Protein YIPF

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein YIPF

Gene product:

terbinafine resistance locus protein (yip1)

Species:

Leishmania major

UniProt:

Q86MW5_LEIMA

TriTrypDb:

LmjF.23.0240 , LMJLV39_230007600 , LMJSD75_230007900

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005802	trans-Golgi network	4	2
GO:0016020	membrane	2	11
GO:0031984	organelle subcompartment	2	2
GO:0098791	Golgi apparatus subcompartment	3	2
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	9

Expansion

Sequence features

Q86MW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q86MW5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	11
GO:0009987	cellular process	1	11
GO:0016192	vesicle-mediated transport	4	11
GO:0046907	intracellular transport	3	11
GO:0048193	Golgi vesicle transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.346
CLV_PCSK_SKI1_1	106	110	PF00082	0.347
CLV_PCSK_SKI1_1	166	170	PF00082	0.255
CLV_PCSK_SKI1_1	27	31	PF00082	0.363
DEG_MDM2_SWIB_1	86	94	PF02201	0.419
DEG_Nend_Nbox_1	1	3	PF02207	0.727
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.338
DOC_MAPK_DCC_7	166	176	PF00069	0.479
DOC_MAPK_gen_1	34	40	PF00069	0.545
DOC_PP1_RVXF_1	104	110	PF00149	0.506
LIG_14-3-3_CanoR_1	159	169	PF00244	0.537
LIG_BRCT_BRCA1_1	82	86	PF00533	0.322
LIG_deltaCOP1_diTrp_1	52	60	PF00928	0.465
LIG_FHA_1	180	186	PF00498	0.338
LIG_FHA_2	14	20	PF00498	0.588
LIG_LIR_Gen_1	112	121	PF02991	0.332
LIG_LIR_Gen_1	182	189	PF02991	0.338
LIG_LIR_Gen_1	83	94	PF02991	0.322
LIG_LIR_LC3C_4	167	171	PF02991	0.483
LIG_LIR_Nem_3	182	186	PF02991	0.342
LIG_LIR_Nem_3	54	59	PF02991	0.318
LIG_LIR_Nem_3	83	89	PF02991	0.322
LIG_NRBOX	124	130	PF00104	0.382
LIG_NRBOX	21	27	PF00104	0.647
LIG_PDZ_Class_2	184	189	PF00595	0.338
LIG_Pex14_1	56	60	PF04695	0.419
LIG_Pex14_2	177	181	PF04695	0.346
LIG_Pex14_2	82	86	PF04695	0.318
LIG_Pex3_1	125	136	PF04882	0.349
LIG_REV1ctd_RIR_1	155	163	PF16727	0.465
LIG_SH2_STAT5	113	116	PF00017	0.328
LIG_SH2_STAT5	118	121	PF00017	0.297
LIG_SH2_STAT5	178	181	PF00017	0.339
LIG_SH3_3	167	173	PF00018	0.465
LIG_SH3_3	36	42	PF00018	0.524
LIG_SUMO_SIM_anti_2	167	172	PF11976	0.537
LIG_TRFH_1	118	122	PF08558	0.343
MOD_CK1_1	13	19	PF00069	0.520
MOD_CK1_1	67	73	PF00069	0.385
MOD_CK2_1	13	19	PF00069	0.593
MOD_CMANNOS	149	152	PF00535	0.343
MOD_CMANNOS	53	56	PF00535	0.265
MOD_Cter_Amidation	32	35	PF01082	0.323
MOD_GlcNHglycan	162	165	PF01048	0.311
MOD_GlcNHglycan	82	85	PF01048	0.364
MOD_GSK3_1	67	74	PF00069	0.367
MOD_N-GLC_1	71	76	PF02516	0.429
MOD_NEK2_1	102	107	PF00069	0.440
MOD_NEK2_1	109	114	PF00069	0.417
MOD_NEK2_1	158	163	PF00069	0.506
MOD_NEK2_1	94	99	PF00069	0.367
MOD_PKA_2	158	164	PF00069	0.465
MOD_Plk_4	21	27	PF00069	0.571
MOD_Plk_4	64	70	PF00069	0.419
MOD_SUMO_rev_2	23	32	PF00179	0.542
TRG_ENDOCYTIC_2	113	116	PF00928	0.419
TRG_ENDOCYTIC_2	178	181	PF00928	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2J5	Leptomonas seymouri	76%	100%
A0A0S4JG02	Bodo saltans	53%	99%
A0A1X0NG82	Trypanosomatidae	62%	100%
A0A3Q8IBE6	Leishmania donovani	95%	86%
A0A3S7WXG4	Leishmania donovani	95%	100%
A0A422MU05	Trypanosoma rangeli	61%	100%
A4HCN9	Leishmania braziliensis	88%	100%
A4I064	Leishmania infantum	95%	100%
A6QLC6	Bos taurus	40%	80%
E9AW27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O64614	Arabidopsis thaliana	37%	67%
O94348	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	83%
Q28CH8	Xenopus tropicalis	40%	81%
Q4QQU5	Rattus norvegicus	40%	80%
Q54RZ2	Dictyostelium discoideum	43%	100%
Q5M7T4	Rattus norvegicus	27%	77%
Q5ZJD7	Gallus gallus	27%	76%
Q6IQ85	Danio rerio	41%	79%
Q6NYF1	Danio rerio	30%	80%
Q8BR70	Mus musculus	39%	80%
Q8C407	Mus musculus	27%	77%
Q93VH1	Arabidopsis thaliana	37%	68%
Q96EC8	Homo sapiens	40%	80%
Q9BSR8	Homo sapiens	27%	77%
Q9P6P8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	84%