100%
A0A3S5H574	Leishmania donovani	94%	100%
A0A422NN81	Trypanosoma rangeli	44%	100%
A4H3S8	Leishmania braziliensis	87%	100%
A4HS03	Leishmania infantum	93%	100%
C9ZY01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AJZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P0DPD7	Homo sapiens	29%	96%
P0DPE0	Mus musculus	29%	96%
V5BI94	Trypanosoma cruzi	46%	100%