LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase 4

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase 4
Gene product:
phosphoglycan beta 1,3 galactosyltransferase 4
Species:
Leishmania major
UniProt:
Q7YXV1_LEIMA
TriTrypDb:
LmjF.36.0010 , LMJLV39_310043200 , LMJSD75_020006900
Length:
846

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 52
NetGPI no yes: 0, no: 52
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 15
GO:0016020 membrane 2 53
GO:0031090 organelle membrane 3 15
GO:0098588 bounding membrane of organelle 4 15
GO:0110165 cellular anatomical entity 1 53

Expansion

Sequence features

Q7YXV1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q7YXV1

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 53
GO:0006807 nitrogen compound metabolic process 2 53
GO:0008152 metabolic process 1 53
GO:0019538 protein metabolic process 3 53
GO:0036211 protein modification process 4 53
GO:0043170 macromolecule metabolic process 3 53
GO:0043412 macromolecule modification 4 53
GO:0043413 macromolecule glycosylation 3 53
GO:0044238 primary metabolic process 2 53
GO:0070085 glycosylation 2 53
GO:0071704 organic substance metabolic process 2 53
GO:1901564 organonitrogen compound metabolic process 3 53
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 53
GO:0008194 UDP-glycosyltransferase activity 4 15
GO:0016740 transferase activity 2 53
GO:0016757 glycosyltransferase activity 3 53
GO:0016758 hexosyltransferase activity 4 53

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 125 127 PF00675 0.455
CLV_NRD_NRD_1 139 141 PF00675 0.433
CLV_NRD_NRD_1 316 318 PF00675 0.590
CLV_NRD_NRD_1 432 434 PF00675 0.666
CLV_NRD_NRD_1 522 524 PF00675 0.657
CLV_NRD_NRD_1 643 645 PF00675 0.556
CLV_NRD_NRD_1 714 716 PF00675 0.515
CLV_NRD_NRD_1 833 835 PF00675 0.555
CLV_PCSK_FUR_1 137 141 PF00082 0.385
CLV_PCSK_KEX2_1 125 127 PF00082 0.455
CLV_PCSK_KEX2_1 139 141 PF00082 0.443
CLV_PCSK_KEX2_1 316 318 PF00082 0.581
CLV_PCSK_KEX2_1 432 434 PF00082 0.664
CLV_PCSK_KEX2_1 643 645 PF00082 0.546
CLV_PCSK_KEX2_1 706 708 PF00082 0.586
CLV_PCSK_KEX2_1 714 716 PF00082 0.535
CLV_PCSK_KEX2_1 762 764 PF00082 0.550
CLV_PCSK_KEX2_1 832 834 PF00082 0.556
CLV_PCSK_KEX2_1 96 98 PF00082 0.476
CLV_PCSK_PC1ET2_1 706 708 PF00082 0.533
CLV_PCSK_PC1ET2_1 762 764 PF00082 0.550
CLV_PCSK_PC1ET2_1 96 98 PF00082 0.473
CLV_PCSK_PC7_1 828 834 PF00082 0.504
CLV_PCSK_SKI1_1 433 437 PF00082 0.590
CLV_PCSK_SKI1_1 548 552 PF00082 0.575
CLV_PCSK_SKI1_1 595 599 PF00082 0.553
CLV_PCSK_SKI1_1 662 666 PF00082 0.507
CLV_PCSK_SKI1_1 725 729 PF00082 0.498
CLV_Separin_Metazoa 301 305 PF03568 0.336
DEG_Kelch_Keap1_1 324 329 PF01344 0.409
DEG_Nend_UBRbox_3 1 3 PF02207 0.597
