DNA-directed DNA polymerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial DNA polymerase I protein A, putative

Species:

Leishmania major

UniProt:

Q8IS90_LEIMA

TriTrypDb:

LmjF.34.1260 , LMJLV39_340020800 , LMJSD75_340020800

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q8IS90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q8IS90

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006260	DNA replication	5	8
GO:0006261	DNA-templated DNA replication	6	8
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003824	catalytic activity	1	8
GO:0003887	DNA-directed DNA polymerase activity	5	8
GO:0005488	binding	1	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0034061	DNA polymerase activity	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.499
CLV_NRD_NRD_1	19	21	PF00675	0.613
CLV_NRD_NRD_1	35	37	PF00675	0.583
CLV_NRD_NRD_1	40	42	PF00675	0.650
CLV_NRD_NRD_1	445	447	PF00675	0.298
CLV_NRD_NRD_1	504	506	PF00675	0.254
CLV_NRD_NRD_1	585	587	PF00675	0.582
CLV_NRD_NRD_1	682	684	PF00675	0.254
CLV_NRD_NRD_1	744	746	PF00675	0.230
CLV_NRD_NRD_1	793	795	PF00675	0.254
CLV_NRD_NRD_1	825	827	PF00675	0.275
CLV_NRD_NRD_1	880	882	PF00675	0.296
CLV_PCSK_KEX2_1	163	165	PF00082	0.527
CLV_PCSK_KEX2_1	19	21	PF00082	0.650
CLV_PCSK_KEX2_1	35	37	PF00082	0.688
CLV_PCSK_KEX2_1	387	389	PF00082	0.325
CLV_PCSK_KEX2_1	42	44	PF00082	0.745
CLV_PCSK_KEX2_1	585	587	PF00082	0.582
CLV_PCSK_KEX2_1	682	684	PF00082	0.254
CLV_PCSK_KEX2_1	744	746	PF00082	0.258
CLV_PCSK_KEX2_1	748	750	PF00082	0.251
CLV_PCSK_KEX2_1	793	795	PF00082	0.254
CLV_PCSK_KEX2_1	825	827	PF00082	0.279
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.527
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.809
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.325
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.745
CLV_PCSK_PC1ET2_1	748	750	PF00082	0.254
CLV_PCSK_PC7_1	744	750	PF00082	0.254
CLV_PCSK_SKI1_1	160	164	PF00082	0.582
CLV_PCSK_SKI1_1	208	212	PF00082	0.336
CLV_PCSK_SKI1_1	376	380	PF00082	0.404
CLV_PCSK_SKI1_1	388	392	PF00082	0.375
CLV_PCSK_SKI1_1	446	450	PF00082	0.296
CLV_PCSK_SKI1_1	457	461	PF00082	0.296
CLV_PCSK_SKI1_1	65	69	PF00082	0.559
CLV_PCSK_SKI1_1	745	749	PF00082	0.258
CLV_PCSK_SKI1_1	831	835	PF00082	0.254
CLV_PCSK_SKI1_1	855	859	PF00082	0.254
CLV_PCSK_SKI1_1	882	886	PF00082	0.281
DEG_APCC_DBOX_1	401	409	PF00400	0.358
DEG_APCC_DBOX_1	445	453	PF00400	0.496
DEG_APCC_DBOX_1	880	888	PF00400	0.465
DEG_Nend_UBRbox_3	1	3	PF02207	0.565
DEG_SPOP_SBC_1	718	722	PF00917	0.496
DOC_CYCLIN_RxL_1	454	462	PF00134	0.465
DOC_CYCLIN_RxL_1	62	72	PF00134	0.613
DOC_CYCLIN_yCln2_LP_2	902	908	PF00134	0.454
DOC_MAPK_DCC_7	208	218	PF00069	0.331
DOC_MAPK_gen_1	384	393	PF00069	0.374
DOC_MAPK_gen_1	744	752	PF00069	0.410
DOC_MAPK_gen_1	860	868	PF00069	0.496
DOC_MAPK_gen_1	881	889	PF00069	0.465
DOC_MAPK_MEF2A_6	120	128	PF00069	0.375
DOC_MAPK_MEF2A_6	177	186	PF00069	0.401
DOC_MAPK_MEF2A_6	305	312	PF00069	0.437
DOC_MAPK_MEF2A_6	384	393	PF00069	0.374
DOC_MAPK_MEF2A_6	397	405	PF00069	0.387
DOC_MAPK_MEF2A_6	882	891	PF00069	0.465
DOC_MAPK_NFAT4_5	388	396	PF00069	0.345
DOC_PP1_RVXF_1	746	753	PF00149	0.496
DOC_PP2B_LxvP_1	902	905	PF13499	0.454
DOC_USP7_MATH_1	132	136	PF00917	0.443
DOC_USP7_MATH_1	142	146	PF00917	0.455
DOC_USP7_MATH_1	175	179	PF00917	0.401
DOC_USP7_MATH_1	286	290	PF00917	0.493
DOC_USP7_MATH_1	29	33	PF00917	0.660
DOC_USP7_MATH_1	347	351	PF00917	0.504
DOC_USP7_MATH_1	6	10	PF00917	0.631
DOC_USP7_MATH_1	833	837	PF00917	0.496
DOC_USP7_MATH_1	890	894	PF00917	0.465
DOC_USP7_MATH_1	91	95	PF00917	0.423
DOC_USP7_UBL2_3	35	39	PF12436	0.719
DOC_USP7_UBL2_3	457	461	PF12436	0.465
DOC_WW_Pin1_4	13	18	PF00397	0.538
DOC_WW_Pin1_4	528	533	PF00397	0.617
DOC_WW_Pin1_4	577	582	PF00397	0.620
DOC_WW_Pin1_4	58	63	PF00397	0.620
DOC_WW_Pin1_4	614	619	PF00397	0.796
LIG_14-3-3_CanoR_1	149	155	PF00244	0.422
LIG_14-3-3_CanoR_1	164	173	PF00244	0.528
LIG_14-3-3_CanoR_1	208	216	PF00244	0.341
LIG_14-3-3_CanoR_1	410	419	PF00244	0.324
LIG_14-3-3_CanoR_1	480	488	PF00244	0.496
LIG_14-3-3_CanoR_1	525	532	PF00244	0.507
LIG_14-3-3_CanoR_1	585	594	PF00244	0.612
LIG_14-3-3_CanoR_1	627	633	PF00244	0.547
LIG_14-3-3_CanoR_1	645	653	PF00244	0.406
LIG_14-3-3_CanoR_1	65	71	PF00244	0.606
LIG_14-3-3_CanoR_1	819	823	PF00244	0.513
LIG_14-3-3_CanoR_1	825	829	PF00244	0.480
LIG_Actin_WH2_2	445	463	PF00022	0.465
LIG_BIR_III_4	30	34	PF00653	0.545
LIG_BRCT_BRCA1_1	166	170	PF00533	0.485
LIG_BRCT_BRCA1_1	565	569	PF00533	0.579
LIG_Clathr_ClatBox_1	693	697	PF01394	0.454
LIG_EH1_1	897	905	PF00400	0.454
LIG_eIF4E_1	292	298	PF01652	0.394
LIG_FHA_1	198	204	PF00498	0.394
LIG_FHA_1	286	292	PF00498	0.464
LIG_FHA_1	307	313	PF00498	0.428
LIG_FHA_1	641	647	PF00498	0.454
LIG_FHA_1	660	666	PF00498	0.454
LIG_FHA_1	776	782	PF00498	0.579
LIG_FHA_1	90	96	PF00498	0.391
LIG_FHA_2	481	487	PF00498	0.454
LIG_FHA_2	511	517	PF00498	0.496
LIG_FHA_2	719	725	PF00498	0.485
LIG_LIR_Apic_2	191	197	PF02991	0.388
LIG_LIR_Gen_1	105	115	PF02991	0.367
LIG_LIR_Gen_1	167	176	PF02991	0.416
LIG_LIR_Gen_1	293	301	PF02991	0.374
LIG_LIR_Gen_1	520	528	PF02991	0.521
LIG_LIR_Gen_1	695	706	PF02991	0.454
LIG_LIR_Gen_1	94	104	PF02991	0.509
LIG_LIR_Nem_3	105	111	PF02991	0.373
LIG_LIR_Nem_3	150	155	PF02991	0.442
LIG_LIR_Nem_3	167	173	PF02991	0.334
LIG_LIR_Nem_3	293	297	PF02991	0.395
LIG_LIR_Nem_3	364	369	PF02991	0.393
LIG_LIR_Nem_3	520	524	PF02991	0.441
LIG_LIR_Nem_3	695	701	PF02991	0.454
LIG_LIR_Nem_3	94	100	PF02991	0.368
LIG_NRBOX	226	232	PF00104	0.303
LIG_NRBOX	368	374	PF00104	0.392
LIG_NRBOX	391	397	PF00104	0.322
LIG_PCNA_APIM_2	455	461	PF02747	0.465
LIG_PCNA_yPIPBox_3	224	235	PF02747	0.378
LIG_Pex14_2	681	685	PF04695	0.454
LIG_Rb_LxCxE_1	641	662	PF01857	0.473
LIG_SH2_CRK	194	198	PF00017	0.370
LIG_SH2_CRK	294	298	PF00017	0.331
LIG_SH2_CRK	366	370	PF00017	0.342
LIG_SH2_CRK	504	508	PF00017	0.588
LIG_SH2_CRK	521	525	PF00017	0.483
LIG_SH2_CRK	629	633	PF00017	0.346
LIG_SH2_NCK_1	194	198	PF00017	0.345
LIG_SH2_NCK_1	698	702	PF00017	0.478
LIG_SH2_PTP2	97	100	PF00017	0.413
LIG_SH2_SRC	514	517	PF00017	0.496
LIG_SH2_STAT5	361	364	PF00017	0.379
LIG_SH2_STAT5	458	461	PF00017	0.496
LIG_SH2_STAT5	514	517	PF00017	0.454
LIG_SH2_STAT5	814	817	PF00017	0.496
LIG_SH2_STAT5	97	100	PF00017	0.384
LIG_SH3_3	341	347	PF00018	0.544
LIG_SH3_3	619	625	PF00018	0.577
LIG_SH3_3	90	96	PF00018	0.451
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.425
LIG_SUMO_SIM_anti_2	864	870	PF11976	0.496
LIG_SUMO_SIM_par_1	692	697	PF11976	0.455
LIG_SUMO_SIM_par_1	849	854	PF11976	0.496
LIG_SUMO_SIM_par_1	904	909	PF11976	0.496
LIG_TRAF2_1	103	106	PF00917	0.399
LIG_TRAF2_1	610	613	PF00917	0.627
LIG_TRAF2_1	740	743	PF00917	0.496
LIG_TYR_ITIM	502	507	PF00017	0.346
LIG_TYR_ITIM	696	701	PF00017	0.287
LIG_TYR_ITIM	95	100	PF00017	0.418
LIG_UBA3_1	226	235	PF00899	0.378
LIG_UBA3_1	391	397	PF00899	0.364
LIG_UBA3_1	902	911	PF00899	0.287
LIG_WRC_WIRS_1	218	223	PF05994	0.302
MOD_CDK_SPxK_1	13	19	PF00069	0.538
MOD_CDK_SPxxK_3	13	20	PF00069	0.539
MOD_CDK_SPxxK_3	58	65	PF00069	0.559
MOD_CK1_1	13	19	PF00069	0.638
MOD_CK1_1	131	137	PF00069	0.457
MOD_CK1_1	145	151	PF00069	0.383
MOD_CK1_1	259	265	PF00069	0.469
MOD_CK1_1	322	328	PF00069	0.589
MOD_CK1_1	5	11	PF00069	0.667
MOD_CK1_1	546	552	PF00069	0.790
MOD_CK1_1	592	598	PF00069	0.685
MOD_CK1_1	69	75	PF00069	0.670
MOD_CK1_1	824	830	PF00069	0.346
MOD_CK1_1	864	870	PF00069	0.346
MOD_CK1_1	894	900	PF00069	0.346
MOD_CK2_1	100	106	PF00069	0.464
MOD_CK2_1	479	485	PF00069	0.287
MOD_CK2_1	510	516	PF00069	0.346
MOD_CK2_1	594	600	PF00069	0.621
MOD_CK2_1	606	612	PF00069	0.577
MOD_CK2_1	644	650	PF00069	0.287
MOD_CK2_1	737	743	PF00069	0.275
MOD_CK2_1	824	830	PF00069	0.346
MOD_GlcNHglycan	102	105	PF01048	0.445
MOD_GlcNHglycan	130	133	PF01048	0.447
MOD_GlcNHglycan	156	159	PF01048	0.599
MOD_GlcNHglycan	265	268	PF01048	0.477
MOD_GlcNHglycan	30	34	PF01048	0.604
MOD_GlcNHglycan	349	352	PF01048	0.487
MOD_GlcNHglycan	4	7	PF01048	0.655
MOD_GlcNHglycan	461	464	PF01048	0.392
MOD_GlcNHglycan	526	529	PF01048	0.525
MOD_GlcNHglycan	591	594	PF01048	0.707
MOD_GlcNHglycan	596	599	PF01048	0.685
MOD_GlcNHglycan	612	617	PF01048	0.824
MOD_GlcNHglycan	721	724	PF01048	0.421
MOD_GlcNHglycan	8	11	PF01048	0.664
MOD_GlcNHglycan	808	811	PF01048	0.287
MOD_GlcNHglycan	840	843	PF01048	0.287
MOD_GlcNHglycan	893	896	PF01048	0.346
MOD_GSK3_1	128	135	PF00069	0.413
MOD_GSK3_1	150	157	PF00069	0.451
MOD_GSK3_1	164	171	PF00069	0.504
MOD_GSK3_1	2	9	PF00069	0.649
MOD_GSK3_1	237	244	PF00069	0.328
MOD_GSK3_1	259	266	PF00069	0.406
MOD_GSK3_1	281	288	PF00069	0.583
MOD_GSK3_1	361	368	PF00069	0.387
MOD_GSK3_1	480	487	PF00069	0.330
MOD_GSK3_1	524	531	PF00069	0.563
MOD_GSK3_1	54	61	PF00069	0.599
MOD_GSK3_1	542	549	PF00069	0.777
MOD_GSK3_1	563	570	PF00069	0.523
MOD_GSK3_1	588	595	PF00069	0.590
MOD_GSK3_1	640	647	PF00069	0.271
MOD_GSK3_1	66	73	PF00069	0.570
MOD_GSK3_1	817	824	PF00069	0.346
MOD_GSK3_1	85	92	PF00069	0.514
MOD_GSK3_1	890	897	PF00069	0.346
MOD_N-GLC_1	150	155	PF02516	0.468
MOD_N-GLC_1	2	7	PF02516	0.688
MOD_NEK2_1	321	326	PF00069	0.565
MOD_NEK2_1	372	377	PF00069	0.367
MOD_NEK2_1	459	464	PF00069	0.451
MOD_NEK2_1	473	478	PF00069	0.261
MOD_NEK2_1	510	515	PF00069	0.346
MOD_NEK2_1	587	592	PF00069	0.787
MOD_NEK2_1	775	780	PF00069	0.346
MOD_NEK2_1	804	809	PF00069	0.346
MOD_NEK2_1	891	896	PF00069	0.404
MOD_NEK2_1	906	911	PF00069	0.229
MOD_NEK2_1	912	917	PF00069	0.287
MOD_NEK2_2	361	366	PF00069	0.374
MOD_NEK2_2	484	489	PF00069	0.346
MOD_NEK2_2	628	633	PF00069	0.432
