LeishMANIAdb
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Thioredoxin family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin family protein
Gene product:
protein disulfide isomerase
Species:
Leishmania donovani
UniProt:
Q8I7Z7_LEIDO
TriTrypDb:
LdBPK_061090.1 , LdCL_060016000 , LDHU3_06.1230
Length:
133

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 7, no: 2
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

Q8I7Z7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0003756 protein disulfide isomerase activity 3 10
GO:0003824 catalytic activity 1 10
GO:0016853 isomerase activity 2 10
GO:0016860 intramolecular oxidoreductase activity 3 10
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4 10
GO:0140096 catalytic activity, acting on a protein 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 4 6 PF00675 0.428
CLV_PCSK_KEX2_1 106 108 PF00082 0.403
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.403
CLV_PCSK_SKI1_1 42 46 PF00082 0.389
DEG_APCC_DBOX_1 4 12 PF00400 0.465
DOC_MAPK_gen_1 5 12 PF00069 0.445
DOC_MAPK_JIP1_4 60 66 PF00069 0.403
DOC_MAPK_MEF2A_6 5 14 PF00069 0.443
DOC_PP4_FxxP_1 48 51 PF00568 0.354
DOC_USP7_UBL2_3 102 106 PF12436 0.413
DOC_USP7_UBL2_3 38 42 PF12436 0.426
LIG_14-3-3_CanoR_1 5 9 PF00244 0.484
LIG_BIR_II_1 1 5 PF00653 0.446
LIG_FHA_1 5 11 PF00498 0.483
LIG_FHA_2 60 66 PF00498 0.376
LIG_GBD_Chelix_1 8 16 PF00786 0.382
LIG_LIR_Apic_2 114 118 PF02991 0.373
LIG_LIR_Gen_1 62 71 PF02991 0.403
LIG_LIR_Nem_3 122 127 PF02991 0.426
LIG_LIR_Nem_3 62 66 PF02991 0.403
LIG_LIR_Nem_3 68 73 PF02991 0.426
LIG_LIR_Nem_3 84 89 PF02991 0.366
LIG_LYPXL_yS_3 70 73 PF13949 0.321
LIG_NRBOX 7 13 PF00104 0.459
LIG_Pex14_2 48 52 PF04695 0.354
LIG_REV1ctd_RIR_1 101 111 PF16727 0.379
LIG_SH2_CRK 86 90 PF00017 0.426
LIG_SH2_STAT5 127 130 PF00017 0.439
LIG_SH3_3 34 40 PF00018 0.413
LIG_SUMO_SIM_anti_2 7 12 PF11976 0.382
MOD_CK2_1 59 65 PF00069 0.321
MOD_GlcNHglycan 108 112 PF01048 0.479
MOD_GlcNHglycan 120 124 PF01048 0.363
MOD_PKA_2 4 10 PF00069 0.485
MOD_Plk_1 119 125 PF00069 0.470
MOD_Plk_4 59 65 PF00069 0.445
MOD_SUMO_for_1 21 24 PF00179 0.477
TRG_DiLeu_BaEn_2 119 125 PF01217 0.379
TRG_ENDOCYTIC_2 70 73 PF00928 0.321
TRG_ENDOCYTIC_2 86 89 PF00928 0.564

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I216 Leptomonas seymouri 34% 94%
A0A0N1I5T9 Leptomonas seymouri 53% 100%
A0A0N1IJS7 Leptomonas seymouri 26% 81%
A0A0S4JA26 Bodo saltans 50% 80%
A0A1X0NGQ4 Trypanosomatidae 33% 90%
A0A1X0NT33 Trypanosomatidae 33% 80%
A0A3R7NHA8 Trypanosoma rangeli 48% 73%
A0A422NM49 Trypanosoma rangeli 33% 89%
A4H4R8 Leishmania braziliensis 78% 100%
A4H4T0 Leishmania braziliensis 29% 100%
A4HES2 Leishmania braziliensis 25% 80%
A4HSZ7 Leishmania infantum 99% 100%
A4HT10 Leishmania infantum 31% 100%
C9ZTP4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 88%
C9ZTP5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 99%
E9AKY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E9AKZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
G4NFB7 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 28% 78%
O64394 Triticum aestivum 31% 100%
P00275 Corynebacterium nephridii 31% 100%
P07887 Corynebacterium nephridii 30% 100%
P08629 Gallus gallus 36% 100%
P11232 Rattus norvegicus 30% 100%
P23400 Chlamydomonas reinhardtii 34% 95%
P25372 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 100%
P29451 Macaca mulatta 31% 100%
P33791 Kitasatospora aureofaciens 29% 100%
P52228 Corynebacterium nephridii 29% 92%
Q10N04 Oryza sativa subsp. japonica 30% 90%
Q4QIV7 Leishmania major 31% 70%
Q4QIX1 Leishmania major 90% 100%
Q5JMR9 Oryza sativa subsp. japonica 36% 79%
Q7M1B9 Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) 31% 100%
Q8GYD1 Arabidopsis thaliana 27% 91%
Q8L7S9 Arabidopsis thaliana 33% 80%
Q8S091 Oryza sativa subsp. japonica 33% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS