Putative tyrosine phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lipid-like atypical dual specificity phosphatase, putative

Species:

Leishmania major

UniProt:

Q95Z86_LEIMA

TriTrypDb:

LmjF.04.0560 , LMJLV39_040010700 , LMJSD75_040011100

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q95Z86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q95Z86

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004725	protein tyrosine phosphatase activity	4	5
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	138	140	PF00082	0.376
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.376
CLV_PCSK_SKI1_1	44	48	PF00082	0.376
DEG_COP1_1	7	15	PF00400	0.437
DEG_MDM2_SWIB_1	166	173	PF02201	0.544
DEG_SCF_FBW7_1	171	178	PF00400	0.567
DEG_SPOP_SBC_1	248	252	PF00917	0.593
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.531
DOC_MAPK_DCC_7	161	169	PF00069	0.345
DOC_MAPK_DCC_7	8	17	PF00069	0.437
DOC_MAPK_gen_1	42	49	PF00069	0.581
DOC_MAPK_MEF2A_6	161	169	PF00069	0.345
DOC_MAPK_MEF2A_6	8	17	PF00069	0.437
DOC_PP2B_LxvP_1	162	165	PF13499	0.541
DOC_PP2B_LxvP_1	198	201	PF13499	0.556
DOC_USP7_MATH_1	2	6	PF00917	0.684
DOC_USP7_MATH_1	221	225	PF00917	0.605
DOC_USP7_MATH_1	268	272	PF00917	0.793
DOC_USP7_MATH_1	273	277	PF00917	0.710
DOC_USP7_UBL2_3	203	207	PF12436	0.681
DOC_WW_Pin1_4	160	165	PF00397	0.496
DOC_WW_Pin1_4	171	176	PF00397	0.378
DOC_WW_Pin1_4	291	296	PF00397	0.606
LIG_14-3-3_CanoR_1	139	147	PF00244	0.576
LIG_14-3-3_CanoR_1	176	180	PF00244	0.552
LIG_APCC_ABBA_1	131	136	PF00400	0.576
LIG_BRCT_BRCA1_1	13	17	PF00533	0.440
LIG_FHA_1	113	119	PF00498	0.492
LIG_FHA_1	172	178	PF00498	0.442
LIG_FHA_1	244	250	PF00498	0.604
LIG_FHA_1	97	103	PF00498	0.576
LIG_LIR_Apic_2	45	51	PF02991	0.505
LIG_LIR_Gen_1	14	25	PF02991	0.565
LIG_LIR_Gen_1	149	160	PF02991	0.563
LIG_LIR_Gen_1	163	173	PF02991	0.430
LIG_LIR_Gen_1	79	89	PF02991	0.492
LIG_LIR_Nem_3	132	137	PF02991	0.502
LIG_LIR_Nem_3	14	20	PF02991	0.592
LIG_LIR_Nem_3	149	155	PF02991	0.501
LIG_LIR_Nem_3	163	169	PF02991	0.454
LIG_LIR_Nem_3	79	84	PF02991	0.492
LIG_Pex14_2	166	170	PF04695	0.532
LIG_SH2_CRK	156	160	PF00017	0.540
LIG_SH2_CRK	196	200	PF00017	0.599
LIG_SH2_CRK	35	39	PF00017	0.530
LIG_SH2_PTP2	152	155	PF00017	0.492
LIG_SH2_SRC	54	57	PF00017	0.576
LIG_SH2_STAP1	196	200	PF00017	0.535
LIG_SH2_STAT5	152	155	PF00017	0.572
LIG_SH2_STAT5	48	51	PF00017	0.499
LIG_SH3_3	262	268	PF00018	0.725
LIG_SH3_3	7	13	PF00018	0.492
LIG_SH3_3	81	87	PF00018	0.433
LIG_SUMO_SIM_par_1	129	136	PF11976	0.492
LIG_SUMO_SIM_par_1	245	252	PF11976	0.556
LIG_TYR_ITIM	194	199	PF00017	0.599
MOD_CDK_SPK_2	171	176	PF00069	0.574
MOD_CK1_1	129	135	PF00069	0.492
MOD_CK1_1	243	249	PF00069	0.786
MOD_CK1_1	252	258	PF00069	0.703
MOD_CK1_1	271	277	PF00069	0.654
MOD_CK1_1	280	286	PF00069	0.642
MOD_CK2_1	129	135	PF00069	0.576
MOD_CK2_1	179	185	PF00069	0.609
MOD_GlcNHglycan	223	226	PF01048	0.592
MOD_GlcNHglycan	242	245	PF01048	0.622
MOD_GlcNHglycan	251	254	PF01048	0.652
MOD_GlcNHglycan	26	29	PF01048	0.310
MOD_GlcNHglycan	270	273	PF01048	0.806
MOD_GlcNHglycan	275	278	PF01048	0.698
MOD_GlcNHglycan	279	282	PF01048	0.642
MOD_GlcNHglycan	4	7	PF01048	0.593
MOD_GlcNHglycan	93	96	PF01048	0.287
MOD_GSK3_1	11	18	PF00069	0.565
MOD_GSK3_1	171	178	PF00069	0.460
MOD_GSK3_1	208	215	PF00069	0.636
MOD_GSK3_1	221	228	PF00069	0.531
MOD_GSK3_1	24	31	PF00069	0.492
MOD_GSK3_1	243	250	PF00069	0.659
MOD_GSK3_1	263	270	PF00069	0.802
MOD_GSK3_1	271	278	PF00069	0.714
MOD_GSK3_1	280	287	PF00069	0.611
MOD_N-GLC_1	15	20	PF02516	0.365
MOD_N-GLC_1	207	212	PF02516	0.689
MOD_N-GLC_1	33	38	PF02516	0.353
MOD_NEK2_1	169	174	PF00069	0.528
MOD_NEK2_1	194	199	PF00069	0.459
MOD_NEK2_1	288	293	PF00069	0.562
MOD_PIKK_1	263	269	PF00454	0.764
MOD_PK_1	42	48	PF00069	0.492
MOD_PKA_2	175	181	PF00069	0.578
MOD_Plk_1	15	21	PF00069	0.565
MOD_Plk_1	33	39	PF00069	0.562
MOD_Plk_4	114	120	PF00069	0.572
MOD_Plk_4	129	135	PF00069	0.423
MOD_Plk_4	175	181	PF00069	0.482
MOD_Plk_4	194	200	PF00069	0.461
MOD_Plk_4	284	290	PF00069	0.735
MOD_Plk_4	33	39	PF00069	0.517
MOD_ProDKin_1	160	166	PF00069	0.497
MOD_ProDKin_1	171	177	PF00069	0.370
MOD_ProDKin_1	291	297	PF00069	0.606
MOD_SUMO_rev_2	132	140	PF00179	0.576
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.576
TRG_ENDOCYTIC_2	137	140	PF00928	0.492
TRG_ENDOCYTIC_2	152	155	PF00928	0.527
TRG_ENDOCYTIC_2	156	159	PF00928	0.626
TRG_ENDOCYTIC_2	196	199	PF00928	0.594
TRG_ENDOCYTIC_2	35	38	PF00928	0.530
TRG_ER_diArg_1	41	44	PF00400	0.576
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JUF6	Bodo saltans	62%	97%
A0A3S5H5B2	Leishmania donovani	92%	97%
A4H3X6	Leishmania braziliensis	79%	100%
A4HS51	Leishmania infantum	92%	97%
E9AK38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%