Inhibitor of cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inhibitor of cysteine peptidase

Species:

Leishmania major

UniProt:

Q868G9_LEIMA

TriTrypDb:

LmjF.24.1770 , LMJLV39_240025300 , LMJSD75_240024600

Length:

117

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q868G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q868G9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002020	protease binding	4	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.551
CLV_MEL_PAP_1	18	24	PF00089	0.252
CLV_NRD_NRD_1	85	87	PF00675	0.491
CLV_PCSK_SKI1_1	48	52	PF00082	0.467
DEG_Nend_UBRbox_3	1	3	PF02207	0.506
DOC_MAPK_gen_1	86	94	PF00069	0.419
DOC_MAPK_HePTP_8	18	30	PF00069	0.405
DOC_MAPK_MEF2A_6	109	116	PF00069	0.360
DOC_MAPK_MEF2A_6	21	30	PF00069	0.405
DOC_MAPK_NFAT4_5	109	117	PF00069	0.408
DOC_PP1_RVXF_1	40	46	PF00149	0.291
DOC_PP4_FxxP_1	100	103	PF00568	0.252
DOC_PP4_FxxP_1	81	84	PF00568	0.252
DOC_USP7_MATH_1	74	78	PF00917	0.471
DOC_USP7_UBL2_3	12	16	PF12436	0.610
DOC_USP7_UBL2_3	61	65	PF12436	0.367
DOC_USP7_UBL2_3	83	87	PF12436	0.369
DOC_WW_Pin1_4	60	65	PF00397	0.454
LIG_14-3-3_CanoR_1	109	113	PF00244	0.426
LIG_14-3-3_CanoR_1	21	27	PF00244	0.252
LIG_APCC_ABBA_1	26	31	PF00400	0.252
LIG_FHA_1	109	115	PF00498	0.385
LIG_FHA_1	23	29	PF00498	0.398
LIG_FHA_1	4	10	PF00498	0.598
LIG_FHA_1	77	83	PF00498	0.353
LIG_FHA_2	8	14	PF00498	0.479
LIG_LIR_Apic_2	79	84	PF02991	0.493
LIG_LIR_Gen_1	39	46	PF02991	0.277
LIG_LIR_Gen_1	77	85	PF02991	0.369
LIG_LIR_Nem_3	39	43	PF02991	0.308
LIG_LIR_Nem_3	77	81	PF02991	0.426
LIG_SH2_CRK	96	100	PF00017	0.389
LIG_SH2_NCK_1	96	100	PF00017	0.337
LIG_SH2_STAP1	110	114	PF00017	0.408
LIG_SH2_STAP1	78	82	PF00017	0.419
LIG_SH2_STAT5	110	113	PF00017	0.474
LIG_SH2_STAT5	38	41	PF00017	0.350
LIG_SH2_STAT5	62	65	PF00017	0.401
LIG_SH2_STAT5	78	81	PF00017	0.408
LIG_SH3_4	83	90	PF00018	0.369
MOD_CDK_SPK_2	60	65	PF00069	0.252
MOD_CK1_1	60	66	PF00069	0.461
MOD_CK2_1	21	27	PF00069	0.369
MOD_GlcNHglycan	67	70	PF01048	0.443
MOD_GSK3_1	3	10	PF00069	0.532
MOD_GSK3_1	32	39	PF00069	0.305
MOD_GSK3_1	56	63	PF00069	0.387
MOD_N-GLC_2	15	17	PF02516	0.499
MOD_NEK2_1	56	61	PF00069	0.405
MOD_NEK2_2	76	81	PF00069	0.252
MOD_PK_1	16	22	PF00069	0.359
MOD_PKA_2	108	114	PF00069	0.429
MOD_Plk_2-3	49	55	PF00069	0.486
MOD_Plk_4	67	73	PF00069	0.443
MOD_Plk_4	76	82	PF00069	0.433
MOD_ProDKin_1	60	66	PF00069	0.454
TRG_ENDOCYTIC_2	78	81	PF00928	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR0	Leptomonas seymouri	45%	100%
A0A1X0NX79	Trypanosomatidae	35%	100%
A0A1X0NXG1	Trypanosomatidae	32%	90%
A0A3Q8IC64	Leishmania donovani	81%	100%
A0A3R7MAP9	Trypanosoma rangeli	39%	100%
A4HDN8	Leishmania braziliensis	58%	100%
C9ZWC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	97%
E9AH84	Leishmania infantum	81%	100%
E9AX22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q6KCA4	Entamoeba histolytica	33%	100%
Q966X9	Trypanosoma cruzi	39%	100%