LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase 3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase 3
Gene product:
phosphoglycan beta 1,3 galactosyltransferase 3
Species:
Leishmania major
UniProt:
Q7YXV2_LEIMA
TriTrypDb:
LmjF.02.0010 , LMJLV39_310043200 , LMJSD75_020006900
Length:
814

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 52
NetGPI no yes: 0, no: 52
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 15
GO:0016020 membrane 2 53
GO:0031090 organelle membrane 3 15
GO:0098588 bounding membrane of organelle 4 15
GO:0110165 cellular anatomical entity 1 53

Expansion

Sequence features

Q7YXV2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q7YXV2

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 53
GO:0006807 nitrogen compound metabolic process 2 53
GO:0008152 metabolic process 1 53
GO:0019538 protein metabolic process 3 53
GO:0036211 protein modification process 4 53
GO:0043170 macromolecule metabolic process 3 53
GO:0043412 macromolecule modification 4 53
GO:0043413 macromolecule glycosylation 3 53
GO:0044238 primary metabolic process 2 53
GO:0070085 glycosylation 2 53
GO:0071704 organic substance metabolic process 2 53
GO:1901564 organonitrogen compound metabolic process 3 53
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 53
GO:0008194 UDP-glycosyltransferase activity 4 15
GO:0016740 transferase activity 2 53
GO:0016757 glycosyltransferase activity 3 53
GO:0016758 hexosyltransferase activity 4 53

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 131 135 PF00656 0.378
CLV_NRD_NRD_1 107 109 PF00675 0.432
CLV_NRD_NRD_1 284 286 PF00675 0.593
CLV_NRD_NRD_1 490 492 PF00675 0.654
CLV_NRD_NRD_1 611 613 PF00675 0.566
CLV_NRD_NRD_1 682 684 PF00675 0.514
CLV_NRD_NRD_1 801 803 PF00675 0.550
CLV_PCSK_FUR_1 105 109 PF00082 0.382
CLV_PCSK_KEX2_1 107 109 PF00082 0.442
CLV_PCSK_KEX2_1 284 286 PF00082 0.584
CLV_PCSK_KEX2_1 611 613 PF00082 0.555
CLV_PCSK_KEX2_1 64 66 PF00082 0.476
CLV_PCSK_KEX2_1 674 676 PF00082 0.590
CLV_PCSK_KEX2_1 682 684 PF00082 0.534
CLV_PCSK_KEX2_1 730 732 PF00082 0.548
CLV_PCSK_KEX2_1 800 802 PF00082 0.552
CLV_PCSK_PC1ET2_1 64 66 PF00082 0.473
CLV_PCSK_PC1ET2_1 674 676 PF00082 0.537
CLV_PCSK_PC1ET2_1 730 732 PF00082 0.548
CLV_PCSK_PC7_1 796 802 PF00082 0.499
CLV_PCSK_SKI1_1 401 405 PF00082 0.586
CLV_PCSK_SKI1_1 480 484 PF00082 0.450
CLV_PCSK_SKI1_1 516 520 PF00082 0.593
CLV_PCSK_SKI1_1 563 567 PF00082 0.551
CLV_PCSK_SKI1_1 630 634 PF00082 0.518
CLV_Separin_Metazoa 269 273 PF03568 0.340
