Protein farnesyltransferase subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

farnesyltransferase beta subunit

Species:

Leishmania major

UniProt:

Q8WR00_LEIMA

TriTrypDb:

LmjF.26.1470 , LMJLV39_260020600 , LMJSD75_260019000

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005965	protein farnesyltransferase complex	4	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

Q8WR00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q8WR00

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0018342	protein prenylation	4	12
GO:0018343	protein farnesylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0097354	prenylation	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004659	prenyltransferase activity	4	12
GO:0004660	protein farnesyltransferase activity	4	12
GO:0005488	binding	1	12
GO:0008318	protein prenyltransferase activity	3	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008270	zinc ion binding	6	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.700
CLV_C14_Caspase3-7	644	648	PF00656	0.574
CLV_C14_Caspase3-7	66	70	PF00656	0.741
CLV_NRD_NRD_1	395	397	PF00675	0.290
CLV_NRD_NRD_1	592	594	PF00675	0.270
CLV_PCSK_KEX2_1	278	280	PF00082	0.283
CLV_PCSK_KEX2_1	395	397	PF00082	0.298
CLV_PCSK_KEX2_1	534	536	PF00082	0.599
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.278
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.599
CLV_PCSK_PC7_1	274	280	PF00082	0.344
CLV_PCSK_SKI1_1	279	283	PF00082	0.287
CLV_PCSK_SKI1_1	440	444	PF00082	0.585
CLV_PCSK_SKI1_1	577	581	PF00082	0.530
DEG_SCF_FBW7_1	189	196	PF00400	0.560
DEG_SPOP_SBC_1	46	50	PF00917	0.759
DEG_SPOP_SBC_1	72	76	PF00917	0.599
DOC_ANK_TNKS_1	178	185	PF00023	0.513
DOC_CYCLIN_RxL_1	274	283	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	215	218	PF00134	0.708
DOC_MAPK_gen_1	278	284	PF00069	0.487
DOC_MAPK_gen_1	474	484	PF00069	0.549
DOC_MAPK_gen_1	91	100	PF00069	0.543
DOC_MAPK_MEF2A_6	336	343	PF00069	0.542
DOC_PP2B_LxvP_1	215	218	PF13499	0.585
DOC_PP2B_LxvP_1	684	687	PF13499	0.559
DOC_USP7_MATH_1	174	178	PF00917	0.600
DOC_USP7_MATH_1	193	197	PF00917	0.584
DOC_USP7_MATH_1	363	367	PF00917	0.569
DOC_USP7_MATH_1	46	50	PF00917	0.759
DOC_USP7_MATH_1	552	556	PF00917	0.599
DOC_USP7_MATH_1	62	66	PF00917	0.491
DOC_USP7_MATH_1	649	653	PF00917	0.644
DOC_USP7_MATH_1	687	691	PF00917	0.629
DOC_USP7_MATH_1	692	696	PF00917	0.536
DOC_USP7_MATH_1	70	74	PF00917	0.757
DOC_WW_Pin1_4	141	146	PF00397	0.460
DOC_WW_Pin1_4	189	194	PF00397	0.563
DOC_WW_Pin1_4	359	364	PF00397	0.553
DOC_WW_Pin1_4	467	472	PF00397	0.588
DOC_WW_Pin1_4	51	56	PF00397	0.737
DOC_WW_Pin1_4	699	704	PF00397	0.502
LIG_14-3-3_CanoR_1	15	22	PF00244	0.518
LIG_14-3-3_CanoR_1	279	285	PF00244	0.516
LIG_14-3-3_CanoR_1	302	306	PF00244	0.476
LIG_14-3-3_CanoR_1	535	545	PF00244	0.622
LIG_14-3-3_CanoR_1	640	650	PF00244	0.684
LIG_14-3-3_CanoR_1	699	703	PF00244	0.479
LIG_14-3-3_CanoR_1	711	719	PF00244	0.518
LIG_Actin_WH2_2	514	531	PF00022	0.626
LIG_BRCT_BRCA1_1	701	705	PF00533	0.473