MOD_PIKK_1	867	873	PF00454	0.346
MOD_PKA_1	164	170	PF00069	0.464
MOD_PKA_1	505	511	PF00069	0.346
MOD_PKA_2	164	170	PF00069	0.507
MOD_PKA_2	479	485	PF00069	0.346
MOD_PKA_2	524	530	PF00069	0.441
MOD_PKA_2	607	613	PF00069	0.648
MOD_PKA_2	644	650	PF00069	0.287
MOD_PKA_2	818	824	PF00069	0.370
MOD_PKB_1	503	511	PF00069	0.346
MOD_Plk_1	150	156	PF00069	0.434
MOD_Plk_1	286	292	PF00069	0.508
MOD_Plk_1	484	490	PF00069	0.287
MOD_Plk_1	864	870	PF00069	0.346
MOD_Plk_1	920	926	PF00069	0.391
MOD_Plk_2-3	281	287	PF00069	0.549
MOD_Plk_4	234	240	PF00069	0.399
MOD_Plk_4	286	292	PF00069	0.508
MOD_Plk_4	322	328	PF00069	0.624
MOD_Plk_4	361	367	PF00069	0.384
MOD_Plk_4	510	516	PF00069	0.346
MOD_Plk_4	563	569	PF00069	0.563
MOD_Plk_4	776	782	PF00069	0.346
MOD_Plk_4	818	824	PF00069	0.326
MOD_Plk_4	833	839	PF00069	0.229
MOD_Plk_4	864	870	PF00069	0.346
MOD_ProDKin_1	13	19	PF00069	0.538
MOD_ProDKin_1	528	534	PF00069	0.621
MOD_ProDKin_1	577	583	PF00069	0.621
MOD_ProDKin_1	58	64	PF00069	0.620
MOD_ProDKin_1	614	620	PF00069	0.791
TRG_ENDOCYTIC_2	294	297	PF00928	0.375
TRG_ENDOCYTIC_2	366	369	PF00928	0.350
TRG_ENDOCYTIC_2	370	373	PF00928	0.347
TRG_ENDOCYTIC_2	398	401	PF00928	0.371
TRG_ENDOCYTIC_2	450	453	PF00928	0.287
TRG_ENDOCYTIC_2	504	507	PF00928	0.475
TRG_ENDOCYTIC_2	521	524	PF00928	0.321
TRG_ENDOCYTIC_2	629	632	PF00928	0.376
TRG_ENDOCYTIC_2	698	701	PF00928	0.287
TRG_ENDOCYTIC_2	97	100	PF00928	0.413
TRG_ER_diArg_1	164	166	PF00400	0.499
TRG_ER_diArg_1	18	20	PF00400	0.669
TRG_ER_diArg_1	585	587	PF00400	0.582
TRG_ER_diArg_1	681	683	PF00400	0.287
TRG_ER_diArg_1	744	746	PF00400	0.226
TRG_ER_diArg_1	793	795	PF00400	0.287
TRG_ER_diArg_1	811	814	PF00400	0.287
TRG_NLS_Bipartite_1	19	40	PF00514	0.655
TRG_NLS_MonoCore_2	35	40	PF00514	0.674
TRG_NLS_MonoExtC_3	34	39	PF00514	0.816
TRG_NLS_MonoExtN_4	160	167	PF00514	0.515
TRG_NLS_MonoExtN_4	35	40	PF00514	0.678
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	727	731	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	794	798	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	813	817	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I668	Leptomonas seymouri	64%	73%
A0A1X0P9E5	Trypanosomatidae	42%	94%
A0A3Q8IH45	Leishmania donovani	94%	100%
A4HAP3	Leishmania braziliensis	78%	74%
A4I9T9	Leishmania infantum	94%	74%
E9B4V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%