DEG_SCF_FBW7_1 17 23 PF00400 0.626
DEG_SCF_FBW7_1 484 491 PF00400 0.453
DEG_SPOP_SBC_1 470 474 PF00917 0.331
DOC_CKS1_1 17 22 PF01111 0.624
DOC_CKS1_1 485 490 PF01111 0.456
DOC_CYCLIN_yCln2_LP_2 281 287 PF00134 0.329
DOC_CYCLIN_yCln2_LP_2 482 488 PF00134 0.501
DOC_CYCLIN_yCln2_LP_2 56 59 PF00134 0.643
DOC_CYCLIN_yCln2_LP_2 664 670 PF00134 0.323
DOC_MAPK_DCC_7 46 56 PF00069 0.660
DOC_MAPK_DCC_7 604 613 PF00069 0.348
DOC_MAPK_gen_1 137 146 PF00069 0.537
DOC_MAPK_gen_1 330 339 PF00069 0.380
DOC_MAPK_gen_1 528 535 PF00069 0.356
DOC_MAPK_gen_1 593 601 PF00069 0.295
DOC_MAPK_gen_1 671 679 PF00069 0.277
DOC_MAPK_gen_1 725 734 PF00069 0.271
DOC_MAPK_JIP1_4 330 336 PF00069 0.357
DOC_MAPK_JIP1_4 593 599 PF00069 0.303
DOC_MAPK_MEF2A_6 139 148 PF00069 0.572
DOC_MAPK_MEF2A_6 330 339 PF00069 0.324
DOC_MAPK_MEF2A_6 512 519 PF00069 0.432
DOC_MAPK_MEF2A_6 568 577 PF00069 0.285
DOC_MAPK_MEF2A_6 593 601 PF00069 0.312
DOC_MAPK_MEF2A_6 604 613 PF00069 0.335
DOC_MAPK_MEF2A_6 674 681 PF00069 0.288
DOC_MAPK_NFAT4_5 332 340 PF00069 0.274
DOC_MAPK_NFAT4_5 512 520 PF00069 0.333
DOC_MAPK_NFAT4_5 674 682 PF00069 0.279
DOC_PP1_RVXF_1 546 553 PF00149 0.419
DOC_PP1_RVXF_1 620 626 PF00149 0.311
DOC_PP1_RVXF_1 726 732 PF00149 0.310
DOC_PP2B_LxvP_1 337 340 PF13499 0.270
DOC_PP2B_LxvP_1 482 485 PF13499 0.503
DOC_PP2B_LxvP_1 56 59 PF13499 0.643
DOC_PP2B_LxvP_1 575 578 PF13499 0.297
DOC_PP4_FxxP_1 738 741 PF00568 0.259
DOC_USP7_MATH_1 124 128 PF00917 0.647
DOC_USP7_MATH_1 254 258 PF00917 0.464
DOC_USP7_MATH_1 273 277 PF00917 0.484
DOC_USP7_MATH_1 288 292 PF00917 0.343
DOC_USP7_MATH_1 321 325 PF00917 0.462
DOC_USP7_MATH_1 403 407 PF00917 0.353
DOC_USP7_MATH_1 470 474 PF00917 0.381
DOC_USP7_MATH_1 69 73 PF00917 0.706
DOC_USP7_UBL2_3 524 528 PF12436 0.355
DOC_USP7_UBL2_3 752 756 PF12436 0.321
DOC_WW_Pin1_4 112 117 PF00397 0.643
DOC_WW_Pin1_4 16 21 PF00397 0.620
DOC_WW_Pin1_4 184 189 PF00397 0.446
DOC_WW_Pin1_4 450 455 PF00397 0.490
DOC_WW_Pin1_4 484 489 PF00397 0.428
LIG_14-3-3_CanoR_1 125 132 PF00244 0.660
LIG_14-3-3_CanoR_1 201 209 PF00244 0.382
LIG_14-3-3_CanoR_1 355 359 PF00244 0.465
LIG_14-3-3_CanoR_1 459 463 PF00244 0.403
LIG_14-3-3_CanoR_1 512 516 PF00244 0.311
LIG_14-3-3_CanoR_1 595 600 PF00244 0.376
LIG_14-3-3_CanoR_1 622 628 PF00244 0.274
LIG_Actin_WH2_2 570 587 PF00022 0.257
LIG_BRCT_BRCA1_1 185 189 PF00533 0.407
LIG_EH_1 650 654 PF12763 0.326
LIG_FHA_1 160 166 PF00498 0.457
LIG_FHA_1 21 27 PF00498 0.632
LIG_FHA_1 227 233 PF00498 0.481
LIG_FHA_1 291 297 PF00498 0.479
LIG_FHA_1 370 376 PF00498 0.352
LIG_FHA_1 458 464 PF00498 0.369
LIG_FHA_1 46 52 PF00498 0.701
LIG_FHA_1 470 476 PF00498 0.401
LIG_FHA_1 596 602 PF00498 0.348
LIG_FHA_1 608 614 PF00498 0.381
LIG_FHA_1 97 103 PF00498 0.669
LIG_FHA_2 358 364 PF00498 0.410
LIG_FHA_2 402 408 PF00498 0.453
LIG_FHA_2 771 777 PF00498 0.310
LIG_FHA_2 813 819 PF00498 0.340
LIG_IBAR_NPY_1 666 668 PF08397 0.295
LIG_Integrin_RGD_1 807 809 PF01839 0.559
LIG_LIR_Apic_2 448 454 PF02991 0.348
LIG_LIR_Apic_2 534 540 PF02991 0.450
LIG_LIR_Gen_1 186 193 PF02991 0.464
LIG_LIR_Gen_1 238 249 PF02991 0.365
LIG_LIR_Gen_1 514 520 PF02991 0.369
LIG_LIR_Gen_1 571 581 PF02991 0.340
LIG_LIR_Gen_1 654 664 PF02991 0.280
LIG_LIR_Gen_1 673 683 PF02991 0.372
LIG_LIR_Gen_1 730 738 PF02991 0.354
LIG_LIR_Nem_3 186 192 PF02991 0.470
LIG_LIR_Nem_3 238 244 PF02991 0.364
LIG_LIR_Nem_3 357 361 PF02991 0.467
LIG_LIR_Nem_3 438 443 PF02991 0.371
LIG_LIR_Nem_3 514 519 PF02991 0.330
LIG_LIR_Nem_3 549 555 PF02991 0.357
LIG_LIR_Nem_3 558 563 PF02991 0.371
LIG_LIR_Nem_3 571 577 PF02991 0.303
LIG_LIR_Nem_3 654 659 PF02991 0.295
LIG_LIR_Nem_3 673 679 PF02991 0.395
LIG_LIR_Nem_3 730 734 PF02991 0.356
LIG_NRBOX 143 149 PF00104 0.308
LIG_NRBOX 659 665 PF00104 0.330
LIG_NRP_CendR_1 845 846 PF00754 0.581
LIG_PCNA_yPIPBox_3 657 671 PF02747 0.278
LIG_Pex14_2 801 805 PF04695 0.274
LIG_PTB_Apo_2 240 247 PF02174 0.372
LIG_PTB_Phospho_1 240 246 PF10480 0.368
LIG_RPA_C_Fungi 710 722 PF08784 0.304
LIG_SH2_NCK_1 408 412 PF00017 0.468
LIG_SH2_NCK_1 814 818 PF00017 0.410
LIG_SH2_STAP1 246 250 PF00017 0.500
LIG_SH2_STAP1 555 559 PF00017 0.513
LIG_SH2_STAP1 627 631 PF00017 0.361
LIG_SH2_STAP1 668 672 PF00017 0.415
LIG_SH2_STAP1 825 829 PF00017 0.449
LIG_SH2_STAT3 312 315 PF00017 0.414
LIG_SH2_STAT5 30 33 PF00017 0.534
LIG_SH2_STAT5 379 382 PF00017 0.515
LIG_SH2_STAT5 429 432 PF00017 0.418
LIG_SH2_STAT5 496 499 PF00017 0.370
LIG_SH2_STAT5 557 560 PF00017 0.364
LIG_SH2_STAT5 565 568 PF00017 0.366
LIG_SH2_STAT5 574 577 PF00017 0.377
LIG_SH2_STAT5 580 583 PF00017 0.366
LIG_SH2_STAT5 639 642 PF00017 0.298
LIG_SH2_STAT5 676 679 PF00017 0.410
LIG_SH2_STAT5 746 749 PF00017 0.540
LIG_SH2_STAT5 814 817 PF00017 0.460
LIG_SH3_3 482 488 PF00018 0.581
LIG_SH3_3 558 564 PF00018 0.415
LIG_SH3_3 596 602 PF00018 0.449
LIG_SH3_3 603 609 PF00018 0.457
LIG_SH3_3 738 744 PF00018 0.335
LIG_SH3_4 524 531 PF00018 0.416
LIG_SUMO_SIM_anti_2 171 178 PF11976 0.534
LIG_SUMO_SIM_anti_2 730 736 PF11976 0.283
LIG_SUMO_SIM_par_1 609 615 PF11976 0.364
LIG_TRAF2_1 773 776 PF00917 0.390
LIG_TYR_ITIM 359 364 PF00017 0.542
MOD_CDK_SPxxK_3 20 27 PF00069 0.520
MOD_CK1_1 159 165 PF00069 0.512
MOD_CK1_1 187 193 PF00069 0.500
MOD_CK1_1 324 330 PF00069 0.550
MOD_CK1_1 388 394 PF00069 0.641
MOD_CK1_1 546 552 PF00069 0.241
MOD_CK1_1 98 104 PF00069 0.611
MOD_CK2_1 168 174 PF00069 0.553
MOD_CK2_1 323 329 PF00069 0.518
MOD_CK2_1 357 363 PF00069 0.490
MOD_CK2_1 401 407 PF00069 0.581
MOD_CK2_1 65 71 PF00069 0.577
MOD_CK2_1 770 776 PF00069 0.415
MOD_CK2_1 812 818 PF00069 0.368
MOD_CMANNOS 307 310 PF00535 0.299
MOD_Cter_Amidation 843 846 PF01082 0.360
MOD_Cter_Amidation 94 97 PF01082 0.577
MOD_GlcNHglycan 126 129 PF01048 0.544
MOD_GlcNHglycan 20 23 PF01048 0.548
MOD_GlcNHglycan 211 214 PF01048 0.495
MOD_GlcNHglycan 247 250 PF01048 0.565
MOD_GlcNHglycan 275 278 PF01048 0.595
MOD_GlcNHglycan 393 396 PF01048 0.498
MOD_GlcNHglycan 478 481 PF01048 0.517
MOD_GlcNHglycan 500 503 PF01048 0.531
MOD_GlcNHglycan 67 70 PF01048 0.632
MOD_GlcNHglycan 71 74 PF01048 0.614
MOD_GlcNHglycan 842 845 PF01048 0.400
MOD_GlcNHglycan 92 95 PF01048 0.646
MOD_GSK3_1 156 163 PF00069 0.463
MOD_GSK3_1 16 23 PF00069 0.512
MOD_GSK3_1 183 190 PF00069 0.569
MOD_GSK3_1 209 216 PF00069 0.510
MOD_GSK3_1 254 261 PF00069 0.618
MOD_GSK3_1 267 274 PF00069 0.499
MOD_GSK3_1 319 326 PF00069 0.542
MOD_GSK3_1 385 392 PF00069 0.596
MOD_GSK3_1 457 464 PF00069 0.515
MOD_GSK3_1 476 483 PF00069 0.495
MOD_GSK3_1 484 491 PF00069 0.405
MOD_GSK3_1 65 72 PF00069 0.638
MOD_GSK3_1 785 792 PF00069 0.403
MOD_GSK3_1 85 92 PF00069 0.638
MOD_GSK3_1 98 105 PF00069 0.622
MOD_N-GLC_1 242 247 PF02516 0.461
MOD_N-GLC_1 258 263 PF02516 0.502
MOD_N-GLC_1 369 374 PF02516 0.396
MOD_N-GLC_1 595 600 PF02516 0.419
MOD_N-GLC_1 776 781 PF02516 0.444
MOD_N-GLC_2 119 121 PF02516 0.529
MOD_NEK2_1 117 122 PF00069 0.561
MOD_NEK2_1 209 214 PF00069 0.449
MOD_NEK2_1 272 277 PF00069 0.530
MOD_NEK2_1 531 536 PF00069 0.473
MOD_NEK2_1 597 602 PF00069 0.430
MOD_NEK2_1 797 802 PF00069 0.358
MOD_NEK2_2 226 231 PF00069 0.601
MOD_PIKK_1 156 162 PF00454 0.448
MOD_PIKK_1 319 325 PF00454 0.552
MOD_PIKK_1 543 549 PF00454 0.523
MOD_PIKK_1 57 63 PF00454 0.575
MOD_PIKK_1 776 782 PF00454 0.421
MOD_PIKK_1 785 791 PF00454 0.379
MOD_PK_1 267 273 PF00069 0.478
MOD_PKA_1 523 529 PF00069 0.593
MOD_PKA_1 96 102 PF00069 0.556
MOD_PKA_2 124 130 PF00069 0.532
MOD_PKA_2 200 206 PF00069 0.442
MOD_PKA_2 255 261 PF00069 0.611
MOD_PKA_2 324 330 PF00069 0.560
MOD_PKA_2 354 360 PF00069 0.574
MOD_PKA_2 45 51 PF00069 0.616
MOD_PKA_2 458 464 PF00069 0.501
MOD_PKA_2 511 517 PF00069 0.437
MOD_PKA_2 89 95 PF00069 0.596
MOD_PKA_2 96 102 PF00069 0.561
MOD_Plk_1 235 241 PF00069 0.461
MOD_Plk_1 242 248 PF00069 0.433
MOD_Plk_1 595 601 PF00069 0.343
MOD_Plk_2-3 385 391 PF00069 0.501
MOD_Plk_2-3 770 776 PF00069 0.347
MOD_Plk_4 267 273 PF00069 0.507
MOD_Plk_4 28 34 PF00069 0.524
MOD_Plk_4 354 360 PF00069 0.491
MOD_Plk_4 458 464 PF00069 0.448
MOD_Plk_4 511 517 PF00069 0.371
MOD_Plk_4 546 552 PF00069 0.255
MOD_Plk_4 727 733 PF00069 0.478
MOD_Plk_4 790 796 PF00069 0.372
MOD_ProDKin_1 112 118 PF00069 0.543
MOD_ProDKin_1 16 22 PF00069 0.510
MOD_ProDKin_1 184 190 PF00069 0.532
MOD_ProDKin_1 450 456 PF00069 0.612
MOD_ProDKin_1 484 490 PF00069 0.514
MOD_SUMO_rev_2 518 526 PF00179 0.406
MOD_SUMO_rev_2 754 764 PF00179 0.343
TRG_DiLeu_BaEn_1 760 765 PF01217 0.365
TRG_DiLeu_BaLyEn_6 641 646 PF01217 0.398
TRG_DiLeu_LyEn_5 760 765 PF01217 0.363
TRG_ENDOCYTIC_2 30 33 PF00928 0.550
TRG_ENDOCYTIC_2 361 364 PF00928 0.585
TRG_ENDOCYTIC_2 557 560 PF00928 0.525
TRG_ENDOCYTIC_2 574 577 PF00928 0.248
TRG_ENDOCYTIC_2 676 679 PF00928 0.471
TRG_ENDOCYTIC_2 683 686 PF00928 0.406
TRG_ER_diArg_1 124 126 PF00400 0.559
TRG_ER_diArg_1 137 140 PF00400 0.545
TRG_ER_diArg_1 316 318 PF00400 0.455
TRG_ER_diArg_1 432 434 PF00400 0.563
TRG_ER_diArg_1 643 645 PF00400 0.394
TRG_ER_diArg_1 714 716 PF00400 0.362
TRG_ER_diArg_1 831 834 PF00400 0.415
TRG_NLS_MonoExtN_4 525 532 PF00514 0.439
TRG_NLS_MonoExtN_4 704 709 PF00514 0.325
TRG_Pf-PMV_PEXEL_1 231 235 PF00026 0.443
TRG_Pf-PMV_PEXEL_1 643 647 PF00026 0.435
TRG_Pf-PMV_PEXEL_1 763 767 PF00026 0.380

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 83% 100%
A0A3S5H4Y6 Leishmania donovani 40% 100%
A0A3S5H4Y9 Leishmania donovani 33% 85%
A0A3S7WT86 Leishmania donovani 36% 82%
A0A3S7WWA6 Leishmania donovani 83% 100%
A0A451EJD9 Leishmania donovani 74% 100%
A0A451EJF4 Leishmania donovani 41% 100%
A0A451EJF6 Leishmania donovani 40% 100%
A0A451EJF8 Leishmania donovani 37% 100%
A0A451EJF9 Leishmania donovani 40% 98%
A4H3A9 Leishmania braziliensis 42% 100%
A4H3B4 Leishmania braziliensis 41% 100%
A4H3B6 Leishmania braziliensis 39% 100%
A4H3B8 Leishmania braziliensis 40% 100%
A4H3B9 Leishmania braziliensis 33% 95%
A4H4W8 Leishmania braziliensis 63% 100%
A4HJ20 Leishmania braziliensis 39% 100%
A4HNK3 Leishmania braziliensis 71% 100%
A4HNK6 Leishmania braziliensis 62% 100%
A4HRL9 Leishmania infantum 42% 100%
A4HRM0 Leishmania infantum 38% 100%
A4HRM1 Leishmania infantum 40% 100%
A4HRS1 Leishmania infantum 40% 98%
A4HRS3 Leishmania infantum 32% 85%
A4HRS5 Leishmania infantum 37% 100%
A4HZM0 Leishmania infantum 74% 100%
A4I7C7 Leishmania infantum 75% 100%
A4IAQ2 Leishmania infantum 72% 100%
E9AC91 Leishmania major 43% 100%
E9AC92 Leishmania major 43% 100%
E9AC94 Leishmania major 32% 72%
E9AC95 Leishmania major 38% 100%
E9AC96 Leishmania major 41% 100%
E9AC98 Leishmania major 33% 100%
E9AEH8 Leishmania major 81% 100%
E9AHA6 Leishmania infantum 74% 100%
E9AIP8 Leishmania braziliensis 64% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 86%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
Q4Q5T6 Leishmania major 84% 100%
Q4QCL8 Leishmania major 95% 100%
Q4QFJ3 Leishmania major 37% 82%
Q4QIG9 Leishmania major 96% 100%
Q7YXU9 Leishmania major 94% 100%
Q7YXV2 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS