Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q95Z83_LEIMA

TriTrypDb:

LmjF.04.0590 , LMJLV39_040011000 , LMJSD75_040011400

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q95Z83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q95Z83

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.452
CLV_NRD_NRD_1	162	164	PF00675	0.408
CLV_NRD_NRD_1	170	172	PF00675	0.430
CLV_NRD_NRD_1	19	21	PF00675	0.350
CLV_NRD_NRD_1	5	7	PF00675	0.517
CLV_NRD_NRD_1	66	68	PF00675	0.652
CLV_PCSK_KEX2_1	118	120	PF00082	0.452
CLV_PCSK_KEX2_1	162	164	PF00082	0.408
CLV_PCSK_KEX2_1	170	172	PF00082	0.430
CLV_PCSK_KEX2_1	19	21	PF00082	0.389
CLV_PCSK_KEX2_1	7	9	PF00082	0.461
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.458
CLV_PCSK_SKI1_1	141	145	PF00082	0.459
DOC_CKS1_1	9	14	PF01111	0.651
DOC_MAPK_gen_1	170	179	PF00069	0.641
DOC_MAPK_gen_1	19	26	PF00069	0.565
DOC_MAPK_gen_1	6	15	PF00069	0.644
DOC_PP1_RVXF_1	150	156	PF00149	0.613
DOC_PP2B_LxvP_1	13	16	PF13499	0.649
DOC_PP4_MxPP_1	206	209	PF00568	0.407
DOC_USP7_MATH_1	101	105	PF00917	0.380
DOC_USP7_MATH_1	107	111	PF00917	0.474
DOC_USP7_MATH_1	130	134	PF00917	0.667
DOC_USP7_MATH_1	260	264	PF00917	0.395
DOC_WW_Pin1_4	26	31	PF00397	0.591
DOC_WW_Pin1_4	50	55	PF00397	0.443
DOC_WW_Pin1_4	8	13	PF00397	0.673
LIG_14-3-3_CanoR_1	235	241	PF00244	0.713
LIG_14-3-3_CanoR_1	261	265	PF00244	0.315
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BRCT_BRCA1_1	21	25	PF00533	0.635
LIG_BRCT_BRCA1_1	41	45	PF00533	0.395
LIG_FHA_1	184	190	PF00498	0.493
LIG_FHA_1	8	14	PF00498	0.688
LIG_FHA_2	135	141	PF00498	0.670
LIG_FHA_2	26	32	PF00498	0.605
LIG_FHA_2	51	57	PF00498	0.427
LIG_IRF3_LxIS_1	82	89	PF10401	0.450
LIG_LIR_Gen_1	42	49	PF02991	0.357
LIG_LIR_Gen_1	89	97	PF02991	0.395
LIG_LIR_Nem_3	42	48	PF02991	0.357
LIG_LIR_Nem_3	89	93	PF02991	0.485
LIG_MLH1_MIPbox_1	41	45	PF16413	0.395
LIG_NRBOX	33	39	PF00104	0.320
LIG_SH2_CRK	202	206	PF00017	0.345
LIG_SH2_GRB2like	246	249	PF00017	0.304
LIG_SH2_PTP2	246	249	PF00017	0.315
LIG_SH2_STAP1	202	206	PF00017	0.345
LIG_SH2_STAT5	14	17	PF00017	0.607
LIG_SH2_STAT5	236	239	PF00017	0.634
LIG_SH2_STAT5	243	246	PF00017	0.551
LIG_SH2_STAT5	44	47	PF00017	0.395
LIG_SH3_1	6	12	PF00018	0.689
LIG_SH3_3	129	135	PF00018	0.730
LIG_SH3_3	15	21	PF00018	0.638
LIG_SH3_3	6	12	PF00018	0.670
LIG_SH3_3	76	82	PF00018	0.497
LIG_Sin3_3	253	260	PF02671	0.370
LIG_SUMO_SIM_anti_2	186	193	PF11976	0.358
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.395
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.320
LIG_SUMO_SIM_par_1	186	193	PF11976	0.324
LIG_SUMO_SIM_par_1	254	259	PF11976	0.236
LIG_SUMO_SIM_par_1	83	89	PF11976	0.444
MOD_CK1_1	75	81	PF00069	0.529
MOD_CK2_1	130	136	PF00069	0.670
MOD_CK2_1	25	31	PF00069	0.591
MOD_Cter_Amidation	65	68	PF01082	0.733
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.674
MOD_GlcNHglycan	34	37	PF01048	0.393
MOD_GSK3_1	130	137	PF00069	0.668
MOD_GSK3_1	190	197	PF00069	0.315
MOD_GSK3_1	256	263	PF00069	0.352
MOD_NEK2_1	25	30	PF00069	0.628
MOD_NEK2_1	256	261	PF00069	0.324
MOD_NEK2_1	39	44	PF00069	0.345
MOD_NEK2_1	47	52	PF00069	0.284
MOD_NEK2_2	165	170	PF00069	0.567
MOD_NEK2_2	236	241	PF00069	0.652
MOD_PK_1	19	25	PF00069	0.602
MOD_PKA_1	19	25	PF00069	0.635
MOD_PKA_1	7	13	PF00069	0.652
MOD_PKA_2	19	25	PF00069	0.591
MOD_PKA_2	260	266	PF00069	0.315
MOD_PKA_2	66	72	PF00069	0.447
MOD_PKA_2	7	13	PF00069	0.657
MOD_PKA_2	75	81	PF00069	0.471
MOD_PKB_1	70	78	PF00069	0.523
MOD_Plk_4	101	107	PF00069	0.395
MOD_Plk_4	19	25	PF00069	0.589
MOD_Plk_4	200	206	PF00069	0.310
MOD_Plk_4	260	266	PF00069	0.301
MOD_Plk_4	75	81	PF00069	0.422
MOD_ProDKin_1	26	32	PF00069	0.585
MOD_ProDKin_1	50	56	PF00069	0.450
MOD_ProDKin_1	8	14	PF00069	0.670
TRG_ENDOCYTIC_2	202	205	PF00928	0.345
TRG_ENDOCYTIC_2	246	249	PF00928	0.351
TRG_ENDOCYTIC_2	44	47	PF00928	0.362
TRG_ER_diArg_1	118	120	PF00400	0.652
TRG_ER_diArg_1	169	171	PF00400	0.621
TRG_ER_diArg_1	18	20	PF00400	0.581
TRG_ER_diArg_1	6	9	PF00400	0.730
TRG_ER_diArg_1	70	73	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB33	Leptomonas seymouri	52%	100%
A0A3S7WNS4	Leishmania donovani	94%	100%
A4H3X9	Leishmania braziliensis	74%	100%
A4HS54	Leishmania infantum	94%	100%
E9AK41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%