LIG_Clathr_ClatBox_1	19	23	PF01394	0.582
LIG_Clathr_ClatBox_1	313	317	PF01394	0.428
LIG_DCNL_PONY_1	1	4	PF03556	0.611
LIG_deltaCOP1_diTrp_1	572	580	PF00928	0.593
LIG_FHA_1	15	21	PF00498	0.504
LIG_FHA_1	196	202	PF00498	0.783
LIG_FHA_1	309	315	PF00498	0.535
LIG_FHA_1	411	417	PF00498	0.487
LIG_FHA_1	6	12	PF00498	0.552
LIG_FHA_1	699	705	PF00498	0.438
LIG_FHA_2	190	196	PF00498	0.743
LIG_FHA_2	239	245	PF00498	0.508
LIG_FHA_2	318	324	PF00498	0.508
LIG_FHA_2	362	368	PF00498	0.547
LIG_FHA_2	615	621	PF00498	0.562
LIG_FHA_2	642	648	PF00498	0.648
LIG_FHA_2	651	657	PF00498	0.527
LIG_GBD_Chelix_1	149	157	PF00786	0.535
LIG_Integrin_isoDGR_2	410	412	PF01839	0.276
LIG_LIR_Apic_2	84	90	PF02991	0.518
LIG_LIR_Gen_1	439	446	PF02991	0.533
LIG_LIR_Gen_1	539	550	PF02991	0.567
LIG_LIR_Nem_3	118	124	PF02991	0.453
LIG_LIR_Nem_3	439	445	PF02991	0.523
LIG_LIR_Nem_3	539	545	PF02991	0.567
LIG_NRBOX	376	382	PF00104	0.517
LIG_PCNA_yPIPBox_3	374	384	PF02747	0.501
LIG_PCNA_yPIPBox_3	391	401	PF02747	0.581
LIG_PCNA_yPIPBox_3	592	601	PF02747	0.537
LIG_RPA_C_Fungi	706	718	PF08784	0.506
LIG_SH2_GRB2like	589	592	PF00017	0.385
LIG_SH2_NCK_1	582	586	PF00017	0.577
LIG_SH2_SRC	582	585	PF00017	0.577
LIG_SH2_SRC	663	666	PF00017	0.557
LIG_SH2_STAP1	421	425	PF00017	0.348
LIG_SH2_STAP1	438	442	PF00017	0.431
LIG_SH2_STAP1	542	546	PF00017	0.554
LIG_SH2_STAT3	589	592	PF00017	0.385
LIG_SH2_STAT5	24	27	PF00017	0.551
LIG_SH2_STAT5	305	308	PF00017	0.344
LIG_SH2_STAT5	372	375	PF00017	0.328
LIG_SH2_STAT5	438	441	PF00017	0.538
LIG_SH2_STAT5	589	592	PF00017	0.343
LIG_SH2_STAT5	598	601	PF00017	0.308
LIG_SH2_STAT5	654	657	PF00017	0.457
LIG_SH2_STAT5	663	666	PF00017	0.459
LIG_SH2_STAT5	87	90	PF00017	0.535
LIG_SH3_3	114	120	PF00018	0.524
LIG_SH3_3	226	232	PF00018	0.685
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.484
LIG_SUMO_SIM_anti_2	480	485	PF11976	0.437
LIG_SUMO_SIM_par_1	17	23	PF11976	0.536
LIG_SUMO_SIM_par_1	339	345	PF11976	0.522
LIG_SUMO_SIM_par_1	480	485	PF11976	0.430
LIG_TRAF2_1	241	244	PF00917	0.525
LIG_TRAF2_1	530	533	PF00917	0.394
LIG_TYR_ITIM	122	127	PF00017	0.415
LIG_UBA3_1	380	384	PF00899	0.413
MOD_CDC14_SPxK_1	54	57	PF00782	0.701
MOD_CDK_SPxK_1	51	57	PF00069	0.701
MOD_CDK_SPxxK_3	467	474	PF00069	0.538
MOD_CK1_1	135	141	PF00069	0.342
MOD_CK1_1	155	161	PF00069	0.425
MOD_CK1_1	196	202	PF00069	0.768
MOD_CK1_1	419	425	PF00069	0.329
MOD_CK1_1	47	53	PF00069	0.769
MOD_CK1_1	56	62	PF00069	0.742
MOD_CK1_1	629	635	PF00069	0.328
MOD_CK1_1	669	675	PF00069	0.718
MOD_CK1_1	73	79	PF00069	0.698
MOD_CK2_1	189	195	PF00069	0.592
MOD_CK2_1	238	244	PF00069	0.514
MOD_CK2_1	361	367	PF00069	0.427
MOD_CK2_1	527	533	PF00069	0.561
MOD_CK2_1	650	656	PF00069	0.542
MOD_CK2_1	670	676	PF00069	0.749
MOD_GlcNHglycan	146	149	PF01048	0.451
MOD_GlcNHglycan	176	179	PF01048	0.651
MOD_GlcNHglycan	206	209	PF01048	0.754
MOD_GlcNHglycan	211	214	PF01048	0.714
MOD_GlcNHglycan	471	474	PF01048	0.570
MOD_GlcNHglycan	49	52	PF01048	0.816
MOD_GlcNHglycan	497	500	PF01048	0.598
MOD_GlcNHglycan	507	510	PF01048	0.304
MOD_GlcNHglycan	529	532	PF01048	0.571
MOD_GlcNHglycan	62	65	PF01048	0.654
MOD_GlcNHglycan	628	631	PF01048	0.326
MOD_GlcNHglycan	668	671	PF01048	0.710
MOD_GlcNHglycan	672	675	PF01048	0.699
MOD_GlcNHglycan	689	692	PF01048	0.515
MOD_GlcNHglycan	713	716	PF01048	0.477
MOD_GlcNHglycan	75	78	PF01048	0.730
MOD_GSK3_1	111	118	PF00069	0.500
MOD_GSK3_1	155	162	PF00069	0.460
MOD_GSK3_1	189	196	PF00069	0.763
MOD_GSK3_1	204	211	PF00069	0.668
MOD_GSK3_1	357	364	PF00069	0.413
MOD_GSK3_1	436	443	PF00069	0.465
MOD_GSK3_1	46	53	PF00069	0.744
MOD_GSK3_1	505	512	PF00069	0.561
MOD_GSK3_1	56	63	PF00069	0.695
MOD_GSK3_1	666	673	PF00069	0.740
MOD_GSK3_1	707	714	PF00069	0.489
MOD_GSK3_1	72	79	PF00069	0.740
MOD_GSK3_1	81	88	PF00069	0.671
MOD_N-GLC_1	103	108	PF02516	0.510
MOD_N-GLC_1	687	692	PF02516	0.551
MOD_N-GLC_1	70	75	PF02516	0.687
MOD_NEK2_1	152	157	PF00069	0.454
MOD_NEK2_1	194	199	PF00069	0.775
MOD_NEK2_1	25	30	PF00069	0.522
MOD_NEK2_1	416	421	PF00069	0.328
MOD_NEK2_1	545	550	PF00069	0.598
MOD_NEK2_1	659	664	PF00069	0.549
MOD_NEK2_1	697	702	PF00069	0.473
MOD_NEK2_2	111	116	PF00069	0.510
MOD_NEK2_2	280	285	PF00069	0.363
MOD_NEK2_2	621	626	PF00069	0.385
MOD_OFUCOSY	156	163	PF10250	0.540
MOD_PIKK_1	370	376	PF00454	0.344
MOD_PK_1	717	723	PF00069	0.498
MOD_PKA_2	14	20	PF00069	0.547
MOD_PKA_2	204	210	PF00069	0.724
MOD_PKA_2	25	31	PF00069	0.577
MOD_PKA_2	301	307	PF00069	0.328
MOD_PKA_2	666	672	PF00069	0.679
MOD_PKA_2	698	704	PF00069	0.421
MOD_PKA_2	81	87	PF00069	0.652
MOD_Plk_1	103	109	PF00069	0.514
MOD_Plk_2-3	318	324	PF00069	0.559
MOD_Plk_4	111	117	PF00069	0.498
MOD_Plk_4	211	217	PF00069	0.651
MOD_Plk_4	258	264	PF00069	0.453
MOD_Plk_4	309	315	PF00069	0.355
MOD_Plk_4	650	656	PF00069	0.510
MOD_Plk_4	692	698	PF00069	0.587
MOD_ProDKin_1	141	147	PF00069	0.460
MOD_ProDKin_1	189	195	PF00069	0.562
MOD_ProDKin_1	359	365	PF00069	0.437
MOD_ProDKin_1	467	473	PF00069	0.584
MOD_ProDKin_1	51	57	PF00069	0.737
MOD_ProDKin_1	699	705	PF00069	0.499
MOD_SUMO_rev_2	177	187	PF00179	0.631
MOD_SUMO_rev_2	485	495	PF00179	0.520
MOD_SUMO_rev_2	530	536	PF00179	0.558
TRG_DiLeu_BaEn_1	607	612	PF01217	0.363
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.552
TRG_ENDOCYTIC_2	124	127	PF00928	0.390
TRG_ENDOCYTIC_2	542	545	PF00928	0.566
TRG_ENDOCYTIC_2	582	585	PF00928	0.577
TRG_ER_diArg_1	394	396	PF00400	0.363
TRG_ER_diArg_1	476	479	PF00400	0.530
TRG_ER_diArg_1	574	577	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	401	406	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	593	597	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA19	Leptomonas seymouri	56%	100%
A0A0S4KLG2	Bodo saltans	38%	100%
A0A1X0NSS5	Trypanosomatidae	37%	100%
A0A3S7WZW4	Leishmania donovani	93%	100%
A0A422NJ04	Trypanosoma rangeli	39%	100%
A4HF02	Leishmania braziliensis	79%	100%
A4I281	Leishmania infantum	94%	100%
C9ZRR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AYC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DA92	Trypanosoma cruzi	40%	100%