Rab7-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Rab7-like protein

Gene product:

rab7 GTP binding protein, putative

Species:

Leishmania braziliensis

UniProt:

Q8T6H9_LEIBR

TriTrypDb:

LbrM.18.0950 , LBRM2903_180015200

Length:

223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q8T6H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q8T6H9

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.333
CLV_NRD_NRD_1	126	128	PF00675	0.303
CLV_PCSK_KEX2_1	111	113	PF00082	0.273
CLV_PCSK_KEX2_1	126	128	PF00082	0.287
CLV_PCSK_KEX2_1	4	6	PF00082	0.509
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.534
CLV_PCSK_SKI1_1	191	195	PF00082	0.621
CLV_PCSK_SKI1_1	5	9	PF00082	0.471
CLV_PCSK_SKI1_1	54	58	PF00082	0.380
DEG_APCC_DBOX_1	4	12	PF00400	0.481

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z9	Leptomonas seymouri	34%	94%
A0A0N0P6K4	Leptomonas seymouri	30%	100%
A0A0N0P6P8	Leptomonas seymouri	38%	100%
A0A0N0P8G7	Leptomonas seymouri	36%	100%
A0A0N0P8I1	Leptomonas seymouri	84%	100%
A0A0N1HU31	Leptomonas seymouri	30%	90%
A0A0N1HYV5	Leptomonas seymouri	35%	100%
A0A0N1I011	Leptomonas seymouri	36%	100%
A0A0N1I5E3	Leptomonas seymouri	31%	100%
A0A0N1I9K4	Leptomonas seymouri	35%	95%

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