DEG_Kelch_Keap1_1 292 297 PF01344 0.408
DEG_Nend_UBRbox_3 1 3 PF02207 0.658
DEG_SCF_FBW7_1 452 459 PF00400 0.476
DEG_SPOP_SBC_1 438 442 PF00917 0.351
DOC_CKS1_1 453 458 PF01111 0.479
DOC_CYCLIN_RxL_1 477 486 PF00134 0.232
DOC_CYCLIN_yCln2_LP_2 249 255 PF00134 0.342
DOC_CYCLIN_yCln2_LP_2 450 456 PF00134 0.524
DOC_CYCLIN_yCln2_LP_2 632 638 PF00134 0.330
DOC_MAPK_DCC_7 14 24 PF00069 0.658
DOC_MAPK_DCC_7 572 581 PF00069 0.346
DOC_MAPK_gen_1 105 114 PF00069 0.537
DOC_MAPK_gen_1 298 307 PF00069 0.380
DOC_MAPK_gen_1 561 569 PF00069 0.294
DOC_MAPK_gen_1 639 647 PF00069 0.287
DOC_MAPK_HePTP_8 102 114 PF00069 0.551
DOC_MAPK_JIP1_4 298 304 PF00069 0.357
DOC_MAPK_JIP1_4 561 567 PF00069 0.303
DOC_MAPK_MEF2A_6 105 114 PF00069 0.572
DOC_MAPK_MEF2A_6 298 307 PF00069 0.324
DOC_MAPK_MEF2A_6 480 487 PF00069 0.433
DOC_MAPK_MEF2A_6 536 545 PF00069 0.302
DOC_MAPK_MEF2A_6 561 569 PF00069 0.311
DOC_MAPK_MEF2A_6 572 581 PF00069 0.333
DOC_MAPK_MEF2A_6 642 649 PF00069 0.301
DOC_MAPK_NFAT4_5 480 488 PF00069 0.334
DOC_MAPK_NFAT4_5 642 650 PF00069 0.293
DOC_PP1_RVXF_1 478 485 PF00149 0.322
DOC_PP1_RVXF_1 514 521 PF00149 0.436
DOC_PP1_RVXF_1 588 594 PF00149 0.306
DOC_PP1_RVXF_1 694 700 PF00149 0.308
DOC_PP2B_LxvP_1 450 453 PF13499 0.528
DOC_PP2B_LxvP_1 543 546 PF13499 0.311
DOC_USP7_MATH_1 222 226 PF00917 0.481
DOC_USP7_MATH_1 241 245 PF00917 0.498
DOC_USP7_MATH_1 256 260 PF00917 0.357
DOC_USP7_MATH_1 289 293 PF00917 0.464
DOC_USP7_MATH_1 37 41 PF00917 0.708
DOC_USP7_MATH_1 371 375 PF00917 0.397
DOC_USP7_MATH_1 438 442 PF00917 0.400
DOC_USP7_UBL2_3 720 724 PF12436 0.322
DOC_WW_Pin1_4 152 157 PF00397 0.471
DOC_WW_Pin1_4 418 423 PF00397 0.489
DOC_WW_Pin1_4 452 457 PF00397 0.450
DOC_WW_Pin1_4 690 695 PF00397 0.330
DOC_WW_Pin1_4 80 85 PF00397 0.629
LIG_14-3-3_CanoR_1 169 177 PF00244 0.435
LIG_14-3-3_CanoR_1 323 327 PF00244 0.466
LIG_14-3-3_CanoR_1 427 431 PF00244 0.405
LIG_14-3-3_CanoR_1 491 501 PF00244 0.337
LIG_14-3-3_CanoR_1 502 506 PF00244 0.313
LIG_14-3-3_CanoR_1 563 568 PF00244 0.374
LIG_14-3-3_CanoR_1 779 785 PF00244 0.347
LIG_Actin_WH2_2 538 555 PF00022 0.278
LIG_BRCT_BRCA1_1 153 157 PF00533 0.436
LIG_Clathr_ClatBox_1 482 486 PF01394 0.237
LIG_EH_1 618 622 PF12763 0.347
LIG_FHA_1 128 134 PF00498 0.450
LIG_FHA_1 14 20 PF00498 0.701
LIG_FHA_1 195 201 PF00498 0.542
LIG_FHA_1 259 265 PF00498 0.489
LIG_FHA_1 338 344 PF00498 0.351
LIG_FHA_1 426 432 PF00498 0.371
LIG_FHA_1 438 444 PF00498 0.422
LIG_FHA_1 564 570 PF00498 0.344
LIG_FHA_1 576 582 PF00498 0.381
LIG_FHA_2 129 135 PF00498 0.372
LIG_FHA_2 326 332 PF00498 0.410
LIG_FHA_2 370 376 PF00498 0.493
LIG_FHA_2 739 745 PF00498 0.309
LIG_FHA_2 781 787 PF00498 0.337
LIG_IBAR_NPY_1 634 636 PF08397 0.301
LIG_Integrin_RGD_1 775 777 PF01839 0.561
LIG_LIR_Apic_2 416 422 PF02991 0.348
LIG_LIR_Apic_2 504 508 PF02991 0.432
LIG_LIR_Gen_1 154 161 PF02991 0.513
LIG_LIR_Gen_1 206 217 PF02991 0.403
LIG_LIR_Gen_1 539 549 PF02991 0.357
LIG_LIR_Gen_1 641 649 PF02991 0.383
LIG_LIR_Gen_1 698 706 PF02991 0.352
LIG_LIR_Nem_3 154 160 PF02991 0.518
LIG_LIR_Nem_3 206 212 PF02991 0.405
LIG_LIR_Nem_3 325 329 PF02991 0.468
LIG_LIR_Nem_3 406 411 PF02991 0.367
LIG_LIR_Nem_3 517 523 PF02991 0.377
LIG_LIR_Nem_3 526 531 PF02991 0.405
LIG_LIR_Nem_3 539 545 PF02991 0.319
LIG_LIR_Nem_3 641 647 PF02991 0.405
LIG_LIR_Nem_3 698 702 PF02991 0.353
LIG_NRBOX 111 117 PF00104 0.308
LIG_NRBOX 627 633 PF00104 0.342
LIG_NRP_CendR_1 813 814 PF00754 0.576
LIG_PCNA_yPIPBox_3 625 639 PF02747 0.288
LIG_Pex14_2 769 773 PF04695 0.268
LIG_PTB_Apo_2 208 215 PF02174 0.411
LIG_PTB_Phospho_1 208 214 PF10480 0.410
LIG_RPA_C_Fungi 678 690 PF08784 0.301
LIG_SH2_NCK_1 376 380 PF00017 0.504
LIG_SH2_NCK_1 782 786 PF00017 0.402
LIG_SH2_STAP1 214 218 PF00017 0.545
LIG_SH2_STAP1 523 527 PF00017 0.559
LIG_SH2_STAP1 636 640 PF00017 0.419
LIG_SH2_STAP1 793 797 PF00017 0.444
LIG_SH2_STAT3 280 283 PF00017 0.425
LIG_SH2_STAT5 347 350 PF00017 0.517
LIG_SH2_STAT5 397 400 PF00017 0.425
LIG_SH2_STAT5 464 467 PF00017 0.376
LIG_SH2_STAT5 525 528 PF00017 0.414
LIG_SH2_STAT5 533 536 PF00017 0.383
LIG_SH2_STAT5 542 545 PF00017 0.396
LIG_SH2_STAT5 548 551 PF00017 0.391
LIG_SH2_STAT5 644 647 PF00017 0.430
LIG_SH2_STAT5 714 717 PF00017 0.541
LIG_SH2_STAT5 782 785 PF00017 0.456
LIG_SH3_3 302 308 PF00018 0.380
LIG_SH3_3 450 456 PF00018 0.614
LIG_SH3_3 526 532 PF00018 0.461
LIG_SH3_3 564 570 PF00018 0.444
LIG_SH3_3 571 577 PF00018 0.452
LIG_SH3_3 89 95 PF00018 0.445
LIG_SUMO_SIM_anti_2 140 146 PF11976 0.546
LIG_SUMO_SIM_anti_2 698 704 PF11976 0.279
LIG_SUMO_SIM_par_1 577 583 PF11976 0.364
LIG_TRAF2_1 741 744 PF00917 0.387
LIG_TYR_ITIM 327 332 PF00017 0.541
MOD_CDK_SPxK_1 690 696 PF00069 0.353
MOD_CDK_SPxxK_3 80 87 PF00069 0.474
MOD_CK1_1 155 161 PF00069 0.575
MOD_CK1_1 292 298 PF00069 0.549
MOD_CK1_1 356 362 PF00069 0.643
MOD_CK1_1 441 447 PF00069 0.429
MOD_CK1_1 514 520 PF00069 0.266
MOD_CK2_1 162 168 PF00069 0.518
MOD_CK2_1 291 297 PF00069 0.516
MOD_CK2_1 325 331 PF00069 0.489
MOD_CK2_1 369 375 PF00069 0.635
MOD_CK2_1 738 744 PF00069 0.412
MOD_CK2_1 780 786 PF00069 0.363
MOD_CMANNOS 275 278 PF00535 0.309
MOD_Cter_Amidation 62 65 PF01082 0.568
MOD_Cter_Amidation 811 814 PF01082 0.355
MOD_GlcNHglycan 164 167 PF01048 0.511
MOD_GlcNHglycan 179 182 PF01048 0.532
MOD_GlcNHglycan 215 218 PF01048 0.606
MOD_GlcNHglycan 243 246 PF01048 0.607
MOD_GlcNHglycan 35 38 PF01048 0.628
MOD_GlcNHglycan 39 42 PF01048 0.616
MOD_GlcNHglycan 446 449 PF01048 0.544
MOD_GlcNHglycan 468 471 PF01048 0.530
MOD_GlcNHglycan 60 63 PF01048 0.637
MOD_GlcNHglycan 708 711 PF01048 0.271
MOD_GlcNHglycan 810 813 PF01048 0.396
MOD_GSK3_1 151 158 PF00069 0.608
MOD_GSK3_1 177 184 PF00069 0.571
MOD_GSK3_1 222 229 PF00069 0.639
MOD_GSK3_1 235 242 PF00069 0.508
MOD_GSK3_1 287 294 PF00069 0.544
MOD_GSK3_1 33 40 PF00069 0.636
MOD_GSK3_1 353 360 PF00069 0.599
MOD_GSK3_1 425 432 PF00069 0.517
MOD_GSK3_1 437 444 PF00069 0.481
MOD_GSK3_1 448 455 PF00069 0.502
MOD_GSK3_1 53 60 PF00069 0.636
MOD_GSK3_1 66 73 PF00069 0.624
MOD_GSK3_1 753 760 PF00069 0.406
MOD_N-GLC_1 210 215 PF02516 0.511
MOD_N-GLC_1 226 231 PF02516 0.509
MOD_N-GLC_1 337 342 PF02516 0.396
MOD_N-GLC_1 563 568 PF02516 0.416
MOD_N-GLC_1 744 749 PF02516 0.444
MOD_NEK2_1 170 175 PF00069 0.591
MOD_NEK2_1 177 182 PF00069 0.502
MOD_NEK2_1 240 245 PF00069 0.552
MOD_NEK2_1 501 506 PF00069 0.450
MOD_NEK2_1 565 570 PF00069 0.425
MOD_NEK2_1 594 599 PF00069 0.342
MOD_NEK2_1 621 626 PF00069 0.421
MOD_NEK2_1 706 711 PF00069 0.275
MOD_NEK2_2 194 199 PF00069 0.697
MOD_PIKK_1 170 176 PF00454 0.504
MOD_PIKK_1 25 31 PF00454 0.565
MOD_PIKK_1 287 293 PF00454 0.553
MOD_PIKK_1 511 517 PF00454 0.552
MOD_PIKK_1 655 661 PF00454 0.282
MOD_PIKK_1 744 750 PF00454 0.420
MOD_PIKK_1 753 759 PF00454 0.383
MOD_PK_1 235 241 PF00069 0.482
MOD_PKA_1 491 497 PF00069 0.594
MOD_PKA_2 13 19 PF00069 0.619
MOD_PKA_2 168 174 PF00069 0.523
MOD_PKA_2 223 229 PF00069 0.631
MOD_PKA_2 292 298 PF00069 0.559
MOD_PKA_2 322 328 PF00069 0.575
MOD_PKA_2 33 39 PF00069 0.509
MOD_PKA_2 426 432 PF00069 0.503
MOD_PKA_2 501 507 PF00069 0.440
MOD_PKA_2 57 63 PF00069 0.587
MOD_Plk_1 203 209 PF00069 0.516
MOD_Plk_1 210 216 PF00069 0.481
MOD_Plk_1 563 569 PF00069 0.340
MOD_Plk_2-3 353 359 PF00069 0.503
MOD_Plk_2-3 738 744 PF00069 0.344
MOD_Plk_4 235 241 PF00069 0.511
MOD_Plk_4 322 328 PF00069 0.492
MOD_Plk_4 426 432 PF00069 0.450
MOD_Plk_4 514 520 PF00069 0.280
MOD_Plk_4 695 701 PF00069 0.474
MOD_Plk_4 758 764 PF00069 0.377
MOD_ProDKin_1 152 158 PF00069 0.576
MOD_ProDKin_1 418 424 PF00069 0.609
MOD_ProDKin_1 452 458 PF00069 0.545
MOD_ProDKin_1 690 696 PF00069 0.377
MOD_ProDKin_1 80 86 PF00069 0.524
MOD_SUMO_rev_2 486 494 PF00179 0.406
MOD_SUMO_rev_2 646 656 PF00179 0.310
MOD_SUMO_rev_2 722 732 PF00179 0.342
TRG_DiLeu_BaEn_1 728 733 PF01217 0.362
TRG_DiLeu_BaLyEn_6 609 614 PF01217 0.409
TRG_DiLeu_LyEn_5 728 733 PF01217 0.359
TRG_ENDOCYTIC_2 329 332 PF00928 0.583
TRG_ENDOCYTIC_2 525 528 PF00928 0.575
TRG_ENDOCYTIC_2 542 545 PF00928 0.267
TRG_ENDOCYTIC_2 644 647 PF00928 0.491
TRG_ER_diArg_1 105 108 PF00400 0.540
TRG_ER_diArg_1 284 286 PF00400 0.460
TRG_ER_diArg_1 611 613 PF00400 0.407
TRG_ER_diArg_1 682 684 PF00400 0.361
TRG_ER_diArg_1 799 802 PF00400 0.406
TRG_NLS_MonoExtN_4 672 677 PF00514 0.332
TRG_Pf-PMV_PEXEL_1 199 203 PF00026 0.494
TRG_Pf-PMV_PEXEL_1 611 615 PF00026 0.449
TRG_Pf-PMV_PEXEL_1 731 735 PF00026 0.377

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 82% 100%
A0A3S5H4Y6 Leishmania donovani 38% 100%
A0A3S5H4Y9 Leishmania donovani 31% 82%
A0A3S7WT86 Leishmania donovani 36% 79%
A0A3S7WWA6 Leishmania donovani 82% 100%
A0A451EJD9 Leishmania donovani 73% 100%
A0A451EJF4 Leishmania donovani 41% 100%
A0A451EJF6 Leishmania donovani 40% 100%
A0A451EJF8 Leishmania donovani 38% 100%
A0A451EJF9 Leishmania donovani 39% 94%
A4H3A9 Leishmania braziliensis 41% 100%
A4H3B4 Leishmania braziliensis 41% 100%
A4H3B6 Leishmania braziliensis 38% 100%
A4H3B8 Leishmania braziliensis 41% 98%
A4H3B9 Leishmania braziliensis 33% 91%
A4H4W8 Leishmania braziliensis 62% 100%
A4HJ20 Leishmania braziliensis 39% 100%
A4HNK3 Leishmania braziliensis 71% 100%
A4HNK6 Leishmania braziliensis 62% 100%
A4HRL9 Leishmania infantum 41% 100%
A4HRM0 Leishmania infantum 40% 100%
A4HRM1 Leishmania infantum 40% 100%
A4HRS1 Leishmania infantum 39% 94%
A4HRS3 Leishmania infantum 30% 82%
A4HRS5 Leishmania infantum 38% 100%
A4HZM0 Leishmania infantum 73% 100%
A4I7C7 Leishmania infantum 74% 100%
A4IAQ2 Leishmania infantum 71% 100%
E9AC91 Leishmania major 42% 100%
E9AC92 Leishmania major 43% 100%
E9AC94 Leishmania major 31% 69%
E9AC95 Leishmania major 39% 100%
E9AC96 Leishmania major 42% 100%
E9AC98 Leishmania major 32% 100%
E9AEH8 Leishmania major 79% 100%
E9AHA6 Leishmania infantum 72% 100%
E9AIP8 Leishmania braziliensis 63% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 82%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4Q5T6 Leishmania major 82% 100%
Q4QCL8 Leishmania major 93% 100%
Q4QFJ3 Leishmania major 36% 100%
Q4QIG9 Leishmania major 94% 100%
Q7YXU9 Leishmania major 92% 100%
Q7YXV1 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS